85results about How to "Multi-target" patented technology

The invention provides a metformin hydrochloride / voglibose sugar-lowering oral preparation composition and a preparation method thereof. The weight ratio of two main medicines is 8000:1-375:1, preferably 2500:1-625:1. Except for the main medicines, the composition also can further contain commonly used medicine accessories, such as a binder, a filling agent, a disintegrating agent, a lubricant, a flavoring agent, a wetting agent and a flow agent, and the obtained composition can be prepared into tablets, granules, soft and hard capsules, sustained and controlled release preparations, optimum enteric-coated tablets, enteric-coated granules and enteric-coated soft and hard capsules by conventional methods. The composition provided by the invention has action mechanism complementation of the main medicines, multiple target points, good compliance of patients, and the like. The sugar-lowering oral preparation composition can be used for the first-line therapy of type 2 diabetes, or can be used for second-line therapy under the condition that the metformin hydrochloride or sulfonylurea medicines fail to singly and effectively control blood sugar; and the sugar-lowering oral preparation composition is especially suitable for the therapy of diabetic patients suffering from latent autoimmune diabetes in adults (LADA) and hyperinsulinemia.

The invention provides a traditional Chinese medicine pharmacokinetics-pharmacodynamics combined analysis method, which determines various endogenous metabolites in blood samples of a blank control group, a model group and a model treatment group by a GC-MS method, uses an abnormally-changed metabolite group of the model group as a biomarker group, uses an effect index with obvious callback of the abnormally-changed metabolite group after traditional Chinese medicine intervention as an efficacy marker group, determines the contents of various drugs in the blood samples of a model animal after single dose by a LC-MS method, draws a plasma concentration-time curve, calculates the pharmacokinetic parameters of each component; determines the amount of the endogenous efficacy marker group in the blood samples of the model animal single dose group by a GC-MS method, draws a time-effect curve, performs PK-PD combined analysis by combining with the plasma concentration-time curve and parameters. The invention reveals the efficacy substance base of traditional Chinese medicine in the treatment of cardiovascular diseases, and provides an effective method for traditional Chinese medicine pharmacokinetics-pharmacodynamics combined analysis.

The invention discloses a total alkaloid extract and making method of eye drip, which comprises the following parts: opium alkaline, tetrahydropalmatine, cumic acid, alcaine palmatine, corydaline, summer alkaline and other biological alkalines. The preparing method comprises the following steps: adopting summer non as raw material; optimizing hypercritical CO2 flow to extract; collecting extract; drying; obtaining the total alkalilne extract; fitting for tablet, pill, suppository, percutaneous absorption agent, oral rapid-breaking agent, release-control agent and freeze dried.

The invention relates to a shooting target, in particular to the shooting target which is high in precision and is provided with polygonal-star-shaped target paper, multiple target points, and a shooting inducing light spot in the center of a target plate. The shooting target comprises the target plate, the target paper, a support and a laser designator. The shooting target is characterized in that a hole is formed in the center of the target plate, the star-shaped target paper is arranged on the front face of the target plate, the center of the target paper is overlapped with the center of the hole, target rings are arranged on the upper face of the target paper, the support comprises a stand bar below the target plate, an inclined supporting bar extending backwards is arranged on the lower portion of the target plate, the laser designator is arranged on the inclined supporting bar, and laser light emitted by the laser designator irradiates the center of the hole. When the shooting target is used, the laser light penetrates through the hole and irradiates on the bake face of the target paper, and when firearms are adjusted, deviation angles of sighting devices are directly and accurately corrected according to bullet touching points of the star-shaped target and positions out of the target center. A trainee carries out collimation on the bright point of the target center through a collimation mechanism of a firearm, and shoot can be simply fired. The trainee shoots the target center or any position of the triangular target points according to the requirements of a coach, and the purpose of multiple-position training on one piece of target paper is achieved.

