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Pharmaceutical composition for treating myocardial ischemia as well as preparation method and use of pharmaceutical composition

A technology of myocardial ischemia and composition, which is applied in the field of medicine, can solve problems such as large side effects, achieve remarkable effects, good development and application prospects, and simple preparation process

Inactive Publication Date: 2015-07-01
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned above, the current chemical drugs for the treatment of this disease have a certain curative effect, but the side effects are relatively large. It is against this background that the present invention emerges as the times require. After long-term research and development and clinical practice, the inventor has obtained a A pharmaceutical composition for treating myocardial ischemia with ideal therapeutic effect, no toxic and side effects, simple preparation process and low cost, opens up a new path for the application of traditional Chinese medicine in cardiovascular diseases, and has very good development and application prospects and far-reaching social benefits

Method used

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  • Pharmaceutical composition for treating myocardial ischemia as well as preparation method and use of pharmaceutical composition
  • Pharmaceutical composition for treating myocardial ischemia as well as preparation method and use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: Sanqi 30g, Clematis 20g, Piper 20g, Peach Kernel 30g, Guizhi 30g, Tangerine Peel 20g, Aescin 20g, Elderberry 25g, Astragalus 30g, Myrrh 10g, Fairy Spleen 25g, Rehmannia glutinosa 25g.

[0027] Preparation method:

[0028] (1) According to the ratio of the above formula, weigh the twelve traditional Chinese medicines of Panax notoginseng, Clematis, Piperia, peach kernel, cinnamon twig, tangerine peel, Aescin, elderberry, astragalus, myrrh, xianlingpi, and rehmannia glutinosa , dried, pulverized, mixed evenly, and set aside;

[0029] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, add 9 times the amount of water (by weight) each time, decoct for 2 hours each time, combine the three decoctions, and filter;

[0030] (3) Concentrate the filtrate obtained in step (2) into a clear paste (80°C) with a relative density of 1.05-1.15, add ethanol until the alcohol content is 70% (v / v), stir, let stand for 24 hours...

Embodiment 2

[0032] Prescription: Sanqi 40g, Clematis 30g, Piper 30g, Peach Kernel 40g, Guizhi 40g, Tangerine Peel 30g, Aescin 30g, Elderberry 35g, Astragalus 40g, Myrrh 15g, Fairy Spleen 35g, Rehmannia glutinosa 35g.

[0033] Preparation method:

[0034] (1) According to the ratio of the above formula, weigh the twelve traditional Chinese medicines of Panax notoginseng, Clematis, Piperia, peach kernel, cinnamon twig, tangerine peel, Aescin, elderberry, astragalus, myrrh, xianlingpi, and rehmannia glutinosa , dried, pulverized, mixed evenly, and set aside;

[0035] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, add 12 times the amount of water (by weight) each time, decoct for 3 hours each time, combine three decoctions, and filter;

[0036] (3) Concentrate the filtrate obtained in step (2) into a clear paste (80°C) with a relative density of 1.05-1.15, add ethanol until the alcohol content is 80% (v / v), stir, let stand for 24 hours, a...

Embodiment 3

[0038] Prescription: Sanqi 20g, Clematis 10g, Piper 10g, Peach Kernel 20g, Guizhi 20g, Tangerine Peel 10g, Aescin 10g, Elderberry 15g, Astragalus 20g, Myrrh 5g, Xianlingpi 15g, Rehmannia glutinosa 15g.

[0039] Preparation method:

[0040](1) According to the ratio of the above formula, weigh the twelve traditional Chinese medicines of Panax notoginseng, Clematis, Piperia, peach kernel, cinnamon twig, tangerine peel, Aescin, elderberry, astragalus, myrrh, xianlingpi, and rehmannia glutinosa , dried, pulverized, mixed evenly, and set aside;

[0041] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, add 6 times the amount of water (by weight) each time, decoct for 1.5 hours each time, combine three decoctions, and filter;

[0042] (3) Concentrate the filtrate obtained in step (2) into a clear paste (80°C) with a relative density of 1.05-1.15, add ethanol until the alcohol content is 60% (v / v), stir, let stand for 12 hours, and ...

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Abstract

The invention belongs to the medicinal field and particularly relates to a pharmaceutical composition for treating myocardial ischemia, in particular to the pharmaceutical composition for treating myocardial ischemia and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese medicine materials in parts by weight: 20-40 parts of pseudo-ginseng, 10-30 parts of radix clematidis, 10-30 parts of long peppers, 20-40 parts of peach kernels, 20-40 parts of cassia twigs, 10-30 parts of dried tangerine or orange peel, 10-30 parts of paris polyphylla, 15-35 parts of elderberry, 20-40 parts of astragalus, 5-15 parts of myrrh, 15-35 parts of herba epimedii and 15-35 parts of prepared rehmannia roots. The pharmaceutical composition disclosed by the invention is safe and effective, simple in preparation process, free of toxic or side effects, relatively high in compliance of a patient, and very good in development and application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating myocardial ischemia, a preparation method and application thereof. Background technique [0002] Cardiovascular disease, also known as circulatory system disease, refers to the organs and tissues that transport blood in the human body, mainly including the heart and blood vessels, which can be subdivided into acute and chronic diseases, and are generally related to arteriosclerosis. Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in reduced oxygen supply to the heart, abnormal myocardial energy metabolism, and failure to support the normal work of the heart. Coronary stenosis caused by coronary atherosclerosis is the most important and common cause of myocardial ischemia, which in turn leads to myocardial ischemia and hypoxia. Therefore, coronary heart di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K36/896A61P9/10A61P39/06
Inventor 郭丹丹于思明
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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