The present invention discloses a quercetin metal nano drug and a preparation method and an application thereof. In the provided quercetin metal nano drug, quercetin and transition metal elements arecoordinated by coordination bonds, and the quercetin metal nano drug is formed by surface modification of polymers containing carbonyl groups or hydroxyl groups. The nano drug is a multifunctional nanomaterial with a tumor targeting function, can inhibit growth, invasion, metastasis, recurrence, etc. of tumor cells, even eliminates the tumor cells, and has various modes of preventing the tumors such as photothermal therapy, photodynamic therapy and radiation therapy. In addition, when the nano drug is degraded and metabolized in vivo, a produced quercetin molecule can exert the anti-tumor effect for a longer period of time, aggregation, distribution and metabolism in vivo can also be traceable, an excellent diagnosis and treatment integrated nano-platform can be formed, and the quercetin metal nano drug has a good application prospect and a broad development space in the field of medicines.