32 results about "HOTAIR" patented technology

Long non-coding RNAs (lincRNAs), a relatively recently recognized class of widely transcribed genes, are thought to affect chromatin state and epigenetic regulation, but their mechanisms of action and potential roles in human disease are poorly understood. The present invention shows that long non-coding RNAs in the human HOX loci are systematically dysregulated during breast cancer progression, and that expression levels of the lincRNA termed HOTAIR can predict cancer metastasis. Elevated levels of HOTAIR can lead to altered patterns of Polycomb binding to the genome. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.

The invention provides a using method of a full-automatic production line of slices, and belongs to the field of decoction pieces processing devices. The using method comprises the following steps ofcleaning by using an ultrasonic cleaner, shaping by using a root stock shaping machine, slicing by using a reciprocating slicer, elevating and feeding by using a bucket elevator, drying by using a hotair dryer, separating by using a rail-mounted reciprocating separating screen, and storing by using a moistureproof storage tank. Traditional Chinese medicine decoction pieces prepared from the rootstocks of bupleurum chinense realizes automatic assembly line production.

The invention discloses a crushing device for production and processing of organic fertilizers. The crushing device comprises a case. A crushing bin is mounted on one side of the upper surface of thecase, and a collecting groove communicating with the crushing bin is formed in the top end in the case. A drying bin is connected to the position under the collecting groove through a pipeline. A hotair blower is mounted at the side, close to the drying bin, of the interior of the case. A purifying box is fixed to the side, opposite to the hot air blower, of the interior of the case. A hot air pipe is connected between one end of the hot air blower and the bottom of the drying bin. The bottom end of the drying bin is connected with a discharging pipe. According to the crushing device, crushedmaterials can be dried efficiently and evenly, water in the materials is effectively removed, later production and storage of the organic fertilizers are facilitated, meanwhile, recycling of water resources can be achieved, the utilization rate of the water resources is increased, waste of the water resources is avoided, the more energy-saving effect of the crushing device is achieved, in addition, exhaust gas can further be purified, air pollution is prevented, and the more environment-friendly effect of the crushing device is achieved.

The invention relates to an LED tube with an automatic cooling function. The tube comprises a casing and two connecting blocks, the casing is internally provided with a substrate and a plurality of lamp beads, a side, away from the lamp beads, of the substrate is provided with a plurality of cooling assemblies, air intake pipes are disposed below the two ends of the casing, each cooling assembly comprises an opening, a cooling pipe, a heat absorbing block, a pressing ring, a limiting ring and a plurality of springs, each cooling pipe is internally provided with a sealing plate, a sealing blockand a vertical rod, a plurality of through holes are formed in the outer circumferences of the ends, located in the casing, of the cooling pipes, the LED tube with the automatic cooling function absorbs heat through the heat absorbing block and then expands into a support pipe to support the vertical rod, so that the sealing block is separated from a sealing hole, convenience is provided for hotair in the casing to be discharged, external cold air enters the casing, thereby achieving the purpose of cooling, the service life of the LED tube is prolonged, and the practicability of the LED tubeis improved.

The invention discloses a household intelligent shoe cabinet integrating storage and drying. The cabinet comprises a cabinet body and a drying box, and the drying box is connected to one side of the cabinet body; a placement rack is connected to the cabinet body, a row of storage cabinets are connected to the placement rack, the cabinet body is internally partitioned into a plurality of shoe racksby partition plates, and a hot air fan is installed at the bottom in the cabinet body; the drying box is internally partitioned into a drying cavity and a heating cavity, an air outlet end of the hotair fan is communicated with the heating cavity, a heating pipe is installed in the heating cavity, and a microcomputer time control switch installed in the cabinet body is connected with the hot airfan and the heating pipe through wires; a plurality of supporting pipes placed in the drying cavity are communicated with the upper portion of the heating cavity, and drying pipes are communicated with the two sides of each supporting pipe. According to the intelligent shoe cabinet, the heating pipe and the hot air fan can be controlled on time through the microcomputer time control switch, shoeson the drying pipes are dried on time, items can be placed on the placement rack, the storage cabinets can store objects, the shoe cabinet has the intelligently-controlled drying function, and the items are convenient to store and place.

