Ligament-bone bionic support with initial self-fixing function and forming method of support

A bone support and self-fixation technology, applied in ligaments, bone implants, medical science, etc., can solve the problems of neglect of ligament connection and fixation, fusion of autologous bone and ligament tissue, and poor clinical efficacy.

Inactive Publication Date: 2013-08-14
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
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Problems solved by technology

However, the existing artificial ligaments are mostly considered in terms of strength, while ignoring the connection and fixation between the ligament and the autogenous bone. It is difficult to form a firm tissue between the autologous bone and the ligament only through the "mechanical connection" of the autologous bone with surgical wires and medical screws. Fusion, poor long-term clinical efficacy

Method used

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  • Ligament-bone bionic support with initial self-fixing function and forming method of support
  • Ligament-bone bionic support with initial self-fixing function and forming method of support
  • Ligament-bone bionic support with initial self-fixing function and forming method of support

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Embodiment Construction

[0018] The present invention will be described in detail below in conjunction with examples and accompanying drawings.

[0019] refer to figure 1 , a ligament-bone biomimetic scaffold with initial self-fixation function, including ligament support 1, transition layer 2 and bone support 3 with inherent initial self-fixation function, the connection interface between ligament support 1 and bone support 3 is perfused by three different The transition layer 2 structure of the composite solution mixed with β-TCP and silk fibroin in proportion to simulate the natural ligament-bone interface, the ligament scaffold 1 is composed of silk fibroin oriented fibers spun by electrospinning technology, and the bone scaffold 3 is bone-oriented scaffold Porous ceramics formed by solidification of the β-TCP solution perfused in the negative mold. There are more than two evenly distributed inverted triangular structures 4 on the surface of the bone support 3. The inverted triangular structures 4...

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Abstract

Disclosed are a ligament-bone bionic support with an initial self-fixing function and a forming method of the support. The method includes: using a computer to design a bone support, using a fast forming technique to prepare a resin model of the bone support, and using the resin model as a core to prepare a negative silicon rubber mold of the bone support; using static spinning technology to prepare a directional ordered nano fiber film, and coiling the nano fiber film to form a nano fiber ligament support; matching and positioning the ligament support and the negative bone support, sequentially filling bone support material solution into the negative silicon rubber mold to obtain the bone support with the inherent initial self-fixing function; filing composite solution mixed with bone support materials and ligament support materials to form a transition layer; and performing post-treatment in a freeze drier to obtain the ligament-bone bionic support with the initial self-fixing function. By changing surface structures of the bone support, the bone support is allowed to be matched with autogenous bones, and initial fixing strength and stability are improved.

Description

technical field [0001] The invention relates to the technical field of biomanufacturing of tissue engineering scaffolds, in particular to a ligament-bone bionic scaffold with initial self-fixation function and a forming method. Background technique [0002] Natural ligament is a fibrous connective tissue that connects bone tissue and plays an important role in maintaining the stability of joint movement and normal physiological activities. Accidental injuries often lead to non-healing damage or rupture of ligaments, and ligament reconstruction surgery is required clinically to restore their physiological functions. At present, the autologous ligaments and allogeneic ligaments used in ligament reconstruction surgery have problems such as limited donor sources, secondary surgical injuries, immune rejection, and social ethics. Using artificial ligaments to reconstruct ligament function is the future development direction. However, the existing artificial ligaments are mostly c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61F2/28A61F2/08A61L27/46A61L27/42
Inventor 贺健康李涤尘靳忠民秦霆张文友李翔连芩刘亚雄王玲
Owner XI AN JIAOTONG UNIV
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