58 results about "Sleep deprivation" patented technology

The present invention addresses the problem of providing a novel compound that has an OX2R agonist activity.　The present invention relates to a substituted sulfonamide compound which is represented by formula (I) or a pharmacologically acceptable salt thereof. A compound according to the present invention, or a pharmacologically acceptable salt thereof, has an agonist activity against OX2R, and is useful as, for example, a therapeutic agent for sleep disorders associated with OX2R (for example, narcolepsy, idiopathic hypersomnia, Kleine-Levin syndrome, hypersomnia associated with a physical disease, hypersomnia associated with a mental disease, hypersomnia associated with a drug or a substance, circadian rhythm sleep-wake disorders, insufficient sleep syndrome, and extended sleep).

The spliced sleep deprivation mouse cage comprises a plurality of square cage bodies, a tray and a food box, the square cage bodies are transparent structural members, the top of each square cage body is provided with an organism inlet and at least one square notch, the square notches are formed in the side edges of the square cage bodies, and the food box is arranged on the tray. A plurality of water leakage holes are evenly formed in the bottoms of the square cage bodies at intervals, clamping grooves are formed in the tray, the square cage bodies can be spliced and embedded into the clamping grooves, circulation gaps are formed between the bottom walls of the square cage bodies and the inner bottom wall of the tray, and a water injection opening is formed in the side wall of the tray. When the sides, provided with the square notches, of any four square cage bodies are spliced, a containing groove communicated with the four square cage bodies is formed, and the food box is arranged in the containing groove. The splicing type sleep deprivation mouse cage can effectively deprive the sleep of mice, the problems of poor sleep deprivation and wire entanglement caused by mixed feeding of the mice are solved, the water level height in each mouse cage is consistent, and meanwhile, the water quality is convenient to replace.

The invention relates to the field of medical biology, and discloses a construction method and device of a bipolar disorder experimental animal model and application, the construction method comprises the following steps: selecting a healthy experimental animal to carry out environmental adaptation feeding before modeling, then carrying out sleep deprivation stimulation for 3-5 days continuously, and carrying out sleep deprivation stimulation for 15-18 hours continuously and 6-9 hours for rest every day so as to freely eat and feed water; and after the sleep deprivation stimulation is finished, evaluating the surface validity of the disease model for the experimental animal by adopting behavioral test. The construction method provided by the invention is simple to operate and easy to repeat, can better simulate the disease of a clinical bipolar disorder patient, and provides a new model normal form for pathogenesis research and clinical drug screening of the bipolar disorder, and the disease model can be maintained for a long time.

The invention discloses bifidobacterium longum capable of regulating circadian rhythm and remarkably improving cognitive memory ability and application of the bifidobacterium longum, and belongs to the technical field of microorganisms. The bifidobacterium longum GDMCC No: 65850 provided by the invention can effectively relieve rhythm gene expression disorder caused by sleep deprivation, thereby relieving cognitive defects of mice with circadian rhythm disorder. Besides, the intervention of the bifidobacterium longum GDMCC No: 65850 can regulate the intestinal flora health and the change of the intestinal metabolite level, promote the generation of neuroprotective metabolite and reduce the cognitive ability decline caused by circadian rhythm disorder. According to the bifidobacterium longum, the application range of the bifidobacterium longum as probiotics is expanded, and the bifidobacterium longum has a huge application prospect in products for relieving cognitive memory ability decline induced by circadian rhythm disorder.

The present invention addresses the problem of providing a novel compound that has OX2R agonist activity.　The present invention relates to a substituted sulfonamide macrocyclic compound represented by formula (I) or a pharmacologically acceptable salt thereof. This compound, or a pharmacologically acceptable salt thereof, has agonist activity against OX2R, and is useful as a treatment agent, etc., for sleep disorders involving OX2R (e.g., narcolepsy, idiopathic hypersomnia, Kleine-Levin syndrome, hypersomnia associated with a physical disease, hypersomnia associated with a mental disease, hypersomnia associated with a drug or a substance, circadian rhythm sleep-wake disorder, insufficient sleep syndrome, and extended sleep).

