171 results about "Clematis chinensis" patented technology

The invention provides a traditional Chinese medicine composition for treating rheumatic arthritis, a preparation and application, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following medicinal raw materials: 12-18 parts of sailong bone, 6-12 parts of radix aconiti lateralis preparata, 3-9 parts of radix aconiti preparata, 9-15 parts of cassia twig, 1-4 parts of asarum, 9-15 parts of radix clematidis, 20-40 parts of astragalus membranaceus, 3-9 parts of scorpio, 9-15 parts of earthworm, 9-15 parts of caulis sinomenii, 12-18 parts of bighead atractylodes rhizome, 12-18 parts of poria cocos, 9-15 parts of gentiana macrophylla, 12-18 parts of angelica sinensis, 20-40 parts of caulis spatholobi, 9-15 parts of rhizoma drynariae, 12-18 parts of radix paeoniae alba, 3-9 parts of honey-fried licorice root and 6-12 parts of rhizoma zingiberis. According to the traditional Chinese medicine composition for treating rheumatic arthritis, the medicine raw material composition of the traditional Chinese medicine composition for treating rheumatic arthritis is reasonably designed, four pathological links of cold, dampness, stasis and deficiency of rheumatic arthritis are covered through precise compatibility of monarch, minister, assistant and guide, and the traditional Chinese medicine composition has triple curative effects of anti-inflammatory analgesia, immunoregulation and bone protection.

The invention belongs to the technical field of traditional Chinese medicines, and provides an external traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment. The traditional Chinese medicine composition comprises the following components: prepared kusnezoff monkshood root, lycopodium clavatum, garden burnet, rheum officinale, radix clematidis, ligusticum wallichii, rhizoma zingiberis, angelica sinensis, Sinkiang lithospermum, peach kernel, fried gardenia, turmeric, radix angelicae pubescentis, asarum, notopterygium root, sappan wood, red paeony root, garden balsam stem, vinegar frankincense, vinegar corydalis tuber, vinegar myrrh, vinegar rhizoma cyperi, bran-fried fructus aurantii and golden cypress. The invention further discloses a preparation method and application of the traditional Chinese medicine composition for tendon injury, blood stasis, swelling and pain and bone impediment. The traditional Chinese medicines perform respective functions in monarch, minister, assistant and guide, the whole formula has the effects of promoting blood circulation to remove blood stasis, activating meridians to stop pain, dispelling wind and eliminating dampness, and reducing swelling and removing stasis, a synergistic treatment effect on tendon injury, blood stasis, swelling and pain and bone impediment is formed through a multi-target-point synergistic effect, the limitation that a traditional Chinese medicine with a single effect is difficult to comprehensively deal with is solved, and the effect of treating both symptoms and root causes is achieved; the traditional Chinese medicine composition has remarkable social benefits and clinical application value.

This invention provides a traditional Chinese medicine composition for the prevention and treatment of knee arthritis. The active ingredients, by weight, include: 15-25 parts of Salvia miltiorrhiza, 8-15 parts of Ligusticum chuanxiong, 12-20 parts of Angelica sinensis, 7-15 parts of Lycopus lucidus, 15-30 parts of Poria cocos, 8-15 parts of Placenta hominis, 18-30 parts of Clematis chinensis, 15-25 parts of Spatholobus suberectus, 25-40 parts of Paeonia lactiflora, 12-20 parts of Rehmannia glutinosa, and 8-15 parts of Glycyrrhiza uralensis. Using Salvia miltiorrhiza, Ligusticum chuanxiong, Angelica sinensis, Lycopus lucidus, Poria cocos, Placenta hominis, Clematis chinensis, Spatholobus suberectus, Paeonia lactiflora, Rehmannia glutinosa, and Glycyrrhiza uralensis as raw materials, this invention follows the principle of "principal, assistant, adjuvant, and guide" in traditional Chinese medicine. The combined use of these herbs can tonify the liver and kidneys, promote blood circulation and remove blood stasis, and has a good therapeutic effect on knee arthritis caused by liver and kidney deficiency and qi stagnation and blood stasis.

