51 results about "Anxiety depression" patented technology

The invention relates to a traditional Chinese medicine composition for treating functional dyspepsia combined with anxiety and depression and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 200-781 parts of rhizoma pinellinae praeparata, 50-365 parts of coptis chinensis, 100-521 parts of scutellaria baicalensis, 150-625 parts of rhizoma zingiberis, 50-313 parts of ginseng, 100-417 parts of liquorice, 150-625 parts of Chinese dates and 150-521 parts of immature bitter orange. The traditional Chinese medicine composition has a good effect of treating functional dyspepsia combined with anxiety and depression, and the preparation method of the traditional Chinese medicine composition is simple and suitable for large-scale production and popularization.

The invention relates to the technical field of intelligent wearing monitoring, in particular to a multifunctional head-mounted device for improving anxiety and depression symptoms in the perioperative period, which comprises a main body base, an electric treatment assembly and a power supply assembly are arranged on the main body base, extending ear hooks are arranged at two ends of the main body base, binding straps are arranged on the extending ear hooks, and a nose pad block is arranged at the bottom of the main body base. The electric treatment assembly is in signal connection with an evaluation and control system, heart rate monitoring assemblies are arranged on the extension ear hooks, and an eye movement monitoring assembly is arranged at the bottom of the main body base; a displacement monitoring assembly is arranged on the main body base, and a respiration monitoring assembly is arranged on the nose pad block. According to the invention, physiological parameter monitoring, anxiety and depression assessment and percutaneous nerve stimulation treatment functions are integrated, and multi-node fixed design and real-time dynamic data processing are combined, so that redundant steps depending on preposed medical assessment in the traditional technology are omitted, doctors can remotely and accurately adjust personalized schemes based on dynamic data, and the accuracy of diagnosis and treatment is improved. The anxiety depression intervention efficiency and reliability in the perioperative period are improved.

This invention discloses a method for quantifying anxiety and depression comorbidities using partial label learning based on brain imaging, belonging to the fields of medical image processing and artificial intelligence. The method is based on a dataset constructed using brain imaging measurements. It selects representative typical anxiety and depression samples with distinctive brain imaging features from clinically diagnosed groups and constructs a sparse nearest neighbor graph by comprehensively considering the relationships between each sample and its nearest ordinary and typical neighbor samples. Partial label learning modeling and optimization are performed through an iterative label propagation mechanism, ultimately outputting label confidence matrices for clinical anxiety patients, depression patients, and patients with comorbid anxiety and depression. This enables a quantitative assessment of the anxiety and depression levels in patients with comorbid anxiety and depression and completes the classification of comorbidity subtypes. This invention improves the accuracy and objectivity of anxiety and depression comorbidity assessment, providing auxiliary support for the clinical diagnosis, pathological mechanism research, and intervention target screening of anxiety and depression comorbidities.

The application discloses a traditional Chinese medicine composition for treating postprandial discomfort syndrome with sleep disorder, which comprises the following components in parts by weight: 15-20 parts of Radix Bupleuri, 15-20 parts of Rhizoma Atractylodis Macrocephalae, 20-25 parts of Radix Codonopsis, 10-15 parts of Fructus Aurantii Immaturus, 15-20 parts of Radix Paeoniae Alba, 10-15 parts of Pericarpium Citri Reticulatae, 10-15 parts of Rhizoma Pinelliae Praeparatum, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of Fructus Amomi Rotundus, and 10-15 parts of Radix Glycyrrhizae Praeparata Cum Melle. The traditional Chinese medicine composition has the effects of soothing liver and invigorating spleen, regulating qi and adjusting center, and has good effects on improving symptoms such as upper abdominal pain and postprandial fullness, and has good safety. Meanwhile, the traditional Chinese medicine composition can effectively relieve symptoms such as anxiety and depression caused by gastrointestinal discomfort, and has remarkable curative effects on postprandial discomfort syndrome with sleep disorder.

