105 results about "Autogenous bone" patented technology

The invention provides implants such as bone nails, bone plates, cages, trays or slices which can form needed appropriate shape states according to expectation or bone-filling implants for replacing autogenous bones. A medical hollow-out rack implant comprises at least one or more than two small three-dimensional hollow-out units different in multiple dimensions, three-dimensional wire rack molding bodies and radially-formed radial hollow-out bodies, wherein the small three-dimensional hollow-out units spliced in a rule-oriented manner or overlapped in a staggered manner are hollow-out bodies which are all composed of multidimensional wire poles and are equal or different in size and in three-dimensional geometric shapes of roundness, square, octagon or sphere and the like, a small solid unit overlapping array is arranged between every two small three-dimensional hollow-out units, and each three-dimensional wire rack molding body is provided with multidimensional mesh open spaces different in density. Since various-sized rule-oriented and configurable hollow-out body arrays are formed by the wire poles, the racks of the implants can be controlled in hole shape and size according to different hardness and hyperplasia speeds of soft and hard tissues, and further support intensity and the best mechanical performance required by the implants can be regulated. Besides, the medical hollow-out rack implant can control the hyperplasia speed.

The present invention provides improved systems and methods for the minimally invasive treatment of heart tissue deficiency, damage and/or loss, especially in patients suffering from disorders characterized by insufficient cardiac function, such as congestive heart failure or myocardial infarction. In certain embodiments, a cell composition comprising autologous skeletal myoblasts and, optionally, fibroblasts, cardiomyocytes and/or stem cells, is delivered to a subject's myocardium at or near the site of tissue deficiency, damage or loss, using an intravascular catheter with a deployable needle. Preferably, the cell transplantation is performed after identifying a region of the subject's myocardium in need of treatment. The inventive procedure, which can be repeated several times over time, results in improved structural and/or functional properties of the region treated, as well as in improved overall cardiac function. In particular, the inventive therapeutic methods may be performed on patients that have previously undergone CABG or LVAD implantation.

Disclosed are a ligament-bone bionic support with an initial self-fixing function and a forming method of the support. The method includes: using a computer to design a bone support, using a fast forming technique to prepare a resin model of the bone support, and using the resin model as a core to prepare a negative silicon rubber mold of the bone support; using static spinning technology to prepare a directional ordered nano fiber film, and coiling the nano fiber film to form a nano fiber ligament support; matching and positioning the ligament support and the negative bone support, sequentially filling bone support material solution into the negative silicon rubber mold to obtain the bone support with the inherent initial self-fixing function; filing composite solution mixed with bone support materials and ligament support materials to form a transition layer; and performing post-treatment in a freeze drier to obtain the ligament-bone bionic support with the initial self-fixing function. By changing surface structures of the bone support, the bone support is allowed to be matched with autogenous bones, and initial fixing strength and stability are improved.

The invention provides a bone repair material allowing injection of a multi-pore structure and a preparation method of the bone repair material. The bone repair material comprises powder, a curing solution A and a curing solution B, wherein the powder is hydroxyapatite composite polylactic acid-glycolic acid copolymer porous microspheres, the curing solution A is a collagen solution, the curing solution B is a dopamine-hyaluronic acid aqueous solution, the powder is dispersed in the curing solution A and then uniformly mixed with the curing solution B, the pH value is adjusted to 7.5-8.5, thehydroxyapatite composite polylactic acid-glycolic acid copolymer porous microspheres and collagen are distributed in a 3D network structure of dopamine-hyaluronic acid copolymer hydrogel. The bone repair material has the multi-pore structure suitable for cell growth, can increase the tightness of combination of the bone repair material and autogenous bone and is expected to be applied to fields oftissue repair such as skin filling and beauty through adjustment of the composition proportion.

Various tools and procedures are provided for implantation of an implant at a target site. The procedure can comprise performing an osteotomy at the target site; placing a guide sleeve into the osteotomy; inserting a coring tool into the guide sleeve; coring the target site up to a depth less than the depth of the osteotomy, the coring tool being configured to collect autogenous bone material from the target site during the coring of the target site; placing the implant at the implant site; and grafting the autogenous bone material into selected portions of the target site.

The invention relates to a mineralization guided tissue regeneration membrane and a preparation method and application thereof, wherein the mineralization guided tissue regeneration membrane comprises: a loose layer formed by compositing type I collagen and nano hydroxyapatite; a compact layer positioned on the loose layer and formed from type collagen. The double-layer mineralization guided tissue regeneration membrane is constructed herein, wherein the loose layer is consistent to autogenous bone in terms of composition, and the membrane may be attached to diseased oral bone defect surface to induce the generation of new bones; the surface of the compact layer is smooth, a diseased area may be isolated from surrounding tissues by making good use of physical barrier function of the membrane, regenerating capacity of a specific tissue is given to maximum play, and the prepared mineralization guided tissue regeneration membrane has high tensile strength and elasticity.

