82 results about "Anxiety depression" patented technology

The invention relates to the technical field of wisdom medical treatment, in particular to a cooperative intervention system and method based on multi-modal emotion perception and five-tone therapy, and realizes precision of emotion recognition and individuation of intervention strategies through cooperative intervention of multi-modal emotion perception and traditional Chinese medicine five-tone therapy. Physiological and behavior signals of a user in different states are comprehensively captured, emotion recognition is carried out in combination with a deep learning model, the accuracy and real-time performance of emotion recognition are remarkably improved, the system can intelligently match music tracks most suitable for the current emotion state based on the five-internal-organ-five-sound theory of traditional Chinese medicine and modern music psychology, and the user experience is improved. And an intervention strategy is continuously optimized through reinforcement learning, so that more targeted and effective emotion regulation is realized, and the method is particularly suitable for long-term management and intervention of negative emotions such as anxiety and depression.

The invention relates to a traditional Chinese medicine composition for treating functional dyspepsia combined with anxiety and depression and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 200-781 parts of rhizoma pinellinae praeparata, 50-365 parts of coptis chinensis, 100-521 parts of scutellaria baicalensis, 150-625 parts of rhizoma zingiberis, 50-313 parts of ginseng, 100-417 parts of liquorice, 150-625 parts of Chinese dates and 150-521 parts of immature bitter orange. The traditional Chinese medicine composition has a good effect of treating functional dyspepsia combined with anxiety and depression, and the preparation method of the traditional Chinese medicine composition is simple and suitable for large-scale production and popularization.

The invention provides an application of a pediococcus pentosaceus strain A20001 in preparation of a product for improving memory concentration and anxiety and depression behaviors, and belongs to the technical field of biological medicines. Animal experiments show that the pediococcus pentosaceus strain A20001 has the functions of resisting anxiety behavior, resisting depression, improving cognitive function and improving memory concentration. Therefore, the invention provides the application of the pediococcus pentosaceus strain A20001 in the preparation of the medicine for preventing and / or treating the anxiety disorder, the depression or the cognitive impairment and improving the memory, and further provides the application of the pediococcus pentosaceus strain A20001 in the preparation of the medicine for preventing and / or treating the anxiety disorder, the depression or the cognitive impairment.

The invention relates to the technical field of intelligent wearing monitoring, in particular to a multifunctional head-mounted device for improving anxiety and depression symptoms in the perioperative period, which comprises a main body base, an electric treatment assembly and a power supply assembly are arranged on the main body base, extending ear hooks are arranged at two ends of the main body base, binding straps are arranged on the extending ear hooks, and a nose pad block is arranged at the bottom of the main body base. The electric treatment assembly is in signal connection with an evaluation and control system, heart rate monitoring assemblies are arranged on the extension ear hooks, and an eye movement monitoring assembly is arranged at the bottom of the main body base; a displacement monitoring assembly is arranged on the main body base, and a respiration monitoring assembly is arranged on the nose pad block. According to the invention, physiological parameter monitoring, anxiety and depression assessment and percutaneous nerve stimulation treatment functions are integrated, and multi-node fixed design and real-time dynamic data processing are combined, so that redundant steps depending on preposed medical assessment in the traditional technology are omitted, doctors can remotely and accurately adjust personalized schemes based on dynamic data, and the accuracy of diagnosis and treatment is improved. The anxiety depression intervention efficiency and reliability in the perioperative period are improved.

The invention relates to a psychological health assessment method and equipment based on an optical fiber sensor and a storage medium. The method comprises the following steps: acquiring an original physiological signal of a person to be detected through an optical fiber sensor, and performing data preprocessing on the original physiological signal to obtain a preprocessed signal; constructing a transfer learning model, and obtaining a public physiological signal data set to train the transfer learning model to obtain an evaluation model; performing physiological signal feature extraction on the preprocessed signals, performing series fusion on the extracted features of the physiological signals to form a multi-modal feature vector, and inputting the multi-modal feature vector into the evaluation model to obtain a classification probability output result; and generating a mental health assessment report according to the classification probability output result. A complete, efficient and accurate quantitative evaluation system for anxiety depression, emotion stress, fatigue level and pressure sensitivity can be constructed, and high-precision and real-time monitoring and evaluation of the mental health state are achieved.

