87 results about "Inflammatory pathways" patented technology

The invention relates to the technical field of natural plant extracts, and particularly discloses a plant extract composition with anti-inflammatory and soothing effects and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in percentage by weight: 1 to 5 percent of radix cynanchi atrati extract, 1 to 3 percent of flos magnoliae extract, 1 to 5 percent of flos hibisci mutabilis extract, 0.5 to 1 percent of herba andrographitis extract, 1 to 3 percent of citrus peel extract, 0.5 to 1 percent of rhizoma paridis extract and the balance of solvent. Six plant extracts with different anti-inflammatory mechanisms are scientifically screened and proportioned, the extraction process is optimized, the plant extracts have a synergistic effect, and the anti-inflammatory effect is improved by adjusting the proportion; the six components respectively act on different links of inflammatory response to form a complementary anti-inflammatory network, the plant extract composition with multiple anti-inflammatory pathways and synergistic interaction is developed, and the problems of single anti-inflammatory effect, insufficient permeability and the like in the prior art are solved.

Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.

The invention relates to the technical field of daily chemicals, in particular to a soothing composition as well as a preparation method and application thereof. The composition is prepared from saccharomycetes fermentation lysate filtrate, peony root extract, spanishneedles herb extract, liquorice root extract, glycerol and tremella fuciformis extract. Small molecule peptides in the fermentation lysate and flavone, polyphenol and triterpenoid components in the plant extract can inhibit inflammation pathways (such as TNF-alpha, IL-6 and COX-2) in a multi-target mode, and skin redness is effectively relieved. The skin barrier repairing capability is high: the tremella acidic polysaccharide and the yeast polypeptide form a synergistic network, so that the water content of a cuticle is favorably enhanced, and barrier lipid synthesis is promoted; a polysaccharide-polypeptide cross-linked chain structure is broken through a high-shear homogenizing treatment technology, so that the wiredrawing and colloid decorous feeling of a finished product are remarkably reduced, and a refreshing skin feeling is obtained.

This invention relates to the field of medical information management technology, including an AI-based endometriosis management system. The system comprises a thickness dynamic monitoring module, an inflammation level assessment module, a lesion spread analysis module, a periodic lesion tracking module, and a disease progression analysis module. In this invention, AI is used to segment ultrasound image data, enabling dynamic monitoring of lesion areas. Lesion boundaries are extracted, and changes in local inflammatory marker concentrations are calculated, making the screening of abnormal inflammatory areas more accurate and enabling early identification of lesion development. The tracking of periodic lesions, combined with analysis of lesion contour changes and area increases / decreases, enhances the quantitative control of disease progression. The future development trend of lesions, combined with the calculation of periodic inflammatory pathways, makes the prediction of disease evolution more consistent with physiological changes. Multi-dimensional lesion analysis combined with AI intelligent calculation expands the diagnosis and treatment of endometriosis from static assessment to dynamic trend prediction, improving the adaptability of personalized treatment plans.

The invention provides a pulmonary nodule targeting food and medicine homologous composition based on metabonomics screening and application thereof. By analyzing a pulmonary nodule specific metabolic profile, active components, namely platycodin D, mogroside V, oyster active peptide and fermented cordycepin, which can cooperatively regulate and control an arachidonic acid inflammation pathway, a glutathione antioxidant pathway and a tricarboxylic acid cycle energy pathway are reversely screened out. Animal experiments prove that the composition can reduce the volume of pulmonary nodules by 58.3%, human body application shows that the nodules of 76.7% of subjects are reduced, and liver and kidney toxicity is avoided. The composition can be prepared into tablets, capsules and other dosage forms, can be used as functional food or adjuvant therapy drugs for high risk groups of pulmonary nodules, and realizes accurate nutrition intervention.

Disclosed herein are methods of treating ALS in a subject by administering to the subject a therapeutically effective amount of a composition comprising, for example, EV derived from nerve cells, such as neural progenitor cells. The EVs may be administered distally or peripherally to the CNS such that these EVs cross the blood-brain barrier and exert their therapeutic function in the CNS. The methods may reduce inflammation (e.g., NLRP3 inflammatory pathway signaling), reduce disease activity or progression, and / or improve motor or neurological performance, signs or symptoms associated with ALS, or survival in an ALS subject as compared to a control ALS subject. Also provided are methods of inhibiting necroptosis in a cell by contacting the cell with a therapeutically effective amount of a composition comprising EV.

Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.

Chronic obstructive pulmonary disease is a major clinical challenge mostly due to cigarette smoke exposure and affects more than 200 million people. The inventors tested if exposure to the Bordetella pertussis BPZE1 strain could modulate outcomes of chronic exposure to cigarette smoke in mice. In particular, they showed in mice chronically exposed to cigarette smoke that preventive and / or curative vaccination using BPZE1 could limit the lung inflammation and strongly contribute to the prevention of lung function decline. BPZE1 vaccination modulated pulmonary antigen presenting cells (macrophages and dendritic cells) to switch the immune response, by decreasing the IL-17 inflammatory pathway involved in the pathology of COPD itself, and by favouring a tolerogenic response (IL-10). Together, the data show that vaccination with BPZE1 of mice chronically exposed to cigarette smoke limits the development of chronic obstructive pulmonary disease outcomes and thus represents an interesting therapy.

The invention provides a traditional Chinese medicine composition for regulating scalp micro-ecology, an external preparation containing the traditional Chinese medicine composition and application of the external preparation, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition for regulating and controlling scalp micro-ecology is prepared from cacumen biotae, rhizoma cyperi, fructus cnidii, cortex dictamni, radix sanguisorbae, herba ecliptae and herba menthae. Based on the compatibility principle of monarch, minister, assistant and guide, the composition takes fructus cnidii for eliminating dampness and killing parasites as monarch, cortex dictamni and cacumen biotae for removing heat to cool blood as minister, garden burnet, eclipta and rhizoma cyperi for astringing, detoxifying, nourishing yin and regulating qi as assistant, and mint for guiding the medicine to move upwards and transdermal permeation as guide, so that multiple effects of inhibiting bacteria, resisting inflammation, repairing a barrier, regulating sebum secretion and the like are synergistically realized. Modern pharmacological studies show that the active ingredients can inhibit malassezia proliferation, regulate and control inflammatory pathways of NF-kB, TLR4 and the like, reduce expression of proinflammatory factors of IL-6, TNF-alpha and the like, and promote skin barrier repair. Clinical observation shows that the composition can significantly improve the scalp seborrheic dermatitis symptom.

The invention discloses a preparation rich in polygonatum sibiricum polypeptide and application of the preparation in diabetes mellitus. The composition is prepared from rhizoma polygonati polypeptide, semeglutide, astaxanthin, an active agent and a ferroptosis mixture. Pharmacodynamic experiments show that in a diabetic mouse model, fasting blood glucose can be remarkably reduced, the serum insulin level can be increased, renal function indexes can be improved, and expression of NLRP3 inflammation pathway related proteins (NLRP3, Caspase-1 and IL-1beta) in pancreatic tissue can be remarkably inhibited. By integrating multiple mechanisms of blood glucose reduction, oxidation resistance, inflammation resistance, ferroptosis resistance and the like, multi-target collaborative intervention is realized, the pharmaceutical composition is remarkably superior to a single component in the aspects of blood glucose reduction, pancreas islet function protection and complication alleviation, and a new clinical strategy is provided for treatment of diabetes mellitus, especially type 1 diabetes mellitus.

The invention discloses a cell cellulose composition and application thereof in skin care products, and belongs to the technical field of cellulose preparation. According to the composition, bacterial cellulose, modified amphiphilic grafted cellulose micelles and cellulose nanocrystals are taken as cores, an isoflavone active group is grafted to a cellulose chain through an RAFT polymerization technology, an amphiphilic carrier capable of loading an oil-soluble active matter is formed, grape seed oil, resveratrol and other active ingredients can be loaded, slow release and controlled release are achieved, and the composition has a good application prospect. A bacterial cellulose three-dimensional network and nanocrystals form a protective film on the skin surface, hyaluronic acid can enhance cuticle lipid arrangement and accelerate skin barrier function reconstruction, an isoflavone grafted structure provides ultraviolet protection and anti-inflammatory pathway regulation and control, inflammatory factor release is remarkably inhibited, and the anti-inflammatory effect is achieved. A cellulose nanocrystal and bacterial cellulose composite network is provided to improve the stability of the emulsion, the problem that a traditional product is prone to layering is solved, and the emulsion has the effects of physical barrier, long-acting moisturizing and repairing and is suitable for anti-allergy repairing type skin care products such as essence and masks.

