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Biological consistent natural polymer hydrogel and preparation method thereof

A natural polymer and biocompatible technology, applied in the field of biocompatible natural polymer hydrogel and its preparation, to achieve the effects of good air permeability and flexibility, superior hydrophilicity, and no side effects

Inactive Publication Date: 2009-02-18
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation of the above-mentioned hydrogel, there are residual monomers, other by-products, or degraded products that cannot be well eliminated from the body

Method used

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  • Biological consistent natural polymer hydrogel and preparation method thereof
  • Biological consistent natural polymer hydrogel and preparation method thereof

Examples

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Embodiment 1

[0032] A method for preparing a biocompatible natural polymer hydrogel, comprising the steps of:

[0033] (1) Disperse chitosan and 1-hydroxybenzotriazole with a molar ratio of 1:4 in water, so that the mass percent concentration of chitosan is 2%, and stir until a transparent solution is formed;

[0034] (2) With chitosan and N-acetyl-L-cysteine ​​at a mass ratio of 1:5, add N-acetyl-L-cysteine ​​to the above solution, and then add the chitosan and shell In an aqueous solution prepared with 1-ethyl-(3-dimethylaminopropyl)carbodiimide equal to the mass of polysaccharide, adjust the pH to 5, and stir at 20°C for 3 hours;

[0035] (3) Take out the reaction solution, and dialyze 3 times with 5mmol / L hydrochloric acid aqueous solution containing 2μmol / L EDTA in 3 days at 12°C in the dark, and then dialyze 3 times with 5mmol / L hydrochloric acid aqueous solution containing 1g / L NaCl, It was then dialyzed three times with 1mmol / L hydrochloric acid aqueous solution.

[0036] The pre...

Embodiment 2

[0040] A method for preparing a biocompatible natural polymer hydrogel, comprising the steps of:

[0041] (1) Disperse dextran and 1-hydroxybenzotriazole in a molar ratio of 1:1 in water so that the mass percent concentration of dextran is 1%, and stir until a transparent solution is formed;

[0042] (2) With dextran and 2,3-dimercaptosuccinic acid in a mass ratio of 1:0.5, add 2,3-dimercaptosuccinic acid to the above solution, and then add it dropwise with dextran In an aqueous solution prepared with an equal mass of 1-ethyl-(3-dimethylaminopropyl)carbodiimide, adjust the pH to 6, and stir at 15°C for 4h;

[0043] (3) Take out the reaction solution, and dialyze twice with 5mmol / L hydrochloric acid aqueous solution containing 2μmol / L EDTA within 4 days at 8°C in the dark, and then dialyze 5 times with 5mmol / L hydrochloric acid aqueous solution containing 1g / L NaCl, It was then dialyzed 5 times with 1mmol / L hydrochloric acid aqueous solution.

Embodiment 3

[0045] A method for preparing a biocompatible natural polymer hydrogel, comprising the steps of:

[0046] (1) Disperse gelatin and 1-hydroxybenzotriazole in a molar ratio of 1:8 in water so that the mass percent concentration of gelatin is 3%, and stir until a transparent solution is formed;

[0047] (2) With gelatin and N-acetyl-L-cysteine ​​at a mass ratio of 1:10, add N-acetyl-L-cysteine ​​to the above solution, and then add gelatin equal mass In the aqueous solution prepared with 1-ethyl-(3-dimethylaminopropyl)carbodiimide, adjust the pH to 4, and stir at 25°C for 2h;

[0048] (3) Take out the reaction solution, and dialyze it 4 times with 5mmol / L hydrochloric acid aqueous solution containing 2μmol / L EDTA within 2 days at 15°C in the dark, and then dialyze it twice with 5mmol / L hydrochloric acid aqueous solution containing 1g / L NaCl, Then dialyze twice with 1mmol / L hydrochloric acid aqueous solution.

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Abstract

The invention discloses a biocompatible natural polymer hydrogel and a preparation method thereof. The hydrogel is produced by the following steps: chitosan or glucan or gelatin and 1-Hydroxy benzotriazole are dispersed in the water, and stirred until transparent solution is formed; N-Acetyl-L-Cysteine or 2,3-Dimercaptosuccinic acid is added, then dripped into the water solution prepared with 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, the pH is adjusted, stirred for 2-4h; dialyzed with 5mmol / L hydrochloric acid solution containing 2Mu mol / L EDTA under lucifugal condition within 2-4 days, dialyzed with 5mmol / L hydrochloric acid solution containing 1g / L NaCl, and then dialyzed with 1mmol / L hydrochloric acid solution to achieve the desired product. The hydrogel has excellent hydrophilicity, moisture retaining property, permeability and flexibility, the degradation product has no toxic or adverse effect to the body, and can meet the requirements of modern medical science on dressing to the largest extent.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a biocompatible natural polymer hydrogel and a preparation method thereof. technical background [0002] Hydrogel is a three-dimensional network-like polymer material that swells in dilute solution without dissolving. It is widely used in biomedical fields, such as soft contact lenses, wound dressings, drug delivery systems, biosensors and implantable devices in tissue engineering. Most of the polymers used to prepare hydrogels include polyhydroxyethylmethacrylate, polyacrylic acid, polymethylmethacrylate, and polydiethylaminoethylmethacrylate, among others. However, these synthetic polymers cannot be degraded by hydrolysis or enzymolysis, which limits their applications in implantable devices and biosensors. In contrast, biodegradable polymers such as polysaccharides and polyamino acids enable the preparation of various hydrogels. Because they are biocom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/02C08L5/08C08L89/00C08K5/3472
Inventor 李朝兴张新歌郑超王鑫王瑱
Owner NANKAI UNIV
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