36 results about "Chronic alcoholism" patented technology

The invention belongs to the technical field of medicine, and relates to a Chinese medicinal composition, in particular to a Chinese medicinal composition for treating chronic alcoholic toxic liver disease and a preparation method thereof. Aiming at the current technological defects that the chronic alcoholic toxic liver disease cannot be treated comprehensively and effectively and chemical treatment has the defects of high relapse rate and discontinuous curative effect, the Chinese medicinal composition for treating or preventing the chronic alcoholic liver toxic disease comprises the following components in parts by weight: 10 parts of corydalis tuber, 15 parts of fourstamen stephania root, 6 parts of virgate wormwood herb, 10 parts of glossy privet fruit, 10 parts of Szechuan lovage rhizome, 6 parts of Chinese angelica, 20 parts of sophora flower, 20 parts of tribulus terrestris, 10 parts of Chinese thorowax root, 12 parts of baikal skullcap root, 15 parts of baikal skullcap root, 30 parts of cassia twig, 6 parts of Indian buead and 10 parts of liquoric root. The Chinese medicinal composition has a very good treatment effect on the chronic alcoholic toxic liver disease, and has a remarkable clinical popularization value.

The invention relates to a butylphenyl phthaleine, a medical salt thereof or an application of a medical compound which contains any one of the butylphenyl phthaleine and the medical salt thereof in preparing a medicament for preventing or treating chronic alcoholism. The medicament or medical compound is characterized by being efficient, harmless and free from addiction in the application of preventing or treating the chronic alcoholism.

The invention discloses the application of total triterpenoids of Pteridocarpus to protect chronic alcoholic liver injury, and belongs to the technical field of biomedicine. A dose-escalating drinking method was used to simulate the process of chronic alcohol-induced liver injury in humans. The total triterpenoids of Pteridocarpus can inhibit GOT and GPT to a certain extent, and the inhibitory effect is positively correlated with the dose. The purified total triterpenoids of Viburnum fern have strong antioxidant capacity in vivo, and its hepatoprotective mechanism may be to effectively alleviate the damage caused by alcohol to the liver by enhancing the body's antioxidant capacity and effectively removing unfavorable free radicals. Medium and high doses of purified total triterpenoids of Viburnum fern can effectively alleviate the oxidative damage caused by lipid peroxidation and free radical attack in the liver, reduce the degree of hepatocyte enlargement, necrosis and fatty degeneration, and regulate cells to restore normal metabolism and Physiological function, its effect is better than that of the positive control drug bifendate within a certain concentration range, indicating that the total triterpenoids of Pteridocarpus have a certain protective effect on chronic alcoholic liver injury.

The invention discloses a one-step synthesis method of medicinal metadoxine. The method comprises the steps that vitamin B6 is adopted as a starting raw material and directly reacts with L-pyroglutamic acid after alkali dissociation to obtain metadoxine through one-step synthesis. The proper solvent, the reaction raw material ratio and the proper reaction temperature are adopted, the medicinal metadoxine with the stable crystal form, the good flowability and high purity can be produced industrially without recrystallization or purification, the preparation steps are simplified, operation is easy, the solvent usage amount is decreased, and the production cost is saved. The medicinal metadoxine can be used for treating acute and chronic alcoholism and alcoholic liver diseases.

The invention provides an application of 5-methyltetrahydrofolate and a composition containing the 5-methyltetrahydrofolate. The 5-methyltetrahydrofolate or the composition containing the same is usedfor treating, relieving or preventing various diseases or symptoms caused by acute alcoholism and chronic alcoholism. The injuries or the diseases caused by the acute alcoholism include headache caused by alcohol drinking, negative emotion or depression caused by alcohol drinking, and the hangover symptom after alcohol drinking. The injuries or the diseases caused by the chronic alcoholism include alcoholic fatty liver, central nervous system (CNS) inflammation and the like.