Application of 5-methyltetrahydrofolate and composition containing 5-methyltetrahydrofolate

A technology of methyltetrahydrofolate and composition, applied in the field of medicine, can solve the problems of complex traditional Chinese medicine components, difficult to distinguish liver toxicity components, damage and the like

Active Publication Date: 2021-02-02
LIANYUNGANG JINKANG HEXIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of traditional Chinese medicine ingredients, it is difficult to distinguish whether any of them are hepatotoxic, and long-term use may cause drug-induced liver damage

Method used

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  • Application of 5-methyltetrahydrofolate and composition containing 5-methyltetrahydrofolate
  • Application of 5-methyltetrahydrofolate and composition containing 5-methyltetrahydrofolate
  • Application of 5-methyltetrahydrofolate and composition containing 5-methyltetrahydrofolate

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Embodiment Construction

[0040] In the present invention, the term "5-methyltetrahydrofolate" includes 5-methyl-(6S)tetrahydrofolate, 5-methyl-(6R)tetrahydrofolate, 5-methyl-(6R,S)tetrahydrofolate, Hydrofolate, including optical isomers of 5-methyltetrahydrofolate, especially pure optical natural isomers, mixtures of optical isomers, such as racemic mixtures, and their physiologically acceptable salts . Of these, 5-methyl-(6S)tetrahydrofolate (also known as L-5-methyltetrahydrofolate) is particularly preferred.

[0041] The physiologically acceptable salt refers to the conversion of the basic group in 5-methyltetrahydrofolate into the corresponding acid addition salt, and the acid can be an inorganic acid, such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid; Organic acids such as formic acid, acetic acid, propionic acid, diethylacetic acid, malonic acid, succinic acid, fumaric acid, maleic acid, lactic acid, tartaric acid, malic acid, citric acid, gluconic acid, ascorbic acid or ni...

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Abstract

The invention provides an application of 5-methyltetrahydrofolate and a composition containing the 5-methyltetrahydrofolate. The 5-methyltetrahydrofolate or the composition containing the same is usedfor treating, relieving or preventing various diseases or symptoms caused by acute alcoholism and chronic alcoholism. The injuries or the diseases caused by the acute alcoholism include headache caused by alcohol drinking, negative emotion or depression caused by alcohol drinking, and the hangover symptom after alcohol drinking. The injuries or the diseases caused by the chronic alcoholism include alcoholic fatty liver, central nervous system (CNS) inflammation and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a medicine or health food composition containing 5-methyltetrahydrofolate and an application thereof. Background technique [0002] Folic acid (folic acid) is vitamin B9, also known as pteroylglutamic acid (PGA). It has a variety of biochemical functions, for example, it can promote the maturation of immature cells in the bone marrow. If folic acid is lacking in humans, it can cause megaloblastic anemia and leukopenia, and it is especially important for pregnant women. As a nutritional supplement, the recommended dosage of folic acid for adults is 400 μg. Since the synthetic folic acid needs to be transformed into 5-methyltetrahydrofolate by the human body through a complex process and enters the blood circulation to participate in various physiological activities of the human body, exceeding this recommended dosage may cause adverse effects on the human body. Various side effects. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K31/12A61P39/02A61P25/00A61P25/24A61P29/00A61P25/06A61P1/16A23L33/15
CPCA61K31/519A61K31/12A61P39/02A61P25/00A61P25/24A61P29/00A61P25/06A61P1/16A23L33/15A23V2002/00A61K2300/00A23V2200/30A23V2200/322A23V2200/334A23V2200/3262A23V2200/326A23V2250/7058A23V2250/7056A23V2250/51084A23V2250/2112A23V2250/51088A23V2250/55A61P9/00A61P25/32A61P3/02A61P3/06A61P25/04A61K31/4985A61K31/047A23L33/10
Inventor 成永之连增林
Owner LIANYUNGANG JINKANG HEXIN PHARMA CO LTD
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