The present disclosure discloses a composition of GLP-1 and PYY3-36 polypeptide analogues, a preparation method and use thereof, and relates to the technical field of biomedicines. The composition includes a GLP-1 polypeptide analogue and a PYY3-36 polypeptide analogue. Compared with the natural sequence of GLP-1 and the natural sequence of PYY3-36, the composition of the GLP-1 polypeptide analogue and the PYY3-36 polypeptide analogue has remarkable effects in ameliorating metabolic diseases such as obesity, diabetes mellitus, and fatty liver, and mood disorders such as anxiety and depression.

The invention relates to a cancer patient mental health prediction model based on multi-source data and application. The model comprises the following steps: utilizing electronic health record (EHR) data and longitudinal data of cancer patients in prospective queue research; constructing and verifying a prediction model in combination with multiple factors; carrying out model training and verification by utilizing a machine learning algorithm so as to realize early prediction of anxiety, depression and psychotic disorders; and quantifying the contribution of each factor to the psychological health risk through model interpretive analysis. Through multi-source data fusion and an advanced algorithm, the early recognition rate of the psychological health problem of the cancer patient can be effectively improved, resource waste and diagnosis delay are reduced, and the treatment effect and life quality of the patient are improved.

The invention discloses application of Cacumen biotae-derived extracellular vesicles in preparation of drugs for treating anxiety, depression or insomnia. The EVs are separated and purified from cacumen biotae through a specific differential ultracentrifugation method, the EVs have a typical double-layer membrane structure, the average particle size is about 100 nm, about 1012 EVs can be extracted from each gram of cacumen biotae, and 62 volatile components are contained. Cacumen biotae EVs can be taken by PC12 cells, and corticosterone-induced neuron damage can be relieved; for chronic constraint stress model mice, anxiety behaviors and spatial learning and memory disorders can be improved, and central nervous inflammation can be inhibited; for chronic unpredictable mild stress model mice, the weight, the sucrose preference rate and the cognitive ability can be recovered, and the levels of 5-hydroxytryptamine and gamma-aminobutyric acid are increased; and for 4-chloro-DL-phenylalanine induced insomnia model mice, the sleep condition can be improved, the neurotransmitter level can be recovered, and the effect is equivalent to that of positive drugs such as citalopram, fluoxetine, diazepam and the like.

The invention provides a traditional Chinese medicine composition with functions of softening hardness and dredging collaterals as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition with the functions of softening hardness and dredging collaterals is prepared from the following raw material medicines in parts by weight: 20-40 parts of turtle shells, 20-40 parts of radix paeoniae alba, 14-22 parts of sedum sarmentosum, 9-21 parts of teasel roots, 9-21 parts of rhizoma acori graminei, 9-21 parts of astragalus membranaceus, 14-22 parts of ligusticum wallichii and 3-15g of honey-fried licorice roots. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition adopts a treatment method of softening hardness to dissipate stagnation, dredging collaterals and relieving spasm, and can improve clinical symptoms such as cognitive impairment related to small cerebral vasculopathy of a patient, and / or anxiety and depression, and / or sleep disorder and the like. In-vitro experiments prove that the traditional Chinese medicine composition has a protection effect on human brain microvascular endothelial cell injury caused by hypoxia and reoxygenation, and can promote cell proliferation and inhibit cell apoptosis. Therefore, the traditional Chinese medicine composition can be applied to prevention and / or treatment of clinical symptoms related to small cerebral vasculopathy under the pathological mechanism of pulse stagnation and collateral arthralgia.

The invention relates to a composition with an emotion conditioning function as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composition comprises core components: calcium 6S-5-methyltetrahydrofolate, N-acetylneuraminic acid, spirulina maxima powder and betaine, and further comprises synergistic components such as vitamin B6, vitamin B12, a zinc source, a selenium source and vitamin B1, vitamin B2, nicotinic acid and pantothenic acid. The composition is designed on the basis of an intestine-brain linkage mechanism, and the brain-intestine axis function is systematically adjusted through multi-target cooperation of intestinal barrier repair, neurotransmitter efficient synthesis, neural network structure support and the like. Experiments show that the composition can effectively improve anxiety, depression and other emotional states, provides a synergistic and safe nutrition intervention scheme for related people, and has a definite application prospect in the fields of emotional health functional foods and brain-intestine axis targeted special diet foods.

