18 results about "Alcohol Toxicity" patented technology

The invention belongs to the technical field of biological medicines, and relates to application of mannatide in preparation of a medicine for treating alcoholic gastric ulcer. The mannatide disclosed by the invention can be used for remarkably relieving gastric tissue hemorrhagic lesion and ulcer conditions of alcoholic gastric ulcer for the first time, and the mechanism comprises the following steps: reducing active oxygen generated by alcohol toxicity, and improving oxidative stress of a body by improving antioxidant enzyme activity of the gastric tissue; the inflammatory response of the organism is regulated by regulating and controlling an Akt / NF-kB pathway; a Bax-related apoptosis pathway is inhibited to protect gastric mucosa cells from alcohol-induced apoptosis, so that the integrity of gastric tissue mucosa is protected; the intestinal flora disorder caused by alcohol intake is regulated and controlled, and the acute alcoholic gastric ulcer is prevented by improving the intestinal flora composition of the alcoholic gastric ulcer. The application range of the mannatide is widened, and more solutions are provided for prevention or treatment of acute alcoholic gastric ulcer.

The application discloses a high-activity UGT1A1 enzyme based on tree shrew and a feed composition for enhancing alcohol metabolism. The catalytic efficiency of the recombinant tree shrew UGT1A1 enzyme on ethanol is significantly higher than that of human isozyme. The core of the application is to provide a complex feed system containing the enzyme, which solves the key bottleneck of poor stability and low delivery efficiency of exogenous enzymes in application through the synergistic effect of enzyme stabilizers, cell penetration enhancers, enteric coatings and coenzyme supply agents. Animal experiments show that the composition can safely and effectively accelerate in vivo alcohol elimination and reduce blood ethanol concentration, and can be used for developing alcoholism products, acute alcoholism treatment drugs and alcoholic liver disease prevention preparations.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for improving alcohol tolerance of a user and relieving uncomfortable symptoms of the user after drinking. Compared with modern medical treatment, the traditional Chinese medicine compound is started from multiple mechanisms of relieving alcoholism, protecting liver and stomach and dredging collaterals and blood stasis, whole-course intervention from acute symptom control to organ injury repair is achieved, and the traditional Chinese medicine compound is more suitable for the complex pathogenesis of alcoholism multi-system injury. According to the formula, an effective traditional Chinese medicine scheme is provided for drunkenness patients according to the core treatment principle of separately eliminating and draining, and clearing away heat and toxic materials. The composition can significantly improve the alcohol tolerance of a user, alleviate the vomiting symptom of the user after drinking, and improve the discomfort symptom of the user after sobering up. The traditional Chinese medicine composition is a pure traditional Chinese medicine formula, is safe and has no toxic or side effect.

This invention discloses a functional beverage based on ginseng polysaccharides for relieving alcohol poisoning and reducing liver damage, and its preparation method. It relates to the field of functional foods and is made from the following raw materials in parts by weight: 5-15 parts ginseng polysaccharide extract, 3-10 parts Hovenia dulcis extract, 2-8 parts Pueraria lobata extract, 1-3 parts B vitamins, 1-5 parts amino acid composition, 0.1-1 parts food-grade absorption promoter, and the remainder food-grade excipients and water. This beverage, by adding an absorption promoter and pre-treating the ginseng polysaccharides with enzymatic hydrolysis, improves the bioavailability and absorption rate of various active ingredients in the formula, resulting in a faster onset of hangover relief. By physically separating and sequentially programming the fast-acting hangover-relieving components with the long-acting liver-protecting components, precise delivery of rapid external release and sustained internal release is achieved. This allows the beverage to quickly relieve post-drinking symptoms while continuously providing liver cell protection, significantly enhancing the product's overall hangover-relieving and liver-protecting efficacy.

Nutraceutical compositions and the methods for preventing and / or mitigating veisalgia by the administration thereof. The nutraceutical compositions address the challenged state of the individual and potentiate their ability to be compliant with treatment when the metabolic functions of the liver are overwhelmed as alcohol metabolism depletes hepatic supplies of needed molecules. The methods provide the nutraceutical composition directly to the end organs where alcohol and toxin infused blood is also metabolized and neutralized.

The invention belongs to the technical field of traditional Chinese medicine, and provides traditional Chinese medicine freeze-dried powder for dispelling effects of alcohol and protecting liver and a preparation method thereof. The mass ratio of the freeze-dried powder of radix puerariae to the freeze-dried powder of semen hoveniae to the freeze-dried powder of schisandra chinensis is (0.8-1.2): (0.8-1.2): (0.8-1.2) The radix puerariae promotes alcohol metabolism, the hovenia dulcis thunb relieves alcohol toxicity, the schisandra chinensis protects the liver, the synergistic effect of the three traditional Chinese medicinal materials is fully played, the alcohol effect relieving and liver protecting effects are enhanced, the freeze drying technology is adopted, drying is completed under the low-temperature condition, damage of high temperature to active ingredients is avoided, and the stability of the product in the storage process is remarkably improved; the freeze-dried powder exists in a fine particle state, so that the contact surface area with a human body is increased, the release and absorption of effective components are facilitated, and the bioavailability is improved.