The invention discloses a method for detecting a fatigue state based on a multi-modal data fusion technology, and the method comprises the following steps: S1, collecting multi-modal training data through a sleep deprivation experiment, and carrying out the training of a model. Comprising fNIRS, ECG, PPG, GSP and Resp, hemoglobin concentration data, obtained through a fNIRS headband, of the forehead lobe of the brain is obviously related to fatigue, data of electrocardio, pulse waves, skin electricity and respiratory waves are obtained through an electrocardio sensor (pectoral girdle), a PPG bracelet, a GSR ring and a respiratory wave (Resp) sensor (waistband), the data collected by different devices are objective, the defects of psychological experiment methods are effectively overcome, and the psychological experiment accuracy is improved. And different modalities can provide complementary information, and even capture the features of the target from multiple angles.

The invention belongs to the technical field of nutritional compositions, and particularly relates to a composition, a preparation method thereof and application of the composition in protecting brain health. The composition provided by the invention is prepared from docosahexaenoic acid, 3-sialic acid lactose and phosphatidylserine. The composition is clear in sleep improvement effect, can effectively solve the problem of sleep maintenance caused by sleep deprivation, has the effects of protecting neural functions, improving memory and relieving anxiety from multiple dimensions, and can repair brain tissue damage and protect brain health. Based on the composition, products for assisting in improving memory, preventing and treating insomnia and anxiety, regulating neurodevelopmental disorders, protecting brain health and improving concentration can be developed, the health requirements of different people are comprehensively met, and the application value is high.

The invention discloses a method for extracting and preparing an oligosaccharide extract from codonopsis pilosula and application of the oligosaccharide extract in prevention and treatment of neurodegenerative disease Alzheimer's disease, and belongs to the technical field of traditional Chinese medicine pharmacy. According to the present invention, the oligosaccharide extract is enriched and prepared from Codonopsis pilosala (Franch.) Nanf., wherein the Codonopsis pilosala (Franch.) Nanf. Is a plant of the family of Platycodon grandiflorum, and the activity test of the oligosaccharide extract on the improvement of cognitive dysfunction in the animal body is performed; results show that in a mouse cognitive function impairment model caused by sleep deprivation, the high-dose codonopsis pilosula oligosaccharide has a prominent effect on improving the learning and memory ability of a Morris water maze and a neuroprotective effect, the efficacy of the codonopsis pilosula oligosaccharide is equivalent to that of a positive control drug manntranet, and no obvious toxic or side effect is found. The codonopsis pilosula oligosaccharide is expected to be further developed into functional food, health care products and / or medicines with the effect of preventing and / or improving cognitive impairment.

The application relates to the technical field of animal activity behavior monitoring, and discloses an animal behavior activity monitoring device, which comprises a supporting seat, supporting columns are symmetrically arranged at the bottom end of the supporting seat, a supporting frame is fixedly connected to the top end of the supporting seat, a monitoring body is arranged at the top end of the supporting frame, a receiving cavity is arranged in the supporting seat, a discharging pipe, which is in communication with the receiving cavity, is arranged at the bottom end of the supporting seat, an annular track is arranged at the top end of the supporting seat, an opening is arranged at the bottom end of the annular track, and a supporting and discharging assembly is arranged in the opening; the two feeding frames can be driven to move in the annular track, the feeding frames can push the mice to move to achieve sleep deprivation of the mice, the problem that, when a traditional feeding frame with a cuboid structure is fixedly arranged, the mice are driven to move only by a deprivation rod and the sleep deprivation of the mice is interrupted due to a gap caused by the deprivation rod is solved, and the sleep deprivation of the mice can be realized continuously.

Systems and methods of the present disclosure are directed to neural stimulation via audio and visual stimulations. The combination and / or sequence of audio and visual brain stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stems from sleep deprivation. In doing so, the present systems and methods can reduce sleep fragmentation, improve sleep quality, and slow the progression of cognitive decline in a subject with Alzheimer's disease and MCI.