Provided are heterocyclic compounds represented by formula (I), stereoisomers or pharmaceutically acceptable salts of said compounds, a pharmaceutical composition of said compounds, and an application of said compounds in the preparation of a drug for the prevention and / or treatment of a central nervous system disease.

The invention relates to a novel health care product with effects of reducing weight, lowering blood fat, expelling toxin and beautifying. The novel health care product is prepared from the following components in percentage by weight: 10 to 70 percent of natto, 1.5 to 20 percent of tea polyphenol, 10 to 80 percent of L-carnitine, 10 to 70 percent of seabuckthorn seed oil and 0.1 to 5 percent of vitamin E. The novel health care product is mainly used for reducing the weight, lowering the blood fat, expelling the toxin from human bodies, whitening and repairing skin, eliminating freckles, beautifying, resisting oxidation, improving female climacteric syndrome and the like. The product has the characteristics of novel raw materials, clear pharmacological action, quick effects of weight reduction and beautifying, no relapse after weight reduction, safe use, wide adaptable range for people, easy industrial popularization, positive social and economic benefits and the like.

The invention discloses an active site composition of isatis roots, as well as a preparation method and the application thereof. The active site composition of isatis roots is prepared from a general phenylpropanoid part of isatis roots, a total alkaloid part, a total organic acid part and a total polysaccharide part. The active site composition obtained by the invention has high effective component contents and accurate active components. Proved by experimental results, the active site composition of isatis roots has obvious antiviral activity and favorable antibacterial and antipyretic activities. After being combined, the effective components reach favorable synergy, exert the antiviral, antibacterial and antipyretic activities at a plurality of targets spots through multiple paths, can be used for treating a viral disease with the bacterial inflammation of a febrile disease and have a wider clinical application range. Moreover, the invention optimizes and designs the extracting and refining process according to the physicochemical properties of the effective components, the active parts obtained through preparation has high effective component contents, and the preparation method has strong maneuverability and can realize industrialized mass production.

The invention discloses the use of cactus pear fruit polysaccharides extracted from cactus pear fruit in the preparation of medicaments or health-care products for reducing blood pressure, blood fat, blood sugar and resisting tumors. The cactus pear fruit polysaccharides can control the occurrence and development of hypertension, have an active significance for preventing the occurrence and development of hyperlipidemia and fatty degeneration of liver, have potential applications in the prevention and treatment of diabetes and complications and have certain antitumor effect. Therefore, the invention lays a foundation for the development of medicaments or health-care products for preventing and treating hypertension, hyperlipaemia and diabetes and resisting tumors, and promotes the full use of the cactus pear fruit polysaccharides effectively. The cactus pear fruit is a natural plant resource with remarkable medicinal and health-care effects as well as regulation and protection effects on human organs and systems. The price of the cactus pear fruit is relatively low, and the side effects of the cactus pear fruit are relatively fewer. Thus, the cactus pear fruit polysaccharides have good application prospect in the preparation of the medicaments or health-care products for reducing blood pressure, blood fat, blood sugar and resisting tumors.

The invention discloses granules for strengthening the spleen, dissolving turbidity and regulating fat. The granules are prepared from the following components in parts by mass: 15-22.5 parts of codonopsis pilosula, 10-15 parts of lotus leaf, 15-22.5 parts of poria cocos, 10-15 parts of rhizoma atractylodis macrocephalae, 10-15 parts of pericarpium citri reticulatae, 20-30 parts of coix seed, 10-15 parts of rhizoma alismatis and 10-15 parts of loofah. The method for preparing the granules comprises the following steps: weighing and decocting the traditional Chinese medicinal materials; filtering, concentrating, precipitating with ethanol, and reclaiming ethanol to obtain extract; mixing the extract with dextrin, adding ethanol to dry, and adding water to prepare the granules which are the finished products of the granules for strengthening the spleen, dissolving turbidity and regulating fat. The granules for strengthening the spleen, dissolving turbidity and regulating fat have remarkable effects on treating formation of lipid turbidity, obesity, hyperlipemia, atherosclerosis and atherosclerotic plaque caused by impaired transportation due to spleen deficiency, congestion due to phlegm turbidity and stagnation of qi and blood stasis.