The invention discloses a long chain noncoding RNA marker for auxiliary diagnosis of colorectal cancer (CRC). Long chain noncoding RNA is HOTAIR; auxiliary diagnosis or prediction of patient conditiondevelopment of the CRC can be realized by detecting expression quantity of the long chain noncoding RNA; differentiation, infiltration depth, proliferation and metastasis conditions of the CRC can bepredicted by monitoring expression conditions of p21 and a value of judging prognosis is realized. Expression level of LncRNA HOTAIR gene can be detected by RT-qPCR, real-time quantitative PCR, immunodetection, in-situ hybridization, chip or a high-throughput sequencing platform; meanwhile, the invention also discloses silencing HOTAIR which can obviously inhibit the proliferation, migration andinvasion abilities of CRC cells, reduce the expression of PCNA, Ki67, cyclin E and CDK2 and medicate expression increase of p21. The invention provides a molecular marker for the CRC and provides theoretical basis for mechanism research and clinical individualized therapy of the CRC; a brand-new treatment strategy can be provided for clinically treating the CRC by monitoring the expression of theLncRNA HOTAIR in the CRC.

The invention relates to forming equipment of PLA dual spraying film paper tableware. The forming equipment comprises a rack and a bottom heater arranged at the bottom of the rack. The bottom heater comprises a heating furnace mold. A hot air blowing mold is mounted in the heating furnace mold and is provided with air blowing holes, and the air blowing holes are arranged obliquely. The included angle formed by the center axis of each air blowing hole and the longitudinal straight line is an oblique angle. According to the forming equipment, the hot air blowing mold structure of the bottom hotair heater is changed, the air blowing holes of the hot air blowing mold are arranged obliquely, the oblique angle of each air blowing hole is set to be 30 degrees + / - 2 degrees, meanwhile, the hole diameter of each air blowing hole is set to be 0.8 mm, and therefore the air blowing area of the bottom hot air heater to the cup bottom is changed; and the phenomena of layering, blistering and the like caused by the situation that the bottom hot air heater blows a cup body are avoided, and the quality of the PLA dual spraying film paper tableware is guaranteed.

The invention discloses a processing device for waste residues of biological pharmacy. The processing device comprises a box body. The bottom end of the inner portion of the box body is connected witha drying mesh plate through bolts, wherein the drying mesh plate is horizontally arranged. The inner wall of the bottom of the box body is connected with hot air pipes through bolts, wherein the hotair pipes are distributed at equal intervals. The positions, located below the drying mesh plate, of the tops of the hot air pipes are connected with spray nozzles in a threaded manner, wherein the spray nozzles are distributed at equal intervals. The middles of the inner walls of the two sides of the box body are each connected with chain wheels through rotating shafts and bearings, wherein the chain wheels are distributed at equal intervals. According to the processing device, the waste residues are added in the box body through a feeding pipe, and by conducting suction and smashing at the position of a pipe opening of the feeding pipe through a double-shaft motor, it can be effectively avoided that the feeding pipe is stuck by the waste residues; meanwhile, it is ensured that the wasteresidues are evenly dispersed in the box body, and the processing efficiency of the waste residues is improved; and in the reciprocated movement process of a chain, rake teeth stir and overturn the waste residues on the surface of the drying mesh plate all the time, the waste residues make sufficient contact with hot air, moisture in the waste residues can be rapidly evaporated, and the drying efficiency of the waste residues is improved.

The invention discloses a novel air conditioner outdoor unit heat radiator, which comprises a case, a heat radiation fin and a heat radiation fan, wherein an air inlet hole is formed in one side of the case; an air suction pipe is sleeved and connected in the air inlet hole; an exhaust hole is formed in the other side of the case; an exhaust pipe is sleeved and connected onto the exhaust hole; theheat radiation fin is arranged in the case; the heat radiation fan is arranged between the heat radiation fin and the exhaust hole; a water storage device is arranged on the top of the case; the topof the water storage device is connected with a condensing water pipe; a water cooling pipe is arranged between the heat radiation fin and the air inlet hole; one end of the water cooling pipe is connected with the water storage device. The heat radiation fan rotates; outside cold air flows into the case through the air suction pipe; the cold air brings away heat on the heat radiation fin; the hotair is ejected to the high position at a high speed after being exhausted from the exhaust pipe; the hot air is prevented from being sucked into the heat radiator again; the high air speed of an airconditioning is started; condensing water in the water storage device flows into the water cooling pipe; the water cooling pipe further cools cold air in the case; the cold air subjected to temperature reduction flows through the heat radiation fin; the heat radiation effect is improved.

