109 results about "Sleep deprivation" patented technology

Visual methods and systems are described for detecting alertness and vigilance of persons under conditions of fatigue, lack of sleep, and exposure to mind altering substances such as alcohol and drugs. In particular, the intention can have particular applications for truck drivers, bus drivers, train operators, pilots and watercraft controllers and stationary heavy equipment operators, and students and employees during either daytime or nighttime conditions. The invention robustly tracks a person's head and facial features with a single on-board camera with a fully automatic system, that can initialize automatically, and can reinitialize when it need's to and provide outputs in realtime. The system can classify rotation in all viewing direction, detects' eye / mouth occlusion, detects' eye blinking, and recovers the 3D(three dimensional) gaze of the eyes. In addition, the system is able to track both through occlusion like eye blinking and also through occlusion like rotation. Outputs can be visual and sound alarms to the driver directly. Additional outputs can slow down the vehicle cause and / or cause the vehicle to come to a full stop. Further outputs can send data on driver, operator, student and employee vigilance to remote locales as needed for alarms and initiating other actions.

An efficient, objective, flexible and easily deployable system for conducting evaluations of mental and physiological state and recommending individualized treatment to improve said state is described. The method and system are based on commensurate measurement of mental functions, levels of stress and anxiety, and / or biologically active molecules such as neurotransmitters, immune markers including cytokines and hormones. The method and system are designed to assess an individual's cognitive function and the underlying physiology in order to delineate various disease processes, injuries, drug states, training stages, fatigue levels, stress levels, aging processes, predict susceptibility to stress and / or sleep deprivation, identify aptitude for training and / or characterize effects of any experimental conditions. The system and method may be used in recommending individualized treatment protocols, as well as to guide the treatment process by assessing the efficacy of such therapies in the clinical trials process.

Methods and systems for determining the likelihood that a person is impaired, generally comprising gathering ambient data from sensors operably coupled to a primary measuring device (PMD), analyzing and / or identifying the ambient data, querying at least one database to identify baseline data regarding the person, and comparing the ambient data to the baseline data to determine the likelihood that the person is impaired. The methods and systems advantageously detect medical and / or cognitive impairment without the need for specialized devices, examination by specialists, consent of the person being evaluated, and compliance with recommendations to be examined, and may be applied to estimating the level of impairment of a person due to alcohol, drugs, exposure to toxic chemicals, changes to mental status, insufficient sleep, medical problems, changes to blood sugar levels, divided attention, vision changes, hearing changes, use of a mobile device while walking or operating a vehicle, and other factors.

The invention relates to compositions and methods for preventing, treating, or managing sleeplessness, restlessness, weight gain including weight gain due to stress or lack of sleep, or all three comprising the administration of a prophylactically and therapeutically effective amount of Magnoliaceae plant or extracts thereof to a mammal in need of such therapy. Preferably the mammal is human and the compositions have comprise at least two compounds selected from magnolol, honokiol, and magnoflorine. Alternatively, the compositions may also comprise about 2% honokiol by weight of the composition.

The invention provides methods of treating symptoms of sleep deprivation using a hypocretin agonist. The invention also provides methods of treating Parkinson's disease using a hypocretin agonist.

This document provides systems and methods for testing and assessing cognitive performance of a user over a period of time in order to test environmental effects and other factors on the performance of the user. For example, cognitive performance over a period of time can be assessed for users experiencing stress conditions including hypoxia (oxygen deprivation), hypothermia, sleep deprivation, fatigue or other factors that may cause degradation in cognitive performance. Furthermore, the systems and methods described herein can be used to identify when hypoxia has manifested in the cerebral circulation of an individual rather than merely in the extremities of an individual.

Apparatus and methods for treating psychiatric disorders, mood disorders and circadian rhythm disorders with a multi-stage light protocol are disclosed. The presently disclosed multi-stage light protocol provides a synergistic treatment including up to 4 types of therapies: bright light therapy, extended sleep deprivation therapy, dawn simulation therapy and short to medium wavelength light therapy. According to some embodiments, the first stage of the protocol includes a first time window of 20 minutes during which, for a majority of the time, the light intensity is between 50 lux and 2000 lux. According to some embodiments, the second stage of the protocol includes a second time window of at least 90 minutes during which, for every 10 minute period within the second time window, for a majority of the time, the light intensity is exceeds 100 lux. According to some embodiments, the third stage of the protocol includes a third time window of 60 minutes during which, for a majority of the time, the light intensity exceeds 2000 lux In some embodiments, the light is provided by apparatus including a plurality of LEDs. Typically, the light includes white light having a broad spectrum. In some embodiments, the light further includes light having a medium wavelength, for example, wavelengths between 520 nm and 535 nm.