The invention discloses a traditional Chinese medicine composition for breaking diseases, removing food retention and removing stasis, a preparation and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition for breaking diseases, removing food retention and removing stasis is prepared from the following traditional Chinese medicinal materials in parts by weight: 12-18 parts of ardisia japonica, 5-9 parts of rhizoma dioscoreae nipponicae, 8-14 parts of berba aristolochiae mollissimae, 3-7 parts of radix araliae armatae, 7-11 parts of radix tetrastigme, 6-10 parts of herba cistanche and 3-7 parts of lithospermum erythrorhizon. The traditional Chinese medicine compound disclosed by the invention is rigorous in compatibility, takes both symptoms and root causes into consideration, takes effects of breaking diseases, removing food retention, removing blood stasis and dredging collaterals as the core, also takes effects of dispelling wind, eliminating dampness, clearing away heat and toxic materials, tonifying kidney, strengthening bones and supporting healthy energy into consideration, can quickly relieve pain symptoms, can fundamentally improve the core pathogenesis of wind-cold damp evil invasion, qi stagnation, blood stasis and meridian obstruction, and reduces the recurrence rate.

The invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application, and particularly belongs to the technical field of traditional Chinese medicine. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 20-50 parts of parched white peony root, 8-15 parts of pawpaw, 10-20 parts of radix clematidis, 20-40 parts of caulis spatholobi, 5-12 parts of honey-fried licorice root, 10-20 parts of fructus broussonetiae, 10-20 parts of radix cyathulae and 5-12 parts of cassia twig. The traditional Chinese medicine composition has great potential in the aspects of treating kOA and inhibiting osteophyte formation, and can be used for improving kOA cartilage injury. Through in-vitro experiments, network pharmacology and in-vivo experiments, the curative effect of XBD in treating kOA and the effect of XBD in inhibiting osteophyte formation are verified, it is proved that XBD has a regulation effect on cartilage degeneration and osteophyte formation, and an important thought is provided for developing innovative drugs with cartilage protection and abnormal osteophyte formation inhibition functions.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine application for relieving neck-shoulder and lumbocrural pain and a preparation method thereof. The traditional Chinese medicine application is prepared from, by mass, 15-50 g of obscured homalomena rhizome, 15-50 g of cortex illicii, 15-50 g of herba lycopodii, 15-50 g of rhizoma curcumae longae, 15-50 g of rhizoma corydalis, 15-50 g of radix puerariae, 15-50 g of garden balsam stem, 15-50 g of radix saposhnikoviae, 15-50 g of flos carthami, 15-50 g of radix cyathulae, 15-50 g of rhizoma seu radix notopterygii, 15-50 g of radix angelicae pubescentis, 15-50 g of lumbricus, 15-20 g of frankincense, 15-20 g of myrrh and 20-30 g of radix clematidis. Compared with traditional medicine application with a single effect, the traditional Chinese medicine application has the advantages that the pain relieving effect is quicker, the symptom improvement is more thorough, meanwhile, the application range of treating the neck, shoulder, waist and leg pain is expanded, and a patient can operate the traditional Chinese medicine application at home without assistance of professional medical equipment.

This invention discloses a targeted antibacterial and repairing scalp shampoo containing a four-herb compound and its segmented preparation process, belonging to the technical field of functional herbal hair care products. Based on the traditional Chinese medicine theory of principal, assistant, and adjuvant herbs, this invention uses a precise compound of four herbs—Platycladus orientalis leaf, Clematis chinensis, Dictamnus dasycarpus bark, and Paeonia suffruticosa—combined with an amino acid cleansing system and multiple antibacterial and repairing components to create a synergistic formula. It employs a unique segmented salt-addition and low-temperature step-by-step feeding process, locking in the activity of the herbs at 35℃~40℃. Stability is regulated through two salt additions, and properties are optimized through constant-temperature maturation, solving the problems of traditional products such as activity loss, poor stability, single efficacy, and disordered formulation. This product can target and inhibit Malassezia, eradicate stubborn dandruff, reduce inflammation and itching, balance oil and water, repair the scalp barrier, and nourish hair roots. Its pH is suitable for the slightly acidic environment of the scalp, making it gentle and non-irritating, suitable for long-term treatment of sensitive, seborrheic, and permed / dyed scalps. The formula and process are novel, creative, and practical, and can be industrially mass-produced.