The invention discloses a traditional Chinese medicine composition for treating anxiety and depression disorder, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 9 to 30 parts of radix codonopsis, 9 to 30 parts of radix astragali preparata, 6 to 12 parts of radix angelicae sinensis, 10 to 15 parts of poria cocos, 6 to 10 parts of fried fructus gardeniae, 6 to 12 parts of fermented soybean, 3 to 10 parts of fingered citron, 3 to 10 parts of fructus citri and 2 to 10 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition provided by the invention highlights the characteristic of both medicine and food, the components meet the supervision requirement of'both medicines and foods', the component compatibility is scientific and reasonable, and the traditional Chinese medicine composition has the effects of soothing liver-qi stagnation, tonifying qi and spleen, clearing heat and relieving restlessness, is safe to take, good in curative effect and small in side effect, can be effectively used for treating anxiety and depressive disorder, and has a wide application prospect. And the traditional Chinese medicine composition is a great innovation in drugs for treating anxiety and depressive disorder, and has remarkable economic and social benefits.

The invention provides a relaxation and decompression device for relieving anxiety and depression. The relaxation and decompression device structurally comprises a positioning block, a bottom plate, a supporting column, a control panel, a sound box, an exercise structure and a rest structure. After the rest structure is further improved, the folded rotating plate and the extension structure are overturned and positioned through the positioning frame and the convex block of the parallel plate, so that the hindering condition generated when the exercise structure is used is prevented; after the patient is subjected to high-intensity exercise, a rotating plate can be pulled down by 90 degrees, so that an extension structure is parallel to the upper part of a bottom plate, then a bearing plate of the extension structure is turned over again by using a rotating wheel, the extension plate is ensured to be located at the upper layer position of a solid plate, and then the extension plate is pulled out through a sliding block; therefore, the whole body of the patient can lie flat through three groups of length superposition of the extension plate, the solid plate and the rotating plate, the original mode that the patient only has a sitting state to have a rest is replaced, and the convenience of the patient to have a rest at the original point can be improved.

This invention discloses a method for quantifying anxiety and depression comorbidities using partial label learning based on brain imaging, belonging to the fields of medical image processing and artificial intelligence. The method is based on a dataset constructed using brain imaging measurements. It selects representative typical anxiety and depression samples with distinctive brain imaging features from clinically diagnosed groups and constructs a sparse nearest neighbor graph by comprehensively considering the relationships between each sample and its nearest ordinary and typical neighbor samples. Partial label learning modeling and optimization are performed through an iterative label propagation mechanism, ultimately outputting label confidence matrices for clinical anxiety patients, depression patients, and patients with comorbid anxiety and depression. This enables a quantitative assessment of the anxiety and depression levels in patients with comorbid anxiety and depression and completes the classification of comorbidity subtypes. This invention improves the accuracy and objectivity of anxiety and depression comorbidity assessment, providing auxiliary support for the clinical diagnosis, pathological mechanism research, and intervention target screening of anxiety and depression comorbidities.

The application discloses a traditional Chinese medicine composition for treating postprandial discomfort syndrome with sleep disorder, which comprises the following components in parts by weight: 15-20 parts of Radix Bupleuri, 15-20 parts of Rhizoma Atractylodis Macrocephalae, 20-25 parts of Radix Codonopsis, 10-15 parts of Fructus Aurantii Immaturus, 15-20 parts of Radix Paeoniae Alba, 10-15 parts of Pericarpium Citri Reticulatae, 10-15 parts of Rhizoma Pinelliae Praeparatum, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of Fructus Amomi Rotundus, and 10-15 parts of Radix Glycyrrhizae Praeparata Cum Melle. The traditional Chinese medicine composition has the effects of soothing liver and invigorating spleen, regulating qi and adjusting center, and has good effects on improving symptoms such as upper abdominal pain and postprandial fullness, and has good safety. Meanwhile, the traditional Chinese medicine composition can effectively relieve symptoms such as anxiety and depression caused by gastrointestinal discomfort, and has remarkable curative effects on postprandial discomfort syndrome with sleep disorder.

The present disclosure discloses a composition of GLP-1 and PYY3-36 polypeptide analogues, a preparation method and use thereof, and relates to the technical field of biomedicines. The composition includes a GLP-1 polypeptide analogue and a PYY3-36 polypeptide analogue. Compared with the natural sequence of GLP-1 and the natural sequence of PYY3-36, the composition of the GLP-1 polypeptide analogue and the PYY3-36 polypeptide analogue has remarkable effects in ameliorating metabolic diseases such as obesity, diabetes mellitus, and fatty liver, and mood disorders such as anxiety and depression.