The invention discloses a traditional Chinese medicine composition for preventing and treating swine enzootic pneumonia. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6 parts of radix ophiopogonis, 6 parts of thunberg fritillary bulb, 6 parts of astragalus membranaceus, 6 parts of aristolochia debilis, 4 parts of scutellaria, 4 parts of cortex mori radicis, 4 parts of schisandra chinensis, 3 parts of honeysuckle, 3 parts of rhizoma anemarrhenae, 3 parts of bighead atractylodes rhizome, 3 parts of semen lepidii and 2 parts of radix glycyrrhizae. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition for preventing and treating swine enzootic pneumonia has the benefits and advantages that the swine enzootic pneumonia can be effectively prevented and treated, and the preventing and treating effects are good; (2) the medicine can be fed by adopting water drinking or feed mixing, the operation is simple and the cost is low; (3) as the traditional Chinese medicine composition is Chinese herbal medicine preparation, the problems of drug tolerance and the like are avoided, and the probability of preventing and treating failure is greatly reduced; (4) the traditional Chinese medicine composition is pure traditional Chinese medicine compound, and has the advantages of multiple target, low residue in swine and good biosecurity when being acted on mycoplasma.

The invention discloses new use of a globe artichoke stem-leaf extract. The globe artichoke stem-leaf extract has the efficacies of resisting inflammation and preventing and treating chronic alcoholic liver injury and non-alcoholic fatty liver disease by decreasing the expression quantity of TLR4, NF-kappaB, IL-1beta, IL-6 and IL-8. The globe artichoke stem-leaf extract disclosed by the invention can play roles of multiple effects, multiple target points and multiple functions. Compared with existing oral alcohol-dispelling liver-protecting drugs, the globe artichoke stem-leaf extract has the advantages that the safety is relatively high; the globe artichoke stem-leaf extract is convenient to prepare and wide in market application prospects, can be applied to the preparation of medicines, health foods, food additives, feed additives, antioxidants and the like and has wide application prospects and huge economic benefits in the fields of processing and application.

The invention discloses a sweet dew brick tea composition and a preparing method and application thereof. The composition is prepared from 82-99 parts of black tea, 0.23-3.99 parts of cape jasmine, 0.23-3.99 parts of the fruit of Chinese wolfberry, 0.13-3.0 parts of chrysanthemum, 0.13-3.0 parts of hawthorn, 0.13-3.0 parts of schisandra chinensis, 0.13-3.0 parts of dogwood, 0.13-3.0 parts of yam, 0.13-3.0 parts f lotus leaf, 0.06-1.5 parts of dendrobe and 0.05-0.6 part of liquorice. The composition has an obvious liver protecting effect and is a healthy black tea deep processing product capable of being drunk by sub-health and liver-damage people for a long time.

The invention discloses a multi-target-point anti-tumor polypeptide medicine conjugate and a preparation method and application thereof. The method comprises the following steps of: with a micromolecule polypeptide which can target a plurality of tyrosinase receptor family members including FGFR2 and Her2, as a target head, selecting effector molecules and connector molecules, which are frequentlyused in current ADC medicine research and development, and performing combination and coupling, so as to form a novel polypeptide medicine conjugate, wherein the amino acid sequence of the micromolecule polypeptide is (Hyp)-(D-Asn)-(D-Leu)-(D-Lys)-(Cit)-(Acpc)-(D-Asp)-(Aad)-(Nva). The prepared polypeptide medicine conjugate disclosed by the invention is relatively small in molecular weight and good in penetrability, has multiple targeting properties, can exert effects on tumors high in expression of a plurality of tyrosine kinase receptors including Her2 and FGFR2, and is relatively stable inactivity, so that the polypeptide medicine conjugate can be used for the field of tumor treatment.