The invention discloses a traditional Chinese medicine composition for treating acute gout, an external gel and a preparation method thereof, and the traditional Chinese medicine composition comprises the following raw material components in parts by mass: 5-20 parts of radix clematidis, 5-20 parts of polygonum cuspidatum, 5-20 parts of honeysuckle stem, 5-15 parts of radix aconiti preparata, 5-15 parts of pine nodular branch, 1-5 parts of corydalis tuber and 1-3 parts of asarum. The gel disclosed by the invention is an external gel prepared by researching through a traditional Chinese medicine composition intermediate extraction process and a preparation forming process, has the effective effects of directly reaching an affected part, taking effect quickly, being good in patient compliance and the like, and can realize industrial production through pilot scale-up experiment verification. Animal experiment research results show that the radix clematidis pain-relieving gel has remarkable anti-inflammatory and pain-relieving effects.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to an external traditional Chinese medicine ointment for treating acute gouty arthritis and a preparation method thereof. Comprising the following components in parts by mass: 18-22 parts of rheum officinale, 20-26 parts of turmeric, 15-19 parts of cortex phellodendri, 15-19 parts of indigo naturalis, 15-19 parts of rhizoma smilacis glabrae, 14-18 parts of radix clematidis, 14-18 parts of moutan bark, 14-18 parts of herba lycopi, 10-14 parts of semen plantaginis, 8-12 parts of radix stephaniae tetrandrae, 8-12 parts of rhizoma corydalis and 5-9 parts of liquorice. The ointment not only aims at inflammation and pain in the acute stage of gout, but also promotes uric acid excretion through medicines such as rhizoma smilacis glabrae and semen plantaginis, and has a certain auxiliary uric acid reduction effect. The compound design of the traditional Chinese medicine composition integrates the functions of clearing heat and promoting diuresis and promoting blood circulation to remove blood stasis, body metabolism is regulated from multiple targets, symptoms are relieved, pathogenesis conditioning is also considered, and a more comprehensive solution is provided for treatment of gouty arthritis.

The invention discloses application of a yang-warming and cold-dispelling traditional Chinese medicine composition in preparation of a medicine for improving cold limbs, and belongs to the field of traditional Chinese medicines. The prescription consists of folium artemisiae argyi, cassia twig, ligusticum wallichii, notopterygium root, divaricate saposhnikovia root, ginger, pepper, safflower, radix clematidis, radix aconiti carmichaeli, dried ginger and cinnamon according to a specific mass part ratio. The prescription disclosed by the invention has the effects of warming channels and expelling cold, and promoting blood circulation to remove meridian obstruction, and is mainly used for improving the symptoms such as cold hands and feet, intolerance of cold and sensation of chill, joint crymodynia and the like caused by insufficiency of yang qi and congealing cold in meridians. The invention also provides a preparation method of dosage forms such as an application agent of the prescription. Clinical tests show that the prescription preparation, especially the acupoint application agent, can obviously improve the symptoms, the total effective rate can reach 93.3%, the safety is good, and a safe, effective and convenient-to-use external treatment choice is provided for related diseases.

The composition is composed of a herbal medicine alcohol extract and an alcohol solvent, the herbal medicine comprises Jinfo grass, radix angelicae, solidago decurrens, oldenlandia diffusa, fructus kochiae, fructus cnidii, bletilla striata, radix clematidis, cortex dictamni, portulaca grandiflora and gallnut, and the herbal medicine is scientifically proportioned according to the principle of monarch, minister and guide. The preparation method comprises the following steps: processing medicinal materials such as fructus cnidii, crushing, soaking with high-concentration alcohol according to a specific ratio, extracting, and finally filling into a spray bottle. The traditional Chinese medicine composition integrates multiple functions of disinfection, hemostasis, detumescence, pain relieving, itching relieving and the like, is suitable for multiple skin problems such as traumatic bleeding, burns and scalds, eczema and mosquito bites, and can be used for skin disinfection during epidemic situations so as to reduce epidemic risks. The product takes effect quickly, is convenient to use and is safe and effective, and the preparation process integrates tradition and efficiency.

