35 results about "Aminooxyacetic acid" patented technology

The invention discloses an application of aminooxyacetic acid to preparation of medicines for treating hepatocellular carcinoma. Research results indicate that the aminooxyacetic acid can significantly reduce the modification level of O-N-acetylglucosamine of liver cancer cells, can show favorable liver cancer cell proliferation, invasion and transfer restraining effects, and can be used for developing new medicines for treating the hepatocellular carcinoma.

The invention belongs to the technical field of medicines, and relates to an application of a hydrogen sulfide synthase inhibitor AOAA (aminooxyacetic acid) to preparation of a medicine for treating endometriosis. The potential value of the hydrogen sulfide synthase inhibitor AOAA in treatment of EMS (endometriosis) is evaluated by experimental study, results display that the expression level of hydrogen sulfide synthase CBS in an ectopic endometrium of an EMS patient is higher than that of a normal endometrium, participation of hydrogen sulfide in the disease progression process is prompted,sodium hydrosulfide obviously promotes ESC (endometrial stromal cell) proliferation, and growth of an ectopic focus is remarkably inhibited by the hydrogen sulfide synthase inhibitor AOAA. The resultsindicate that the hydrogen sulfide synthase inhibitor AOAA can be used for preparing the medicine for treating the endometriosis. The new pharmaceutical application of the hydrogen sulfide synthase inhibitor AOAA is provided, and a new method and a new idea are provided for clinic treatment of the EMS.

The invention discloses a water-retaining and sterilizing coating solution for mango, which is composed of shellac, monoglyceride, sodium carbonate, myristic acid, aminooxyacetic acid and a solvent, wherein the mass concentration of shellac is 15-20%, and the single The mass concentration of glyceride is 0.1-0.2%, the mass concentration of sodium carbonate is 0.3-0.5%, the mass concentration of myristic acid is 0.002-0.004%, and the mass concentration of aminooxyacetic acid is 0.001-0.002%. The invention can reduce the fresh-keeping cost, does not produce cold-resistant pathogenic bacteria, can inhibit the respiration of mango and the growth of surface pathogenic bacteria, and prevent rot. The water-retaining and sterilizing coating solution is stable and can be stored for half a year without deterioration. The water-retaining and sterilizing coating liquid of the present invention can make the surface of mango bright, and after 100 days, the bad fruit rate is less than 5%, the water loss rate is less than 10%, and the taste is kept fresh.

The invention provides a drug for relieving body injury caused by chronic alcoholic poisoning. The drug comprises an effective ingredient of AOAA (aminooxyacetic acid). Learning and memory ability evaluation is performed on chronic alcoholic poisoned rats and normal rats by use of a Y-type electric maze by establishing a rate chronic alcoholic poisoning model. Experimental results prove that compared with normal control groups, the chronic alcoholic poisoning model group of rats has remarkably reduced learning and memory ability. After AOAA intervention is given, the training times required for rats of a remedy group to learn spatial discrimination are reduced, and difference has statistical significance. Accordingly, AOAA can relieve memory deterioration caused by the chronic alcoholic poisoned rats, improves the learning memory ability and provides a scientific basis for research of chronic alcoholic poisoning injury mechanism and treatment by AOAA.