410 results about "High dosage" patented technology

A dosage form comprising of a high dose, high solubility active ingredient as modified release and a low dose active ingredient as immediate release where the weight ratio of immediate release active ingredient and modified release active ingredient is from 1:10 to 1:15000 and the weight of modified release active ingredient per unit is from 500 mg to 1500 mg; a process for preparing the dosage form.

Multiple-variable dose methods for treating TNFα-related disorders, including Crohn's disease and psoriasis, comprising administering TNFα inhibitors, including TNFα antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.

These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).

This invention discloses an apparatus and method for producing microcavitational activity in aqueous fluids for non-invasive macromolecule delivery into living cells. A standard electrohydraulic shock wave lithotripter is fitted with an adjustable ring reflector that shares the same foci as the standard lithotripter hemi-ellipsoidal reflector. A small portion of the spherical shock wave, generated by the spark discharge at the first focus (F1), is reflected and diffracted by the ring reflector, resulting in a weak preceding shock wave approximately 8.5 mus in front of the lithotripter shock wave reflected and diffracted by the hemi-ellipsoidal reflector. The peak negative pressure of the preceding weak shock wave or pulse at F2 can be adjusted from -0.96 to -1.91 MPa, using an output voltage of 25 kV. Living cells are exposed to the preceding shock wave and the lithotripter shock wave. With optimal pulse combination, the maximum efficiency of shock wave-induced cell membrane permeabilization can be enhanced substantially (up to 91%), by applying to the living cells a low dosage of, for example, 50 shocks. In addition, injury to mouse lymphoid cells is significantly increased at high dosage (up to 50% with shock number >100). The invention thus enables shock wave-inertial microbubble interaction to be used selectively to either enhance the efficiency of shock wave-mediated macromolecule delivery at low dosage or tissue destruction at high dosage.

An infusion device capable of administering liquid medication at a continuous flow rate, and upon user demand delivers a controlled volume dosage of liquid medication at a higher dosage flow rate. The dosage reservoir remains empty until the user actuates it by selectively and temporarily removing the pressure source, such as a spring. During actuation, fluid rapidly flows from the medication reservoir to fill the dosage reservoir. After actuation, the pressure source exerts a higher pressure on the dosage reservoir than the medication reservoir pressure, which results in a temporary higher bolus flow rate. Thus, two distinct flow rates are achieved with one flow restrictor element.

The invention discloses an axially chiral R-enantiomer and an axially chiral S-enantiomer of the drug Lesinurad. The axially chiral R-enantiomer shows excellent URAT1 inhibition effect, overcomes the problems that a high dosage of Lesinurad racemate leads to renal toxicity and a low dosage Lesinurad racemate cannot produce additional drug effect, and can be applied to treatment or prevention of symptoms of abnormal tissue uric acid levels.

The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

The invention discloses a continuous pass-type radiation scanning system. The system comprises a radiation source, a collimator, a radiation detector, an imaging device, a first detection unit (105), a second detection unit (108) and a control module; the first detection (105) is used for detecting whether a target object achieves a preset position which is located at the upstream of a scanning region and apart from the upstream side border of the scanning region by a first length L1, wherein the scanning region is a region covered with radiation source rays in a detection channel; the second detection unit (108) is used for detecting whether a part required to be subjected to the scanning of low-dosage rate rays in the target object leaves a scanning region and a part required to be subjected to the canning of high-dosage rate rays in the target object is about to enter the scanning region; and the control module is used for receiving signals from various detection units and controlling the radiation source according to the signals. The system and the method disclosed by the invention can be used for achieving the condition that a large quantity of to-be-detected vehicles can continuously and fast pass through the detection channel to finish the radiation scanning examination.

The invention relates to a methods and devices of delivering gaseous nitric oxide to a mammal or surface at a concentration ranging from about 1000 ppm to about 50,000 ppm of gaseous nitric oxide. Different conditions which can be treated by high dosage administration of gNO include but are not limited to: topical treatments with gNO, cosmetic applications of gNO, vasodilation conditions with gNO, inhalation treatments with gNO, treatments of the blood with gNO, treatment of the skin or tissue with gNO, treatment of infections with gNO, treatment of inflammation on or within the body, and treatments of biofilms with gNO. Other conditions, aliments, or symptoms that may be treated with high dosage gNO include bronchoconstriction, reversible pulmonary vasoconstriction, asthma, pulmonary hypertension, adult respiratory distress syndrome (ARDS), and persistent pulmonary hypertension of the newborn (PPHN).

A system for delivery of high dosage of radiation to a targeted spinal area is provided. This is accomplished by a system which provides for precise immobilization and positioning of the treated spinal area during dose planning and treatment via stereotactic radiosurgery. Advantages of the system include convenience to the patient, enhanced efficacy, and reduced risk of radiotoxicity to non-target tissues.

The invention provides a new Lactobacillus plantarum bacterial strain YJG which was preserved in the China General Microbiological Culture Collection Center (CGNCC) with the collection number of CGMCC No. 2994 on march, 30th, 2009. The Lactobacillus plantarum bacterial strain YJG can produce broad-spectrum bacteriostatic activity bacteriocin with high yield, and can express bacteriostasis for staphylococcus aureus, salmonella and E.coli of gram-negative bacterium, L. plantarum, L.brevis, Streptococcus and Bacillus of gram-positive bacterium, and the like. A virus attacking tests with high dosage proves that the Lactobacillus plantarum bacterial strain YJG is safe to animal bodies. The Lactobacillus plantarum bacterial strain YJG and a zymophyte liquid thereof can be used for preparing additives of green animal feeds, and the bacteriocin of the Lactobacillus plantarum bacterial strain YJG can be used for preparing green biological veterinary drugs, environmental-friendly biopreservatives, biocontrol drugs and the like.