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a construction method of a specific chromatogram of caulis clematidis armandii or derivative products thereof. The invention provides a construction method of a characteristic chromatogram of caulis clematidis armandii or a derivative product thereof, which comprises the following steps: by taking octadecylsilane chemically bonded silica as a filler and a mobile phase comprising a formic acid-containing aqueous solution and acetonitrile, carrying out a specific gradient elution procedure to obtain 22 common characteristic peaks, and realizing effective separation of the common characteristic peaks, so that the separation degree is good, and the accuracy is high. The obtained characteristic spectrum has more characteristic peaks and better baseline separation, and is easier to position and qualitatively analyze; the precision, the stability and the repeatability are relatively good; compared with the prior art, the method has the advantages that the characteristic peaks are more, six characteristic components including the straight clematis seed B, the lariciresinol, the secoisolariciresinol, the lariciresinol-4-O-beta-D-glucoside, the caffeic acid and the ferulic acid are identified, and a basis is provided for quality detection and content determination of the caulis clematidis armandii or derivative products of the caulis clematidis armandii.

The present application relates to a kind of traditional Chinese medicine composition for treating acute exacerbation of chronic bronchitis, the traditional Chinese medicine composition is made of the following weight parts of raw medicinal materials: 10-14 parts of pinellia ternata, 7-11 parts of apricot kernel, 7-11 parts of persicae semen, 7-11 parts of dried tangerine or orange peel, 10-14 parts of radix codonopsis, 13-17 parts of oyster shell, 13-17 parts of concha mactrae, 13-17 parts of ophiopogon japonicus, 7-11 parts of radix clematidis, 1-5 parts of soap plant thorn.The present application is mainly used for treating syndrome of phlegm-dampness accumulating in lung;Effect: dry dampness and resolve phlegm, regulate qi and relieve cough;The monarch drug pinellia ternata in the present application is pungent, flat, warm and dry, and is good at dry dampness and resolve phlegm, and can descend adverse qi and relieve panting.Peach kernel and apricot kernel are used as ministers, which is a wonderful use of qi-blood confrontation: peach kernel enters blood and regulates qi, and apricot kernel enters qi and regulates blood, and the two are complementary, helping pinellia ternata to rotate qi and restore ascending and descending. The use of auxiliary drugs has three meanings: one is to attack evil, radix clematidis can pass through twelve meridians and remove phlegm, soap plant thorn is sharp and can break and soften, and is good at attacking stubborn phlegm. The combination of various drugs can attack and tonify, and is suitable for moistening dryness, and can achieve the effect of dry dampness and resolve phlegm, regulate qi and relieve cough.

This invention discloses a topical traditional Chinese medicine composition for relieving pain and its preparation method, belonging to the field of traditional Chinese medicine preparation technology. The topical traditional Chinese medicine composition for relieving pain is made from the following raw materials in parts by weight: Angelica sinensis 5-25 parts, Ligusticum striatum 5-20 parts, Lycopodium clavatum 10-35 parts, Artemisia argyi 5-25 parts, artificial Phellodendron chinense 3-18 parts, Clematis chinensis 10-40 parts, and Angelica dahurica 5-20 parts. This invention uses steam distillation to extract volatile oils and a dual-solvent gradient extraction method with the residue, which not only fully extracts the volatile fat-soluble components from Angelica sinensis, Ligusticum striatum, and Angelica dahurica, but also efficiently extracts the water-soluble components from artificial Phellodendron chinense, Lycopodium clavatum, and other medicinal materials. Experimental results show that the extraction rates of ferulic acid, ligustilide, imperatorin, and berberine hydrochloride in Example 1 of this invention reached 89.23%, 92.56%, 90.12%, and 93.45%, respectively, which are 110.7%, 223.1%, 75.8%, and 23.6% higher than those of conventional water decoction process, thus improving the utilization rate of raw materials.

