This invention relates to the field of concentration
crystallization reactor technology, and discloses a concentration
crystallization reactor for
drug preparation, including a reactor body, a lid, a
piping assembly, a drive mechanism, a stirring and scraping mechanism, and a protective
assembly. The reactor body has a material chamber and a
temperature control chamber inside. The lid is installed on the reactor body, and the
piping assembly connects the reactor body and the lid. The drive mechanism is installed at the top of the lid. The stirring and scraping mechanism is installed inside the reactor body, and a protective assembly is fitted around the outside of the stirring and scraping mechanism. A through hole is opened at the bottom of the reactor body. This invention, by setting a variable-
diameter stirring assembly, can adjust the radial range of the stirring blades, preventing the liquid from adhering to the reactor wall and causing
crystal agglomeration. Combined with an intermittent bottom scraping assembly, it cleans the crystallized material deposited at the bottom of the reactor body, preventing material residue. The linkage of stirring and scraping actions improves the concentration
crystallization efficiency, reduces damage to the
drug crystal structure, ensures that the precipitated
drug crystals have uniform particle size and intact morphology, and improves product purity and quality.