The invention discloses an antifoaming agent composition for papermaking and a preparation method thereof. The antifoaming agent composition comprises, by weight part, a first component and a second component. The first component comprises, by weight part, fatty acid metal soup, fatty acid amide, higher aliphatic acid-terminated polyether ester, higher aliphatic acid ester, ethyl vinyl ether, sodium dodecyl sulfate, hydrophobic white carbon black, an emulsifier and a dispersant. The second component comprises, by weight part, organic silicone resin, dimethicone, lysine, fatty acid polyglycol ester, silica, sodium carbonate and calcium chloride. The preparation has simple processes and realizes a low cost. The antifoaming agent composition has small viscosity and can be easily emulsified and dispersed. Calcium chloride inorganic nanoparticles can inhibit inorganic component bubble generation in a system so that foam in an inorganic substance-organic substance mixed system is fast eliminated, a dehydration process is accelerated, paper pulp washing effects are improved, a water use amount is reduced, later pollution is avoided and paper pulp quality is improved.