The invention provides a tendon-relaxing, collateral-activating and pain-relieving breast plaster for shoulder, neck, lumbar vertebra, arthralgia and traumatic injury. The plaster is prepared from the following raw materials in parts by weight: 22-35 parts of frankincense, 41-55 parts of mirabilite, 26-40 parts of ligusticum wallichii, 31-40 parts of lycopodium clavatum, 5-20 parts of dragon's blood, 5-20 parts of pseudo-ginseng, 10-25 parts of radix clematidis, 40-55 parts of pawpaw, 35-45 parts of radix angelicae pubescentis, 40-50 parts of pericarpium zanthoxyli, 40-50 parts of ginger, 30-35 parts of rhizoma drynariae, 42-47 parts of radix aconiti kusnezoffii, 43-48 parts of radix aconiti, 45-50 parts of asarum, 40-50 parts of 20 to 30 parts of chamomile, 10 to 25 parts of menthol oil, 10 to 25 parts of camphor oil, 15 to 25 parts of lavender essential oil and 10 to 25 parts of wintergreen oil; 15-25 parts of radix saposhnikoviae oil, 15-25 parts of garden balsam stem oil and 15-30 parts of safflower oil. The ointment has special effects on shoulder, neck and lumbar vertebra, arthralgia, traumatic injury, tendon relaxing, collateral activating and pain relieving; and the traditional Chinese medicine composition has the effect of treating both symptoms and root causes without relapse and side effects.

This invention discloses a traditional Chinese medicine composition for treating degenerative bone diseases, its preparation method, and its application. It is made from the following raw materials in parts by weight: 30-50 parts Rehmannia glutinosa (processed), 15-30 parts deer antler glue, 20-80 parts Cistanche deserticola, 15-50 parts Morinda officinalis, 15-50 parts tortoise shell glue, 30-80 parts Lycium barbarum, 10-50 parts Curculigo orchioides, 15-50 parts Eucommia ulmoides, 20-80 parts Cuscuta chinensis, and 30-50 parts Dioscorea opposita. 0 parts, Drynaria fortunei 15-50 parts, Achyranthes bidentata 10-50 parts, Taxillus chinensis 20-50 parts, Broussonetia papyrifera 15-30 parts, Clematis chinensis 15-50 parts, Acanthopanax senticosus 15-50 parts; Through the formulation strategy of "regulating the liver and kidneys, nourishing essence and blood, and combining tonification and purging", combined with a specific extraction process, it systematically regulates the balance of bone metabolism, achieves dual prevention and treatment of osteoporosis and bone hyperplasia, and treats both the symptoms and the root cause, and has high safety for long-term use.

The invention provides a traditional Chinese medicine composition for treating heart failure as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 4-6 parts of red ginseng, 16-24 parts of raw astragalus membranaceus, 7.2-10.8 parts of cassia twig, 12-18 parts of semen lepidii, 12-18 parts of semen plantaginis, 4-6 parts of motherwort, 12-18 parts of radix clematidis, 12-18 parts of caulis spatholobi and 7.2-10.8 parts of rhizoma curculiginis. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition has a multi-target synergistic effect, gives consideration to the pathogenesis of'deficiency in root and excess in excess', is scientific in cold-warm compatibility, reduces the risk of side effects, has the efficacy superior to that of pure western medicines (such as diuretic, ACEI and SGLT2i), and is remarkable in clinical curative effect, high in safety and suitable for being taken for a long time.

The invention discloses a preparation method of a traditional Chinese medicine external formula with a bone fracture rehabilitation effect. The preparation method comprises the following steps: step 1, preparing a traditional Chinese medicine extract; the preparation method comprises the following steps: 1, weighing the following raw material medicines in proportion: radix clematidis, cortex mori radicis, flos carthami, radix stephaniae tetrandrae, herba lycopodii, fructus liquidambaris, radix gentianae macrophyllae, radix saposhnikoviae, radix angelicae sinensis, radix angelicae dahuricae, fructus chaenomelis, vinegar-processed rhizoma corydalis, poria peel, processed frankincense and processed myrrh; 2, the raw material medicines are smashed and then mixed or the raw material medicines are mixed and then smashed, and a mixture is obtained.On the basis of the PCT concept, in-vitro shock wave treatment and an external formula are applied to treatment of a patient suffering from plantar fasciitis, compared with single in-vitro shock wave treatment, the inflammatory factor level can be better reduced through combination of the in-vitro shock wave treatment and the external formula, and the curative effect is better. Meanwhile, the production method of the external use formula disclosed by the invention is few in steps and simple to operate.

