Acrylic compound bone cement with partial degradation function and preparation method of acrylic compound bone cement with partial degradation function

An acrylic and bone cement technology, used in medical science, prosthesis, etc., can solve the problems of lack of interfacial activity of PMMA bone cement, inability to form a stable and firm interface, poor polymer biocompatibility, etc., to reduce fracture or regression. change risk, reduce the risk of loosening, reduce the effect of stress shielding

Active Publication Date: 2016-02-03
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PMMA has some disadvantages, such as the polymerization monomer has certain toxicity and the polymer biocompatibility is poor, a large amount of exothermic heat damages the surrounding tissue during the polymerization reaction, and the mechanical strength is much higher than that of the surrounding natural bone, which is easy to form stress shielding, etc., resulting in its May be accompanied by different degrees of complications in clinical application
[0005] At the same time, PMMA bone cement lacks interfacial activity, and cannot form a stable and firm interfacial bond between the bone and the implant. After a long time, it is easy to cause loosening and sinking problems, especially aseptic loosening (PMMA bone cement and bone tissue interface The micro-movement between the implanted PMMA material is caused by the covering of fibrous tissue, which in turn leads to inflammation), which has become the main reason for the failure of the operation
Moreover, heat is generated during the curing process of acrylic bone cement, forming local high temperature, which may lead to necrosis of adjacent bone tissue

Method used

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  • Acrylic compound bone cement with partial degradation function and preparation method of acrylic compound bone cement with partial degradation function
  • Acrylic compound bone cement with partial degradation function and preparation method of acrylic compound bone cement with partial degradation function
  • Acrylic compound bone cement with partial degradation function and preparation method of acrylic compound bone cement with partial degradation function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Preparation of bone cement powder and liquid 19.6 parts by weight of polymethyl methacrylate powder (average particle diameter: 50 μm, average molecular weight 150000, particle shape: spherical, purchased from (AlfaAesar (China) Chemical Co., Ltd. .)) and 0.4 parts by weight of benzoyl peroxide (purchased from Jiangsu Qiangsheng Functional Chemical Co., Ltd.) were mixed uniformly, thus providing a mixed powder component.

[0042] On the other hand, 0.109 g of N,N-dimethyl-p-toluidine (purchased from AlfaAesar (China) Chemical Co., Ltd.) was added to 9.4 parts by weight of methyl methacrylate (purchased from Sinopharm Chemical Reagent Co., Ltd.) and mixed Homogeneous, thereby providing a liquid component.

[0043] Then, the thus obtained mixed powder component and mixed liquid component were used to prepare a bone cement composition kit comprising a first component consisting of 20 g of the mixed component and a second set consisting of 9.509 g of the mixed liqui...

Embodiment 2

[0044] Embodiment 2 Magnesium ball / PMMA composite bone cement with partial degradation function and preparation method thereof

[0045] The third component in this bone cement is respectively 10g, 20g, 40g of magnesium balls (accounting for 33%, 50%, 67% of the total solid mass, purchased from AlfaAesar (China) Chemical Co., Ltd., with a particle size of 150-900 μm ) as a porogen.

[0046] The first component of the bone cement composition kit (mixed powder component: 20 g) was charged into a stirring container made of agate, followed by the second component of the bone cement kit (mixed liquid Component: 9.509g), stirred for 3 minutes to obtain the PMMA bone cement of the drawing stage. At this point, the third component is added to the PMMA bone cement, and fully stirred to obtain a magnesium ball / PMMA composite bone cement with a partially degradable function. The control group did not add the third component.

Embodiment 3

[0047] Example 3 Hydroxyapatite-coated magnesium ball / PMMA composite bone cement with partial degradation function and its preparation method

[0048] Magnesium spheres (purchased from AlfaAesar (China) Chemical Co., Ltd., with a particle size of 150-900 μm) were corroded with 1 mol / L hydrochloric acid for 5 minutes, taken out, and quickly cleaned in distilled water. Then put it in 0.5mol / L sodium hydroxide solution at a temperature of 100°C, take it out after 30 minutes, and clean it with distilled water. Prepare a 0.1mol / L calcium chloride solution and a 0.1mol / L dipotassium hydrogen phosphate solution, place the acid-base treated magnesium balls in the calcium chloride solution, and then slowly add an equal volume of dipotassium hydrogen phosphate Potassium solution, after stirring for 1 hour, take it out and wash it with distilled water. Finally, the pre-calcified magnesium spheres were immersed in 10 times the simulated body fluid for 2 hours to obtain hydroxyapatite-coa...

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Abstract

The invention provides acrylic compound bone cement with a partial degradation function and a preparation method of the acrylic compound bone cement with the partial degradation function. The acrylic compound bone cement is composed of acrylic polymer powder, contrast medium doped solid powder, acrylic monomers and a pore-forming agent with a degradation function, and the pore-forming agent is made from degradable microspheres or particles 100-1500 micrometers in diameter. Compared with acrylic bone cement in the prior art, the acrylic compound bone cement has the advantages that partial degradation is realized, voids generated in degradation of the pore-forming agents enable growth of new bones, the new bones and the undegraded bone cement are engaged mutually to form a steady interfacial bonding function, and accordingly the risk of looseness of the bone cement can be remarkably reduced. In addition, the modulus of compression of the acrylic compound bone cement is low and closer to that of autogenous bone, and the risk of degeneration or fracture of adjacent segments can be effectively reduced.

Description

technical field [0001] The invention relates to biomaterial technology in the field of biomedical engineering, in particular to a partially degradable bone repair cement material and its preparation technology, in particular to acrylic bone cement added with a degradable porogen and its preparation method. Background technique [0002] Osteoporotic or traumatic fractures are very common. In the United States, there are about 1.5 million cases of osteoporotic fractures each year, of which 750,000 cases occur in the spine, which is much higher than other diseases such as heart disease. The cost of medical care exceeded 13.8 billion US dollars in 1995, and it is expected that in 2030 it will exceed $60 billion. Vertebral compression fractures (Vertebral Compression Fractures, VCF) not only have a high incidence rate, but also have serious consequences. The spinal deformity caused by vertebral compression fractures gradually affects lung and gastrointestinal functions, and may ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/16A61L27/50A61L27/56A61L27/58
Inventor 李斌翟庆盼朱彩虹韩凤选杨惠林
Owner SUZHOU UNIV
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