The invention relates to the technical field of biomedical treatment, in particular to a construction method of a Parkinson's disease animal model. According to the method, a virus solution carrying taCasp3 is used for ablating dopaminergic neurons of the compact part of nigra of the brain of an animal, anxiety and depression behaviors of the animal are induced, and the animal model of the Parkinson's disease is obtained. The Parkinson's disease animal model can stably reproduce nervous and psychiatric symptoms such as anxiety and depression, and is of great significance to improvement and treatment of anxiety or depression symptoms of Parkinson's disease.

The invention discloses a traditional Chinese medicine composition for treating glaucoma-sleep-emotion co-disease and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: 15g of fructus mume, 12g of schisandra chinensis, 12g of angelica sinensis, 12g of safflower carthamus, 6g of cassia twig, 15g of codonopsis pilosula, 15g of semen plantaginis, 6g of golden cypress and 6g of radix aconiti lateralis preparata. The formula of the traditional Chinese medicine composition is a mind-regulating and eyesight-improving formula obtained by the inventor in combination with traditional Chinese medicine classic and years of practical experience, and the formula can effectively reduce intraocular pressure of a glaucoma-sleep-emotion codisease patient, stabilize intraocular pressure rhythm, improve traditional Chinese medicine syndromes and sleep quality, and relieve anxiety and depression emotion. Therefore, the formula for regulating mind and improving eyesight is exact in curative effect, and has wide application prospects in simultaneous treatment of glaucoma and simultaneous regulation of brain and eyes.

The application discloses a traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression and a preparation method of the traditional Chinese medicine composition. The composition comprises the following components in parts by weight: American ginseng powder 3-10 parts, panax notoginseng powder 3-6 parts, amber powder 1-2 parts, curcuma zedoaria powder 3-10 parts and hypericum perforatum powder 1-5 parts. The composition can effectively treat coronary heart disease combined with anxiety and depression.

The present invention relates to a food composition for improving and preventing estrogen deficiency, comprising a circium japonicum extract and a circium japonicum and thyme composite extract as active ingredients. The traditional Chinese medicine composition has the advantages of relieving estrogen deficiency of menopause women and improving the symptoms caused by estrogen deficiency, such as facial flushing, sweating, fatigue, anxiety, depression, dysmnesia, insomnia, increase of cholesterol in blood, weight gain, reduction of bone mineral density and the like.

This invention belongs to the field of pharmaceutical formulation technology, specifically disclosing a gastrodin transdermal patch and its preparation method. The patch consists of a backing layer, a drug-containing matrix layer, and an anti-adhesive layer, using gastrodin as the active ingredient. It employs HP-β-CD inclusion technology, combined with an HPMC and PVP polymer backbone and an oleic acid-menthol composite transdermal enhancement system. The preparation utilizes solvent casting and low-temperature vacuum drying processes, which are mild and controllable. This invention effectively solves the problems of difficult transdermal absorption, easy recrystallization, and low bioavailability of gastrodin. The resulting patch has excellent adhesion, no skin irritation, high transdermal penetration, and good skin biocompatibility. It can efficiently cross the blood-brain barrier, regulate the neuroinflammatory microenvironment in the brain, significantly inhibit the colonization and progression of non-small cell lung cancer brain metastases, and strongly reverse tumor-related anxiety and depression-like mood disorders. It provides a novel drug delivery regimen with great clinical translational potential for the non-invasive synergistic treatment of brain tumors and their associated mood disorders.

The present application belongs to the technical field of biological medicine, and particularly relates to a new use of a 5-HT6 receptor agonist in the preparation of a medicine for treating chronic pain complicated with anxiety and depression, and especially an application of the 5-HT6 receptor agonist in the preparation of a medicine for simultaneously treating chronic neuropathic pain and relieving anxiety and / or depression caused by the chronic pain. The present application discloses for the first time that in a pathological state of chronic pain (such as trigeminal neuralgia) secondary anxiety / depression, the expression of 5-HT6R in the mPFC brain region is significantly down-regulated, and a 5-HT6R agonist can dose-dependently specifically relieve anxiety / depression-like behaviors induced by chronic pain, and has no obvious effect on the behavior of normal animals, which indicates that the 5-HT6R agonist has good safety and targeting, and provides a theoretical basis for developing more effective medicines in the clinic.