The application discloses a traditional Chinese medicine composition for regulating inflammation-oxidative stress-bone metabolism axis and application thereof, and belongs to the field of kidney disease treatment. The traditional Chinese medicine composition is composed of Herba Epimedii, Rhizoma Drynariae, Radix Eucommiae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae, Olibanum, Poria, Rhizoma Atractylodis Macrocephalae, Radix Trichosanthis, Radix Clematidis, Caulis Spatholobi and Radix Glycyrrhizae. The composition can be prepared into pharmaceutically acceptable dosage forms such as granules, granules for oral taking, capsules, tablets, pills, oral liquid or ointments. The traditional Chinese medicine composition has the characteristics of sustained curative effect, good safety and comprehensive regulation of multiple targets, and can be used for preparing drugs for regulating inflammation-oxidative stress-bone metabolism axis, improving mineral and bone metabolism abnormalities of chronic kidney disease and treating chronic musculoskeletal pain of patients with maintenance hemodialysis.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a traditional Chinese medicine composition for treating rheumatoid arthritis, its preparation method, and its application. The traditional Chinese medicine composition consists of *Sargentodoxa cuneata*, *Acanthopanax senticosus*, *Ligusticum striatum*, *Drynaria fortunei*, and *Clematis chinensis*. Its preparation method includes the following steps: extraction; filtration; and concentration. Animal experiments and clinical trials have confirmed that the traditional Chinese medicine composition provided by this invention has a significant therapeutic effect on rheumatoid arthritis, with good safety and no obvious adverse reactions, and has great clinical application value.

The invention discloses a traditional Chinese medicine composition for treating primary dysmenorrhea and a preparation method, and belongs to the field of medical treatment and public health. The composition is based on the wind-expelling and pain-relieving theory and clinical experience of the nationwide nationwide traditional Chinese medicine weekly inscription instructor, is prepared from 10 to 20g of notopterygium root, 10 to 20g of divaricate saposhnikovia root, 10 to 20g of radix angelicae, 10 to 30g of radix angelicae pubescentis, 10 to 20g of rhizoma corydalis, 10 to 30g of radix paeoniae alba, 10 to 20g of ligusticum wallichii, 10 to 20g of rhizoma cyperi and 10 to 30g of radix clematidis, and has the effects of expelling wind, relieving pain, warming and activating meridians and dredging collaterals. The preparation method comprises the steps of raw material pretreatment, extraction, concentration and preparation forming, and can be prepared into decoction, granules and other dosage forms. The scheme aims at the pathogenesis of primary dysmenorrhea of'wind pathogen latent in uterus and blocking menstrual blood ', solves the problems of poor long-term curative effect and repeated attack of pain in existing treatment, and is remarkable in clinical curative effect, high in safety and suitable for treatment of primary dysmenorrhea.

The invention relates to a traditional Chinese medicine liquid and a traditional Chinese medicine ointment for expelling toxins from osteoporosis and a preparation method thereof. The traditional Chinese medicine liquid for expelling toxins from osteoporosis is prepared from the following raw materials in parts by weight: 10-15 parts of radix clematidis, 12-18 parts of trifid sopubia herb, 10-15 parts of garden balsam stem, 15-25 parts of suberect spatholobus stem, 6-10 parts of safflower, 9-12 parts of Chinese angelica, 6-8 parts of liquorice and 8-12 parts of folium artemisiae argyi. The preparation method of the bone seam detoxifying traditional Chinese medicine liquid comprises the following steps: a, pretreating the raw materials; b, decocting and extracting; c, filtering and concentrating; d, blending and homogenizing; and e, sterilizing and packaging. The traditional Chinese medicine liquid and the traditional Chinese medicine ointment for detoxifying the bone seams are particularly used for detoxifying toxins such as deep damp turbidity and phlegm stasis in the bone seams, and are suitable for relieving symptoms such as ankylosis, deep pain, hyperostosis and the like caused by deposition of toxins in the bone seams. The bone seam detoxification traditional Chinese medicine liquid and the traditional Chinese medicine ointment have the remarkable advantages of being high in seepage force, comprehensive in detoxification, high in safety, wide in applicability and the like.

