This invention discloses a strain of *
Bifidobacterium pseudosporidis*, its preparation method, and its application in the prevention and treatment of
METH addiction. *
Bifidobacterium pseudosporidis* was isolated from fecal samples of individuals with low levels of
METH addiction, and its strain identity was confirmed after isolation, purification, and identification. A
METH addiction model was constructed by gavage
colonization of C57 mice with this strain, and addiction-related indicators were detected in the model mice. The results showed that compared with the addiction model mice without
colonization of this strain, the conditioned place preference
score of the colonized group was significantly reduced (P<0.05). This *
Bifidobacterium pseudosporidis* has a significant effect on improving METH
addictive behavior and can be used to prepare biological agents with preventive and / or therapeutic functions for METH addiction. This invention reveals that *Bifidobacterium pseudosporidis* has the advantages of high safety and strong targeting, and can achieve the prevention and intervention of METH addiction without complex treatment equipment, providing a novel biological treatment option for the
clinical treatment of METH addiction.