116 results about "N-acetyl-L-cysteine" patented technology

The present invention relates to a nutritional supplement composition, comprising a therapeutically effective amounts of Vitamin C, Vitamin D3, Thiamin, Riboflavin, Niacin, Vitamin B6, Folic acid, Vitamin B12, Pantothenic acid, Calcium, Magnesium, Zinc, Chromium, Sugar, Protein, Acetyl-L-Carnitine, Dimethylaminoethanol complex, Phosphatidylserine complex, L-Glutamine, N-Acetyl-L-Tyrosine, L-Phenylalanine, Taurine, Methionine, Valine, Isoleucine, 5 Hydroxytryptophan, L-Taurine, N-Acetyl-Tyrosine, N-Acetyl-L-Cysteine, Alpha Lipoic Acid, Alpha Glycerylphosphoricholine complex, Bacopa Monnieri extract, Gingko Biloba extract, Passion flower, Lemon Balm, Gotu Kola, Ashwagandha, Choline Bitartrate complex, Panax Ginseng extract, Turmeric, Organic freeze dried fruit juice blends (concord grape, red raspberry, pineapple, cranberry, acai, pomegranate, acerola cherry, bilberry, lingonberry, black currant, aronia, sour cherry, black raspberry), Organic freeze dried greens blends (barley grass, broccoli, beet, carrot, alfalfa, oat), and Protein digestive enzyme blends (Protease 4.5, peptidase, bromelain, protease 6.0, protease 3.0, L planatrum, B bifidum) in a mixture to provide optimal cognitive function.

The components of this invention are chosen because of their complementarity for the prevention or treatment of diseases caused by the herpes simplex virus. L-Lysine favorably increases the physiologic immunomodulation necessary for defense against this virus. Zinc improves and maintains a normal immune response. 2-Deoxy-2-D-glucose and heparin sodium alter the surface interaction between the herpes virus and the cell, preventing fusion and infectivity. N-Acetyl-L-cysteine increases glutathione levels thereby creating a thiol redox barrier to the virus at the cell membrane. Quercetin reduces intraoellular replication of the herpes virus and viral infectivity. Ascorbate, in concert with copper and D-α-tocopherol, provides an antioxidant defense against the herpes virus, which tends to lose latency during period of oxidative, free radical excess. Selenium and quercetin also participate in reducing various oxidative stresses. Together the components of this invention provide the potential for improved resistance to, improved recovery from, and a decreased frequency of recurrence of herpes simplex virus infection.

The invention discloses a biocompatible natural polymer hydrogel and a preparation method thereof. The hydrogel is produced by the following steps: chitosan or glucan or gelatin and 1-Hydroxy benzotriazole are dispersed in the water, and stirred until transparent solution is formed; N-Acetyl-L-Cysteine or 2,3-Dimercaptosuccinic acid is added, then dripped into the water solution prepared with 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, the pH is adjusted, stirred for 2-4h; dialyzed with 5mmol/L hydrochloric acid solution containing 2Mu mol/L EDTA under lucifugal condition within 2-4 days, dialyzed with 5mmol/L hydrochloric acid solution containing 1g/L NaCl, and then dialyzed with 1mmol/L hydrochloric acid solution to achieve the desired product. The hydrogel has excellent hydrophilicity, moisture retaining property, permeability and flexibility, the degradation product has no toxic or adverse effect to the body, and can meet the requirements of modern medical science on dressing to the largest extent.

Radiation-oxidative exposure treatment compositions comprise a mixture of micronutrient multivitamin and trace elements, a mixture of antioxidants and chemopreventative agents, and optionally a mixture of fatty acids. Micronutrient multivitamin and trace elements mixtures include vitamins A, Bp, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E and K; inositol; calcium, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, potassium, boron and vanadium. Mixtures of non-essential antioxidants and chemopreventative agents include bioflavins, alpha lipoic acid, N-acetyl-L-cysteine (optionally) lutein, lycopene, astaxanthin, plant sterols, isoflavones, garlic extract, which provides allicin; green tea extract, cruciferous vegetable extract, fruit extracts, coenzyme Q-10, and resveratrol. Fatty acid mixtures include eicosapentaenoic acid and docosahexaenoic acid.

Methods of treatment of a subject exposed to a radiation source or an oxidative stress with the radiation-oxidative exposure treatment composition include the step of administering to the subject a daily dose of the radiation-oxidative exposure treatment composition such that the life shortening effects induced by the radiation source or the oxidative stress are ameliorated.

