21 results about "Addictive behavior" patented technology

The invention relates to the technical field of medicines, and particularly discloses an application of 4-chloro-2, 5-dimethoxy-N-[(2-methoxyphenyl) methyl] phenylethylamine (25C-NBOMe) in preparation of a medicine for inhibiting addiction, and a preparation method of the 4-chloro-2, 5-dimethoxy-N-[(2-methoxyphenyl) methyl] phenylethylamine (25C-NBOMe). As a selective 5-HT2A receptor agonist, the compound can regulate a neural circuit from the prefrontal cortex to the marginal system and indirectly influence dopamine release, so that active drug foraging, relapse and preference behaviors of addicted individuals are inhibited. The invention further covers pharmaceutical salt forms and structural analogues of the compound and application of the compound in pharmaceutical compositions, and administration can be achieved through multiple dosage forms such as sustained-release implants and nasal spray. Compared with the existing drug for treating addiction, the invention has the advantages of independence, definite target spot, obvious curative effect, high safety and the like, is suitable for intervention of various addiction substances, and provides a new strategy for prevention and treatment of addiction behaviors.

This invention discloses a strain of *Bifidobacterium pseudosporidis*, its preparation method, and its application in the prevention and treatment of METH addiction. *Bifidobacterium pseudosporidis* was isolated from fecal samples of individuals with low levels of METH addiction, and its strain identity was confirmed after isolation, purification, and identification. A METH addiction model was constructed by gavage colonization of C57 mice with this strain, and addiction-related indicators were detected in the model mice. The results showed that compared with the addiction model mice without colonization of this strain, the conditioned place preference score of the colonized group was significantly reduced (P<0.05). This *Bifidobacterium pseudosporidis* has a significant effect on improving METH addictive behavior and can be used to prepare biological agents with preventive and / or therapeutic functions for METH addiction. This invention reveals that *Bifidobacterium pseudosporidis* has the advantages of high safety and strong targeting, and can achieve the prevention and intervention of METH addiction without complex treatment equipment, providing a novel biological treatment option for the clinical treatment of METH addiction.

A pathway planning apparatus includes a processor configured to plan a pathway for implanting an electrode lead into a brain of a patient, wherein the planned pathway satisfies the following condition: if the electrode lead is implanted into the brain of the patient according to the pathway, the electrode lead is capable of simultaneously making contact with an anterior limb of an internal capsule and a nucleus accumbens in one hemisphere of a brain of the patient. The pathway planned by the pathway planning apparatus enables the electrode lead to simultaneously deliver the electrical stimulation to the anterior limb of the internal capsule and the nucleus accumbens such that a combined electrical stimulation therapy is achieved, which has a better effect of treating diseases such as addictive behaviors, depressive disorders, and obsessive-compulsive disorders.

The invention discloses a pharmaceutical composition for treating alcohol dependence and a preparation method and application thereof. The pharmaceutical composition is prepared from 100 to 1,000 mg of ascorbic acid, 10 to 40 mg of pyrroloquinoline quinone and pharmaceutically acceptable auxiliary materials. According to the pharmaceutical composition provided by the invention, ascorbic acid and pyrroloquinoline quinone are combined for application, so that the alcohol preference rate of mice is remarkably reduced. In a mouse alcohol dependence model, a mouse taking the pharmaceutical composition shows obvious reduction of alcohol intake, and the alcohol dependence is lower. The pharmaceutical composition provided by the invention has the potential of inhibiting alcohol craving and relieving alcohol addiction behaviors, and can effectively intervene in formation and maintenance of alcohol dependence.

The invention discloses a living body screening method of a high-throughput addiction inhibitor, which comprises the following steps: acquiring addictive nematodes with a plurality of addiction behavioral phenotypes; applying different addiction inhibitors to the addictive nematodes; the screening of the addiction inhibitors is realized according to the inhibition efficacy of the addiction inhibitors on the addiction behavioral phenotypes of the addiction nematodes, and based on the steps, the drug screening of the addiction inhibitors can be realized through the inhibition efficacy of the addiction inhibitors on the addiction behavioral phenotypes of the addiction nematodes in a high-throughput manner. Compared with the prior art, the medicine screening method of a traditional cell function system is abandoned, and medicine screening is carried out on the living animal behavioristics level in a brand new mode. Meanwhile, the advantages of easiness in large-scale culture, abundant behavioral modes and the like of the nematodes are utilized, and compared with expensive mammal feeding and experimental operation for drug screening, the method has higher cost performance, practical operability and high throughput.