This invention discloses a plant essential oil spray with anti-anxiety and antidepressant effects and its preparation process, available in daytime and nighttime versions. The plant essential oil mixture is prepared by coupled flash extraction with anhydrous ethanol and 1-octyl-3-methylimidazolium bromide, followed by microfiltration-nanofiltration and vacuum distillation. The excipients and essential oils are then mixed and bottled into spray bottles equipped with an automatic spraying device to obtain the daytime and nighttime plant essential oil sprays. The daytime version stimulates the autonomic nervous system, reduces mental fatigue, improves cognitive mood, and exerts an anti-anxiety effect during the day; the nighttime version regulates neurotransmitter levels, significantly calms and soothes the mind, and adapts to the differences in human mood and nervous state between day and night. This invention features high extraction efficiency, stable essential oil quality, and the product possesses both anti-anxiety and antidepressant effects. It is convenient to use, highly safe, and suitable for daily mood regulation, psychological stress relief, and intervention for anxiety and depression tendencies.

The invention relates to particular substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and / or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use as selective agonists or antagonists serotonin (5-HT2A) receptor, preferably non-hallucinogenic biased agonists or antagonists at the serotonin (5-HT2A) receptor, such as having agonism biased towards the beta-arrestin signaling pathway, or as serotonin (5-HT2A) receptor antagonists. Such compounds are useful for the treatment of mood disorders, general anxiety, social anxiety, depression, anhedonia, and other neuropsychiatric diseases.

This invention provides a traditional Chinese medicine composition for treating anxiety, depression, and / or sleep disorders, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition includes the following raw materials: *Aconitum carmichaelii* root slices, calcined magnetite, stir-fried jujube seed, prepared polygala tenuifolia root, prepared pinellia tuber, tangerine peel, stir-fried immature bitter orange, ginger-processed bamboo shavings, albizia bark, poria cocos, coix seed, bamboo leaf bupleurum root, oyster shell, licorice root, and dragon bone. The preparation method includes: first decocting the *Aconitum carmichaelii* root slices, then adding the remaining medicinal ingredients and decocting with water; concentrating the filtrate into a clear paste, adding excipients, and compressing into tablets. Animal experiments show that, compared with the model group, the traditional Chinese medicine composition of this invention can significantly increase the number of times mice enter the central region and the dwell time in the open field test, and improve the number of times mice enter the open arms of the elevated cruciate maze and the dwell time; hippocampal Nielsen staining shows that neurons are neatly arranged and cell density is well restored. This invention has the effects of warming the kidney and suppressing yang, resolving phlegm and calming the mind, and can be used to prepare drugs for treating anxiety, depression, and / or sleep disorders.

The present invention provides novel piperidinyl-containing pain-sensitive peptide receptor ligand compounds and pharmaceutical compositions that are useful in the treatment of neurological diseases and disorders wherein such ligands address the negative effects of such disorders. Such neurological diseases and conditions include acute and chronic pain, substance abuse / dependence, alcohol addiction, anxiety, depression, sleep disorders, gastrointestinal disorders, kidney disease, cardiovascular disease, and Parkinson's disease.

The application discloses a composition of Qixuebengzhi recipe and belongs to the field of traditional Chinese medicines; the composition is mainly prepared from bupleurum, immature fruit of citrus, persicae semen, safflower, chuanxiong and red peony root; the application is based on the concept of treating heart and body simultaneously, and through the ascending and descending of qi and the regulating of liver qi of bupleurum and immature fruit of citrus, the composition can dredge the liver and regulate qi, and through the dispersing of persicae semen and safflower, the composition can dredge the channels and remove stasis, and through the combination of chuanxiong and red peony root, the composition can regulate qi and blood, and the combination of the medicines can directly attack the core pathogenesis of qi stagnation and blood stasis; clinical verification shows that the composition can not only significantly improve the TCM syndromes such as chest pain and chest distress of patients and the frequency of angina pectoris attacks, but also quickly relieve anxiety and depression and improve sleep quality.