The invention discloses a bone-defect regeneration and repair tissue-engineered bone, as well as a construction method and an application thereof. The tissue-engineered bone is a composite laminated structural body formed by three layers of mesenchymal stem cell polymers and two layers of bone matrix particles, wherein the composite laminated structural body is a complex formed by mesenchymal stem cell polymers and bone matrix particles which are alternately arranged; the mesenchymal stem cell polymer comprises mesenchymal stem cells and extracellular matrix which is secreted by the mesenchymal stem cells and is distributed around the mesenchymal stem cells. The tissue-engineered bone formed by adopting the construction method can be used for simultaneously compounding living cells and active factors, the repairing and reconstructing process is quick, the joint of new bone and surrounding autogenous bone is complete and uniform in thickness. The tissue-engineered bone is suitable for bone-defect regeneration and repair, physiological regeneration of bones is realized, and the repairing treatment effect of bone defect is improved.

The invention provides an injectable mineralized collagen bone repair material and a preparing method. The bone repair material is prepared from mineralized collagen, collagen, calcium phosphate particles and an antiwashout agent. The preparing method for the material comprises the steps of preparing mineralized collagen powder; dissolving the antiwashout agent; swelling the collagen; carrying out blending; carrying out mould filling and freeze drying; carrying out cross-linking; carrying out grinding and screening. The bone material can be mixed with autoblood, marrow, normal saline and the like, has a good shape after being kneaded, is formed into dough, and has good cohesiveness, injectability and an antiwashout property. The material can be transplanted into a bone defect part in an injected or open operation mode, has good biocompatibility, promotes new bone generation, and can be used in the bone defect of a non-bearing part, path nailing, tooth fossa pulling, interbody fusion cage interior filling, autogenous bone fragment bonding and prefabricated and formed bone material gap supplementing materials. The bone material can carry antibiotic drugs and has a slow-release effect.

An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body comprising at least an apatite/collagen composite layer and a collagen layer.

An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body obtained by rolling a sheet-shaped apatite/collagen composite, a hollow center portion of the cylindrical body penetrating from one end surface to the other end surface having a diameter of 100-1000 μm.

The invention discloses an intervertebral filling fusion device which is used for being placed between any two adjacent centrum end plates of a human body lumbar vertebra. The intervertebral filling fusion device is characterized in that a wrapping body filled with padding inside and an annular air bag are included, the annular air bag is placed on the outer periphery of the wrapping body in a sleeved mode and is used for abutting an upper centrum end plate and a lower centrum end plate in a supporting mode and supporting the padding, the top portion and the bottom portion of the padding are attached with the surface of the upper centrum end plate and the surface of the lower centrum end plate respectively, and the padding comes from autogenous bones or allogeneic bones or artificial bones. The top face and the bottom face of the device can be attached with the surface of the upper centrum end plate and the surface of the lower centrum end plate respectively, point contact is changed into face contact, a stable mechanical structure can be formed to support a vertebral column, the device can be completely attached with the upper centrum end plate and the lower centrum end plate, and favorable conditions are created for fusion of a supporting body and vertebral sclerotin.

An apatite/collagen composite powder absorbed and replaced by autogenous bone in the living body, a formable-to-any-shape artificial bone paste comprising an apatite/collagen composite powder and a binder, a method for producing an apatite/collagen composite powder by turning a suspension containing a fibrous apatite/collagen composite to liquid drops and rapidly cooling them, and a method for producing an apatite/collagen composite powder by granulating a blend comprising a fibrous apatite/collagen composite.

A guided pin system (GPS) trephine drill may be used for the placement of a dental implant while simultaneously collecting a substantial volume of autogenous bone that otherwise would have been discarded off during the current method of sequentially enlarging diameter spade drills. A method for preparing a dental implant site may include drilling the site with a pilot drill to a depth about 1 mm deeper than the intended length, in the axial direction, of the implant. The GPS trephine drill may be advanced along a straight axial path created by the pilot drill to a final depth determined by the bottoming out of a protruding pin on the trephine drill.

