The invention relates to the technical field of biomedicine, in particular to a MHS cell-derived exosome-loaded forsythin drug delivery system and its application. The drug delivery system is prepared by mixing MHS cell-derived exosomes with forsythin solution, incubation, ice bath ultrasound, constant temperature culture recovery, centrifugation, washing and resuspension, centrifugation, and resuspension; The concentration of cystin was 400-410 μg / mL; in terms of protein amount, the concentration of MHS cell-derived exosomes was 400-410 μg / mL. The Phil-Exos prepared by the invention is well taken up by A549 cells, has a high inhibitory effect on the migration of A549 cells, and significantly improves the anti-tumor cell migration ability of Phil.