The invention relates to the technical field of air conditioner equipment, and particularly relates to a kitchen integrated stove air conditioner. The kitchen integrated stove air conditioner comprises a mounting base, a gas stove, a range hood and an air conditioner body, the gas stove is arranged on the mounting base, the range hood is arranged above the mounting base, the air conditioner body comprises an indoor machine and an outdoor machine connected with each other by a refrigerant tube, the outdoor machine is arranged in a cavity structure of the mounting seat, and the indoor machine isdisposed above the range hood; a hot air vent for discharging hot air is formed in the outdoor machine, and the hot air vent is connected to a kitchen flue through a hot air duct; the indoor machineis provided with a drain pipe, and the drain pipe is connected to a kitchen sewer; the range hood includes a second exhaust fan, an oil fume tuyere for discharging oil fume is formed in the second exhaust fan, and the oil fume tuyere is connected to the kitchen flue through an oil fume duct. The oil fume duct and the hot air duct are connected with the kitchen flue to improve the oil fume and hotair discharge, and improve the refrigeration and oil fume discharge capacity of the kitchen air conditioner, high efficiency and energy saving of the air conditioner is achieved, and user comfort is improved.

The invention discloses a drying device for sauce ingredients. The drying device comprises an electric heating drying room and a hot air drying room, wherein the electric heating drying room is fixedly mounted on the top of the hot air drying room; a packing auger conveyor is arranged in the middle of the electric heating drying room; the top end of the rotary shaft of the packing auger conveyor is connected with an electric motor; an electromagnetic heating coil is mounted on the room wall of the periphery of the lower part of the packing auger conveyor; a telescopic rubber tube is arranged below the electromagnetic heating coil; the telescopic rubber tube is used for communicating an electric heating inner cavity of the electric heating drying room with a hot air inner cavity of the hotair drying room; a hot air cylindrical barrel is mounted inside the hot air drying room; the lower side tube wall of the hot air cylindrical barrel is connected with the room wall of the hot air drying room through a spiral spring; and a hot air tube, a hydraulic oil cylinder and an air suction tube are sequentially connected on the upper side tube wall of the hot air cylindrical barrel from leftto right; and the hot air tube is connected with the upper portion of the air suction tube through a hot air device. The drying device has good drying effect.

The invention discloses a centrifugal stone removing grain dryer. The centrifugal stone removing grain dryer comprises a drying tower and stone removing equipment. The lower end of the drying tower isprovided with the stone removing equipment, and the top end of the drying tower is provided with a feed inlet. One side of the drying tower is connected with a hot air duct. The right end of the hotair duct is connected with a hot air blower. A dispersing drying mechanism is arranged in the drying tower. The centrifugal stone removing grain dryer is simple and reasonable in structure and strongin practicability. Materials entering the drying tower can be maximally dispersed through the arrangement of the dispersing drying mechanism, so that defects existing in a prior device are eliminated,and the material drying effect is greatly improved.

The invention discloses an lncRNA composition as well as application in preparing a kit for diagnosing and predicting Her-2 over-expression breast cancer bone metastasis. According to the invention, serum lncRNAXLOC_004122, SUM01P3 and NBAT-1 can be jointly used for diagnosing and predicting the Luminal A-type breast cancer bone metastasis, the serum lncRNAXLOC_004122, Linc00467 and lncRNAAl049452can be jointly used for diagnosing and predicting the Luminal B-type breast cancer bone metastasis, the serum lncRNAAK043773 and EXOC7 can be jointly used for diagnosing and predicting Her-2 over-expression breast cancer bone metastasis, the lncRNA Lnc01089 and HOTAIR can be jointly used for diagnosing and predicting triple-negative breast cancer bone metastasis, the accuracy is high (90 percentor more), the detection cost is low, and the lncRNA composition is non-invasive, convenient and rapid.

The invention discloses a method for identifying human HOTAIR (HOX antisense intergenic RNA) gene polymorphism rs920778 by using MspI. Genome DNA of a sample is extracted; a forward primer and a reverse primer for amplifying a sequence nearby a human HOTAIR gene polymorphism rs920778 site are provided, to-be-detected human genome DNA is used as a template, a PCR (polymerase chain reaction) amplification reaction is performed, and an amplification product is obtained; the amplification product is subjected to enzyme digestion by using a restriction endonuclease, and a corresponding enzyme digestion product is obtained; the enzyme digestion product is subjected to electrophoresis by the aid of 3% agarose gel so as to judge genotypes of HOTAIR gene polymorphism rs920778. According to the established detection method for the HOTAIR rs920778 polymorphism, endonuclease is very cheap, meanwhile, the PCR product is higher in purity, and the enzyme digestion result is easy to distinguish. The detection method is accurate and reliable in result through sequencing validation.

