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Gold nanocluster/carbon dot composite fluorescent nanoparticles and production method and application in tetracycline detection thereof

A technology of composite fluorescence and gold nanoclusters, applied in nano-optics, nanotechnology, nanotechnology and other directions, can solve the problems of poor water solubility of nanocomposite materials, complex preparation methods, etc., to overcome the lack of stability, simple synthesis method and selectivity. Good results

Inactive Publication Date: 2019-08-23
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently reported method is to physically mix gold nanoclusters and carbon dots, or through electrostatic interaction, or use crosslinking / coupling agents EDC, NHS, carbodiimide, etc. to combine gold nanoclusters and carbon dots to prepare gold nanocarbons. Point fluorescent nanocomposites, complex preparation methods or poor water solubility of nanocomposites

Method used

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  • Gold nanocluster/carbon dot composite fluorescent nanoparticles and production method and application in tetracycline detection thereof
  • Gold nanocluster/carbon dot composite fluorescent nanoparticles and production method and application in tetracycline detection thereof
  • Gold nanocluster/carbon dot composite fluorescent nanoparticles and production method and application in tetracycline detection thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: 20 mL of 10 mmol / L chloroauric acid aqueous solution and 30 mL of 10 mmol / L N-acetyl-L-cysteine ​​aqueous solution were mixed uniformly, and 10 mL of 1.5 mol / L glucose aqueous solution was added to the above solution, After mixing evenly, heat in a 700 W microwave oven for 20 min, and redissolve the reaction product in water to obtain a gold nanocluster / carbon dot composite fluorescent nanoparticle solution. The fluorescence emission peak of the gold nanoclusters / carbon dots composite fluorescent nanoparticles is around 535 nm. Under ultraviolet light, when observed with a black background, it presents yellow-green fluorescence with a quantum yield of 16.5% and a fluorescence lifetime of 3.5 µs.

Embodiment 2

[0019] Example 2: 50 mL of 20 mmol / L chloroauric acid aqueous solution and 50 mL of 20 mmol / L N-acetyl-L-cysteine ​​aqueous solution were mixed uniformly, and 20 mL of 3 mol / L glucose aqueous solution was added to the above solution, After mixing evenly, place it in an 800 W microwave oven and heat for 30 min. The reaction product is redissolved in water to obtain a gold nanocluster / carbon dot composite fluorescent nanoparticle solution. The fluorescence emission peak of the gold nanoclusters / carbon dots composite fluorescent nanoparticles is around 540 nm. Under ultraviolet light, when observed with a black background, it presents yellow-green fluorescence with a quantum yield of 15.5% and a fluorescence lifetime of 2.8 μs.

Embodiment 3

[0020] Embodiment 3: Mix 10 mL 5 mmol / L chloroauric acid aqueous solution and 10 mL 5 mmol / L N-acetyl-L-cysteine ​​aqueous solution, add 2 mL 1 mol / L glucose aqueous solution to the above solution, After mixing evenly, heat in a 500 W microwave oven for 10 min, and redissolve the reaction product in water to obtain a gold nanocluster / carbon dot composite fluorescent nanoparticle solution. The fluorescence emission peak of the gold nanoclusters / carbon dots composite fluorescent nanoparticles is around 530 nm. Under ultraviolet light, when observed with a black background, it exhibits yellow-green fluorescence, with a quantum yield of 16.0% and a fluorescence lifetime of 3.1 μs.

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Abstract

The invention belongs to the technical field of production of nanometer composite materials, and provides gold nanocluster / carbon dot composite fluorescent nanoparticles and a production method and application in tetracycline detection thereof. N-acetyl-L-cysteine and glucose are used as a carbon source and a protective agent, chloroauric acid is used as a gold precursor, and through a one-pot method, a gold nanocluster / carbon dot composite fluorescent nanoparticle solution is produced. The production technology is simple, high in reaction speed and environmentally friendly, the emission wavelength of the yellowish green gold nanocluster / carbon dot composite fluorescent nanoparticles are a long wavelength, thus interference of fluorescence of living bodies can be avoided, and the yellowishgreen gold nanocluster / carbon dot composite fluorescent nanoparticles have good water solubility, a high quantum yield, a long fluorescence lifetime, good photobleaching resistance and good photostability, and shows more excellent optical performance than that of a single material. Only tetracycline can significantly quench fluorescence of the gold nanocluster / carbon dot composite fluorescent nanoparticles, a sensing system with good selectivity and high sensibility is built, and the method can be applied for detecting residual tetracycline medicines in food.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanocomposite materials, and in particular relates to a gold nanocluster / carbon dot composite fluorescent nanoparticle, a preparation method thereof and an application in tetracycline detection. Background technique [0002] Tetracyclines (Tetracyclines, TCs) are antibiotics that have a bactericidal effect at high concentrations and have a good inhibitory effect on Gram-positive bacteria, negative bacteria, and Rickettsia. Due to its good antibacterial activity, easy oral absorption, low toxicity and low cost, it has been widely used in medical fields such as infection treatment. However, misuse of TCs can produce residues in the human body, increasing potential risks. At present, TCs residues have been found in many foods such as honey and milk, which can lead to allergic reactions. There is also a large amount of data showing that long-term intake of excessive TCs may affect the growth ...

Claims

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Application Information

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IPC IPC(8): C09K11/65B82Y20/00B82Y30/00G01N21/64
CPCB82Y20/00B82Y30/00C09K11/65G01N21/6428G01N2021/6419G01N2021/6421G01N2021/6432
Inventor 高鹏飞张彦李天栋董川张国梅双少敏
Owner SHANXI UNIV
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