The invention relates to a cancer patient mental health prediction model based on multi-source data and application. The model comprises the following steps: utilizing electronic health record (EHR) data and longitudinal data of cancer patients in prospective queue research; constructing and verifying a prediction model in combination with multiple factors; carrying out model training and verification by utilizing a machine learning algorithm so as to realize early prediction of anxiety, depression and psychotic disorders; and quantifying the contribution of each factor to the psychological health risk through model interpretive analysis. Through multi-source data fusion and an advanced algorithm, the early recognition rate of the psychological health problem of the cancer patient can be effectively improved, resource waste and diagnosis delay are reduced, and the treatment effect and life quality of the patient are improved.

An oil diffuser device that is a plug-in heat and fan device for diffusing CBD oil into the air. The oil diffuser device comprises a body component with a plurality of ventilation holes for retaining an amount of CBD oil or other suitable oil. A plug-in component comprises a heat source that draws power from an electrical outlet. The plug-in component also comprises a fan for dispersing the heated oil vapors through the plurality of ventilation holes. Users simply attach the body component with CBD oil to the plug-in component and then insert it into an electrical outlet to heat the CBD oil and release the heated oil vapors into the air. Overall, the device can be used to relax people who suffer from anxiety, depression, or stress.

The invention discloses application of Cacumen biotae-derived extracellular vesicles in preparation of drugs for treating anxiety, depression or insomnia. The EVs are separated and purified from cacumen biotae through a specific differential ultracentrifugation method, the EVs have a typical double-layer membrane structure, the average particle size is about 100 nm, about 1012 EVs can be extracted from each gram of cacumen biotae, and 62 volatile components are contained. Cacumen biotae EVs can be taken by PC12 cells, and corticosterone-induced neuron damage can be relieved; for chronic constraint stress model mice, anxiety behaviors and spatial learning and memory disorders can be improved, and central nervous inflammation can be inhibited; for chronic unpredictable mild stress model mice, the weight, the sucrose preference rate and the cognitive ability can be recovered, and the levels of 5-hydroxytryptamine and gamma-aminobutyric acid are increased; and for 4-chloro-DL-phenylalanine induced insomnia model mice, the sleep condition can be improved, the neurotransmitter level can be recovered, and the effect is equivalent to that of positive drugs such as citalopram, fluoxetine, diazepam and the like.

The invention provides a traditional Chinese medicine composition with functions of softening hardness and dredging collaterals as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition with the functions of softening hardness and dredging collaterals is prepared from the following raw material medicines in parts by weight: 20-40 parts of turtle shells, 20-40 parts of radix paeoniae alba, 14-22 parts of sedum sarmentosum, 9-21 parts of teasel roots, 9-21 parts of rhizoma acori graminei, 9-21 parts of astragalus membranaceus, 14-22 parts of ligusticum wallichii and 3-15g of honey-fried licorice roots. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition adopts a treatment method of softening hardness to dissipate stagnation, dredging collaterals and relieving spasm, and can improve clinical symptoms such as cognitive impairment related to small cerebral vasculopathy of a patient, and / or anxiety and depression, and / or sleep disorder and the like. In-vitro experiments prove that the traditional Chinese medicine composition has a protection effect on human brain microvascular endothelial cell injury caused by hypoxia and reoxygenation, and can promote cell proliferation and inhibit cell apoptosis. Therefore, the traditional Chinese medicine composition can be applied to prevention and / or treatment of clinical symptoms related to small cerebral vasculopathy under the pathological mechanism of pulse stagnation and collateral arthralgia.

The invention relates to a bifidobacterium composition for relieving mood disorder caused by constipation and application of the bifidobacterium composition, and belongs to the technical field of probiotics. According to the bifidobacterium composition containing the animal bifidobacterium subsp. Lactis Bb-12 and the bifidobacterium longum subsp. Longum BB536, through the synergistic effect of the Bb-12 and the BB536, the effect of relieving constipation can be achieved by improving the water content of excrement, improving the intestinal tract movement capacity and increasing the content of short-chain fatty acid in the intestinal tract. On the basis that constipation is relieved, emotional disorders caused by constipation can be further relieved, and particularly, the content of anxiety and depression related cranial nerve factors BDNF in hippocampus is increased, and the relative expression quantity of inflammatory factors TNF-alpha is reduced. A new thought is provided for the development of nutritional supplement food for relieving anxiety and depression caused by constipation.

The present invention relates to the use of a tomato extract for modulating the gut microbiota in a subject to confer a health benefit, and to a composition containing a tomato extract formulated for delivery to the large intestine. The tomato extract can be used to improve resistance to infection in the gut, reduce inflammation in the gut, treat or minimize inflammatory bowel disease, or treat or minimize irritable bowel syndrome. The extract can also be used to treat conditions associated with an imbalance of the gut microbiota such as anxiety, depression, type II diabetes, non-alcoholic fatty liver disease, obesity, or cognitive impairment.