The invention discloses an external medicine for treating hyperplasia of mammary glands and a preparation method thereof, belongs to the technical field of medicines, relates to a medicine for treating hyperplasia of mammary glands, and is used for solving the problem that oral hormone medicines are large in toxic and side effects and damage the liver and kidney after long-term use, and operative treatment is great in pain and easy to relapse. The external medicine for treating hyperplasia of mammary glands comprises the components in parts by weight as follows: 2.38-34.09 parts of ternate buttercup root, 1.79-34.09 parts of rhizoma corydalis, 5.35-45.46 parts of muskroot-like semiaquilegia root, 1.79-40.91 parts of edible tulip, 3.57-34.09 parts of edible tulip, 11.36-40.91 parts of saponins, 2.38-34.09 parts of semen momordicae, 2.38-45.46 parts of rhizoma sparganii, 1.79-40.91 parts of tangerine seed and 1.79-38.82 parts of garden balsam herb seed. The medicine disclosed by the invention is long in action time, convenient to use and safe and non-toxic, and has exact curative effect to hyperplasia of mammary glands and can prevent the mammary glands from canceration.

The invention discloses a sanicula lamelligera hance sesquiterpene extract, which is characterized in that: the total sesquiterpene content of the extract is over 30 percent. The sanicula lamelligera hance sesquiterpene extract is prepared by extracting and refining traditional Chinese medicine sanicula lamelligera hance. Pharmacodynamic and toxicologic experiments prove that the sanicula lamelligera hance sesquiterpene extract has the effects of obviously inhibiting the proliferation of influenza virus and resisting mouse influenza viral pneumonia, and has small toxic and side effects. The invention also discloses medicinal application of the sanicula lamelligera hance sesquiterpene extract.

The invention discloses an application of opuntia ficus-indica polysaccharide extracted from opuntia ficus-indica in the preparation of medicines or health products with hypolipidemic effects. Opuntia ficus-indica polysaccharide can be used for inhibiting the occurrence and development of hypertension. Opuntia ficus-indica polysaccharide has a positive significance in the controlling of the occurrences and developments of hyperlipidemia and hepatic steatosis, has a good potential application value in the controlling of diabetes mellitus and complications thereof, and has certain anti-tumor effects. Therefore, the application provided by the invention assists in establishing a basis for the development of medicines or health products used for controlling hyperlipemia. With the application,the opuntia ficus-indica resource can be fully utilized. Opuntia ficus-indica is a natural plant resource with good medical and healthcare effects. Opuntia ficus-indica provides regulation and protection effects on various human organs and systems. The price of opuntia ficus-indica is relatively low, and opuntia ficus-indica causes relatively less side-effects. Therefore, opuntia ficus-indica polysaccharide has a good application prospect in the preparation of medicines or health products with hypolipidemic effects.

The invention relates to the technical field of medicines and particularly discloses application of ilexgenin A in preparation of anti-atherosclerosis drugs. The research finds that ilexgenin A has a good effect on resisting atherosclerosis, and can obviously inhibit the formation of foamed cells in a certain concentration range. The whole experiment shows that ilexgenin A has an improvement effect on Apo E<- / -> mice atherosclerosis. Compared with the existing anti-atherosclerosis drugs, the drug prepared from ilexgenin A has the advantages of high efficiency, multiple targets and low toxic and side effects.

The invention relates to a compound health care product prepared by xanthophyll, phosphatidylserine and multi-vitamin nutrient replenisher, which is a nutritious food prepared by the xanthophyll, the phosphatidylserine, calcium, zinc, ferrum, selenium, vitamin A and vitamin C according to a certain proportion. The compound health care product comprises the raw materials with the proportion (according to the weight percent of daily dose): 3-40mg of xanthophyll (based on C40H56O2), 50-800mg of phosphatidylserine (based on C38H74NO10P), 100-1200mg of calcium (based on Ca), 2-30mg of zinc (based on Zn), 2-30mg of ferrum (based on Fe), 5-400mu g of selenium (based on Se), 100-1500mu g of vitamin A based on retinol equivalent weight, and 10-1000mg of vitamin C (Vit C). The compound health care product comprises oral formulations such as tablets, capsules, granules, oral liquid, pills and the like. The compound health care product is mainly used for vision health care, brain health care and the organism of people needing nutrients such as the calcium, the zinc, the ferrum, the selenium, the vitamin A and the vitamin C. The product has wide usage and remarkable effect, is easy for industrialized production, and has positive social benefit and economic benefit.