This invention relates to the field of bioactive peptide preparation technology, and discloses a method for preparing and applying a bifunctional antioxidant and anti-inflammatory peptide based on porcine skin collagen. The bifunctional peptide has the amino acid sequence GPSGPPGEKGP. Through peptidomics and computer simulation screening, this invention identified five novel antioxidant peptides with good solubility, non-sensitizing properties, and non-toxicity. Using an AFB1-induced HuH7 cell oxidative damage model, in in vitro cell experiments, GP-11 was shown to significantly reduce ALT, AST activity, and ROS levels, enhance the activity of SOD, CAT, and GSH-Px antioxidant enzymes, and activate the Keap1-Nrf2 pathway. It also reduced the levels of inflammatory factors TNF-α and IL-6 by downregulating the classical cGAS-STING inflammatory pathway. GP-11 exhibits both significant antioxidant effects and the ability to reduce the levels of inflammatory factors, demonstrating a dual function of antioxidation and anti-inflammation.

The invention provides a preparation method of anti-inflammatory soothing and repairing microspheres based on Trichoderma reesei-Lactobacillus johnsonii two-stage fermentation. According to the preparation method, Trichoderma reesei fermentation products, Lactobacillus johnsonii metabolites, specific plant active ingredients and mussel mucoprotein are included. According to the invention, the mussel mucoprotein-trichoderma reesei-lactobacillus johnsonii ternary synergistic anti-inflammatory antibacterial system microspheres are innovatively constructed, the targeted delivery efficiency of active ingredients is remarkably improved through the adhesion characteristic of mussel mucoprotein, and the technical bottlenecks of poor permeability and short action time of a traditional anti-inflammatory preparation are solved. A multi-strain synergistic fermentation process is adopted, beta-glucan secreted by trichoderma reesei and short-chain fatty acid generated by lactobacillus johnsonii generate a synergistic anti-inflammatory effect, and meanwhile, an enzymolysis technology is combined to realize efficient conversion of plant active ingredients, so that the inhibition effect on key inflammatory factors such as TNF-alpha and IL-6 is remarkably enhanced. According to the system, inflammatory pathways such as NF-kappa B and the like are regulated and controlled through multiple targets, the inflammatory reaction is reduced while the growth of pathogenic bacteria is inhibited, a remarkable broad-spectrum antibacterial and anti-inflammatory synergistic effect is shown, and an innovative solution is provided for developing an efficient and safe anti-inflammatory antibacterial preparation.

The invention discloses a lactobacillus casei exosome capable of improving skin aging and a preparation method of the lactobacillus casei exosome. The lactobacillus casei is lactobacillus casei RH99, and the preservation number of the lactobacillus casei exosome is CGMCC (China General Microbiological Culture Collection Center) No.32108. The lactobacillus casei RH99 exosome prepared by the preparation method disclosed by the invention has relatively strong acid resistance, and can be orally taken to reach the intestinal tract part; according to the prepared lactobacillus casei RH99 exosome, the ROS level in H2O2 induced HaCaT cells can be reduced, the expression of collagen and elastin genes COL1A1-ELN can be activated, the expression of inflammation pathway related genes TNF-alpha and IL-6 can be reduced, and inflammation damage can be reduced; the composition can inhibit the increase of MDA content in light aging skin of mice, improve the activity of antioxidant enzymes such as SOD, GSH-PX and the like, improve the content of HYP, increase the moisture content of skin and play a role in delaying skin aging; the content of TNF-alpha, IL-6, IL-18 and IL-1beta inflammatory factors in mouse serum can be reduced; the invention has important application significance and research value in preparation of products for preventing or improving skin inflammation, oxidative damage and skin aging.