The invention discloses a method for researching an influence mechanism of gastrodin on anxiety-like behaviors after sleep deprivation, and relates to the technical field of pharmacology and behavioral psychology. Comprising the following steps: selecting an ICR male mouse, establishing a sleep deprivation model through an improved multi-platform water environment method, and observing the influence of the expression level of autophagy related protein of the model group mouse on the anxiety-like behavior of the mouse; the method comprises the following specific steps: S1, experiment preparation and reagent preparation; s2, experimental animal grouping; s3, establishing a sleep deprivation model; s4, performing a sleep deprivation experiment and dosing; s5, performing open field experiment on the mouse; s6, performing an elevated cross maze experiment on the mouse; and S7, performing experimental statistics. According to the application, the influence of gastrodin on anxiety-like behaviors of mice after sleep deprivation is systematically discussed for the first time, the action mechanism of the gastrodin is disclosed from the perspective of autophagy related protein, and a new perspective is provided for clinical application of the gastrodin; the mouse sleep deprivation model is successfully established through an improved multi-platform water environment method, and the method is simple and easy to implement and high in repeatability.

The application discloses a simple method for mechanically depriving fruit flies of sleep, and comprises the following specific steps: S1, sleep baseline determination before sleep deprivation; S2, putting fruit flies which need to be deprived of sleep together with monitoring small tubes into large tubes, plugging the tube openings with sponges, and binding the tubes with rubber bands after determining the same sleep baseline; S3, mechanical oscillation for depriving fruit flies of sleep; S4, sleep monitoring; and S5, analyzing data through sleep analysis software. The application adds a rotating oscillation device on the basis of an original fruit fly behavior monitoring system, realizes short-term deprivation of fruit fly sleep, provides a method for studying acute sleep deprivation of fruit flies, and has the characteristics of simplicity, high efficiency, economy and practicability.

The present application relates to a kind of multifunctional intelligent ecological cabin for depriving the sleep of mouse, including bearing box, protective end cap, drive pump, multi-way valve, forced bearing platform and drive circuit, bearing box upper end surface is connected with protective end cap, forced bearing platform is connected with the bottom of bearing box and is vertically distributed, bearing box bottom is equipped with a sewage outlet, lower half of side wall is equipped with a water inlet, sewage outlet, water inlet are all communicated with multi-way valve, multi-way valve is communicated with drive pump, drive pump and drive circuit are all located the outside surface connection of bearing box.Its use method includes three steps of system assembly, preliminary experimental operation and depth experiment.The present application is flexible on one hand experimental means, can effectively meet the needs of various prompting experimental mouse to participate in experiment, and effectively improve the experimental effect and experimental efficiency of experimental mouse sleep deprivation experiment;On the other hand, it effectively simplifies the labor intensity of experimental operation and equipment maintenance operation, while effectively improving the working environment of experimental mouse sleep deprivation experiment.

The invention provides an animal sleep control device and a sleep control method.The animal sleep control device comprises a wearing part, a first collector and a second collector, the first collector and the second collector are arranged on the wearing part, the wearing part is of a fan-shaped annular structure when unfolded, connecting assemblies are arranged on the two sides of the wearing part in the circumferential direction respectively, and when the connecting assemblies are connected, the first collector and the second collector are connected. The wearing piece encloses and forms a wearing structure with an external expansion shape; the wearing part comprises a control assembly located on the enclosed inner surface, a main control assembly is arranged on the outer surface of the wearing part, the control assembly, the first collector and the second collector are all connected with the main control assembly, and the first collector and the second collector collect signals and transmit the signals to the main control assembly; the main control assembly analyzes the signal and drives the control assembly to work according to the signal; according to the application, through arrangement and cooperation of various control elements, gradual enhancement of animal sleep deprivation stimulation is realized to enhance the sleep deprivation effect, so that the accuracy and authenticity of experimental data acquired by the remote control terminal are improved.