The invention discloses a multifunctional weaving machine. The multifunctional weaving machine comprises a machine body and a dehydration cavity arranged in the machine body and provided with a downward opening, a water collecting cavity with an upward opening is formed in the lower end of the dehydration cavity in a communicating mode, a transition cavity with a forward opening is arranged in theright end of the dehydration cavity, and the right end of the transition cavity is provided with a first drying cavity. The right end of the first drying cavity is provided with a second drying cavity, the top end of the first drying cavity is provided with a hot air cavity, the top end of the second drying cavity is provided with a cold air cavity, the top ends of the cold air cavity and the hotair cavity are provided with a first belt wheel cavity, and the bottom ends of the first drying cavity and the second drying cavity are provided with an air collecting cavity. The rear end of the aircollecting cavity is provided with an air draft cavity with a backward opening, the right end of the machine body is provided with a roller cavity with an upward opening, the rear end of the roller cavity is provided with a second belt wheel cavity, and a third belt wheel cavity is arranged between the second belt wheel cavity and the air draft cavity in a communicating mode.

The invention discloses an lncRNA composition as well as application in preparing a kit for diagnosing and predicting Luminal A-type breast cancer bone metastasis. According to the invention, serum lncRNAXLOC_004122, SUM01P3 and NBAT-1 can be jointly used for diagnosing and predicting the Luminal A-type breast cancer bone metastasis, the serum lncRNAXLOC_004122, Linc00467 and lncRNAAl049452 can bejointly used for diagnosing and predicting the Luminal B-type breast cancer bone metastasis, the serum lncRNAAK043773 and EXOC7 can be jointly used for diagnosing and predicting Her-2 over-expressionbreast cancer bone metastasis, the lncRNA Lnc01089 and HOTAIR can be jointly used for diagnosing and predicting triple-negative breast cancer bone metastasis, the accuracy is high (90 percent or more), the detection cost is low, and the lncRNA composition is non-invasive, convenient and rapid.

The invention discloses a device and method for increasing the hot-pressing speed of a shaving board. According to the method, a hot air treatment device is arranged between a core layer shaving siloand a laying roller before slab laying after completion of sizing of an artificial board, the internal hot air temperature ranges from 60 DEG C to 80 DEG C, and the time spent on passing through a hotair pipeline from top to bottom of shavings is about 3-5 seconds; and after thermal treatment, the temperature of the shavings is increased by 20-30 DEG C on the original basis and reaches 50-70 DEGC. By the adoption of the device and method for increasing the hot-pressing speed of the shaving board, the temperature difference between the slab surface layer and the core layer shavings is reducedremarkably, the fast transmission of the temperature in a slab is achieved, and a resin adhesive is quickly cured, so that the hot-pressing speed of the shaving board is increased, and the moisture content of the savings is controlled within 5-7%; and for the surface layer shavings, no treatment is conducted, and by means of the core layer shaving thermal treatment process, the existing hot-pressing speed of the shaving board is increased greatly and is increased to 10 s / mm from 13 s / mm.

The invention discloses an lncRNA composition and application thereof in preparation of a kit for diagnostic prognostics of Luminal B breast cancer bone metastasis. The invention discovers that serumlncRNAXLOC_004122, SUMO1P3 and NBAT-1 can be combined to be used for diagnostic prognostics of Luminal A breast cancer bone metastasis, lncRNAXLOC_004122, Linc00467 and lncRNAA1049452 can be combinedto be used for diagnostic prognostics of the Luminal B breast cancer bone metastasis, serum lncRNAAK043773 and EXOC7 can be combined to be used for diagnostic prognostics of Her-2 over-expression breast cancer bone metastasis, and lncRNA Lnc01089 and HOTAIR can be combined to be used for diagnostic prognostics of triple negative breast cancer bone metastasis. The lncRNA composition is high in accuracy (90% or higher), low in detection cost, non-invasive, convenient and rapid.