The invention provides a pulse-invigorating capsule for treating carotid artery atherosclerosis as well as preventing and treating ischemic cerebral apoplexy, which is composed of red sage root, coptis, root of kudzu vine and pseudo-ginseng with weight percentage of 50-55%: 15-20%: 15-20%: 5-10%. The pulse-invigorating capsule for treating carotid artery atherosclerosis as well as preventing and treating ischemic cerebral apoplexy has the characteristics of multiple targets and multiple approaches, and has integration and regulation effects with multiple targets on atherosclerotic plaque. The pulse-invigorating capsule can inhibit the formation of neointima through antithrombosis, anti inflammatory, endothelial cells injury restoration, lipid lowering, microcirculation improvement, blood vessel smooth muscle cell propagation inhibition and the like, the antiatherosclerosis effect can be performed, and the pulse-invigorating capsule can promote the restoration of tissue of the operation blood vessel wound, can prevent several phases of a restenosis process at an early stage after a CEA operation, and the several phases comprise a thrombus formation phase, an inflammation reaction phase, an endothelial restoration phase, a blood vessel smooth muscle propagation phase, a matrix formation phase and the like.

The invention discloses application of prickly pear in preparation of medicaments or health-care products for reducing blood pressure, blood fat and blood sugar. Because prickly pear polysaccharides contained in the prickly pear can control the happening and development of high blood pressure, have positive significance for controlling the happening and development of hyperlipemia and fatty degeneration of liver, have good potential application value in preventing and treating diabetes and complications thereof and have a certain anti-tumor effect, so that the application of the prickly pear lays a foundation for developing the medicaments or health-care products for preventing and treating high blood pressure, hyperlipemia and diabetes and effectively promotes full use of prickly pear resources. In addition, because the prickly pear belongs to natural plant resources, has good medicinal effect and heath-care effect, has the effect of regulating and protecting a plurality of organs and systems of human bodies, has relatively low cost and side effect, and treatment based on syndrome differentiation, is flexibly increased and reduced in dosage, and is very suitable for treatment of chronic diseases, the prickly pear has good application prospect in preparation of the medicaments or health-care products for reducing blood pressure, blood fat and blood sugar.

The invention relates to a shooting target, in particular to the shooting target which is high in precision and is provided with polygonal-star-shaped target paper, multiple target points, and a shooting inducing light spot in the center of a target plate. The shooting target comprises the target plate, the target paper, a support and a laser designator. The shooting target is characterized in that a hole is formed in the center of the target plate, the star-shaped target paper is arranged on the front face of the target plate, the center of the target paper is overlapped with the center of the hole, target rings are arranged on the upper face of the target paper, the support comprises a stand bar below the target plate, an inclined supporting bar extending backwards is arranged on the lower portion of the target plate, the laser designator is arranged on the inclined supporting bar, and laser light emitted by the laser designator irradiates the center of the hole. When the shooting target is used, the laser light penetrates through the hole and irradiates on the bake face of the target paper, and when firearms are adjusted, deviation angles of sighting devices are directly and accurately corrected according to bullet touching points of the star-shaped target and positions out of the target center. A trainee carries out collimation on the bright point of the target center through a collimation mechanism of a firearm, and shoot can be simply fired. The trainee shoots the target center or any position of the triangular target points according to the requirements of a coach, and the purpose of multiple-position training on one piece of target paper is achieved.