The invention discloses a human sacral prosthesis fusion device. The device comprises a prosthetic housing according with the sacrum of a patient in contour and size. The prosthetic housing is provided with a bent portion according with the physiological curvature of the sacrum of the patient. An autogenous bone channel used for containing the autogenous bone of the patient is formed in the prosthetic housing, wherein a channel through hole is formed in the wall of the autogenous bone channel. A fixing nail channel is formed in the prosthesis housing. Porous filler is arranged in the prosthetic housing. Fixing ear plates are arranged on both sides of the prosthetic housing, and fixing holes are formed in each fixing ear plate. The invention also discloses a method for preparing the human sacral prosthesis fusion device. The human sacral prosthesis fusion device has the advantages of being high in strength, capable of achieving fusion easily, small in rejection risk and the like, solves the problems of postoperation looseness, rupture, rejection, poor fusion and the like in the prior art, and overcomes the defect of the traditional process that personalized and accurate manufacturing of a sacral prosthesis and porous structure fusion face can not be achieved by means of the 3D printing technique, time consumption is low, and applicability is high.

The invention discloses a tissue engineering bone based on a multi-layer cell grid and a preparation method for the tissue engineering bone. The tissue engineering bone is a mesenchymal stem cell scaffold with a three-dimensional capillary network, wherein the scaffold is a three-dimensional grid formed by three-dimensional printing of a polyion compound PIC material; and methacrylate gelatin wrapping the mesenchymal stem cells and doped with a matrigel and methacrylate gelatin wrapping vascular endothelial cells and doped with the matrigel are alternately filled among three-dimensional gridslayer by layer. According to the invention, the mesenchymal stem cells are induced to form biological bone tissues, and formation of a capillary network in the mesenchymal stem cells can be promoted at the same time, so the biological bone tissue scaffold with the three-dimensional capillary network is finally formed in vitro. The scaffold material provided by the invention has excellent toughnessand rebound resilience, and after the scaffold material is implanted into a body, the scaffold material is fixed to a bone defect in a tension state, so the defect is repaired by using an implant; the effect of distracting autogenous bone osteogenesis is achieved at the same time; and the bone defect repairing effect is improved.

A porous artificial transplant material to replace autogenous bone with excellent biocompatibility, cytocompatibility and biodegradability is provided. More specifically, a porous scaffold for tissue engineering including chitosan/hydroxyapatite-amylopectin (Chitosan/HAp-AP) and a preparation method thereof are provided. The porous scaffold for tissue engineering has cross linkage among chitosan, hydroxyapatite and amylopectin, which provides advantageous effect including superior cell proliferation and transmission, and excellent thermal stability and mechanical strength. Further, considering excellent biocompatibility and biodegradability which do not harm human body, the porous scaffold can be widely used as an artificial transplant material to replace autogenous bone in biomedical field.

The invention relates to an orbital margin tissue engineering bone and application thereof. The orbital margin tissue engineering bone is prepared by the following steps: 1, culturing and inducing bone seed cells; 2, preparing an individual bone repair scaffold; and 3, combining the bone seed cells and the bone repair scaffold in vitro and culturing, wherein the bone seed cells cultured to a second generation are combined with the bone repair scaffold in the step 3 to form a compound of the bone seed cells and the bone repair scaffold. Similar to the tissue structures and characteristics of normal orbital margins, the orbital margin tissue engineering bone constructed and cultured in vitro can facilitate autogenous bone regeneration while a bracket material is degraded, generate rational bone reconstruction and finally be replaced by autogenous bone tissues in vivo so as to realize dual-repair of the shape and the function.

The invention discloses a method for preparing a natural bone repairing material, and relates to a method for preparing a bone repairing material, which is used for solving the problems of small quantity of autogenous bone transplant sources, rejection reaction existing in allogeneic bone transplant as well as low artificial bone induction osteogenic potential and small osteogenesis amount of an artificial bone repairing material existing in the conventional bone defects reconstruction. The method comprises the following steps of: clearing soft tissues and bone marrows on a cancellous bone, cutting into blocks, fixing, flushing, soaking, washing and sterilizing to obtain an antigen-removed cancellous bone; putting the antigen-removed cancellous bone into a thermal treatment furnace for calcining; extracting a fortune's drynaria rhizome extract; extracting an epimedium extract; extracting a Chinese teasel root extract; and putting the calcined cancellous bone into the fortune's drynaria rhizome extract, the epimedium extract or the Chinese teasel root extract for soaking, and drying to obtain the natural bone repairing material. Due to the adoption of the method, the size of the bone repairing material can be controlled, and the prepared bone repairing material has a natural porous structure and a smooth inner wall, is hydroxylapatite with a pure phase and completely-developed crystal gains, and is applied to bone defects reconstruction.

