Application of total triterpenoids of Pteridocarpus in protecting chronic alcoholic liver injury

A technology for alcohol liver damage and total triterpenes, applied in the field of biomedicine, can solve the problems of less research on the chemical components of Viburnum fern and its pharmacology and mechanism, achieve considerable development and application value, and have no toxic and side effects

Active Publication Date: 2017-06-27
SHAANXI NORMAL UNIV
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Problems solved by technology

Up to now, there are few studies on the chemical constituents of Viburnum viburnum and their pharmacology and mechanism

Method used

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  • Application of total triterpenoids of Pteridocarpus in protecting chronic alcoholic liver injury
  • Application of total triterpenoids of Pteridocarpus in protecting chronic alcoholic liver injury
  • Application of total triterpenoids of Pteridocarpus in protecting chronic alcoholic liver injury

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Embodiment Construction

[0023] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0024] 1. Experimental materials

[0025] The pod fern was collected from Xunyangba Town, Ningshan County, Shaanxi Province, and was identified as Matteucciastruthiopteris of the Onocleaceae (Onocleaceae) genus Matteuccia Todaro by Associate Professor Ma Ji, School of Life Sciences, Shaanxi Normal University; the male Kunming species is small 70 mice (body weight 18±2g) were provided by Animal Experiment Center of Fourth Military Medical University.

[0026] Experimental reagents: absolute ethanol, xylene, sodium chloride, and hydrochloric acid were purchased from Tianjin Tianli Chemical Reagent Co., Ltd.; paraformaldehyde, hematoxylin, sectioned paraffin, bifendate, neutral gum, and eosin were purchased from Beijing Chemical Reagent Company; medical alanine aminotransferase (GPT), aspartate...

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Abstract

The invention discloses the application of total triterpenoids of Pteridocarpus to protect chronic alcoholic liver injury, and belongs to the technical field of biomedicine. A dose-escalating drinking method was used to simulate the process of chronic alcohol-induced liver injury in humans. The total triterpenoids of Pteridocarpus can inhibit GOT and GPT to a certain extent, and the inhibitory effect is positively correlated with the dose. The purified total triterpenoids of Viburnum fern have strong antioxidant capacity in vivo, and its hepatoprotective mechanism may be to effectively alleviate the damage caused by alcohol to the liver by enhancing the body's antioxidant capacity and effectively removing unfavorable free radicals. Medium and high doses of purified total triterpenoids of Viburnum fern can effectively alleviate the oxidative damage caused by lipid peroxidation and free radical attack in the liver, reduce the degree of hepatocyte enlargement, necrosis and fatty degeneration, and regulate cells to restore normal metabolism and Physiological function, its effect is better than that of the positive control drug bifendate within a certain concentration range, indicating that the total triterpenoids of Pteridocarpus have a certain protective effect on chronic alcoholic liver injury.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of total triterpenoids of Pteridocarpus to protect chronic alcoholic liver injury. Background technique [0002] At present, liver disease has become one of the diseases that generally plague human health all over the world. Liver injury refers to the invasion of the liver by external factors, resulting in damage to its structure and function. According to the different causes of liver damage, it can be roughly divided into three types: drug-induced hepatitis, alcoholic hepatitis and viral hepatitis. [0003] Alcoholic Liver Disease (ALD) refers to a series of diseases such as liver damage caused by excessive intake of alcohol. The Liver Branch of the Chinese Medical Association has established pathological diagnostic criteria for ALD based on the degree of lesions, and is generally divided into five types according to histology: mild alcoholic l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/11A61P1/16A61P37/00A61P39/06A23L33/00
Inventor 马骥杨晓艳张贵凤
Owner SHAANXI NORMAL UNIV
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