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Use of c-kit as a therapeutic target for behavioral addictions

A therapeutic target, 1.c-kit technology, applied in the field of medicine, can solve problems such as severe addiction and lack of effective drugs, and achieve good effect, the effect of treating behavioral addiction and relapse

Active Publication Date: 2022-04-01
安徽安迪克莱斯医药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that behavioral addiction is becoming more and more serious and lacks effective drugs in the prior art, and provides the application of c-Kit as a target for treating behavioral addiction in the screening of drugs or non-drug treatment techniques for treating behavioral addiction

Method used

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  • Use of c-kit as a therapeutic target for behavioral addictions
  • Use of c-kit as a therapeutic target for behavioral addictions
  • Use of c-kit as a therapeutic target for behavioral addictions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: High-sugar and high-fat food activates c-Kit activity in addiction-related brain regions

[0023] This experiment uses homemade high-sugar and high-fat food (40g of original potato chips, 130g of original chocolate cookies, 130g of peanut butter, 130g of chocolate powder seasoning, 200g of powdered laboratory feed and 180mL of water, mixed in a food processor) , Homemade high-sugar and high-fat foods are rich in sugar, salt and fat (19.6% fat, 14% protein, 58% carbohydrate, 4.5 kcal / g).

[0024] After giving rats high-sugar and high-fat food (free eating) for 60 minutes, immunohistochemistry combined with western-blot to observe the changes of c-Kit activity in the mesolimbic dopamine system including VTA, nucleus accumbens, amygdala, hippocampus, and prefrontal cortex , Immunofluorescence co-labeling to observe the distribution of activated cells, to determine the new molecular mechanism of high-sugar and high-fat food addiction.

[0025] The experimental r...

Embodiment 2

[0026] Example 2: Imatinib mesylate inhibits the formation of conditioned place preference for high-sugar and high-fat food in rats

[0027] In this example, imatinib mesylate was selected as a drug against high-sugar and high-fat food addiction, and a conditioned place preference (conditioned place preference, CPP) model for high-sugar and high-fat food was established to study the effect of imatinib on high-sugar and high-fat food. The role of fat food reward memory aims to determine the role of c-Kit receptor as a drug target in high-sugar and high-fat food addiction, and at the same time select a drug with exact curative effect and low toxicity to treat high-sugar and high-fat addiction.

[0028] 1. Materials and methods

[0029] Drugs and reagents: homemade high-sugar and high-fat food (same as above); imatinib mesylate (Novartis PharmaSteinAG).

[0030] Experimental animals: SPF grade male SD rats, weighing 220-250g. Provided by the Hubei Laboratory Animal Research Cen...

Embodiment 3

[0039] Example 3: Imatinib mesylate blocks conditioned place preference for high-sugar and high-fat food after environmental re-exposure or unconditioned re-exposure

[0040] In this example, imatinib mesylate was selected as a drug against high-sugar and high-fat food addiction, and a conditioned place preference (conditioned place preference, CPP) model for high-sugar and high-fat food was established to study imatinib mesylate's resistance to high-sugar and high-fat food. Breaking down the conditioned place preference of high-sugar and high-fat food reward memory by environmental re-exposure or unconditioned re-exposure; and choosing a drug with definite curative effect and low toxicity to treat high-sugar and high-fat food addiction.

[0041] 1. Materials and methods

[0042] Drugs and reagents: homemade high-sugar and high-fat food; imatinib mesylate (Novartis PharmaStein AG).

[0043] Experimental animals: SPF grade male SD rats, weighing 220-250g. Provided by the Hubei ...

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Abstract

The invention discloses the application of c-Kit as a target for treating behavioral addiction, and belongs to the technical field of medicine. The present invention discovers that behavioral addiction activates the activity of c-Kit receptors in nucleus accumbens neurons, and behavioral addiction can be treated by inhibiting c-Kit activity. The present invention provides the application of c-Kit as a target for the treatment of behavioral addiction in the screening of drugs for the treatment of behavioral addiction and in non-drug treatment techniques; the behavioral addiction includes gambling, diet, sexual behavior, Internet, work, exercise Addictive behaviors in aspects such as mental compulsion and shopping; the drug for treating behavioral addiction is a drug that inhibits c-Kit, such as imatinib or its derivative imatinib mesylate. The present invention provides a target for maintenance treatment of etiology for the treatment of behavioral addiction, and is expected to fundamentally treat behavioral addiction and the prevention and treatment of relapse.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of c-Kit as a target for treating behavioral addiction in screening drugs for treating behavioral addiction. Background technique [0002] Behavioral addictions to gambling, eating, sex, internet, work, exercise, mental compulsions, and shopping have become increasingly serious in recent years. From a clinical point of view, all kinds of behavioral addictions have many common and important features, such as being unable to control one's own addictive behavior, taking addictive behavior as the first need, knowing that it is harmful but continuing to do it, and even having withdrawal symptoms and tolerance. In particular, "recurrent craving" is the clinical manifestation of the basic pathophysiological mechanism of addiction disorders, and it is also one of the diagnostic criteria for addiction disorders in DSM-5. At present, behavioral addictions suc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/506A61K49/00A61P25/30G01N33/50
CPCA61K45/00A61K31/506A61K49/0008A61P25/30G01N33/5008
Inventor 李艳琴朱世敏陈明珠张新宇
Owner 安徽安迪克莱斯医药有限责任公司
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