The invention relates to the technical field of microorganisms, and discloses a plant lactobacillus XJSN202504 and application thereof in acute alcoholism, the plant lactobacillus XJSN202504 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.34746, and the preservation time is June 3, 2025. The invention further discloses a preparation method of the plant lactobacillus XJSN202504. The lactobacillus plantarum XJSN202504 disclosed by the invention can be used for improving liver injury related indexes in serum and expression of inflammation related genes, and also can be used for adjusting the activity of antioxidant enzymes in the liver and relieving alcohol-induced oxidative stress injury; moreover, gastric mucosa, small intestine and colon injuries caused by a large amount of alcohol can be effectively prevented, the anti-inflammatory activity and the antioxidant activity are better, the anti-alcohol function can be achieved through gastrointestinal tracts, and the effects of protecting liver and digestive tract mucosa are achieved.

The application discloses a combined system preparation for preventing and treating alcohol harm, and belongs to the technical field of traditional Chinese medicines. The combined system preparation is composed of sugar-free chewing gum for oral taking and external use acupoint gel ointment. The sugar-free chewing gum is prepared by using homologous medicinal and edible materials such as Flos Puerariae, can be absorbed through oral mucosa, can freshen breath, has the effects of removing alcohol toxicity, refreshing brain, calming nerves, protecting liver and stomach, and the like, relies on natural food seasoning to optimize taste, has mild medicinal properties and is suitable for long-term conditioning, realizes the combination of medicine and food, and achieves the effect of "combining medicine with food". The external use ointment is designed with special formula for five core syndromes, takes the external and internal acupoint matching method as the core, integrates various acupoint matching methods, and realizes the precise correspondence among syndromes, ointments and acupoints. The two can realize double-channel drug delivery, can quickly remove alcohol, protect and nourish viscera from multiple targets, can prevent before drinking, relieve after drinking and long-term conditioning, are in line with the TCM concept of "preventing disease before it occurs", and are suitable for acute drunkenness and long-term drinking population. The preparation process retains active ingredients at low temperature, the ointment adopts modular design, and is suitable for industrial production.

Provided herein are methods for treating acute alcohol toxicity using an agonist for a Fibroblast Growth Factor Receptor (FGFR) and β-Klotho complex such as Fibroblast Growth Factor 21 (FGF21). Also provided are compositions and kits comprising these agonists (e.g., FGF21) for administration to a subject in need.

A system for detecting alcoholism using EEG signal processing, comprising: an EEG signal acquisition module configured to acquire digitized EEG signals from a plurality of electrodes placed on the scalp of a subject according to a 10-20 electrode placement system; a signal preprocessing module operationally connected to the EEG signal acquisition module and configured to preprocess the acquired digitized EEG signals, the preprocessed EEG signals being stored in a database containing signals from both alcohol-dependent and control subjects;a computing unit comprising at least one processor with dedicated memory, wherein the processor is configured to receive the preprocessed digitized EEG signals and perform a multi-resolution signal decomposition based on the discrete cosine harmonic wavelet packet transform (DCHWPT) to generate transformed signal representations corresponding to different frequency subbands; a feature extraction module connected to the computing unit and configured to extract a variety of features from the transformed signal representations; a feature selection module configured to perform a statistical test to reduce the dimensionality of the extracted features and retain only relevant features;a classification module configured to categorize EEG signals into an alcoholic or control category based on the retained relevant features; and an output module connected to the classification module, the output module comprising a user interface configured to display the classified results to the user.

The present invention relates to the field of alcoholism and its treatment and discloses novel hybrid materials and pharmaceutical compositions, methods of their preparation and their use in cases of excessive alcohol consumption. The disclosed hybrid materials comprise (a) an amyloid, such as a fibrillar amyloid, and (b) a plurality of single-site iron coordinated to the amyloid. These hybrid materials can be converted into hydrogels, pharmaceutical compositions comprising such hydrogels and oral dosage forms comprising such hydrogels. Further disclosed are methods of manufacturing such hybrid materials and hydrogels and methods of using such hybrid materials and hydrogels for the treatment of alcoholism.

The present invention relates to the technical field of traditional Chinese medicine and, in particular, to a liver-protecting composition and a method for its preparation. The liver-protecting composition contains, by weight: 10 to 25 parts Lysimachia christinae, 5 to 15 parts Aster tataricus, 5 to 13 parts turmeric, 2 to 8 parts ginseng, 2 to 8 parts Hovenia dulcis Thunb., and a spice additive, wherein the spice additive contains red dates. The present invention relates to a pure traditional Chinese medicinal product that is easy to prepare and convenient to take, has beneficial effects in protecting and nourishing the liver, and also has an effect in alleviating the effects of alcohol.

