Levo-potasisum magnesium asparate infusion injection and preparing method

A potassium-magnesium aspartate infusion needle, technology of potassium-magnesium aspartate, applied in the direction of blood diseases, extracellular fluid diseases, drug combination, etc., can solve the problem of narrow application range, inconvenient use, low concentration of drug solution, etc. problems, to achieve the effect of good stability, easy operation and large dose

Inactive Publication Date: 2002-06-05
于航
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage form of clinical application is water injection, which is likely to cause secondary pollution during clinical use. At the same time, the concentration of the liquid medicine is too low, which is extremely inconvenient to use clinically, and the application range is narrow.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] (1) Preparation prescription:

[0016] L-Aspartic Acid 3400g

[0017] Potassium hydroxide 65.4g

[0018] Magnesium oxide 27.8g

[0019] Mannitol 50000.0g

[0020] Appropriate amount of sodium hydroxide

[0021] Water for injection 250000ml

[0022] Prepare 1000 bottles

[0023] (2) Preparation process: get prescription quantity L-aspartic acid, potassium hydroxide, magnesium oxide and add water for injection 15000ml, stir, and add 40% sodium hydroxide solution to adjust pH5-11.5, make all dissolve; Mannitol adds injection 20000ml of water, stir to dissolve; mix the two liquids and add 0.1% activated carbon for needles, stir at room temperature for 20min, filter to remove carbon, then pass through a microporous membrane to sterilize, add sterile water for injection to 250000ml, after measuring the content, Fill it into a 250ml hard glass infusion bottle and sterilize it to ge...

Embodiment 2

[0025] (1) Preparation prescription:

[0026] Potassium L-Aspartate 3000g

[0027] Magnesium L-Aspartate 3000g

[0028] Glucose 25000.0g

[0029] Disodium hydrogen phosphate appropriate amount

[0030] Water for injection 250000ml

[0031] Prepare 1000 bottles

[0032] (2) Preparation process: with embodiment 1.

Embodiment 3

[0034] (1) Preparation prescription:

[0035] L-Aspartic Acid 8500g

[0036] Potassium carbonate 288.8g

[0037] Magnesium oxide 69.6g

[0038] Dextran-40 15000.0g

[0039] Proper amount of isopropanolamine

[0040] Water for injection 250000ml

[0041] Prepare 1000 sticks

[0042] (2) Preparation process: with embodiment 1.

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PUM

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Abstract

A leveo-potassium magnesium aspartate infusion injection consists of levo-potassium aspartate, levo-magnesium asparatate, osmotic pressure regulator and pH regulator. It is a kind of electrolyte extender for infusion, and has pH value of 5-11.5, high concentration, large dosage, high stability and no pollution. it has wide application range, and is suitable for intravenously guttae to treat arrhythmia caused by various causes, chronic alcoholism fremitus, myocardiopathy as diabetes complication, etc. and applicaltion in heart operation. It is also suitable for acute and chronic hepatitis, intrahepatic cholestasis, and disease of respiratory system, nerve system and metabolic system.

Description

Technical field: [0001] The invention belongs to electrolyte replenishing medicine, in particular to an L-aspartate potassium magnesium infusion injection, and also relates to a preparation method of the injection. Background technique: [0002] Potassium magnesium L-aspartate is a drug with many strong physiological and biochemical effects, and is suitable for adjuvant treatment of arrhythmia and other diseases caused by various reasons. Treatment of alcoholic tremor, diabetes combined with cardiomyopathy, etc. and its application in cardiac surgery. At present, the dosage form of clinical application is water injection, which is likely to cause secondary pollution during clinical use. At the same time, the concentration of the liquid medicine is too low, which is extremely inconvenient to use clinically, and the application range is narrow. Invention content: [0003] The purpose of the present invention is to provide a high concentration, high dosage, good physical and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/197A61P7/08
Inventor 王东凯于航
Owner 于航
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