The invention discloses a high-simulation customized combined artificial vertebra. The high-simulation customized combined artificial vertebra is a high-simulation prosthetic implant reconstructed according to CT three-dimensional data of the lesion part of the vertebra of a patient, the outer surface of the high-simulation customized combined artificial vertebra is in a porous titanium structure, and the high-simulation customized combined artificial vertebra is formed by connecting a vertebral upper part, a vertebral lower part and vertebral accessories of the porous structure. Thus, after a vertebral body is resected, by combining the upper end and lower end of the artificial vertebra in a screw-in mode, the artificial vertebra can be fixed more firmly, autogenous bone or allogeneic bone transplantation can be carried out in a bone transplanting cage in the vertebral body, and the position of a bone transplanting block is ensured to be stable. Medicaments can be injected for treating the local lesion part by a small medicament re-injecting hole and an optional screw-in joint which are reserved at the sides of the vertebral body, thereby being especially suitable for patients with spinal tuberculosis and tumors. In addition, because the outer surface is made of porous titanium materials, the artificial vertebral body has better biocompatibility, can be used as a carrier for in-vitro co-culture of osteoblasts, and can be further used as a good carrier for ingrowth of blood vessels and osseous tissues.

The invention belongs to the field of orthopedic surgery osteotomyorthoses, and particularly relates to a personalized prosthesis for accurate resection pelvic tumor by computer aided design and a manufacturing method of the personalized prosthesis.The manufacturing method includes the following steps that complete pelvic data is collected, a three-dimensional model of a pelvis is established, ifno hip joint replacement is required, an osteotomy position can be directly determined,the personalized prosthesis is designed, if hip joint replacement is required, when an acetabulum is designed onthe personalized prosthesis, when an opposite acetabulum is normal, a prosthesis acetabulum can be designed according to parameters of the opposite acetabulum; when the opposite acetabulum is abnormal, a prosthesis is designed according to normal parameters; and the prosthesis ismanufactured by combining position and directions of fixing nails and an osteotomy knife. The manufacturing method has the beneficial effects that accurate tumor resection and personalized prosthesis positioning are achieved, an autogenous bone of a patient is retained by the prosthesis to the greatest extent, stability of the prosthesis is increased, rapid growth of the interface between the prosthesis and the bone is facilitated, at the same time, the function of the pelvis is ensured to the greatest extent, operation of orthopedic tumor resection and prosthesis replacement operation is simplified, and accuracy of the operation is improved.

The invention discloses a preparation method for a natural basin-based bionic structure bone scaffold. Silk protein and wool protein are taken as main raw materials, a silk protein solution and glycerinum are uniformly mixed according to the mass ratio of 60-120:20-60 and injected in a bone scaffold mold, a wool keratin solution is slowly injected into the mixed solution, and then through -40--20DEG C freezing and -72-5 DEG C vacuum freezing drying under 1.0*105-1.0 Pa, the silk protein/wool keratin bionic bone scaffold material is obtained. The prepared scaffold material is similar to the autogenous bone structure, the porosity rate reaches 70-95%, the hole diameter is uniform in distribution, the outer layer is compact, the hole diameter is smaller, the diameter range is 30-150 microns,the scaffold material has certain mechanical supporting performance, the diameter of inner holes is larger, the diameter range is 250-600 microns, and the scaffold material is suitable for migration,dependence and proliferation of cells.

The invention relates to the bone grafting technical field, and discloses a cervical vertebral fusion cage and a fabrication method of the cervical vertebral fusion cage. In the invention, the cervical vertebral fusion cage is a quadrate or board-shaped bone graft made by processing an allogenic cortical cone, wherein the bone graft is provided with an instrument clamping part and a hollowed chamber having a filling port; the instrument clamping part is arranged at one end of the bone graft; and two groups of opposite sides of the bone graft respectively form certain included angles. The cervical vertebral fusion cage is the quadrate or board-shaped bone graft which meets the requirement of clinical bone grafting; moreover, the bone graft is provided with the hollowed chamber to fill autogenous bone, therefore the cervical vertebral fusion cage is easy to be degraded by human body with good fusion effect, and the rejection can be greatly reduced. Furthermore, disinfection process is carried out to the cervical vertebral fusion cage to reduce the risk caused by viruses or microorganisms which spread disease to the cortical bone, as well as various immunological rejection risks.

The invention discloses a fixing device for neutralizing actions between two vertebral bodies, in particular a fixing device for neutralizing or countervailing actions between two adjacent vertebral bodies. The fixing device is a plate-shaped body, one side of the plate-shaped body is provided with a nail part, and the fixing device is embedded into two corresponding vertebral bodies and intervertebral discs by the nail part. When necessary, the fixing device also can be matched with a support assembly, such as a metal cage, and embedded into the intervertebral discs of the two corresponding vertebral bodies. Therefore, the fixing device can effectively control actions between the two vertebral bodies, such as forward bending, backward bending, left and right incline, left and right turn, and the like, and enable an autogenous bone embedded between the two adjacent vertebral bodies not to generate the problem of non-union or psuedarthrosis because of actions between the vertebral bodies before completely inosculated with the vertebral bodies.