The invention discloses a ratiometric fluorescent probe and a preparation thereof, and an application of the ratiometric fluorescent probe in detection of glutathione. The ratiometric fluorescent probe is prepared through the following steps: with green quantum dots as cores, carrying out embedding in silica nanoparticles, then subjecting the surface of the silica nanoparticles to amination modification, and covalently coupling red quantum dots onto the amination modified surface of the silica nanoparticles so as to obtain the ratiometric fluorescent probe, wherein the green quantum dots are cadmium telluride quantum dots modified by N-acetyl-L-cysteine. According to the invention, a St ber method is utilized to prepare quantum dot embedded silica nanoparticles, so the synthetic method issimple and has less time consumption. The probe provided by the invention has low detection limit and can realize specific detection during detection of GSH; meanwhile, the probe has advantages like simple preparation and good stability, reduces the detection limit of glutathione to 45 nM, and provides convenience for rapid visual detection.

The invention belongs to the technical field of fluorescent nano-materials and provides a red fluorescent copper nano-cluster and a preparation method thereof, which have the advantages of simplicityin operation, moderate conditions and the quantum yield of 0.44 percent. A synthesis method of the prepared red fluorescent copper nano-cluster is simple, and interference caused by self fluorescent light of living organisms can be avoided; the red fluorescent copper nano-cluster has high sensitivity on Ag<+> ions and can be used for constructing a sensing system for detecting the Ag<+> ions. At room temperature, N-acetyl-L-cysteine is used as a protection agent and a reduction agent and a copper nitrate solution is used as a matrix to prepare a fluorescent copper nano-cluster solution throughan ultrasonic method. The addition of a common reduction agent, i.e., sodium borohydride, ascorbic acid, a surfactant and the like is avoided; the preparation method is simple to operate and feasible, has moderate conditions and is environmentally friendly; the prepared copper nano-cluster has good water solubility, high quantum yield and low toxicity, and can be used for highly sensitively and highly selectively identifying and detecting the Ag<+> ions; a detection process is simple and rapid and a detection result is accurate.

A supplement composition for enhancement of methylation process is provided, which contains vitamin B₆ (as pyridoxine HCl), folic acid, vitamin B₁₂ (as cyanocobalamin), betaine HCl, and methylsulfonylmethane; and also contains S-adenosylmethionine. The supplement composition further includes silymarin (from milk thistle seed extract), N-acetyl L-cysteine, and cruciferious blend which includes broccoli (brassica oleracea var. talica), kale (brassica oleracea var. acephala), and radish (raphanus sativus). Further provided is a method of using the supplement composition for enhancement of methylation process.

The invention provides a sputum specimen homogenization method and preparation of a reagent for medical detection of a sputum specimen. The invention further provides a novel sputum digestion solution conforming to clinical detection, and the novel sputum digestion solution is prepared from 0.2% (w/v) of N-acetyl-L-cysteine, 0.1% (w/v) of trypsin, 0.4% (w/v) of triethanolamine, 0.2% (w/v) of potassium chloride, 1.5% (w/v) of potassium dihydrogen phosphate, 0.2% (w/v) of dipotassium hydrogen phosphate and a sterile water solvent.

The invention discloses an NAC (N-acetyl-L-Cysteine) transcription factor gene GmST2 of soybean holy bean No.9 and a plant expression vector of the GmST2. The invention further discloses application of the gene GmST2 in improvement on the salt resistant/drought tolerance in arabidopsis thaliana and soybean plants. Provided by tests, the salt resistance/drought tolerance of a transgenic plant is greatly improved compared with that of a non transgenic plant and theoretical base and practice foundation for improving the salt resistance/drought tolerance of crops through genetic engineering means are provided. The NAC transcription factor gene GmST2 can be widely applied to cultivation of salt-resisting/drought tolerant plant varieties.

The present invention provides cell culture media and methods useful for determining levels of intracellular function of glutathione or cysteine and for providing biochemical analysis of antioxidant function in human lymphocytes.

Disclosed is nucleic acid preserving compositions and methods of manufacturing and using the same. Compositions include a carrier, a chaotropic agent, a buffering agent, a chelating agent, a surfactant, an alcohol, an acid, and a mucolytic agent. Compositions as aqueous solutions can include water as a carrier. Preferred embodiments include water, guanidine thiocyanate, Tris, EDTA, SLS, SDA 3C, HCl, and N-acetyl-L-cysteine. Some embodiments include a colored dye as a visual indicator. Methods of manufacturing include combining the components into a mixture, such as an aqueous solution. Methods of use include providing a biological sample that includes nucleic acid and contacting the biological sample with the composition. Kits include the composition disposed in a portion of a biological sample collection apparatus.