The present invention is directed to a method of continuously monitoring neuronal avalanches in a subject comprising (a) determining a deviation in avalanche exponent (α) or branching parameter (σ) from a predetermined value at rest, wherein the pre-determined value of α is a slope of a size distribution of the synchronized neuronal activity and the predetermined value is −3 / 2 and the pre-determined value of σ is a ratio of successively propagated synchronized neuronal activity and the predetermined value is 1; and (b) repeating step (a) one or more times to continuously monitor neuronal avalanches in a subject. The invention also features methods of determining or monitoring the degree of sleep deprivation in a subject, methods of identifying subjects that are susceptible to a sleep disorder and methods of diagnosing a sleep disorder in a subject.

The present invention is directed to a method of continuously monitoring neuronal synchronization in a subject comprising (a) determining a deviation in mean synchronization (R) from a predetermined value at rest, wherein the pre-determined value of R is 1, and the variability of synchronization H; and (b) repeating step (a) one or more times to continuously monitor synchronization R and its variability H in a subject. The invention also features methods of determining and monitoring the degree of brain excitability. The invention furthermore features methods of determining or monitoring the degree of sleep deprivation in a subject, methods of identifying subjects that are susceptible to a sleep disorder and methods of diagnosing a sleep disorder in a subject.

The invention relates to a mask, and especially relates to a mask having moisturizing and anti-oxidation functions, and its making method. The mask is obtained through using the following raw materials, by weight, 10-20 parts of ginkgo leaf, 15-25 parts of aloe, 5-15 parts of pawpaw, 10-20 parts of chrysanthemum, 5-15 parts of licorice, and 5-15 parts of Lophatherum gracile. The mask having the advantages of scientific and reasonable formula, easily available raw materials, low price, supplementation of abundant natural vitamins for skins, skin pigment removal, prevention of oxidizing damages comprising ultraviolet ray damage, anti-ageing, increase of the skin elasticity, helpfulness for the increase of the immunization and protection effects of skins, restoration of black spots caused by sun exposure and sleep insufficiency, and no anaphylactic reaction, and is an ideal moisturizing and anti-oxidation skin moistening mask.

Apparatus and method for automatically inducing sleep deprivation in rodents with an electroencephalogram measurement and analysis system, an electromyogram measurement and analysis system, sleep deprivation stimulus, stimulus control, acquisition and real-time sleep stage analysis software, and cage with food and water supplies.

A device helps a user to plan the proper timing for setting a next training session based on the intensity of a training stimulus of a previous session. The user is shown when there will have been enough recovery time since the last training session to suggest the best time for starting the next training session. The timing recommendations are based on a supercompensation time curve that depends on a user dependent factor that includes at least the training load of the last training session and preferably also depends on the training status of the user. Further parameters like age and gender and variables like behavior affecting recovery, as there are for example tiredness from lack of sleep, dehydration from insufficient drinking, insufficient calories, protein, mineral or vitamin intake, consumption of alcohol and other drugs, can additionally be used to influence the recovery timing calculations.

The invention provides a Chinese medicinal preparation for treating insomnia and dreaminess. The Chinese medicinal preparation is prepared from the following Chinese herbal medicines of indigofera carlesii, chrysanthemum, divaricate saposhnikovia root, turmeric root-tuber, spina date seed, tortoise shell, gentian, cinnabar, common selfheal fruit-spike, dangshen, grassleaf sweelflag rhizome, cicada shell, blighted wheat, mulberry, mumosa pudica, lotus seed, sharpleaf galangal fruit, bamboo shavings, tuber fleeceflower stem, fortune eupatorium herb, mother of pearl, costus root, common rush, succinite, medicinal indianmulberry root, bamboo leaf, silktree albizzia bark, pawpaw, shelled cedar seed, valerian, red-rooted salvia root, magnetite, uncaria, apricot kernel and lily. The Chinese medicinal preparation has a scientific formula and is prepared on the basis of many years of clinical tests. The Chinese medicinal preparation is characterized in that the treatment course is short, and the Chinese medicinal preparation does not have any toxic or side effects, has a good curative effect on the most common symptoms of insomnia, such as lack of sleep, difficulty in falling asleep, unsound sleep, early awakening, difficulty in falling asleep again after awakening, awakening with a start from a nightmare, nightmares for a whole night, fatigue after sleep and the like, and has a good effect on various symptoms and mental states caused by insomnia.

