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Liver-protecting composite and preparation method thereof

A technology of a composition and a pharmaceutical preparation, applied in the field of medicine, can solve problems such as increasing the burden on the liver after drinking, and achieve the effects of preventing alcoholic liver cirrhosis, preventing chronic alcoholism, and having wide application prospects.

Active Publication Date: 2011-05-04
BEIJING ADINOVO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, Western medicines are the main liver-protecting drugs. The liver is the largest metabolic organ in the human body. Drugs must be decomposed, transformed, and detoxified in the liver, which will increase the burden on the liver after drinking.

Method used

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  • Liver-protecting composite and preparation method thereof
  • Liver-protecting composite and preparation method thereof
  • Liver-protecting composite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Preparation of the hepatoprotective composition of the present invention

[0035] Preparation of drug extract by water extraction method: Weigh 30 parts of kudzu flower, 30 parts of Hovenia dulcis, and 30 parts of Alisma, add 20 times the weight of deionized water to soak at room temperature for 8 hours, put them in an extraction tank and heat at 65°C for 90 minutes, The extract is collected, ultrafiltered through a 200nm ultrafiltration membrane with a pore size, and the ultrafiltrate from which residue and large particle components have been removed is vacuum-concentrated to 1 / 5 of the volume of the ultrafiltrate to obtain a water extract.

[0036] Add 4% methionine and 6% vitamin C in g / ml to the volume ratio of the water extract, stir and mix well, sterilize by heating at 70-80°C, and vacuum aseptically dispense into ampoules 10m / piece.

Embodiment 2

[0037] Embodiment 2: Preparation of the hepatoprotective composition of the present invention

[0038] Preparation of drug extract by water extraction method: Weigh 30 parts of kudzu flower, 30 parts of Hovenia dulcis, and 30 parts of Alisma, add 20 times the weight of deionized water to soak at room temperature for 8 hours, put them in an extraction tank and heat at 65°C for 90 minutes, Collect the extract, ultrafiltrate it through a 200nm ultrafiltration membrane with a pore size, take the ultrafiltrate that removes residue and large particle components, and vacuum concentrate to 1 / 5 of the total volume of 30 parts of Pueraria japonica, 30 parts of Hovenia dulcis, and 30 parts of Alisma That is the water extract.

[0039] Then add 6% cysteine ​​and 8% vitamin C in g / ml to the volume ratio of the water extract, stir and mix well, heat to 70-80°C for sterilization, and vacuum aseptically dispense to 10m / branch in ampoule.

Embodiment 3

[0040] Embodiment 3: Preparation of the hepatoprotective composition of the present invention

[0041]Preparation of drug extract by water extraction method: Weigh 25 parts of Pueraria japonica, 25 parts of Hovenia dulcis, and 25 parts of Alisma, add 20 times the weight of deionized water to soak at room temperature for 12 hours, put them into an extraction tank and heat at 70°C for 60 minutes. The extract is collected, ultrafiltered through a 100nm ultrafiltration membrane, and the ultrafiltrate from which residues and large particle components have been removed is removed, and vacuum concentrated to 1 / 3 of the total volume of the raw material of the traditional Chinese medicine to obtain the water extract.

[0042] Then add 6% S-adenosylmethionine and 8% vitamin C in g / ml in terms of mass and volume ratio of the water extract, and stir evenly to obtain the hepatoprotective composition.

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Abstract

The invention relates to the medical field, and discloses a liver-protecting composite. The raw materials comprise one of S-ademetionine, cysteine or methionine, vitamin C, flower of kudzuvine, hovenia dulcis thumb and rhizoma alismatis. The invention also provides a preparation method of the liver-protecting composite. The liver-protecting composite is taken after drinking, thus being capable of preventing chronic alcoholism and alcoholic cirrhosis; and the liver-protecting composite can be taken for a long term as a liver-protecting health care product, thus having wide application prospects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hepatoprotective composition and a preparation method thereof. Background technique [0002] my country has thousands of years of brewing and drinking history, and wine has become a part of "Chinese culture". However, excessive or long-term drinking is harmful to health, so it is of great significance to develop liver protection products. [0003] Ethanol is the main component of wine. 5% of the ingested ethanol is excreted without metabolism, and 95% is absorbed into the blood circulation, metabolized by the liver, and converted into acetaldehyde by alcohol dehydrogenase (alcoholdehydrogenase, ADH) in the liver cytoplasm. One molecule of coenzyme I (nicotinamide-adenine dinucleotide, NAD) is required for each molecule of ethanol metabolism. After the dehydrogenation reaction, NAD is converted into reduced coenzyme I (NADH), and the reaction formula is as follows: [0004] [0005]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P1/16A61K31/198A61K31/375A61K31/7076
Inventor 白玉杰唐铁军薛丽
Owner BEIJING ADINOVO TECH
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