The invention belongs to the technical field of production of nanometer composite materials, and provides gold nanocluster/carbon dot composite fluorescent nanoparticles and a production method and application in tetracycline detection thereof. N-acetyl-L-cysteine and glucose are used as a carbon source and a protective agent, chloroauric acid is used as a gold precursor, and through a one-pot method, a gold nanocluster/carbon dot composite fluorescent nanoparticle solution is produced. The production technology is simple, high in reaction speed and environmentally friendly, the emission wavelength of the yellowish green gold nanocluster/carbon dot composite fluorescent nanoparticles are a long wavelength, thus interference of fluorescence of living bodies can be avoided, and the yellowishgreen gold nanocluster/carbon dot composite fluorescent nanoparticles have good water solubility, a high quantum yield, a long fluorescence lifetime, good photobleaching resistance and good photostability, and shows more excellent optical performance than that of a single material. Only tetracycline can significantly quench fluorescence of the gold nanocluster/carbon dot composite fluorescent nanoparticles, a sensing system with good selectivity and high sensibility is built, and the method can be applied for detecting residual tetracycline medicines in food.

An antioxidant supplement composition is provided, which contains vitamin E, resveratrol, and alpha-lipoic acid. The supplement composition can further contain N-acetyl-L-cysteine. Further provided is a method of using the antioxidant supplement composition for enhancing an individual's resistance to oxidative damages. The method includes administering the antioxidant supplement composition daily in a dosage contains from 50 to 200 IU of vitamin E, from 5 to 40 mg of resveratrol, from 50 to 400 mg of alpha-lipoic acid. In a higher strength treatment, the daily dosage further includes from 150 to 600 mg of N-acetyl-L-cysteine.

A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

The invention discloses a visual ratio fluorescent system for detecting a cyanide ion, and a preparation method and an application of the system. The visual ratio fluorescent system comprises an N-acetyl-L-cysteine modified CdTe quantum dot, a carbon dot, a copper ion and a phosphate buffer solution. In the visual ratio fluorescent system, the concentration of the copper ion is 0.7-1.2micromoles/L; the concentration of the N-acetyl-L-cysteine modified CdTe quantum dot is 20nmol/L; in a testing system, a ratio of fluorescent intensity of the carbon dot to fluorescent peak intensity of the N-acetyl-L-cysteine modified CdTe quantum dot quenched by the copper ion is (25-35):1; and a pH (potential of hydrogen) value of the visual ratio fluorescent system is 7-8.8. The visual ratio fluorescent system is simple and convenient to prepare, and cheap, and has good cyanide ion selectivity and sensitivity, a wide linear range and a very low limit of detection.

The invention discloses a growth promoting agent for promoting the growth of a weaned pig and an application. The growth promoting agent consists of N-acetyl-L-cysteine and acetaminophen at a certain ratio, and is prepared according to the following steps: step A, proportionally weighing the N-acetyl-L-cysteine; step B, proportionally weighing the acetaminophen; step C, sequentially adding the weighed N-acetyl-L-cysteine and acetaminophen into a mixer and fully mixing to obtain the growth promoting agent applicable to the weaned pig. The invention also discloses the application of the growth promoting agent for the weaned pig to feeds for the weaned pig. The feed additive can be used for relieving weaning stress of the pig, increasing the average daily gain of the weaned pig by more than 230%, reducing the feed to gain ratio by more than 40%, reducing the incidence of diarrhea by more than 54% and remarkably improving the growth performance of the pig, causes no resistance to drugs, can be used for effectively replacing an antibiotic growth promoting agent and satisfies a healthy breeding development direction.

The invention belongs to the technical field of assisted reproduction, in particular to a one-step embryo culture medium. A composition for preparing the one-step embryo culture medium is prepared from(+/-)-alphal-lipoic acid, N-acetyl-L-cysteine according to a molar ratio of (0.055-0.098) : (0.702 to 0.858). The one-step embryo culture medium prepared by using the composition keeps effective components secreted into the culture medium by an embryo, plays a role in protecting cells and restraining, decomposing and utilizing harmful products, and the problem of low blastocyst forming rate caused by mechanical injury in the embryo transplanting process and stress reaction due to different culture environments is solved.