The invention relates to the technical field of traditional Chinese medicine, in particular to application of garter snake antipruritic pills to preparation of medicine for preventing and treating mental disorder diseases. Clinical research proves that the garter snake antipruritic pill has the effect of preventing and treating mental disorder diseases. The effect is confirmed in comparison of anxiety and depression scores of hospitals before and after treatment by adopting random clinical research design and observing 120 patients with anxiety and depression combined with pruritic dermatosis.

The application provides a traditional Chinese medicine composition for improving digestive system diseases caused by brain-gut disorder, which is made of the following traditional Chinese medicines in parts by weight: Gastrodia 1-35 parts, Astragalus 1-35 parts, Fructus Alpiniae oxyphyllae 1-20 parts, Atractylodes 1-20 parts, Hypericum 1-20 parts, Cinnamomum 1-10 parts, and Dried Ginger 1-10 parts, and further provides a preparation method and application of the composition. The traditional Chinese medicine composition can intervene in the brain-gut disorder related digestive system diseases from the perspective of brain-gut interaction, has the effects of improving anxiety and depression-like behaviors, reducing visceral pain sensitivity, protecting and repairing intestinal mucosal barrier, reducing intestinal local inflammatory response, and regulating intestinal flora structure, so as to realize the comprehensive regulation of emotional abnormalities and digestive system symptoms in brain-gut disorder related digestive system diseases, and has a good clinical application prospect.

The application belongs to the technical field of pharmaceutical preparations, and specifically discloses an acetyl gastrodin transdermal patch and a preparation method thereof. The transdermal patch takes acetyl gastrodin as an effective component, is encapsulated in cubic phase liposomes composed of glycerol monostearate, cholesterol and Pluronic F127, is dispersed in a complex matrix of hydroxypropyl methyl cellulose and ethyl cellulose, and is matched with a complex transdermal enhancer of glyceryl caprylate / caprate and ethanol. In the preparation, the liposome material is first melted to load the drug, and then drug-loaded cubic phase liposomes are formed through ice water bath ultrasonic treatment. Then, the drug-loaded cubic phase liposomes are mixed with the polymer matrix and excipients, are defoamed, are coated, and are dried in two steps to be shaped. The cubic phase liposomes are used to significantly improve the drug penetration rate and stability, realize 24-hour smooth drug release, efficiently penetrate the skin and the blood-brain barrier, significantly inhibit non-small cell lung cancer brain metastases, improve tumor secondary anxiety and depression, have excellent skin compatibility, and provide a new non-invasive synergistic treatment scheme for brain tumors and concurrent emotional disorders.

The invention belongs to the technical field of animal-derived active polypeptides, and discloses a He-prescription crucian carp skin collagen peptide with anti-osteoarthritis activity and application thereof. After being subjected to in-vitro simulated digestion, the He-prescription crucian carp skin collagen peptide comprises 10 peptide fragments which are respectively LVGPPGLT, IGMPGMT, LIGPPGL, NIGMPGM, IGPGPI, LTGFPGAA, GFNGLPGS, MTGPIGL, VGPPGAP and GLPGLAGR. The invention also discloses that the combined-prescription crucian skin collagen peptide has anti-osteoarthritis activity, can be further used for preparing anti-osteoarthritis products, can obviously relieve hyperalgesia behaviors and anxiety depression behaviors caused by osteoarthritis of mice, and can obviously improve the defects of rough surface, serious abrasion and poor anti-osteoarthritis of knee joint cartilage of mice caused by osteoarthritis. The number of cartilage cells is reduced, and joint matrix protein is lost.

The invention provides a traditional Chinese medicine composition for relieving coking depression and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions.The traditional Chinese medicine composition is prepared from traditional Chinese medicine extracts, soluble starch, dextrin, fructo-oligosaccharide and a medicinal ethanol solution, the traditional Chinese medicine extract is extracted from the following raw materials: roasted lily, rhizoma anemarrhenae, radix paeoniae alba, roasted polygala tenuifolia, cassia twig and acanthopanax. The traditional Chinese medicine composition for relieving anxiety depression provided by the invention can play the comprehensive effects of nourishing yin blood, clearing deficiency heat, soothing liver-qi depression and soothing mind aiming at the key pathogenesis of heart-spleen depression, and effectively improves and relieves anxiety depression syndromes.