The invention provides an experimental stirrer capable of volatilizing water. A fixing beam is connected with the edge of the barrel mouth of a stirring barrel, the fixing beam is connected with a driving shaft and a motor, the motor is in driving connection with the driving shaft, a stirring cutter is connected with the end, extending into the stirring barrel, of the driving shaft, an exhaust fanis arranged outside the stirring barrel, the exhaust fan is communicated with one end of an air duct, the other end of the air duct is connected with the upper end of the outer side face of the stirring barrel, and thus an air outlet is formed. The inner pipe face of the air duct is attached with a heating wire, when the stirrer works, a user pours a potassium aurous cyanide solution into the stirring barrel, the motor drives the stirring cutter to achieve stirring, the exhaust fan outside the stirring barrel sucks the outside air and exhausts the air out in the air outlet after the air is transmitted through the air duct, the air blows towards the potassium aurous cyanide solution in the stirring barrel, air flowing in the stirring barrel is increased, accordingly the water in the potassium aurous cyanide solution is volatilized, and the effect of volatilizing water is achieved. The heating wire emits heat so that the air flow transmitted through the air duct is heated to form a hotair flow, and thus the effect of volatilizing water is better.

The invention provides a kraft paper gluing machine which sequentially comprises an unwinding mechanism, a front gluing mechanism, a short hot air circulating oven, a rear gluing mechanism, a long hotair circulating oven and a winding mechanism which are arranged on a frame according to a molding sequence. The front gluing mechanism comprises a front gluing roller, a front gluing adjusting rollerand a front gluing groove; and the rear gluing mechanism comprises a rear gluing roller, a rear gluing adjusting roller and a rear gluing groove. The front side and the rear side of kraft paper are glued through the front gluing mechanism and the rear gluing mechanism, meanwhile, the glued sides are heated and subjected to drying molding by using the short hot air circulating oven and the long hot air circulating oven, so that the front side and the rear side of release paper are glued with a water-soluble adhesive, the gluing efficiency and the gluing quality of the release paper are remarkably improved, the waterproof effect and the repeated use of the finished product release paper are effectively ensured, and the paper sources are greatly saved.

The invention discloses a newspaper column capable of effectively reducing fogging of glass, comprising two groups of pillars, an upper cover plate is fixedly installed at the upper end part of the pillar, a cross bar is fixedly installed at the middle part of the pillar, a lithium battery is installed inside the cross bar, the lower support frame is installed at the middle part of the pillar, anda left support frame is arranged on the left side of the top of the lower support frame. The invention relates to a newspaper column which is effective in reducing the fogging condition of glass, hotair is used to remove water mist from the glass, thereby effectively avoiding the occurrence of ash accumulation on the glass window. The invention effectively improves the aesthetics of the glass window, and facilitates the installation and disassembly of the glass window and the maintenance by the mutual cooperation of the lower support frame. Through cooperation of the left support frame, theright support frame, the upper support frame, the fixing bolt, the fixing screw groove, the positioning rod, the positioning groove, the front glass sheet, the rear glass sheet and the rubber connecting groove, a glass window is more convenient to install and disassemble, and the maintenance is more convenient.

The invention finds action of lncRNA-HOTAIR in osteoporosis. The lncRNA-HOTAIR is long-chain non-coding RNA, and the length of the lncRNA-HOTAIR is 2158nt. The long-chain non-coding RNA can be directly used for preparing reagents or medicines for detecting, preventing and / or treating osteoporosis diseases.

The invention particularly relates to a textile silk yarn pre-heating device. The textile silk yarn pre-heating device comprises a drying oven, wherein a feeding opening is formed in the left side ofthe drying oven, a discharging opening is formed in the right side of the drying oven, an air inlet is formed in the bottom of the drying oven, the air inlet of the drying oven is connected with a hotair assembly through an air pipe, and an air outlet is formed in the top of the drying oven. The device can be used for heating textile silk yarns, and meanwhile, the device is simple in structure, convenient to operate and low in cost, and has good practicability.

The invention discloses a wire separating device of a wire drawing machine for a sunshade net. The two-traction wire separating device comprises a traction hot air bellow, a wire separating device body and a shaping and drying device, wherein the wire separating device body is matched with the traction hot air bellow, and the shaping and drying device is matched with the wire separating device body; the traction hot air bellow comprises a box body, a plurality of air blowing ports, an air blower and a solar thermal collector, wherein the box body allows flat filaments to penetrate through thebox body, the inner wall of the box body is provided with the multiple air blowing ports, the air blower is connected to the air blowing ports, and the solar thermal collector is connected to the airblower; and the solar thermal collector is used for heating air to supply hot air to the box body. According to the two-traction wire separating device, by means of the structure, the stretching temperature of the flat filaments is kept, the flat filaments are prevented from being broken, and the quality of the flat filaments is ensured; and the solar thermal collector is adopted to supply the hotair, the heat loss is small, photo-thermal energy is converted into heat energy, so that the wire separating device is more environmentally friendly, and the cost is lowered.