The invention provides a healthcare medicinal liquor for treating insomnia, which is prepared from the raw material of the following traditional Chinese herbal medicines: prepared rehmannia root, medlar, Ophiopogon japonicus, radix rehmanniae, Polygonum multiflorum, Dried Longan Pulp, Chinese angelica, oysters, longan pulp, Dioscorea opposita, rhizoma polygonati, salvia miltrorrhiza, Fructus Ligustri Lucidi, Bashfulgrass, licorice, White Peony Root, chinaroot greenbrier rhizome, Schisandra chinensis, Radix Aucklangiae, Notoginseng, Root or all-grass of Cairo Morningglory, root of carles indigo, rhizoma anemarrhenae, dried orange peel and Villous Amomum Fruit. The healthcare medicinal liquor has the outstanding advantages of no poisonous side effects, short curing course, and good treatment effects on the insomnia symptoms such as insufficient sleep, difficulty in falling asleep, failing to fall heavy sleep, waking early and failing to fall asleep again after waking, often being awakened from nightmare, nightmare feeling all night and feeling not recovered after sleeping, and has a good treatment effect on various uncomfortable symptoms and spiritual expression accompanying insomnia.

The invention discloses medicinal liquor for effectively treating insomnia, and the medicinal liquor is prepared through repeated verification of clinical tests in accordance to the theory of traditional Chinese medicine. The medicinal liquor is prepared from membrane of chicken gizzard, oriental waterplantain rhizome, tuckahoe, cassia twig, morinda officinalis, eucommia bark, Chinese thorowax, bitter orange, tuber fleeceflower stem, liquorice, baikal skullcap root, heterophylly falsestarwort root, longan pulp, thinleaf milkwort root bark, dens draconis, oyster, grass-leaved sweetflag, anemarrhena, dragon bone, tuckahoewithpine, spina date seed, ligusticum wallichii, Chinese angelica, yam, tulip, flower of silktree and platycladi seed. The medicinal liquor has the advantages of no toxic or side effect and short curative period, and has excellent treatment effects to main symptoms of insomnia, such as lack of sleep, difficulty in falling sleep, not sound sleep, early awakening, waking and not getting back to sleep, frequent awakening from nightmare, nightmare feeling all night, not renewed energy after sleep and the like, and also has excellent treatment effects to various uncomfortable symptoms and spiritual manifestation accompanying the insomnia.

A method for treating a person having sleep deprivation includes actively inducing unconsciousness in a person by administering an anesthetic agent to the person; determining an indication of a stage of sleep of the unconscious person by monitoring brainwaves of the person; and maintaining, for a predetermined period of time, the person in a state of sleep indicated to be deep sleep by adjusting the amount of the anesthetic agent being administered to the person. Preferably, the anesthetic agent is administered for about seven hours at different rates, and no surgical or other medical operation is performed. The anesthetic agent preferably is administered for the sole purpose of treating sleep deprivation.

The invention provides a sleep deprivation model system with simulation narrow and small spaces for pilots. The sleep deprivation model system comprises the closed spaces and a tested screening system. The tested screening system is arranged in the closed spaces and comprises a cognitive function assessment subsystem, a sleep quality assessment subsystem, an emotion assessment subsystem, a social function assessment subsystem and a sleep detection device; the cognitive function assessment subsystem is used for assessing cognitive behavior and cognitive functions of testees; the sleep quality assessment subsystem is used for assessing sleep behavior of the testees; the emotion assessment subsystem is used for assessing emotion indexes of the testees; the social function assessment subsystem is used for assessing social parameters of the testees; the sleep detection device is used for detecting sleep parameters of the testees. According to the technical scheme, the sleep deprivation model system has the advantage of accurate detection data.

The invention belongs to the technical field of medical experiments and provides a multi-platform water environment sleep deprivation water tank and system for animals. Platforms are arranged in the bottom of the sleep deprivation water tank. The sleep deprivation system includes a rack, the sleep deprivation water tank, a water inlet / outlet device and a control device controlling experiment time, sewage disposal and cleaning. By adopting the water tank and the system provided by the invention, influence due to elements such as biological instability and the like in a sleep deprivation experiment is avoided. The experiment result is good in stability and high in repeatability. The device is high in operability, high in space utilization rate and good in application effect.

