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A method of preparation of natural bone repair materials

A technology for repairing materials and natural bone, applied in medical science, prosthesis, etc., can solve the problems of allograft bone graft rejection, few sources of autologous bone graft, poor osteogenesis ability, etc., and achieve good tissue compatibility, good mechanical The effect of improving the scientific characteristics and promoting the speed of repair

Inactive Publication Date: 2011-12-14
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims to solve the problems of few sources of autologous bone grafts in existing bone defect repair, rejection of allogeneic bone grafts, poor ability of osteoinductive osteogenesis and low amount of osteogenesis by artificial replacement of artificial bone repair materials, and provides a natural bone repair method. Material preparation method

Method used

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  • A method of preparation of natural bone repair materials
  • A method of preparation of natural bone repair materials
  • A method of preparation of natural bone repair materials

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specific Embodiment approach 1

[0009] Specific embodiment one: the preparation method of a kind of natural bone repair material of this embodiment, carries out according to the following steps: one, remove the soft tissue and bone marrow attached on cancellous bone, then cut into blocks, then put in mass percent concentration and be 1.4 % ~ 1.6% glutaraldehyde sodium phosphate buffer solution for 3 ~ 5h, rinse with distilled water for 3 ~ 5 times, soak in 0.5 ~ 2mol / L NaOH solution for 3 ~ 5h, and then use 0.05 ~ 0.2mol / L of sodium phosphate buffer and washed 3 to 5 times, and the cancellous bone after washing with sodium phosphate buffer was placed in an aspartic acid solution with a pH value of 7.2 to 7.6 and a mass percent concentration of 0.4% to 0.6%. 1 to 2 hours, and then sterilized with cobalt 60 with a radiation dose of 25kGy for 1 to 3 hours to obtain the deantigenated cancellous bone; 2. Place the deantigenated cancellous bone in a heat treatment furnace and calcinate at 830 to 870°C for 1 to 3 h...

specific Embodiment approach 2

[0011] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is: in step 1, fix in 1.5% glutaraldehyde sodium phosphate buffer for 4 hours. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0012] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in Step 1, soak in 1 mol / L NaOH solution for 4 hours. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a method for preparing a natural bone repairing material, and relates to a method for preparing a bone repairing material, which is used for solving the problems of small quantity of autogenous bone transplant sources, rejection reaction existing in allogeneic bone transplant as well as low artificial bone induction osteogenic potential and small osteogenesis amount of an artificial bone repairing material existing in the conventional bone defects reconstruction. The method comprises the following steps of: clearing soft tissues and bone marrows on a cancellous bone, cutting into blocks, fixing, flushing, soaking, washing and sterilizing to obtain an antigen-removed cancellous bone; putting the antigen-removed cancellous bone into a thermal treatment furnace for calcining; extracting a fortune's drynaria rhizome extract; extracting an epimedium extract; extracting a Chinese teasel root extract; and putting the calcined cancellous bone into the fortune's drynaria rhizome extract, the epimedium extract or the Chinese teasel root extract for soaking, and drying to obtain the natural bone repairing material. Due to the adoption of the method, the size of the bone repairing material can be controlled, and the prepared bone repairing material has a natural porous structure and a smooth inner wall, is hydroxylapatite with a pure phase and completely-developed crystal gains, and is applied to bone defects reconstruction.

Description

technical field [0001] The invention relates to a preparation method of a bone repair material. Background technique [0002] The pace of life is accelerating, and the frequent occurrence of diseases, traffic accidents, sports trauma, etc. has caused a sharp increase in people's accidental injuries. The development of biomedical materials for the regeneration and repair of human tissues and organs has significant social benefits. [0003] Currently, bone defect repair methods mainly include autologous bone grafting, allogeneic bone grafting, and synthetic bone. Autologous bone graft has the characteristics of non-antigen, good osteoinductivity and osteoconductivity, but its source is limited. Bone allografts carry risks of transmission of other diseases, and there are legal and ethical issues that need to be addressed. Synthetic bone has better osteoconductivity and certain mechanical strength. It mainly acts as a scaffold to guide bone regeneration after being implanted ...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/54
Inventor 王晶彦李慕勤李德超刘爽马臣曲立杰
Owner JIAMUSI UNIVERSITY
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