The present invention discloses a compound for treating methamphetamine addiction and cognitive impairment, its preparation method and application. The new compound NBU513-1 for treating methamphetamine addiction and cognitive impairment induced by the present invention can significantly improve the addictive behavior of mice for methamphetamine, has a therapeutic effect on the cognitive dysfunction caused by methamphetamine, and can be used to prepare a medicine for treating methamphetamine addiction and cognitive impairment induced by methamphetamine. The present invention provides a total synthesis route of compound NBU513-1. Compared with the preparation method of similar compounds in the prior art, the method of the present invention does not need to react with sodium azide, does not produce powerful explosives and highly toxic substances, has high stability and low reaction risk; the method has mild reaction conditions, simple scheme, safe and reliable production and can prepare target products with higher yields, and is suitable for industrial production.

The invention relates to the technical field of biological medicine, in particular to application of quercetin in preparation of a medicine for treating or preventing methamphetamine addiction. The invention provides an application of quercetin in preparation of a medicine for treating or preventing methylamphetamine addiction. Through an METH (methylamphetamine) self-administration model, it is found that quercetin can significantly reduce the active nasal staking frequency and injection frequency of rats, it is proved that quercetin can significantly inhibit the rat addiction behavior to methylamphetamine, and the quercetin has a wide clinical application prospect.

The present disclosure is directed to a beverage composition comprising from a cannabis extract and a Hericium erinaceus extract. The present disclosure also relates to methods of reducing a withdrawal symptom and / or reducing an addictive behavior comprising administering a therapeutically effective amount of the aforementioned beverage composition to a subject having the withdrawal symptom and / or the addictive behavior, methods for treating alcoholism in a subject comprising administering a therapeutically effective amount of the aforementioned beverage composition to the subject, and method of producing altered perception and / or reduced stress while ameliorating a side effect of THC overconsumption in a subject comprising administering a therapeutically effective amount of the aforementioned beverage composition to the subject.

Certain embodiments are directed to methods of treating or preventing an addictive behavior in a subject, said method comprising administering to said subject an effective amount of a DMTU or a composition comprising same.

The invention discloses a short video anti-addiction method and a mobile terminal, and relates to the technical field of mobile terminal application control, and the method comprises the following steps: S1, detecting a continuous sliding operation state of a user in a short video application; s2, when it is detected that the continuous sliding operation state meets a preset condition, an anti-addiction intervention mechanism is triggered; s3, executing at least one of the following intervention modes: (1) randomly replacing a sliding operation of the user with a return operation; (2) the resistance of sliding operation is increased, and the sliding distance is prolonged; (3) switching the application interface into a black and white display mode; according to the method, the core addiction behavior of high-frequency sliding is detected in real time, the addiction chain can be broken earlier instead of depending on the accumulated time length, gesture replacement, resistance enhancement and black and white display are integrated into the normal operation process of a user, strong interference modes such as forced screen locking and popup shielding do not exist, and the user acceptability is high.

The presnt disclosure is directed to a beverage composition comprising from a cannabis extract and a Hericium erinaceus extract. The present disclosure also relates to methods of reducing a withdrawal symptom and / or reducing an addictive behavior comprising administering a therapeutically effective amount of the aforementioned beverage composition to a subject having the withdrawal symptom and / or the addictive behavior, methods for treating alcoholism in a subject comprising administering a therapeutically effective amount of the aforementioned beverage composition to the subject, and method of producing altered perception and / or reduced stress while ameliorating a side effect of THC overconsumption in a subject comprising administering a therapeutically effective amount of the aforementioned beverage composition to the subject.

The invention relates to the field of biological medicine, and discloses application of lncRNA Meg3 as a target spot in anti-addiction drugs. Through next-generation sequencing, it is found that lncRNA Meg3 in hippocampus tissues of oxycodone addiction mice is highly expressed, and m6A methylation is mediated by METTL3. SiRNA Meg3 is designed aiming at the target spot and is wrapped in lipid nanoparticles, and the oxycodone addiction behavior can be remarkably inhibited through nasal administration. The siRNA lipid particle has no addiction, has no influence on normal behaviors such as sweet water preference and the like, and has specificity. Experiments prove that the compound plays a role by blocking an ERK / MEK signal channel. The invention provides a new strategy for the development of anti-addiction drugs.

The invention relates to an addiction behavior monitoring system and method based on intelligent glasses, and the system comprises the intelligent glasses and a cloud server. The intelligent glasses are used for collecting a first person visual image of a user, starting continuous video recording to generate corresponding multi-modal feature data under the condition that a target terminal exists in the first person visual image, and uploading the multi-modal feature data to the cloud server; and the cloud server is used for receiving the multi-modal feature data, monitoring digital addiction behaviors of the user in a continuous time sequence according to the multi-modal feature data, and performing hierarchical intervention under the condition that the user has an addiction risk. Through the application, all-weather cross-platform accurate monitoring, early warning and graded intervention of the addiction risk by using the intelligent glasses are realized, the condition of the target terminal is identified firstly, then continuous video recording is started, low-power-consumption operation of the intelligent glasses is ensured, and the problem of how to improve the monitoring capability of the digital addiction risk of a user is solved.