The invention discloses application of burdock polysaccharide in relieving motor ability decline and intestinal flora disorder caused by acute sleep deprivation, and belongs to the field of medical biology. The invention verifies the influence of the burdock polysaccharide on motor ability reduction, intestinal flora homeostasis and function reduction caused by acute sleep deprivation, and also verifies the relationship of the burdock polysaccharide on motor ability, body energy metabolism and intestinal flora of an acute sleep deprivation individual and a potential mediation mechanism of the burdock polysaccharide in an intestinal-muscle axis. According to the invention, burdock polysaccharide is used on an acute sleep deprivation model, and the application of burdock polysaccharide in treating motor ability and intestinal injury after acute sleep deprivation is verified. Through athletic ability, energy metabolism, inflammatory factors in serum, oxidative stress in liver and Hamp of ileum tissue; e staining, expression of tight junction protein and determination of indexes such as intestinal flora and the like find that the burdock polysaccharide can effectively improve the athletic ability and the intestinal flora after acute sleep deprivation.

The invention relates to the field of animal models, and discloses an anti-NMDAR encephalitis animal model induced by combination of GluN1 polypeptide active immunization and sleep deprivation as well as an establishment method and application thereof, and the establishment method of the anti-NMDAR encephalitis animal model induced by combination of GluN1 polypeptide active immunization and sleep deprivation comprises the following steps: 1) immunizing an animal with synthesized GluN1359-378 polypeptide according to a primary immunization-enhancement strategy; (2) in the second week after the boosted immunization, sleep deprivation operation is carried out on the animals for 12 hours every day, and the operation lasts for 3 weeks; by adopting the establishment method, the anti-NMDAR encephalitis animal model induced by GluN1 polypeptide active immunization and sleep deprivation can be established; the GluN1 polypeptide active immunization combined sleep deprivation induced anti-NMDAR encephalitis animal model can be applied to research on the morbidity process and mechanism of sleep disorder induced anti-NMDAR encephalitis, research on the morbidity process and mechanism of anti-NMDAR encephalitis, and screening and evaluation of anti-NMDAR encephalitis prevention and treatment drugs.

This invention relates to a method for constructing and evaluating an animal model of Alzheimer's disease characterized by deficiency and blood stasis. Based on APP / PS1 mice, the model was induced by sleep deprivation, hydrocortisone, and carrageenan to induce qi deficiency, kidney deficiency, and blood stasis, respectively, for a total modeling period of 28 days, resulting in an animal model of Alzheimer's disease with deficiency and blood stasis. This model was constructed using a multi-factor combined approach, and its symptom manifestations are consistent with clinical observations. It is simple, effective, and easy to operate, providing a reliable experimental vehicle for the development of innovative drugs and the study of mechanisms of action in Alzheimer's disease with deficiency and blood stasis.

The utility model provides an animal sleep deprivation type device, which is characterized in that a bottom plate is arranged on a supporting platform, one opening end of a cabin body is hermetically connected with the bottom plate, and a top cover is detachably connected with the other opening end of the cabin body; the top cover is provided with a handle cover and a through hole, the handle cover is detachably installed in the through hole, and the handle cover can be pulled out of the through hole through external force. A food trough and a water trough are arranged in the cabin body and are connected with the handle cover; a weighing sensor is arranged in the handle cover, the food trough and the water trough are connected with the weighing sensor, and the weighing sensor is used for measuring the weight of the food trough and the water trough; a rotating rod is arranged on the bottom plate, a driving assembly in driving connection with the rotating rod is arranged in the supporting platform, and the driving assembly drives the rotating rod to rotate. The feeding trough and the water tank are arranged in the cabin body, so that gas exchange with the outside in an experiment process can be reduced, the accuracy of a gas measurement result is improved, and feed and drinking water are convenient to add by arranging the handle cover and the through hole.