The invention belongs to the technical field of devices for rat and mouse experiment study, particularly relates to a rat and mouse quick eyeball movement sleep deprivation water tank and mainly solves the problem that an existing sleep deprivation method is low in reliability of an experiment method and needs experiment personnel for realtime observation. The technical scheme includes that the rat and mouse quick eyeball movement sleep deprivation water tank comprises a water tank body, a partition is arranged on the middle-lower portion of the water tank body, a detachable bottom cover is arranged at the bottom of the water tank, multiple through holes are formed in each of the front side wall and the rear side wall of the detachable bottom cover, multiple uprights are movably arranged on the partition, a magnet is arranged at the bottom of each upright, multiple magnetic nails are arranged on the other side of the bottom of the partition and connected with the magnets at the bottoms of the uprights in a matched manner, a boss is arranged on the inner wall of the middle-upper portion of the water tank body, an isolating net is arranged on the boss movably, a cage cover is arranged at the top of the water tank body, a V-shaped groove is formed in one side of the cage cover, and a triangular partition is arranged in the V-shaped groove and divides the V-shaped groove into a food feeding area and a water feeding area.

The invention discloses an eleutherococcus senticosus-fructus schizandrae oral liquid for improving sleep and a production method thereof. The oral liquid is prepared from an eleutherococcus senticosus extract, a fructus schizandrae extract, honey, potassium sorbate, malic acid and spice through the steps of crushing, pre-dissolving, mixing, pH adjusting, filtering, filling and packaging. The oral liquid provided by the invention has the sleep improvement effect, increases the sleep quality, and relieves amnesia, fatigue, laziness and other symptoms caused by sleeplessness, sleep insufficiency and the like.

C-glycoside compounds having the general formula (I): are useful for protecting and / or stimulating the activity and / or the proliferation of gamma-delta T lymphocyte cells (γδT cells), and are advantageously formulated into cosmetic / pharmaceutical compositions suited for promoting skin tissue repair, for re-equilibrating epidermal proliferation and differentiation disorders which appear with lack of sleep, and for improving the appearance of the head of hair and limiting hair loss.

The invention relates to a traditional Chinese medicinal composition for treating insomnia, and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal composition comprises 8-13g of Bupleurum chinense DC., 4-8g of Rhizoma arisaematis, 5-10g of American ginseng, 6-10g of Juncus effusus, 10-15g of pearl shells, 5-10g of Cortex Albiziae, 10-15g of Chinese yam, 5-7g of licorice root, 10-15g of Poria cocos, 10-15g of Semen Nelumbinis, 10-15g of immature bitter orange, 10-15g of Radix Polygalae, 10-15g of unprocessed keel, 5-10g of spine date seeds, 5-10g of Folium Phyllostachys, 10-15g of lily, 5-10g of chrysanthemum flower, 10-15g of Radix Puerariae, 5-10g of Radix Curcumae Aromaticae, 10-15g of Chinese magnoliavine, 10-15g of Dens Draconis, 8-12g of Chinese Eaglewood, 10-15g of peach seeds, 4-8g of oysters and 5-10g of Fructus Citri Sarcodactylis. A traditional Chinese medicinal capsule for treating insomnia, prepared from various Chinese herbal medicines, has the advantages of no toxic or side effects, easily available raw materials, and short cure course, has good treatment effects on sleep insufficiency, difficulty falling asleep, early awakening, sleeplessness after waking, frequent waking from a nightmare, nightmare suffering all night, and no energy recovery after sleep, and also has a good treatment effect on many discomfort symptoms and spirits associated with insomnia.

Methods and systems for determining the likelihood that a person is impaired, generally comprising gathering ambient data from sensors operably coupled to a primary measuring device (PMD), analyzing and / or identifying the ambient data, querying at least one database to identify baseline data regarding the person, and comparing the ambient data to the baseline data to determine the likelihood that the person is impaired. The methods and systems advantageously detect medical and / or cognitive impairment without the need for specialized devices, examination by specialists, consent of the person being evaluated, and compliance with recommendations to be examined, and may be applied to estimating the level of impairment of a person due to alcohol, drugs, exposure to toxic chemicals, changes to mental status, insufficient sleep, medical problems, changes to blood sugar levels, divided attention, vision changes, hearing changes, use of a mobile device while walking or operating a vehicle, and other factors.