The invention discloses an application of ethyl pyruvate in preparation of a medicine for treating or preventing methamphetamine addiction, belongs to the technical field of medicines, and provides an application of ethyl pyruvate in preparation of a medicine for treating or preventing methamphetamine addiction. According to the present invention, by inhibiting the HMGB1-TLR4-MyD88-PI3K-AKT-NF-KB signal channel, the ethyl pyruvate can reduce the neuroinflammation reaction, and can significantly reduce the addiction behavior and the nerve injury caused by the methamphetamine, such that the new treatment strategy is provided for the treatment of the methamphetamine addiction, and the wide clinical application prospect is provided. Ethyl pyruvate has an obvious nerve protection effect and can relieve nerve injury and promote nerve repair.

The invention provides an EMDR theory-based addiction behavior long-acting intervention system and equipment, and relates to the technical field of artificial intelligence, the system comprises an evaluation module, a processing module, a generation module, a drilling module and an integration module, and a standard system for integrating a Fagger behavior model and an eye movement desensitization reprocessing therapy is constructed. And automatic generation and matching of healthy micro behaviors are realized based on an algorithm, so that the technical problems of weak motivation maintenance, difficult behavior conversion and high recurrence rate in the prior art are solved, and dual-path long-acting intervention from an emotion root to a behavior mode is realized.

The invention discloses application of resveratrol in preparation of a medicine for treating or preventing methamphetamine addiction, belongs to the technical field of biological medicine, and provides application of resveratrol in preparation of a medicine for treating or preventing methamphetamine addiction. According to the application disclosed by the invention, the addiction behavior of a rat METH self-administration model is obviously reduced by virtue of the administration of the resveratrol, so that the resveratrol has obvious clinical application potential; the resveratrol has a potential treatment value in relieving the METH addiction behavior and related neuroinflammation, and a new possibility is provided for treating the METH addiction.

The invention discloses a grease molecule immobilized material as well as a preparation method and application thereof, and belongs to the technical field of foods and medicines. The material has a grease taste, can be used as a fat substitute, and can be used as a food or medical product for correcting fat addiction behaviors of obese people. The oil molecule immobilized material is obtained by immobilizing branched chain fatty acid and / or triglyceride in a glucomannan network, emulsifying and wrapping oil molecules and glucomannan molecules, and then coating the oil molecules and the glucomannan molecules in a cross-linked network. Common raw materials are used, and the production and preparation method is easy to operate, high in production efficiency and suitable for industrial amplification.

The invention discloses a gene-coded opioid receptor fluorescent probe as well as a preparation method and application thereof, the opioid receptor fluorescent probe comprises fusion of a human Mu-chip receptor and a green fluorescent protein, and the amino acid sequence of the opioid receptor fluorescent probe is shown as SEQ ID NO.1. The opioid receptor fluorescent probe constructed by the invention has good membrane positioning capability, good fluorescence signal stability and specificity and large detection range; the compound shows specific response to opioid drugs and endogenous opioid peptides (such as beta-enkephalin and enkephalin) in HEK293T cells, the fluorescence intensity and the ligand concentration are dose-dependent, the compound can be blocked by an antagonist, and the compound has excellent selectivity and pharmacological characteristics. The probe constructed by the invention can be used for novel analgesic drug development, pain mechanism research and addiction behavior monitoring.

Provided herein is a method for weaning a subject suffering from a drug addiction or addictive behaviors involving opioid signaling by sequentially blocking peripheral and CNS opioid receptors and modulating opioid dependence.

The present invention discloses the use of ethyl pyruvate in the preparation of a drug for treating or preventing methamphetamine addiction. The present invention belongs to the field of pharmaceutical technology and provides the use of ethyl pyruvate in the preparation of a drug for treating or preventing methamphetamine addiction. Ethyl pyruvate inhibits the HMGB1-TLR4-MyD88-PI3K-AKT-NF-KB signaling pathway, reduces neuroinflammatory responses, and significantly reduces addictive behaviors and nerve damage caused by methamphetamine. This provides a new therapeutic strategy for the treatment of methamphetamine addiction and has broad clinical application prospects. Ethyl pyruvate has significant neuroprotective effects, can reduce nerve damage, and promote nerve repair.

The present invention relates to methods of treating or preventing addiction and relapse use of addictive agents where the method comprises: (a) administering to a subject a co-therapy treatment with an auricular or peri-auricular electro-acupuncture or neurostimulation device, (b) co-treatment with at least one non-narcotic detoxification agent and (c) administering to the subject an opioid antagonist. The methods and compositions of the invention are useful in the treatment or prevention of addiction to any agent, including alcohol, nicotine, marijuana, cocaine, and amphetamines, as well as compulsive and addictive behaviors, including pathological gambling and pathological overeating.