The invention relates to a composition with an emotion conditioning function as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composition comprises core components: calcium 6S-5-methyltetrahydrofolate, N-acetylneuraminic acid, spirulina maxima powder and betaine, and further comprises synergistic components such as vitamin B6, vitamin B12, a zinc source, a selenium source and vitamin B1, vitamin B2, nicotinic acid and pantothenic acid. The composition is designed on the basis of an intestine-brain linkage mechanism, and the brain-intestine axis function is systematically adjusted through multi-target cooperation of intestinal barrier repair, neurotransmitter efficient synthesis, neural network structure support and the like. Experiments show that the composition can effectively improve anxiety, depression and other emotional states, provides a synergistic and safe nutrition intervention scheme for related people, and has a definite application prospect in the fields of emotional health functional foods and brain-intestine axis targeted special diet foods.

The present invention relates to a Chinese medicine composition for treating functional dyspepsia, which is prepared from the following Chinese medicine raw materials: pinellia, scutellaria, coptis, dried ginger, codonopsis, amomum, rhubarb, curcuma, magnolia bark, white peony root, corydalis, liquorice, jujube. The preparation method is to decoct in water for multiple times, filter, collect the filtrate, and prepare the corresponding preparation. The preferred preparation is a granule. The Chinese medicine composition has excellent clinical effects in treating functional dyspepsia, especially for patients showing symptoms of cold and heat, liver and stomach disharmony, spleen deficiency and qi stagnation, epigastric fullness or distending pain, poor appetite, dry throat, intestinal rumbling and loose stools, pale tongue with yellow or greasy fur, and stringy and thin pulse, and can also improve mental symptoms such as anxiety and depression related to functional dyspepsia.

The invention relates to the technical field of biomedical treatment, in particular to a construction method of a Parkinson's disease animal model. According to the method, a virus solution carrying taCasp3 is used for ablating dopaminergic neurons of the compact part of nigra of the brain of an animal, anxiety and depression behaviors of the animal are induced, and the animal model of the Parkinson's disease is obtained. The Parkinson's disease animal model can stably reproduce nervous and psychiatric symptoms such as anxiety and depression, and is of great significance to improvement and treatment of anxiety or depression symptoms of Parkinson's disease.

The invention discloses a traditional Chinese medicine composition for treating glaucoma-sleep-emotion co-disease and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: 15g of fructus mume, 12g of schisandra chinensis, 12g of angelica sinensis, 12g of safflower carthamus, 6g of cassia twig, 15g of codonopsis pilosula, 15g of semen plantaginis, 6g of golden cypress and 6g of radix aconiti lateralis preparata. The formula of the traditional Chinese medicine composition is a mind-regulating and eyesight-improving formula obtained by the inventor in combination with traditional Chinese medicine classic and years of practical experience, and the formula can effectively reduce intraocular pressure of a glaucoma-sleep-emotion codisease patient, stabilize intraocular pressure rhythm, improve traditional Chinese medicine syndromes and sleep quality, and relieve anxiety and depression emotion. Therefore, the formula for regulating mind and improving eyesight is exact in curative effect, and has wide application prospects in simultaneous treatment of glaucoma and simultaneous regulation of brain and eyes.

The present invention is directed to beneficially directing the bidirectional communication that exists between the brain and the gut so as to influence brain physiology, psychological responses and ultimately behavior in a positive manner by regulating an individual's mood, psychological symptoms, such as anxiety and depression and stress-related changes in brain function, by modifying the gut microbiome of an individual. In various embodiments, an individual's microbiome is modified in a manner to reduce the likelihood of stress, to reduce or treat symptoms affecting mental health and to promote the mental health of the individual. In certain embodiments, administration to an individual of at least three different bacteria species are combined to modify an individual's microbiome, selected from the group of Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. casei and Faecalibacterium prausnitzii, to reduce adverse psychological and / or physiological responses attendant to psychological stress.

The application discloses a traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression and a preparation method of the traditional Chinese medicine composition. The composition comprises the following components in parts by weight: American ginseng powder 3-10 parts, panax notoginseng powder 3-6 parts, amber powder 1-2 parts, curcuma zedoaria powder 3-10 parts and hypericum perforatum powder 1-5 parts. The composition can effectively treat coronary heart disease combined with anxiety and depression.