The invention discloses recombinant lactobacillus casei for expressing sialyltransferase ST6GALNAC1, and belongs to the technical field of genetic engineering and microorganisms. The recombinant bacterium is obtained by cloning an ST6GALNAC1 gene to a pPG612 vector and electrically transforming the ST6GALNAC1 gene into lactobacillus casei ATCC393. Experiments show that the engineering bacterium can significantly enhance glycosylation modification of intestinal mucoprotein MUC2, improve expression of tight junction proteins (ZO-1, Occludin and Claudin-1), inhibit activation of a p38 / MAPK inflammation pathway and regulate an intestinal flora structure, so that intestinal injury and systemic inflammatory response caused by salmonella are effectively relieved. The invention provides a strain basis and technical support for developing a novel oral microecological preparation.

This invention discloses the application of berberine-loaded herbal carbon dots in the preparation of drugs for treating ulcerative colitis. The BLCDs of this invention exert their therapeutic effect through a dual synergistic mechanism: directly scavenging reactive oxygen species through surface oxygen-containing functional groups, and simultaneously inhibiting the NLRP3 inflammatory pathway and downstream pro-inflammatory factors by promoting IL-10 expression. In a DSS-induced ulcerative colitis mouse model, BLCDs showed superior efficacy compared to the positive control drug 5-ASA and its single component, significantly improving intestinal inflammation, oxidative stress, and barrier dysfunction. Their therapeutic advantage stems from the intestinal retention effect conferred by their larger particle size, as well as their regulatory effects on intestinal flora and metabolites, particularly by inhibiting Klebsiella to reduce TMAO production, thereby activating the multi-cascade regulatory network of IL-10.

The invention provides an application of a donepezil or gardenia jasminoides ellis-phellodendron amurense component in preparation of a cholinergic regulation-based immune liver injury resisting medicine, and belongs to the technical field of biological medicines. The pharmaceutical composition for resisting immunological liver injury is a donepezil component or a gardenia jasminoides ellis-phellodendron amurense component. The invention solves the problems of single action target and incomplete regulation and control mechanism of the existing immunological liver injury treatment medicine, provides a treatment scheme with anti-inflammatory, anti-oxidation, liver cell apoptosis inhibition and cholinergic system regulation and control functions, explores a brand new medical application of donepezil, verifies the liver protection effect of donepezil in immunological liver injury, and provides a new application of donepezil in immunological liver injury. The application limitation is broken through; the treatment effect of the Jashima component in an immune liver injury model induced by concanavalin A is defined, a dual regulation mechanism of inhibiting AChE expression and increasing alpha7 nAChR expression is disclosed, and the application scene is expanded; a multi-dimensional regulation and control network of cholinergic anti-inflammatory pathway-NF-kappa B inflammatory pathway-hepatocyte apoptosis is constructed, and a more efficient and comprehensive treatment strategy is provided for immunological liver injury.

A microorganism containing Bacteroides fragilis genes is used as an active ingredient in the preparation of pharmaceuticals, medical devices, or food for treating optic nerve damage. This delivers Bacteroides fragilis (or its functional components) into the gastrointestinal tract, which helps maintain the number of retinal ganglion cells and the thickness of the retinal nerve fiber layer, inhibits the activation of retinal microglia, inhibits the activation of retinal inflammatory pathways and the expression of inflammatory mediators, thereby protecting visual function.

The invention relates to a compound indoleacetic acid and application of the compound indoleacetic acid as an active ingredient in preparation of medicines or foods for treating optic nerve injury, and the indoleacetic acid is given in vivo, so that the number of retinal ganglion cells and the thickness of a retinal nerve fiber layer are favorably maintained, and activation of retinal microglial cells is inhibited; retina inflammation pathway activation and inflammatory mediator expression are inhibited, so that the visual function is protected.

The invention discloses an anti-inflammatory and anti-aging face cream and a preparation method thereof, and belongs to the technical field of cosmetics. The face cream disclosed by the invention is prepared from the following components in percentage by weight: 5.0 to 20.0 percent of broccoli fermentation filtrate, 0.05 to 0.2 percent of andrographolide encapsulated by nano-liposome, 0.5 to 5.0 percent of a skin barrier repairing agent and a matrix. Sulforaphane (greater than or equal to 400 mg / kg) in broccoli is enriched through a lactic acid bacteria fermentation technology, and the stability and the smell of the broccoli are improved; the problem that andrographolide is difficult to dissolve and easy to crystallize is solved through embedding of nano-liposome (the particle size is 40-80 nm, and the encapsulation efficiency is larger than or equal to 85%), and the transdermal property of andrographolide is improved. The two are combined to synergistically activate an Nrf2 antioxidant pathway and inhibit an NF-kappa B inflammation pathway, and the two pathways intervene in inflammatory aging. Human body tests show that after the face cream is used for 4 weeks, the depth of wrinkles can be remarkably reduced (28.6%), the level of skin inflammatory factors TNF-alpha can be reduced (50.4%), and the face cream is free of any irritating reaction, has an excellent anti-aging effect and extremely high safety and is particularly suitable for sensitive skin.