The present application relates to a kind of compositions for preventing and relieving acute drunkenness, which is prepared from the following raw materials by weight: 30 parts of Gegen, 10 parts of Chengma, 10 parts of Zhupencao, 15 parts of Zexie, 15 parts of Baishu, 30 parts of Fuling, 15 parts of Xianhecao, 15 parts of Gaoliangjiang and 30 parts of Baimaogen.The composition provided by the present application is a multi-target and multi-path protective process for treating acute alcoholism, involving anti-inflammatory, anti-allergic, promoting protein synthesis, immunosuppression, anti-shock, regulating blood lipids and cholesterol, participating in alcohol decomposition and metabolic pathways; affecting transcription factors such as SP1, ESR1, RELA (P65), NF-κb1 and STAT3, which can not only prevent acute drunkenness, but also reduce the harm of alcohol metabolism after drunkenness, including hyperlipidemia, dementia, hypercholesterolemia, fatty liver, cognitive impairment, cardiovascular and cerebrovascular diseases, etc. In addition, it can also protect the cardiovascular, nervous and skeletal systems after drunkenness, regulate immunity and enhance the immune capacity after drunkenness.

The invention relates to a medicine for treating liver diseases, and discloses a medicine for alleviating hangover, dissolving alcohol toxicity and preventing and treating alcoholic liver and fatty liver and a preparation method thereof, the medicine comprises the root of kudzu vine, lalang grass rhizome, red yeast rice, malt, endothelium corneum gigeriae galli, gordon euryale seed, hawthorn, Chinese yam, dried orange peel, lily and flower of kudzuvine; the medicine is prepared from 19% of radix puerariae, 2% of pericarpium citri reticulatae, 5% of malt, 5% of hawthorn, 15% of Chinese yam, 15% of gordon euryale seed, 10% of red yeast rice, 5% of lalang grass rhizome, 10% of lily, 5% of endothelium corneum gigeriae galli and 9% of pueraria flower, is based on homology of medicine and food, has great benefits and treatment and prevention effects on drinkers who are injured and pathogenic after drinking, protects the body health of the drinkers, treats and prevents diseases, and is free of toxic and side effects. And the production and preparation method of the product is simple and convenient in process, and the proportion of the effective components can be high.

Disclosed is the use of gabexate for the treatment of alcoholism. More specifically, the present invention provides the use of gabexate (Gabexate) or a pharmaceutically acceptable salt thereof, or a metabolite thereof, in the manufacture of a pharmaceutical composition for the prevention or treatment of alcoholism and / or alcoholic liver disease. Also provided is the use of gabexate or a pharmaceutically acceptable salt thereof, or a metabolite thereof, in the manufacture of an acetaldehyde dehydrogenase 2 (ALDH2) agonist.

The invention discloses a chalcone-lignan glycoside compound separated from hovenia dulcis thunb and an application of the chalcone-lignan glycoside compound in dispelling effects of alcohol and protecting liver. The structure of the aurone-lignan glycoside compound is shown as a formula I or pharmaceutically acceptable salt of the aurone-lignan glycoside compound. The chalcone-lignan glycoside compound can obviously shorten the sobering time of mice suffering from acute alcoholism, reduce the number of autonomous activities of the mice, reduce the content of MDA in the livers of the mice and improve the activity of ADH, SOD and GSH-Px in the livers of the mice, and has remarkable effects of dispelling the effects of alcohol and protecting the liver. The invention discloses application of the chalcone-lignan glycoside compound in preparation of a medicine for dispelling the effects of alcohol and protecting the liver. The invention discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury, and further discloses an application of the chalcone-lignan glycoside compound in preparation of a medicine for treating acute and chronic alcoholic liver injury.

A driver alcohol impairment detection and control system and method for a vehicle a control system configured to access an alcohol impairment detection model, wherein the alcohol impairment detection model is a machine-learning model trained based on a plurality of input parameters including at least (i) parameters of one or more eyes of the driver, (ii) skin conductance of a face of the driver, and (iii) responsiveness of the driver, receive a set of captured images of the driver from a driver monitoring camera system and a set of driver inputs via one or more driver input device sensors, determine whether the driver is impaired by alcohol using the alcohol impairment detection model, the set of captured images, and the set of driver inputs, and perform remedial control of at least one output of the vehicle when the driver is determined to be impaired by alcohol.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a traditional Chinese medicine composition for dispelling effects of alcohol and protecting liver, a preparation method and application. The composition is prepared from the following raw materials in parts by weight: 20 to 60 parts of flos puerariae, 12 to 48 parts of semen hoveniae and 5 to 15 parts of fructus schizandrae. The preparation method comprises the following steps: crushing the raw materials, extracting with water, concentrating and drying to obtain an extract A; or further centrifuging, dialyzing and filtering to obtain an extract B; the composition is suitable for preparing medicines for treating acute alcoholism and alcoholic liver injury, or health-care products / foods with functions of dispelling effects of alcohol, protecting liver and protecting gastric mucosa. The composition is simple (three medicinal materials), contains medicinal and edible components (hovenia dulcis thunb and schisandra chinensis), and is high in safety; an extract A (conventional extraction) and an extract B (high-purity active components) are respectively obtained through a double-preparation process; the traditional Chinese medicine composition has the effects of dispelling effects of alcohol, promoting awakening, repairing liver injury, protecting gastric mucosa and promoting alcohol metabolism.