A method for evaluating the effectiveness of a person to perform a task based on his / her previous or predicted sleep activity is provided. The method can be used to predict changes in task effectiveness at any time of day, based upon numerous patterns of sleep and activity, either experienced or planned for the future. The method takes into account progressive increases in sleep deprivation, the effects of the time of day on performance, and changes in the time when a person sleeps and works. The method also accounts for the quality of a sleep interval and a person's sleep inertia, the temporary slowing of performance immediately after awakening. The method is homeostatic. Gradual decreases in sleep debt decrease sleep intensity. Progressive increases in sleep debt produced by extended periods of less than optimal levels of sleep lead to increased sleep intensity. As a result the method can predict the normal decline in sleep intensity during the sleep period and the normal equilibrium of performance under less than optimal schedules of sleep.

Methods of screening for a sleep altering compositions are disclosed as are the identities of various gene products that are involved in sleep function / dysfunction. Also described are methods for modifying the need for sleep and the response to sleep deprivation in subjects.

This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or chronic sleep deprivation, including enhancement of receptor functioning at synapses in brain networks responsible for higher order behaviors. A still further aspect of the present invention is the use of an active agent as described above for the preparation of a medicament for the treatment of a disorder as described above.

The invention discloses mineral beer. The beer is prepared from the following raw materials: 15 to 20 parts of hops, 10 to 30 parts of malt, 2 to 8 parts of rice, 2 to 5 parts of biological enzyme and 20 to 50 parts of functional mineral water. The production method of the beer comprises the following steps: firstly, filling an aseptic fermentation tank with the hops, the malt and the rice and fermenting at the temperature of 30 DEG C or lower for 15 to 20 days; secondly, raising the temperature; after the temperature reaches 70 DEG C, adding the biological enzyme and the functional mineral water, and then continuously fermenting for 1 to 3 hours; thirdly, quickly raising the temperature to 137 DEG C, sterilizing for 5 seconds, and then quickly cooling to obtain the mineral beer. The mineral beer disclosed by the invention has the adjuvant therapeutic effects on the improvement of symptoms such as hypertension, gout, diabetes mellitus, gastrointestinal discomfort, dyspepsia, anemia, sleep deprivation and malnutrition.

The invention relates to food for resisting sleep deprivation stress damage. The formula comprises the following raw materials in percentage by mass: 53 to 63 percent of seed of spine date, 12 to 22 percent of fruit of roxburgh rose, 13 to 23 percent of ginsenoside and 2 to 12 percent of liquiritin. The food contains an extender, and the extender contains taurine and medlar, wherein the mass rateof the taurine to the medlar is 10:1. The formula of mixing four types of ingredients is applied to the sleep resistance. The ingredients mixed according to the formula can greatly reduce the damage to physical functions under the condition of sleep deprivation and has a certain application prospect in improving physical conditions of the persons(such as students, white collars and servicemen) ina continuous operating process.

A transgenic fly whose genome is modified to express enhanced levels of glutamate-cysteine ligase (GCL) gene is provided. The fly displays phenotypes associated with Alzheimer's disease (AD). Further, a method for diagnosing AD is provided, which includes assessing enzymatic activities in mitochondrial enzymes. Glutathione pathway are investigated by creating Alzheimer's model Drosophila with over-expression of the GCLc gene, inducing redox stress through sleep deprivation, and analyzing mitochondrial electron transport chain (ETC) using colorimetric enzymatic assays. For prevention of AD, it is proposed that the epigenetic approaches be used to increase glutathione levels in vivo before the onset of AD. For treatment of AD, it is proposed that the glutathione levels be increased by GCLc modulation.

The invention relates to a sleep deprivation device for rats / mice, which comprises a working platform, wherein the working platform is provided with standard feeding cages supported by food and waterand a guide rail, the plurality of standard feeding cages are arranged at two sides of the guide rail, at least one sleep deprivation rod walks on the guide rail, one side of each standard feeding cage, close to the guide rail, is provided with an elongated groove, and the sleep deprivation rod is inserted into the elongated groove; the sleep deprivation rod is driven by a motor, and the control end of the motor is connected with an industrial control device capable of setting motion parameters of the sleep deprivation rod; the guide rail is provided with a travel switch of the sleep deprivation rod, and the travel switch is connected with the industrial control device. The device is suitable for molding a plurality of sleep deprivation types, a plurality of groups can be carried out at the same time, and the cost is low; the environment of the mouse feeding cage is simulated by the deprivation cages, the generated stress response is small, and the interference on experimental data issmall; the rod deprivation mode is milder, the mice do not need to be in an exercise state all the time, the sleep deprivation method is mild but the deprivation effect is good, and the sleep deprivation mode more accords with a human sleep deprivation mode.