The present invention discloses a glipizide / acarbose hypoglycemic oral preparation composition and a preparation method thereof, and the glipizide / acarbose hypoglycemic oral preparation composition comprises the following raw materials: glipizide, acarbose, a filler, a disintegrant, a binder and a lubricant, the glipizide and the acarbose are main components, and the filler, the disintegrant, the binder and the lubricant are auxiliary materials. The glipizide / acarbose hypoglycemic oral preparation composition is prepared by sorting, mixing granulation, drying and finished product packaging. The glipizide / acarbose hypoglycemic oral preparation composition has the advantages of complementary main medicine action mechanism, multi targets, good patient compliance, and the like, and is more applicable to type 2 diabetes patients of which blood-glucose rises after meals and fasting blood-glucose rises insignificantly.

The invention provides a Zhuang medicine composition with a treatment effect on acute gouty arthritis, Zhuang medicine particles and a preparation method of the Zhuang medicine composition and the Zhuang medicine particles, and relates to the technical field of ethnic medicines. The Zhuang medicine composition is composed of glabrous sarcandra herb, rhizoma dioscoreae hypoglaucae, plantain herb, polygonum cuspidatum, cynanchum paniculatum, garden balsam stem, honeysuckle stem and liquorice, and clinical application results prove that the Zhuang medicine composition has the effects of clearing heat toxin, removing dampness toxin, dispelling wind toxin, relieving swelling pain, adjusting water channels, dredging long channels and fire channels, and has a remarkable curative effect on gout (gout) caused by wind-damp heat toxin. The Zhuang medicine composition and the Zhuang medicine granules based on the Zhuang medicine composition have very good curative effects on arthralgia, redness and swelling, scorching heat, unfavorable flexion and extension, blood uric acid increase, tophus and the like, and particularly, the Zhuang medicine composition and the Zhuang medicine granules based on the Zhuang medicine composition can be used for treating gouty arthritis induced by MSU crystals, and have the characteristics of multiple targets and low toxicity.

The invention discloses a compound healthcare product, which is prepared from xanthophyll, phosphatidylserine, and multiple nutrients such as calcium, zinc, iron, selenium, vitamin A, vitamin C, and the like according to a certain ratio. More specifically, the daily dosage of the healthcare product is composed of 3 to 40 mg of xanthophyll calculated in the form of C40H56O2, 50 to 800 mg of phosphatidylserine (C38H74NO10P), 100 to 1200 mg of calcium calculate by Ca, 2 to 30 mg of zinc calculated by Zn, 2 to 30 mg of iron calculated by Fe, 5 to 400 [mu]g of selenium calculated by Se, vitamin A with a retinol equivalent of 100 to 1500 [mu]g, and 10 to 1000 mg of vitamin C (VitC). The compound healthcare product can be made into different oral dosage forms such as tablets, capsules, granules, oral liquid, dripping pills, and the like. The compound healthcare product can be used to nourish eyes and brains, and supply calcium, zinc, iron, selenium, vitamin A, and vitamin C to those people who are lack of the elements. The healthcare product has a wide application range and prominent effect, can be applied to industrial production, and generates a big social benefit and economic benefit.

The invention discloses the application of prickly pear and prickly pear polysaccharide extracted from prickly pear in the preparation of the medicines and health care products that have the functions of lowering blood pressure, blood fat and blood sugar and resisting tumor. The prickly pear polysaccharide contained in prickly pear can control the occurrence and development of high blood pressure, has positive significance for preventing the occurrence and development of hyperlipoidemia and fatty degeneration of the liver, has high potential application value for preventing and treating diabetes mellitus and complicating diseases thereof as well as certain anti-tumor function, therefore, the invention lays a foundation for developing the medicines and health care products for preventing and treating hypertension, hyperlipoidemia and diabetes mellitus and for resisting tumor, and effectively promote the full use of prickly pear resources. Belonging to natural plant resources, prickly pear has good medical and health care effect, relatively low price and relatively few side effects, can regulate and protect a plurality of organs and systems in the human body, and is extremely suitable for the treatment of chronic diseases by performing treatment according to syndrome diagnosis and flexibly adding and reducing medicines; therefore, prickly pear and prickly pear polysaccharide have promising application prospect for preparing the medicines and health care products that have the functions of lowering blood pressure, blood fat and blood sugar and resisting tumor.