The invention relates to the field of biological medicine, and discloses application of cycloastragenol in preparation of a medicine for treating lung adenocarcinoma combined anxiety depression. According to the application, cycloastragenol is found to relieve anxiety and depression symptoms by adjusting the level of corticosterone and other stress hormones; the anti-tumor immune response is enhanced by inhibiting the depletion of CD8 + T cells; and the anti-tumor capability of the CD8 + T cells is recovered by inhibiting the expression of Fabp5, so that a new idea and a potential drug choice are provided for clinical treatment of lung adenocarcinoma combined anxiety depression.

The application provides an anxiety and depression detection method and system based on gaze distribution, and relates to the technical field of image processing. The method comprises the following steps: obtaining a facial video of a tester under a test condition; performing feature extraction on the gaze distribution data through a graph convolutional neural network to obtain feature data; inputting the feature data into a first support vector regression model to obtain an anxiety and depression prediction value based on the gaze distribution; inputting a gaze track into a second support vector regression model to obtain an anxiety and depression prediction value based on the gaze track; and fusing the anxiety and depression prediction value based on the gaze distribution and the anxiety and depression prediction value based on the gaze track to obtain a psychological evaluation result of the tester. When detecting anxiety of the tester, the psychological evaluation result of the tester is obtained through the gaze distribution data and the gaze track, and the anxiety and depression diagnosis efficiency and accuracy are improved.

The invention discloses a resonance respiratory training system and method based on synchronous monitoring of electroencephalogram and electrocardiosignals, and belongs to the technical field of medical rehabilitation and biological feedback. According to the system, electroencephalogram and electrocardio or pulse wave signals of a user are synchronously acquired through a multi-modal signal acquisition module, central, peripheral and brain-heart interaction multi-level features are extracted after preprocessing, and brain-heart synchronous scores are constructed. The system adopts a self-adaptive algorithm to dynamically search an individual optimal resonance breathing frequency which maximizes BCSI in a range of 4.0-8.0 times / min, and feeds back a synchronization state in real time through a visual interface to guide a user to carry out closed-loop breathing training. According to the method, the limitation that traditional methods only depend on heart rate variability is broken through, a brain-mandrel regulation mechanism is quantified and used for intervention for the first time, the problems that individual differences of patients suffering from mood disorder and cognitive hypofunction are large, and the intervention effect is not stable are effectively solved, the relaxation feeling and training compliance are remarkably improved, and the method is suitable for non-drug intervention of anxiety, depression and other diseases.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicine for improving or treating mixed anxiety and depressive disorder and application thereof. The medicine is prepared from the following raw materials in parts by weight: 10-30 parts of codonopsis pilosula, 10-30 parts of moutan bark, 10-30 parts of liquorice, 10-30 parts of radix angelicae pubescentis, 10-30 parts of radix bupleuri, 10-30 parts of honey-fried licorice root, 10-30 parts of radix paeoniae alba, 10-30 parts of radix puerariae, 10-20 parts of radix saposhnikoviae, 3-20 parts of rhizoma cimicifugae, 10-20 parts of notopterygium root, 10-30 parts of radix rehmanniae recen, 10-30 parts of poria cocos, 10-30 parts of rhizoma acori graminei and 10-30 parts of polygala tenuifolia. The medicine for improving or treating mixed anxiety and depressive disorder, provided by the invention, treats anxiety and depression after stress by a treatment method mainly comprising invigorating spleen and supplementing qi, and dispersing and clearing fire, not only can improve anxiety and depressive mental symptoms of patients, but also can improve somatochemical symptoms of digestive systems and skeletal muscle systems, and can improve the curative effect of the patients. By reducing blood sugar and serum cortisol rise caused by stress, the anti-anxiety effect can be continuously achieved for 14 days after drug withdrawal, the treatment effect is good, and safety and reliability are achieved.