This invention discloses the use of Chek2 inhibitors in the preparation of drugs for the prevention and / or treatment of postoperative pain sensitization induced or aggravated by chronic sleep disorders, and its intervention methods, relating to the field of biomedical technology. This invention provides the use of Chek2 inhibitors in the preparation of drugs for the prevention and / or treatment of postoperative pain sensitization induced or aggravated by chronic sleep disorders. This invention is the first to discover and validate Chek2 as a key molecular target linking "chronic sleep disorders" and "postoperative pain sensitization." By constructing a composite animal model of chronic sleep deprivation (CSD) combined with postoperative incision pain, the pathological process of increased postoperative pain in patients with sleep disorders was simulated. Using mRNA-seq and Western blot techniques, this invention is the first to discover and confirm that the expression level of Chek2 in the nucleus accumbens (NAc) brain region is significantly upregulated during postoperative pain sensitization induced by chronic sleep disorders, filling a gap in the field of "sleep disorder-pain interaction" regarding specific central targets.

The present invention aims to provide a novel compound which has an OX2R agonist activity.The present invention relates to a cyclopentane compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof has an agonist activity on OX2R and is useful as an agent for the treatment of sleep disorders involving OX2R (for example, narcolepsy, idiopathic hypersomnia, Kleine-Levin syndrome, hypersomnia due to physical diseases, hypersomnia due to psychiatric disorders, hypersomnia due to drugs or substances, circadian rhythm sleep-wake disorder, insufficient sleep syndrome and long sleep) or the like.

The utility model relates to the technical field of test devices, and discloses a sleep deprivation test device, which comprises a box body, wherein a cover is arranged at the top of the box body; the feeding trough is arranged in the box body; a lifting assembly is arranged in the box body, and the lifting assembly comprises a plate body arranged in the box body; the rotating rod is rotationally arranged in the box body; the extrusion block is fixedly arranged on the outer side wall of the rotating rod; according to the test device, the motor is used for driving the rotating rod to rotate through the lifting assembly, so that the extrusion block extrudes the stand column to ascend and descend and drives the platform to ascend and descend, and the laboratory mouse on the platform can be kept awake so as to observe the state of the mouse. And compared with the existing device, the sleep of the laboratory mouse can be better influenced. According to the test device, through the design of the protection assembly and the inclined plate, the laboratory mouse can climb to the platform faster along the inclined plate after falling into water, and it is avoided that the laboratory mouse drowns in water for a long time to affect experimental data.

1. Name of the product in this design: Jammer. 2. Purpose of this design: To be used in animal sleep-related scientific research experiments to interfere with the sleep activities of experimental animals in order to construct a sleep deprivation model and provide equipment support for neuroscience and pharmacology research. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses bifidobacterium longum B18 helpful for improving sleep and relieving anxiety caused by sleep deprivation and a rapid detection method of the bifidobacterium longum B18. The bifidobacterium longum B18 disclosed by the invention is preserved in Guangdong Microbial Culture Collection Center on November 28, 2025, and the preservation number is GDMCC No: 67383. The bifidobacterium longum B18 disclosed by the invention is derived from intestinal tracts of healthy infants in China and is an excellent bacterial strain from local sources. Wherein safety evaluation experiments show that the strain has no hemolytic activity, no drug-resistant gene and no toxicity factor gene, and has the effects of improving sleep, preventing and / or relieving anxiety symptoms and inhibiting inflammation. Wide application prospects are realized in the fields of developing functional foods and medicines for improving sleep and relieving anxiety caused by sleep insufficiency and the like. Compared with the traditional chemical medicines for promoting sleep, the traditional Chinese medicine composition has no toxic or side effect on the ecological environment, has no residual risk, and is green and safe.

The invention discloses application of mitochondrion Rab32 in preparation of a medicine for treating chronic sleep deprivation and a research method of the mitochondrion Rab32, and belongs to the technical field of biological medicine. A chronic sleep deprivation mouse model is established, the relationship between mitochondria Rab32 and in-vivo protein change of an SD mouse is researched, and the result shows that the mitochondria Rab32 participates in cytoskeleton protein function regulation and control and participates in neuronal synaptic regeneration by anchoring Sptan1 in cells. Rab32 is a key molecule for mediating neuron synaptic regeneration of SD mice and adjusting synaptic plasticity and cognitive impairment, and the research result may provide a new target for treatment of SD-related cognitive impairment in future.

