Application of angle flavonoids lignan to preparation of medicaments for treating viral hepatitis B

A flavonoid lignan and horn-shaped technology, which is applied in the field of medicine, can solve problems such as not being effectively developed, and achieve the effects of large-scale production, huge social and economic benefits, and low pollution
CN101953828AInactive Publication Date: 2011-01-26DALI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALI UNIV
Publication Date
2011-01-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to application of an angle flavonoids lignan to preparation of medicaments for treating viral hepatitis B, in particular to application of the angle flavonoids lignan or medicinal salts thereof to preparation of medicaments for inhibiting hepatisis B virus (HBV) DNA replication and treating HBV infection diseases. The flavonoids lignan can exactly inhibit HBV DNA activity; the inhibition activity of the flavonoids lignan with high dosage (20 microgram / ml) to the HBV DNA replication is 189 percent higher than that of alpha-interferon with the maximum concentration of 10,000 unit / ml; and the flavonoids lignan belongs to a strong-effect non-nucleosides inhibition HBV natural product. The pharmacological results show that the angle flavonoids lignan or the medicinal salts thereof can be expected to be used for preparing the medicaments for inhibiting hepatisis B virus (HBV) DNA replication and treating the HBV infection diseases.
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Description

technical field

[0001] The present invention relates to the technical field of medicine, in particular, the present invention relates to an angular flavonoid lignan represented by formula (1) or a pharmaceutically acceptable salt thereof for preparing and inhibiting hepatitis B virus deoxyribonucleic acid HBV DNA replication, treatment The use of hepatitis B drugs. The flavonoid lignans have definite inhibition of hepatitis B virus HBV DNA activity, and its replication inhibitory activity to hepatitis B virus HBV DNA at high doses (20 micrograms / ml) is higher than that of alpha-interferon at the highest concentration of 10,000 units / ml The activity is 189% higher, and it is a potent non-nucleoside natural product for inhibiting hepatitis B virus. The above pharmacodynamic results show that the flavonoid lignan or its pharmaceutically acceptable salt can be expected to be used for the preparation of inhibitors of HBV DNA replication and the treatment of hepatitis B The use of ...

Claims

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