The invention relates to a preparation method of thin-shelled noble metal catalyst, and mainly solves the problems of the prior art of high dosage, poor selectivity and short service life of noble metal. The preparation method better solves the technical problems of the prior art by adopting the technical proposal comprising the following steps of: (a) coating the slurry of a coat porous material on the inner core of an inert carrier, drying the slurry coating and baking the slurry coating at a temperature of between 700 and 1,200 DEG C for 0.5 to 10 hours to obtain a laminar composite carrier; (b) impregnating the surface of the laminar composite carrier with a solution containing noble metal and cocatalyst components, drying the laminar composite carrier, and baking the laminar composite carrier in the air at a temperature of between 200 and 700 DEG C for 1 to 24 hours to obtain a thin-shelled catalyst precursor; and (c) reducing the thin-shelled catalyst precursor in a reducing atmosphere at a temperature between 300 and 800 DEG C for 1 to 24 hours to obtain the thin-shelled noble metal catalyst. The preparation method can be used in the industrial production of gas purification materials which are dehydrogenation-deoxidization catalysts, alkanes and aromatic hydrocarbons for selective hydrogen oxidation in a dehydrogenation process.

The invention discloses an organic selenium crop nutrient and a preparation method for the same. The organic selenium crop nutrient comprises the following raw materials in parts by weight: 0.5-1.5 parts of molasses, 5-15 parts of soybean meal amino acid, 6-9 parts of urea, and 0.04-0.1 part of sodium selenite. The preparation method for the organic selenium crop nutrient comprises the following steps of: oscillating all raw materials for 24-72 hours in the conditions of a rotation speed of 120-200 rpm and a temperature of 35-40 DEG C, and sieving to obtain a filtrate, namely, the organic selenium crop nutrient. The content of organic selenium in the organic selenium crop nutrient disclosed by the invention is greater than 0.3 g/L. Additionally, according to the organic selenium crop nutrient and the preparation method disclosed by the invention, harm brought by the too high dosage of an inorganic selenium fertilizer to a human body, and fertilizer damage phenomena of seedling burning, leaf spots and the like due to the inappropriate dosage of the inorganic selenium fertilizer are overcome.

The invention relates to high-dosage pulverized coal cement and the production method thereof, and belongs to the technical field of cement. The invention aims to realize high-dosage pulverized coal cement with the coal ash quality of over 40 percent and the simple production art. The invention comprises the steps as follows; the coal ash and the cement clinker are taken as the main material, after respectively grinding, a little gypsum and proper water decreasing agent and kindling agent are added, and mixing ball grinding treatment is performed. All properties meet the national coal ash cement standard requirement. The pulverized coal cement produced by the invention has the advantages of large dosage of coal ash, high early intensity, stable product quality, low production cost and small energy consumption. The invention has great significance for adopting coal ash castoff cosmically and saving the cost of cement.

The invention provides a method and a device for realizing zero discharge of desulfurization wastewater and solves problems of the high energy consumption, the high dosage of chemical agents and the high cost in the prior art. The device for realizing zero discharge of the desulfurization wastewater comprises a pre-sedimentation unit, an adjusting unit, a primary flocculation and sedimentation unit, a softening unit, a secondary flocculation and sedimentation unit, an intermediate water tank unit, an evaporation and crystallization unit, two stages of sludge treatment units and a water producing tank, wherein the softening unit and two stages of flocculation and sedimentation units are arranged in front of the evaporation and crystallization unit so as to remove metal ions, F<-> and hardness of the desulfurization wastewater, water inlet requirements of the subsequent evaporation and crystallization unit are met, and the scaling tendency of the evaporation and crystallization unit is relieved. Meanwhile, the content of salt of the desulfurization wastewater is high, the evaporation and crystallization unit enables the salt of the desulfurization wastewater to form valuable industrial salt, and the desulfurization wastewater is recycled. The method and the device have the benefits as follows: the running cost is low, the energy consumption is low, the quality of produced water is good, the design is reasonable, scaling of the evaporation and crystallization unit is effectively prevented, and meanwhile, the desulfurization wastewater can be recycled.

A freeze-dried powder injection of high-dosage (500mg) ambroxol hydrochloride and its preparing process are disclosed.

A semiconductor lithography process. A photoresist film is coated on a substrate. The photoresist film is subjected to a flood exposure to blanket expose the photoresist film across the substrate to a first radiation with a relatively lower dosage. The photoresist film is then subjected to a main exposure using a photomask to expose the photoresist film in a step and scan manner to a second radiation with a relatively higher dosage. After baking, the photoresist film is developed.

The invention relates to a synthesis method of oxime, which belongs to the technical field of organic synthesis. At present, the oxime is synthesized mainly by utilizing the reaction between hydroxylamine salt and ketone and aldehyde, and defects are the high dosage of hydroxylamine salt and the production of a large amount of byproduct (inorganic salt). The technique is an environment-friendly process. In the technical scheme of the invention, reactant (ketone or aldehyde), ammonia and hydrogen peroxide are ordinally added into the reaction system of catalyst containing Ti-MWW-F molecular sieve and solvent, and after stiring, temperature raising and reaction are finished, an oxime product is produced by filtering, distillation, liquor filtering and separation. The invention has the advantages of high conversion rate of ketone or aldehyde, high utilization rate of hydrogen peroxide, usage of water as resolvent, simple post-processing procedure and environment-friendly reaction procedure.