The present invention relates to a food composition for improving and preventing estrogen deficiency, comprising a circium japonicum extract and a circium japonicum and thyme composite extract as active ingredients. The traditional Chinese medicine composition has the advantages of relieving estrogen deficiency of menopause women and improving the symptoms caused by estrogen deficiency, such as facial flushing, sweating, fatigue, anxiety, depression, dysmnesia, insomnia, increase of cholesterol in blood, weight gain, reduction of bone mineral density and the like.

This invention belongs to the field of pharmaceutical formulation technology, specifically disclosing a gastrodin transdermal patch and its preparation method. The patch consists of a backing layer, a drug-containing matrix layer, and an anti-adhesive layer, using gastrodin as the active ingredient. It employs HP-β-CD inclusion technology, combined with an HPMC and PVP polymer backbone and an oleic acid-menthol composite transdermal enhancement system. The preparation utilizes solvent casting and low-temperature vacuum drying processes, which are mild and controllable. This invention effectively solves the problems of difficult transdermal absorption, easy recrystallization, and low bioavailability of gastrodin. The resulting patch has excellent adhesion, no skin irritation, high transdermal penetration, and good skin biocompatibility. It can efficiently cross the blood-brain barrier, regulate the neuroinflammatory microenvironment in the brain, significantly inhibit the colonization and progression of non-small cell lung cancer brain metastases, and strongly reverse tumor-related anxiety and depression-like mood disorders. It provides a novel drug delivery regimen with great clinical translational potential for the non-invasive synergistic treatment of brain tumors and their associated mood disorders.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating coronary heart disease complicated with anxiety and depression, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from coptis chinensis, rhizoma pinelliae preparata, caulis bambusae in taeniam, fried fructus aurantii, pericarpium citri reticulatae, poria cocos, vinegar-processed curcuma zedoary, astragalus membranaceus, cassia twig, angelica sinensis, ligusticum wallichii, cortex albiziae, vinegar-processed rhizoma cyperi and fried semen raphani. The traditional Chinese medicine composition has the effects of tonifying qi, activating blood and soothing liver-qi stagnation, and has a good treatment effect on coronary heart disease combined with anxiety depression through test verification.

1. Name of the Design Product: Venting sandbag. 2. Use of the Design Product: For people to vent their emotions and solve psychological problems such as tension, anxiety, and depression. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photo Most Indicating the Design Key Points: Perspective view 1.

The present application belongs to the technical field of biological medicine, and particularly relates to a new use of a 5-HT6 receptor agonist in the preparation of a medicine for treating chronic pain complicated with anxiety and depression, and especially an application of the 5-HT6 receptor agonist in the preparation of a medicine for simultaneously treating chronic neuropathic pain and relieving anxiety and / or depression caused by the chronic pain. The present application discloses for the first time that in a pathological state of chronic pain (such as trigeminal neuralgia) secondary anxiety / depression, the expression of 5-HT6R in the mPFC brain region is significantly down-regulated, and a 5-HT6R agonist can dose-dependently specifically relieve anxiety / depression-like behaviors induced by chronic pain, and has no obvious effect on the behavior of normal animals, which indicates that the 5-HT6R agonist has good safety and targeting, and provides a theoretical basis for developing more effective medicines in the clinic.

This invention discloses a plant essential oil spray with anti-anxiety and antidepressant effects and its preparation process, available in daytime and nighttime versions. The plant essential oil mixture is prepared by coupled flash extraction with anhydrous ethanol and 1-octyl-3-methylimidazolium bromide, followed by microfiltration-nanofiltration and vacuum distillation. The excipients and essential oils are then mixed and bottled into spray bottles equipped with an automatic spraying device to obtain the daytime and nighttime plant essential oil sprays. The daytime version stimulates the autonomic nervous system, reduces mental fatigue, improves cognitive mood, and exerts an anti-anxiety effect during the day; the nighttime version regulates neurotransmitter levels, significantly calms and soothes the mind, and adapts to the differences in human mood and nervous state between day and night. This invention features high extraction efficiency, stable essential oil quality, and the product possesses both anti-anxiety and antidepressant effects. It is convenient to use, highly safe, and suitable for daily mood regulation, psychological stress relief, and intervention for anxiety and depression tendencies.

The invention relates to particular substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and / or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use as selective agonists or antagonists serotonin (5-HT2A) receptor, preferably non-hallucinogenic biased agonists or antagonists at the serotonin (5-HT2A) receptor, such as having agonism biased towards the beta-arrestin signaling pathway, or as serotonin (5-HT2A) receptor antagonists. Such compounds are useful for the treatment of mood disorders, general anxiety, social anxiety, depression, anhedonia, and other neuropsychiatric diseases.