The invention discloses an lncRNA composition as well as application in preparing a kit for diagnosing and predicting Her-2 over-expression breast cancer bone metastasis. According to the invention, serum lncRNAXLOC_004122, SUM01P3 and NBAT-1 can be jointly used for diagnosing and predicting the Luminal A-type breast cancer bone metastasis, the serum lncRNAXLOC_004122, Linc00467 and lncRNAAl049452can be jointly used for diagnosing and predicting the Luminal B-type breast cancer bone metastasis, the serum lncRNAAK043773 and EXOC7 can be jointly used for diagnosing and predicting Her-2 over-expression breast cancer bone metastasis, the lncRNA Lnc01089 and HOTAIR can be jointly used for diagnosing and predicting triple-negative breast cancer bone metastasis, the accuracy is high (90 percentor more), the detection cost is low, and the lncRNA composition is non-invasive, convenient and rapid.

The invention discloses a non-contact method for stripping an optical fiber coating layer. The non-contact method for stripping the optical fiber coating layer comprises the following steps: placing an optical fiber to be processed on a base, and fixing the optical fiber to be processed through an optical fiber clip; controlling the heating and air outflow of a heat generating device, and the hotair blown by the heat generating device is maintained between 400 degrees Celsius and 600 degrees Celsius; controlling the base to move to the lower side of the heat generating device from an initialposition, so that the hot air is blown vertically to the optical fiber to be processed; adaptively moving the base combining the length range to be stripped of the optical fiber to be processed untilthe stripping of the optical fiber coating layer of the optical fiber to be processed is completed; and controlling the base to move back to the initial position, and taking the bare optical fiber that the stripping of the optical fiber coating layer is completed. The non-contact method for stripping the optical fiber coating layer utilizes different ignition points of the optical fiber coating layer and the cladding layer to rapidly burn and decompose the optical fiber coating layer into carbon dioxide and water vapor, so as to complete the stripping and cleaning of the optical fiber coatinglayer in one time; and the non-contact method for stripping the optical fiber coating layer has the advantages of short time-consuming, high efficiency, no physical damage, convenient and quick.

The invention discloses a multifunctional self-cooling antitheft sun protection device for an automobile tire. The device is in an L shape, a sun shield plate of a vertical part is a square interlayertabular body which is slight larger than the tire in size, and the square interlayer tabular body is provided with a tire hook and a hook lock; a press plate of a horizontal part is an interlayer slab with the ventilating middle. During use, an automobile is driven onto the press plate, cold air below the automobile can enter the sun shield plate through a ventilation port in the press plate, hotair of the sun shield plate is discharged out from the top, and the effects of sun protection, hot prevention and tire protection are achieved; the device can be turned into a T-shaped bridge plate,and thus the devices can cross ditches and small ridges and is used as a difficulty overcoming tool when the automobile is stuck in sandpits and mud.

The invention discloses an lncRNA composition and application thereof in preparation of a kit for diagnostic prognostics of Luminal B breast cancer bone metastasis. The invention discovers that serumlncRNAXLOC_004122, SUMO1P3 and NBAT-1 can be combined to be used for diagnostic prognostics of Luminal A breast cancer bone metastasis, lncRNAXLOC_004122, Linc00467 and lncRNAA1049452 can be combinedto be used for diagnostic prognostics of the Luminal B breast cancer bone metastasis, serum lncRNAAK043773 and EXOC7 can be combined to be used for diagnostic prognostics of Her-2 over-expression breast cancer bone metastasis, and lncRNA Lnc01089 and HOTAIR can be combined to be used for diagnostic prognostics of triple negative breast cancer bone metastasis. The lncRNA composition is high in accuracy (90% or higher), low in detection cost, non-invasive, convenient and rapid.

The invention discloses a radionuclide < 99m > Tc labeled LncRNAHOTAIR targeting probe, a preparation method and a developer, and belongs to the technical field of nuclide labeling and molecular imaging. An antisense oligonucleotide sequence of the targeting probe is a sequence 1, and a synthetic structure of the targeting probe is 5 '-ASON-(CH2)6-NH2-3'; wherein two ends of the sequence 1 are respectively modified by 2'methylation, and two ends of sequence 2 are respectively modified by two basic group sulfo groups; a primary amine structure is connected to 3'end of the sequence 1, and (CH2)6 is used as a linker between NH2 in the primary amine structure and a skeleton of the sequence 1. As ASON can be efficiently, specifically and irreversibly complementarily combined with a target, the LncRNAHOTAIR targeting probe can promptly and accurately reflect cancer detection results.