The invention discloses a traditional Chinese medicine composition for treating rheumatic bone pain and a preparation method of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. The ointment consists of traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components of the ointment are prepared from the following components: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, scorpio, centipede, earthworm, frankincense, myrrh, notopterygium root, radix angelicae pubescentis, radix clematidis, gentiana macrophylla, lycopodium clavatum, safflower and phryma leptostachya; the decoction is prepared from the following components: eucommia ulmoides, longspur epimedium, radix rehmanniae preparata, raw astragalus membranaceus, teasel root, semen cuscutae, radix achyranthis bidentatae, radix clematidis, salvia miltiorrhiza, radix aconiti preparata, prepared kusnezoff monkshood root, angelica sinensis and liquorice. According to the invention, a treatment mode of combining external use of ointment and oral administration of decoction is innovatively adopted, aiming at the pathogenesis characteristics of rheumatism ostalgia, local symptoms are rapidly relieved through the external ointment, the internal organ function is fundamentally conditioned through the oral decoction, the treatment strategy of treating symptoms in emergency and treating root causes in slow is realized, and the clinical curative effect is remarkably improved.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to the application of a traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of lung injury. The traditional Chinese medicine composition includes Astragalus membranaceus, Eupolyphaga sinensis, Morus alba root bark, Fritillaria cirrhosa, Perilla frutescens seed, Lepidium apetalum seed, Prunus armeniaca seed, Pheretima aspergillum, Ephedra sinica, and Clematis chinensis. Experiments show that this traditional Chinese medicine composition can significantly reduce the level of the inflammatory factor TNF-α, decrease the lung index, and alleviate pathological damage to lung tissue, and can be used for the prevention and treatment of lung injury.

This invention belongs to the technical field of skin disease treatment products, specifically relating to a topical hot compress for treating scleroderma and its preparation method. The topical hot compress for treating scleroderma is made from the following raw materials in parts by weight: 20-40 parts of Artemisia argyi, 20-40 parts of Cinnamomum cassia, 10-20 parts of Sparganium stoloniferum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Loranthus parasiticus, 15-30 parts of Gynostemma pentaphyllum, 10-20 parts of Spirodela polyrhiza, 15-30 parts of Spirodela polyrhiza, 15-30 parts of Ephedra sinica, 20-40 parts of Clematis chinensis, 5-15 parts of Eupolyphaga sinensis, 15-25 parts of Eriocaulon buergerianum, 5-15 parts of Carthamus tinctorius, 3-6 parts of Dracaena cochinchinensis, 3-6 parts of processed Strychnos nux-vomica, 20-40 parts of Vaccaria segetalis, 20-40 parts of Astragalus membranaceus, 10-20 parts of Magnolia officinalis, 10-20 parts of Aconitum carmichaelii, and 22-40 parts of rice wine. This invention is a topical medication that eliminates the need for oral administration, treating the disease externally and guiding the pathogenic factors to a cure. It avoids the inconvenience of bitter medications and effectively relieves symptoms and promotes the cure of localized scleroderma.

The invention discloses traditional Chinese medicine external medicinal liquor for treating bone diseases and a preparation method and application thereof. The medicinal liquor is prepared from, by weight, 30 g of ginseng under forest, 60 g of raw radix astragali, 90 g of dragon's blood, 60 g of sargentgloryvine stem, 30 g of radix clematidis, 60 g of radix angelicae, 30 g of scorpion, 60 g of lumbricus, 60 g of dried river crab, 30 g of silkworm larva, 60 g of ground beetle, 30 g of frankincense, 30 g of myrrh, 60 g of teasel root and 60 g of rhizoma drynariae. The traditional Chinese medicine is prepared from 60 g of native copper, 30 g of amber, 30 g of pericarpium zanthoxyli, 25 g of radix aconiti, 25 g of radix aconiti agrestis, 60 g of caulis spatholobi, 30 g of cortex erythrinae, 45 g of semen strychni, 15 g of musk and 30 g of borneol. The medicinal liquor achieves the effects of rapidly relieving swelling and pain, promoting bone healing, dispelling wind and eliminating dampness and the like through the synergistic effect of multiple targets, is especially suitable for arthralgia type osteoarticular diseases and traumatic injuries, and has remarkable curative effects on osteoproliferation, fracture recovery and the like and high safety according to clinical cases.