The invention belongs to the medicinal field and particularly relates to a pharmaceutical composition for treating myocardial ischemia, in particular to the pharmaceutical composition for treating myocardial ischemia and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese medicine materials in parts by weight: 20-40 parts of pseudo-ginseng, 10-30 parts of radix clematidis, 10-30 parts of long peppers, 20-40 parts of peach kernels, 20-40 parts of cassia twigs, 10-30 parts of dried tangerine or orange peel, 10-30 parts of paris polyphylla, 15-35 parts of elderberry, 20-40 parts of astragalus, 5-15 parts of myrrh, 15-35 parts of herba epimedii and 15-35 parts of prepared rehmannia roots. The pharmaceutical composition disclosed by the invention is safe and effective, simple in preparation process, free of toxic or side effects, relatively high in compliance of a patient, and very good in development and application prospect.

The invention discloses a tumor targeting polypeptide and application thereof in preparation of a polypeptide drug conjugate. The amino acid sequence of the tumor targeting polypeptide is (Hyp)-(D-Asn)-(D-Leu)-(D-Lys)-(Cit)-(Acpc)-(D-Asp)-(Aad)-(Nva). According to the present invention, the small molecule polypeptide is adopted as the target head, and effect molecules and linker molecules commonlyused in the ADC drug research and development at present are selected for combination and coupling to form the new polypeptide drug conjugate, and the conjugate has characteristics of relatively small molecular weight, good penetrability, and multi-targeting. The polypeptide can play a role on tumors with high expression of a plurality of tyrosine kinase receptors including Her2 and FGFR2, and can be used as a novel tumor treatment pathway.

The invention discloses a formula and a preparation method of a Chinese and western medicine compound disinfectant / bacteriostatic agent capable of killing coronavirus. The disinfectant / bacteriostaticagent is prepared from a compound traditional Chinese medicine extracting solution, quaternary ammonium salt derivative compounds such as dimethyl benzyl ammonium chloride and octadecyl dimethyl ammonium chloride, a nonionic surfactant, glycerinum, borneol, ethyl alcohol and the like. The disinfectant / bacteriostatic agent disclosed by the invention has the effects of in-vitro disinfection and bacteriostasis, coronary viruses such as HCoV-NL63 and HCoV-HKU1 can be killed, the killing rate of common pathogenic bacteria is higher than that of a hypochlorous acid disinfectant, and the disinfectant / bacteriostatic agent can be used for disinfection and bacteriostasis of object surfaces, public places, equipment, home and office environments, animal fur, vegetation, human skin and mucous membranes.

The invention relates to application of Huatuo Zaizao pills serving as a medicine for relieving the Alzheimer's disease. The Huatuo Zaizao pills are capable of reducing Abeta accumulated in brain tissue and taking protection functions of neural synaptic plasticity into play, thereby treating cognition impairment of the Alzheimer's disease. By adopting modern biological techniques and bioinformatics analysis, functions of the Huatuo Zaizao pills are primarily studied, results show that the Huatuo Zaizao pills have protection functions on synapse proteins and functions, furthermore results showthat the Huatuo Zaizao pills have application of relieving cognition impairment of patients suffering from the Alzheimer's disease, and the Huatuo Zaizao pills can be designed as a targeting medicinefor promoting recovery of cognitive functions of the patients suffering from the Alzheimer's disease, and have great potential application values upon treatment on the Alzheimer's disease.

The invention provides a heterocyclic compound represented by a general formula (I) shown in the description, a stereoisomer or pharmaceutically acceptable salt thereof, a pharmaceutical composition of the heterocyclic compound or the stereoisomer or pharmaceutically acceptable salt thereof and an application of the heterocyclic compound or the stereoisomer or pharmaceutically acceptable salt thereof in preparation of drugs for preventing and / or treating central nervous system diseases.