The invention discloses a Xianglian tablet with effects of clearing heat and drying dampness and a preparation method of the Xianglian tablet, and relates to the technical field of medicines. The tablet is prepared from coptis chinensis, radix aucklandiae, scutellaria baicalensis, parched white peony root, a rhizoma atractylodis extract, an IL-12 / IL-23 inhibitor with a specific structure, a filler, an adhesive, a disintegrating agent and a lubricant. The preparation method comprises the following steps: extracting traditional Chinese medicine water and volatile oil, mixing by an equivalent incremental method, granulating and drying, adsorbing volatile oil and tabletting. Through the synergistic effect of specific chemical drugs and traditional Chinese medicines, the IL-12 / IL-23 inflammatory pathway is accurately blocked, the anti-inflammatory activity and bioavailability are remarkably improved, and the pharmaceutical composition is used for treating dysentery, enteritis and ulcerative colitis caused by damp-heat accumulation.

The invention provides an application of an expression inhibitor of Gadd45a in preparation of a medicine for preventing or reducing the ototoxicity of cis-platinum. In-vivo and in-vitro experiments prove that by locally applying the Gadd45a inhibitor, cochlea hair cells and auditory functions can be effectively protected by activating autophagy, inhibiting an NF-kappaB1 inflammation pathway and regulating JNK-mediated apoptosis, so that hearing loss caused by cis-platinum is relieved. The invention provides a brand-new effective medicine product and a treatment strategy for clinically preventing and treating the ototoxicity of cis-platinum, and has important clinical application value for preventing or relieving the ototoxicity of a patient receiving cis-platinum chemotherapy.

The invention relates to a polyarginine-DNA nanotube material as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. Aiming at the technical problems of unstable structure, low cell uptake rate and easy degradation by nuclease caused by dependence on magnesium ions in the existing DNA nano-material, the invention provides a nano-tube material formed by self-assembly of four DNA single chains (Y1-Y4) according to a molar ratio of 1: 3: 3: 3 induced by polyarginine. The material can load p65 siRNA to form a composite preparation which is used for preparing a medicine for inhibiting lung inflammation. According to the polyarginine-DNA nanotube material disclosed by the invention, the stability and the cell uptake efficiency of the material are remarkably improved; the higher the polymerization degree of arginine is, the stronger the anti-inflammatory activity is; the compound preparation synergistically inhibits the expression of a proinflammatory factor through a dual mechanism of blocking an inflammatory pathway by polyarginine and silencing a p65 signal by p65 siRNA, and provides an efficient delivery carrier for the treatment of acute lung injury.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

Nutritional supplements and compositions for activating cellular signaling genes in innate inflammatory pathways are described in this application. In particular, this application describes a composition containing a solid portion comprising Bacopa monnieri extract having a least 20 percent bacosides, Silybum marianum (milk thistle) extract having 70 percent to about 80 percent silymarin, milk thistle extract, Withania somnifera (ashwagandha) extract, Camellia sinensis (green tea) extract containing at least 40 percent epigallocatechin gallate and about 98 percent polyphenols; and Curcuma longa (turmeric) extract containing at least about 95 percent curcumin. The compositions also comprise a liquid portion comprising fish collagen peptides comprising about 90 percent protein and Formosa ruby quinoa water extract containing about 10 wt % extract and about 90 wt % water. These compositions improved the skin and impacted key regulatory genes associated with several important cellular pathways. Other embodiments are also described.