This invention discloses a fascia knife lubricating composition with muscle relaxation effects and its preparation process, belonging to the field of external traditional Chinese medicine compositions and rehabilitation therapy technology. The composition comprises: sweet almond oil, dimethyl silicone oil, *Lycopodium clavatum* extract, *Clematis chinensis* extract, safflower extract, *Artemisia argyi* extract, azone, carbomer, vitamin E, an encapsulated cooling agent, and deionized water as the balance. The preparation process includes alcohol extraction of traditional Chinese medicine, volatile oil encapsulation, high-pressure homogenization emulsification, and gradient temperature-controlled maturation. After high-pressure homogenization, the oil droplet size of the composition is 100-200 nm, the viscosity at 25℃ is 15000-30000 mPa·s, and the thixotropic index is 3.0-6.0. It possesses both excellent lubrication properties and muscle-relaxing effects, exhibiting a significant physical-biological synergistic effect when used with a fascia knife.

The invention discloses an external traditional Chinese medicine composition for treating cold-heat mixed type diseases. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts of radix aconiti carmichaeli, 4-5 parts of garden balsam stem, 4-5 parts of radix et rhizoma rhei, 2-3 parts of radix clematidis, 2-3 parts of frankincense, 2-3 parts of myrrh, 2-3 parts of herba asari, 2-3 parts of raw rhizoma arisaematis, 2-3 parts of fresh ginger, 2-3 parts of herba taraxaci and 2-3 parts of loofah sponge. Compared with the prior art, the traditional Chinese medicine composition has the advantages that cold and heat are used together, yin and yang are harmonized, exterior syndromes are treated by tonifying yang to condition roots, softening hardness to dissipate stagnation, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, necrotic tissue removing and granulation promoting are adopted to condition and recover, a multi-target and broad-spectrum treatment effect is formed, and the traditional Chinese medicine composition is mainly used for treating cold and heat intermingled diseases and can effectively treat or relieve rheumatoid bone diseases, traumatic injuries, scalds, prostatitis and other diseases.

This invention belongs to the field of biotechnology and discloses the application of plant-derived dehydrogenases or their encoding genes in the conversion of progesterone to 6-dehydroprogesterone. The plant-derived dehydrogenase is selected from the steroid 6-position dehydrogenase MtCYP79 derived from *Clematis chinensis* or the steroid 6-position dehydrogenase PsCYP79 derived from *Ligusticum striatum*. It also discloses a genetically engineered *Saccharomyces cerevisiae* strain that produces 6-dehydroprogesterone, which is based on a progesterone-producing *Saccharomyces cerevisiae* starting strain, into which the steroid 6-position dehydrogenase MtCYP79 or the steroid 6-position dehydrogenase PsCYP79 derived from *Ligusticum striatum* is introduced. The resulting genetically engineered *Saccharomyces cerevisiae* strain can produce both progesterone and 6-dehydroprogesterone.

This invention provides a traditional Chinese medicine composition for treating osteoarthritis, prepared from the following raw materials in the indicated weight ratios: Corydalis Rhizome 8-12 parts, Red Peony Root 7.2-10.8 parts, Achyranthes Root 7.2-10.8 parts, Clematis Root 7.2-10.8 parts, White Peony Root 7.2-10.8 parts, Chaenomeles Root 7.2-10.8 parts, and Liquidambar Root 7.2-10.8 parts. This invention also provides a method for preparing this traditional Chinese medicine composition and its uses. This traditional Chinese medicine composition prioritizes promoting blood circulation and removing blood stasis, while also relaxing muscles and tendons, and nourishing blood and soothing the liver, thus achieving the combined effects of "promoting blood circulation and removing blood stasis, relaxing muscles and tendons." The combination of warming and cooling properties, along with a combination of tonifying and purging effects, removes blood stasis, clears the meridians, and improves joint mobility, thereby relieving knee pain, swelling, and limited mobility. Modern pharmacological studies have shown that the drug of this invention has anti-inflammatory, analgesic, microcirculation-improving, and cartilage-repair-promoting effects, which are highly compatible with the treatment needs of knee osteoarthritis.