The invention discloses a dynamic brain network analysis system for a sleep deprivation injury alertness attention mechanism, and relates to the technical field of medical image processing and analysis. The method comprises the following steps: collecting data of a sober-up state and after 24 hours of sleep deprivation of a subject; a dynamic graph theory method is adopted, dynamic brain network analysis is carried out on resting state functional magnetic resonance data, and brain network changes in a waking state and a sleep deprivation state are studied; the method specifically comprises the steps of collecting fMRI and mental movement alertness task data of a subject in different states, preprocessing image data, calculating a static function connection matrix, and analyzing time-varying function connection by using a sliding window technology; through modular analysis and a time co-occurrence matrix, time flexibility, space-time diversity and normalization centrality are calculated, dynamic space-time characteristics of a brain region are evaluated, and dynamic influences of sleep deprivation on a brain network are compared by using a statistical method.

The invention discloses application of an intestine-brain axis metabolic pathway as a target in screening of drugs for treating depression and anxiety caused by PCOS sleep disorder. According to the application disclosed by the invention, the influence of sleep deprivation on anxiety and depression of PCOS mice is researched by metabonomics analysis on the intestinal-brain axis peroxidized by hippocampal fatty acid for the first time, the intestinal-brain axis action mechanism of depression and anxiety in PCOS sleep disorders is clarified, a new insight of intestinal-brain metabolism regulation of sleep disorder PCOS related anxiety and depression is provided, and the application has a broad application prospect. And a new target and a new direction are provided for the treatment.

The invention relates to a pharmaceutical composition for treating diseases induced by sleep deprivation and application of the pharmaceutical composition, and belongs to the technical field of medicines.The pharmaceutical composition is prepared from 5-60 parts of honey-fried licorice roots, 5-35 parts of dried ginger, 5-35 parts of radix paeoniae alba, 5-35 parts of cinnamon, 5-35 parts of panax notoginseng and 2-12 parts of leeches. The pharmaceutical composition disclosed by the invention can be used for effectively treating or improving diseases such as neuroinflammation, cognitive behavior disorder, blood-brain barrier injury, intestinal leakage and the like induced by sleep deprivation, and these effects prove that the pharmaceutical composition disclosed by the invention can be used for effectively treating or relieving related diseases induced by sleep deprivation.

The invention discloses a TAAD postoperative sleep deprivation risk assessment method based on three-party collaboration, and relates to the field of medical health, and the assessment method comprises the following steps: a digital collaboration platform collects sleep associated data of a patient party, a medical party and a hospital organization management party; constructing a TAAD postoperative sleep deprivation risk assessment model in combination with the sleep associated data; the TAAD postoperative sleep deprivation risk assessment model assesses the real-time sleep associated data collected by the digital collaboration platform and outputs a TAAD postoperative sleep deprivation risk probability value; setting three levels of early warning thresholds respectively corresponding to low, medium and high risk assessment results of sleep deprivation, and generating personalized sleep suggestions, adjusting nursing schemes and environment intervention measures; and the digital cooperation platform pushes personalized sleep suggestions to the patient side, pushes an adjustment nursing scheme to the medical side, and pushes an environment intervention scheme to the hospital organization management side. Through a multi-dimensional cooperation mechanism, the evaluation and intervention efficiency of the postoperative sleep deprivation risk is comprehensively improved.

The application provides a kind of multi-agent sleep intervention system based on reinforcement learning, belongs to mouse sleep experiment technical field, comprising: signal acquisition module, the original eeg signal and heart rate variability signal of mouse are collected;Sleep perception prediction module, the original eeg signal is handled through sleep state Transformer regression model, and continuous sleep depth score and its future change trajectory are obtained;Adaptive decision module, through the sleep agent of meta reinforcement learning, heart rate variability signal, continuous sleep depth score, continuous sleep depth score future change trajectory and historical mouse sleep data are handled, and ideal stimulus feature combination is output;Stimulus execution module is used to store stimulus and is put according to ideal stimulus feature combination.The application solves the problem that in mouse sleep deprivation experiment, due to inaccurate intervention, stress level is high, individual adaptability is poor, and finally sleep deprivation experiment result is inaccurate.