This invention relates to the fields of biomedicine and food nutrition, specifically to the application of purple sweet potato anthocyanins in the preparation of products for preventing or improving intestinal aging. This invention demonstrates that purple sweet potato anthocyanins can significantly improve the degenerative changes and barrier fragility of the colon caused by natural aging, restore colonic crypt morphology and epithelial ultrastructure, and upregulate the expression of tight junction proteins and mucus barrier-related indicators. Furthermore, purple sweet potato anthocyanins can effectively enhance crypt proliferation activity and promote the differentiation of intestinal stem cells into secretory lineages (such as goblet cells and enteroendocrine cells). Its mechanism of action does not rely on direct anti-inflammatory pathways, but rather on remodeling intestinal flora metabolism (such as increasing short-chain fatty acids) and activating intestinal cell autophagy via the PI3K-Akt signaling pathway, thereby supporting the continuous renewal and maintenance of the intestinal barrier. This invention provides a new approach for the development and application of food-derived polyphenols targeting the gut to promote healthy aging.

The invention discloses an exosome composition and method for treating lung diseases, and relates to the technical field of medicines.The composition is composed of human alveolar epithelial cell exosome subjected to hypoxia pretreatment, traditional Chinese medicine compound nano-liposome and an atomization stabilizer, the mass ratio of the exosome to the traditional Chinese medicine compound nano-liposome is 1: 1-1: 3, and the mass ratio of the atomization stabilizer to the human alveolar epithelial cell exosome to the traditional Chinese medicine compound nano-liposome is 1: 1-1: 3. The preparation method comprises the steps of cell culture, exosome purification, traditional Chinese medicine liposome preparation and composition mixing treatment, during treatment, an intelligent atomizer can be used for administration, and abdominal respiration training and traditional Chinese medicine iontophoresis therapy are matched. According to the scheme, the targeting property is high, the side effect is small, the inflammatory pathway can be effectively inhibited, the pulmonary epithelium-mesenchymal transition is reversed, the drug delivery efficiency is improved, and the drug delivery system is suitable for treating idiopathic pulmonary fibrosis, acute attack of asthma and the like.

The present application is generally directed to methods for chelating calcium deposits within calcified blood vessels, as well as methods and compositions for use in regulating various senescence-related inflammatory pathways. Specifically, the present application is directed towards reducing senescent cell accumulation by delivering a nanoparticle comprising a chelating agent to a tissue.

The invention relates to application of Chinese yam protein, in particular to application of Chinese yam active protein in preparation of medicine for regulating blood testis barrier to treat testis dysfunction. L-YP has unique fluorescence characteristics and remarkable antioxidant activity, and can effectively improve testis immune microenvironment disorder by repairing blood testis barriers and inhibiting NLRP3 and TLR4 / MyD88 / NF-kappa B inflammatory pathways. In combination with a molecular docking technology, a molecular mechanism that key components such as YP2 (mitochondrial ornithine aminotransferase) and the like realize immunoregulation through high-affinity binding is clarified for the first time. According to the application disclosed by the invention, a molecular docking technology is creatively combined with system experimental analysis, and a molecular mechanism of improving testis injury by the Chinese yam protein is illuminated from the perspective of a'structure-function-target 'synergistic effect, so that a novel dietary intervention strategy is provided for preventing reproductive toxicity caused by chemotherapy; the application potential of medicinal and edible components in the field of male reproductive health is highlighted.

The application provides a pharmaceutical composition for treating oviduct inflammation and peritonitis of laying hens and a preparation method thereof, and belongs to the technical field of veterinary drugs. The pharmaceutical composition is obtained by mixing 2-10 parts of artemisinic acid, 1-10 parts of marrubiin hydrochloride, 1-10 parts of sodium salicylate, 0.001-0.005 parts of imipenem / cilastatin sodium and auxiliary materials. The pharmaceutical composition can treat oviduct inflammation, peritonitis and intestinal secondary infection of laying hens through anti-pathogenic microorganism infection and anti-inflammatory pathways, and significantly improves the production performance of laying hens. After the chickens are medicated, the effect is fast, the egg production rate is obviously increased, and the substandard egg rate is obviously decreased. The oviduct inflammation and peritonitis of laying hens over 300 days old can be effectively solved, the clinical use is safe and reliable, the meat and egg food quality and safety can be improved, and it is particularly important for large-scale laying hen farms.