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Injectable mineralized collagen bone repair material and preparing method

A technology for mineralized collagen and bone repair, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of reduced strength, poor anti-collapse ability, collapse and other problems, achieve good biocompatibility, good bonding performance, The effect of broad application prospects

Inactive Publication Date: 2016-04-06
谢宝钢 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently existing degradable injectable bone repair materials have poor collapse resistance, and their strength is significantly reduced when they encounter blood, and the collapse phenomenon is obvious, which is not conducive to surgical operation and bone repair.

Method used

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  • Injectable mineralized collagen bone repair material and preparing method
  • Injectable mineralized collagen bone repair material and preparing method
  • Injectable mineralized collagen bone repair material and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1, preparation of injectable / anti-collapse / mineralized collagen bone repair material

[0058] figure 1 Shown is the process flow chart of the preparation method of the injectable mineralized collagen bone repair material of the present invention. according to figure 1 In the steps shown, the preparation method of the injectable mineralized collagen bone repair material is:

[0059] Step 1.1, dissolving 1 gram of collagen in 2 L of acetic acid solution with a concentration of 0.5 mol / L to prepare an acid solution of collagen;

[0060] Step 1.2, keep stirring the solution obtained in step 1.1, and slowly add 100 mL of CaCl with a concentration of 1 mol / L dropwise 2 solution;

[0061] Step 1.3, keep stirring the solution obtained in step 1.2, and slowly add 100 mL of Na with a concentration of 0.6 mol / L dropwise 2 HPO 4 solution;

[0062] Step 1.4, continue to stir the solution obtained in step 1.3, and slowly add 1 mol / L NaOH solution dropwise until the ...

Embodiment 2

[0084] Embodiment 2, preparation of sheet-like injectable mineralized collagen bone repair material

[0085] First, prepare mineralized collagen powder, the specific steps are as follows:

[0086] Step 1.1, dissolving 1 gram of collagen in 4 L of acetic acid solution with a concentration of 0.25 mol / L to prepare an acid solution of collagen;

[0087] Step 1.2, keep stirring the solution obtained in step 1.1, and slowly add 60 mL of CaCl with a concentration of 0.1 mol / L dropwise 2 solution;

[0088] Step 1.3, continue to stir the solution obtained in step 1.2, and slowly add 30 mL of Na with a concentration of 0.12 mol / L dropwise 2 HPO 4 solution;

[0089] Step 1.4, continue to stir the solution obtained in step 1.3, and slowly add 0.5 mol / L NaOH solution dropwise until the pH of the mixed system = 7;

[0090] Step 1.5. The mixed system obtained in step 1.4 was left to stand for 72 hours, the precipitate was separated and impurity ions were washed away, followed by freeze...

Embodiment 3

[0110] Example 3, Preparation of Injectable Mineralized Collagen Bone Repair Material and Its Drug-loading Application

[0111] First, mineralized collagen powder was prepared according to steps 1-1 to 1-5 in Example 1.

[0112] Then, a sheet-like injectable mineralized collagen bone repair material was prepared. Specific steps are as follows:

[0113] Step 2.1, dry the sodium carboxymethyl cellulose in a vacuum drying oven at 50°C to constant weight, and put it in a drying vessel for use;

[0114] Step 2.2, weigh 1.2 grams of sodium carboxymethylcellulose in step 2.1, put it into a glass container with 100ml of purified water, stir and dissolve for 18 hours;

[0115] Step 3, adding 4.5 grams of collagen to the glass container in which sodium carboxymethyl cellulose has been dissolved in step 2.2, stirring and swelling for 72 hours;

[0116] Step 4.1, add 3.8 grams of mineralized collagen powder in step 1-5 to the glass container in step 3;

[0117] Step 4.2, adding 0.5 g ...

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Abstract

The invention provides an injectable mineralized collagen bone repair material and a preparing method. The bone repair material is prepared from mineralized collagen, collagen, calcium phosphate particles and an antiwashout agent. The preparing method for the material comprises the steps of preparing mineralized collagen powder; dissolving the antiwashout agent; swelling the collagen; carrying out blending; carrying out mould filling and freeze drying; carrying out cross-linking; carrying out grinding and screening. The bone material can be mixed with autoblood, marrow, normal saline and the like, has a good shape after being kneaded, is formed into dough, and has good cohesiveness, injectability and an antiwashout property. The material can be transplanted into a bone defect part in an injected or open operation mode, has good biocompatibility, promotes new bone generation, and can be used in the bone defect of a non-bearing part, path nailing, tooth fossa pulling, interbody fusion cage interior filling, autogenous bone fragment bonding and prefabricated and formed bone material gap supplementing materials. The bone material can carry antibiotic drugs and has a slow-release effect.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to an artificial bone repair material, in particular to an injectable mineralized collagen bone repair material which can be used in human body and a preparation method. technical background [0002] Human natural bone tissue is mainly composed of organic components mainly composed of collagen and inorganic components mainly composed of hydroxyapatite, in which collagen presents a regularly arranged multi-level structure and provides a mineralization template for hydroxyapatite, thus forming Orderly arrangement of mineralized collagen complexes. Imitating the composition and structure of natural bone to manufacture bioactive bone repair materials will provide the repair site with a microenvironment similar to natural bone, which is conducive to the attachment and proliferation of bone cells and promotes the repair of bone defects. [0003] At present, most of the degradable bone re...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/12A61L27/50A61L27/54A61L27/20
CPCA61L27/12A61L27/20A61L27/50A61L27/54A61L2300/252A61L2300/406A61L2300/418A61L2430/02C08L1/284C08L1/286
Inventor 何志敏谢宝钢宋天喜仇志烨崔福斋
Owner 谢宝钢
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