Drugs used to reduce the physical damage caused by chronic alcoholism

An alcoholic, chronic technique applied in the field of biomedicine to address neuronal dysfunction, structural changes in synapses, collapse, etc.

Active Publication Date: 2020-06-23
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant studies have proved that ethanol, the main component of alcohol, and its metabolites acetaldehyde, oxygen free radicals and high concentrations of H 2 The toxic effect of S can make the assembly energy deficiency and decomposition of F-actin intensified, resulting in the decrease of F-actin content in the cell and the dissolution, remodeling and collapse of the cytoskeleton, resulting in the change of synaptic structure and the blockage of synaptic transmission. Causes neuronal dysfunction and reduces their intelligence level

Method used

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  • Drugs used to reduce the physical damage caused by chronic alcoholism
  • Drugs used to reduce the physical damage caused by chronic alcoholism
  • Drugs used to reduce the physical damage caused by chronic alcoholism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Effects of aminoglycolic acid on hippocampal mitochondria and fibrous actin in rats with chronic alcoholism

[0020] 1. Materials

[0021] 1. Experimental animals

[0022] 60 clean-grade healthy male SD rats, weighing 120-160 g, were provided by the Animal Management Center of Xinxiang Medical College. Before the experiment, they were raised in the laboratory at 22-25°C for 5-7 days to adapt to the laboratory environment. They were randomly divided into normal control group (Normal control group, NC group), AOAA treatment group (AOAA remedy group, AR group), chronic alcoholism model group (Model group, M group), 20 in each group.

[0023] 2. Instruments and reagents

[0024] The high-speed refrigerated centrifuge was produced by Heraeus Company of Germany; the Eclipse E200 microscope was provided by Nikon Company of Japan; NaHS was provided by ACROS Company of the United States; the ultra-micro total ATPase assay kit, total protein assay kit, and mitochondri...

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Abstract

The invention provides a drug for relieving body injury caused by chronic alcoholic poisoning. The drug comprises an effective ingredient of AOAA (aminooxyacetic acid). Learning and memory ability evaluation is performed on chronic alcoholic poisoned rats and normal rats by use of a Y-type electric maze by establishing a rate chronic alcoholic poisoning model. Experimental results prove that compared with normal control groups, the chronic alcoholic poisoning model group of rats has remarkably reduced learning and memory ability. After AOAA intervention is given, the training times required for rats of a remedy group to learn spatial discrimination are reduced, and difference has statistical significance. Accordingly, AOAA can relieve memory deterioration caused by the chronic alcoholic poisoned rats, improves the learning memory ability and provides a scientific basis for research of chronic alcoholic poisoning injury mechanism and treatment by AOAA.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a medicine for alleviating body damage caused by chronic alcoholism. Background technique [0002] Chronic alcoholism is a potentially fatal disease. Excessive drinking has a certain impact on brain tissue, which can lead to the decline of brain learning, memory, cognitive judgment and other problems, such as neurobehavioral abnormalities, which not only seriously damages the health of patients, but also may cause a series of social security problems. Studies have shown that drinking alcohol can cause learning, memory decline, and mental and behavioral functional deficits. The prevalence of chronic alcoholism in my country has been increasing year by year in recent years, and it has become one of the social public health problems worthy of attention. There is an urgent need to develop drugs with the function of sobering up. Aminooxyacetic acid (AOAA) is an inhibitor of CBS activity, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61P39/02A23L33/175
CPCA23L33/175A23V2200/00A61K31/198A23V2200/334A23V2250/06
Inventor 杜爱林代玄张艳罗晓秋李成长付鹏艳张越秦浩志董家行朱甲婧姚良雪秦玉飞陈桂芳尹诗祎孙嘉翊王婷李徽张瑞岭姜洪波
Owner XINXIANG MEDICAL UNIV
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