Preparation method of health-care medicinal patch capable of dispelling wind and eliminating dampness

Abstract

The invention discloses a preparation method of a health-care medicinal patch capable of dispelling wind and eliminating dampness. According to the invention, a multi-dimensional synergistic effect is realized through organic fusion of a traditional Chinese medicine theory and a modern preparation technology. The monarch drug notopterygium root and radix clematidis play the main effects of dispelling wind and eliminating dampness, and the monarch drug notopterygium root and radix clematidis are matched with a collateral dredging network formed by radix angelicae pubescentis and ligusticum wallichii, so that joint cold-dampness retardation can be deeply relieved; local microcirculation can be activated by the meridian warming characteristic of the cassia twig and the folium artemisiae argyi, and penetration of the medicine effect to deep tissues is enhanced by the bidirectional penetration effect of the lycopodium clavatum and the garden balsam stem. The innovatively introduced capsaicin and clove oil form alternate cold and hot stimulation, so that angiotelectasis is promoted, drug absorption is accelerated, hot burning discomfort of a traditional plaster is relieved through the cooling effect, balanced improvement of treatment comfort is achieved, gradient release of drug components is achieved through the three technologies of nano-powder drug loading, microcapsule controlled release and gel slow release, and the curative effect is improved. And the treatment effect is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of health care medicated patches, and specifically relates to a preparation method of a medicated patch for dispelling wind and dampness and promoting health. Background Art

[0002] Traditional Chinese medicine health care medicated patches are external patches developed based on traditional Chinese medicine theory and combined with modern technology. They select a variety of traditional Chinese medicines, such as angelica, chuanxiong, safflower, frankincense, myrrh, etc. Through scientific proportioning and using advanced extraction and preparation processes, the effective components of the drugs are highly concentrated in the patches. This medicated patch has the effects of promoting blood circulation to remove blood stasis, relaxing tendons and activating collaterals, reducing swelling and relieving pain, and is mainly used to relieve discomfort symptoms such as neck, shoulder, waist and leg pain, joint soreness, and muscle strain caused by traumatic injuries, wind-cold-damp pathogens. Its mechanism of action is through transdermal absorption technology, enabling the drug to directly act on the affected area, avoiding the irritation of oral drugs to the gastrointestinal tract, and being easy to use. After simply cleaning the skin of the affected area, the medicated patch can be applied to the painful area, and each patch can continuously act for 12 - 24 hours. It should be noted that pregnant women, those with skin damage, and those allergic to the components of the patch are prohibited from using it. If discomfort such as skin itching and redness occurs during use, the use should be stopped immediately and a doctor should be consulted. As a safe and effective adjuvant treatment method, traditional Chinese medicine health care medicated patches are widely used in the fields of daily health care and chronic pain management, but they cannot replace regular medical means, and it is recommended to use them reasonably under the guidance of a doctor.

[0003] However, existing medicated patches for dispelling wind and dampness generally have technical limitations such as low drug penetration efficiency and short action time. Traditional rubber matrices are prone to cause skin stuffiness and allergies. The single release mode makes it difficult to balance rapid and sustained release. Chemical penetration enhancers and preservative components are prone to cause irritation reactions. At the same time, the imbalance between cold and heat stimulation leads to poor treatment experience, and the utilization rate of the effective components of traditional Chinese medicines by the conventional pulverization process is insufficient. These defects jointly restrict the coordinated improvement of treatment effects and user experience. Summary of the Invention

[0004] The purpose of the present invention is to provide a preparation method of a medicated patch for dispelling wind and dampness and promoting health in order to solve the above-mentioned problems.

[0005] The technical solution adopted by the present invention is as follows: A preparation method of a medicated patch for dispelling wind and dampness and promoting health, characterized in that: the

[0006] preparation method includes the following steps:

[0007] S1: Put notopterygium root and clematis root into a supercritical CO2 extraction device, set the pressure at 25 MPa and the temperature at 45 °C, separate the fat-soluble extract and concentrate it to a relative density of 1.15;

[0008] S2: Process angelica pubescens through an ultrafine pulverizer until D90 < 10 μm, and prepare 200 - 400 nm nano-powder of chuanxiong using a nano-pulverizer;

[0009] S3: Ramulus Cinnamomi and Folium Artemisiae Argyi are subjected to steam distillation to extract volatile oils, and the essential oil components are collected after condensation for standby.

[0010] S4: Lycopodium clavatum is refluxed and extracted three times with 70% ethanol, and the combined extracts are concentrated under reduced pressure to obtain an alcohol-free extract.

[0011] S5: Clove oil and β-cyclodextrin are mixed at a molar ratio of 1:3, and subjected to magnetic stirring at a constant temperature of 50 °C for 2 hours, followed by spray drying to prepare microcapsules.

[0012] S6: The hydrophilic polymer gel matrix and sodium carboxymethylcellulose are swollen at 50 °C for 1.5 hours, and glycerol, sodium alginate and deionized water are added and stirred uniformly to form a gel.

[0013] S7: Under nitrogen protection, the traditional Chinese medicine extract, nano powder and capsaicin sustained-release microparticles are added in sequence, and a three-way planetary mixer is used for gradient mixing of the medicine for 30 minutes.

[0014] S8: The drug-containing gel is evenly coated on the breathable non-woven fabric with a precision coater, and after laminating with a non-stick release paper, it is dried and cured by hot air circulation at 40 °C.

[0015] S9: The finished product is sterilized by cobalt-60 irradiation and then sealed and packaged. It is balanced in an environment with a humidity < 30% for 24 hours, and stored in the warehouse after the transdermal absorption rate is qualified.

[0016] In a preferred embodiment, in step S1, the raw materials of Notopterygium incisum and Clematis chinensis are processed using a supercritical CO2 extraction device. The extraction pressure is set at 25 MPa, and the system temperature is maintained at 45 °C. It operates continuously for 150 minutes under constant dynamic extraction conditions to ensure the full release of active ingredients. After extraction, the extract is recovered through two-stage separators, and concentrated under reduced pressure in a water bath at 60 °C using a rotary evaporator to finally obtain a concentrated solution with a relative density of 1.15.

[0017] In a preferred embodiment, in step S2, when the raw material of Heracleum hemsleyanum is processed by an ultrafine pulverizer, a zirconia ceramic grinding disc is selected for three-stage pulverization. After initial coarse pulverization to 100 mesh, the final particle size of the finished product is controlled by an air classification system to ensure that more than 90% of the particles are less than 10 microns. Ligusticum chuanxiong is processed using a high-energy nano pulverizer, and cyclic pulverization is carried out under the protection of liquid nitrogen at low temperature. The rotation speed is set at 2800 revolutions per minute, and the pulverization time is 120 minutes to make the particle size stable in the range of 200 - 400 nanometers.

[0018] In a preferred embodiment, in step S3, the cinnamon twig and mugwort raw materials are put into a distillation kettle in a ratio of 1:1, and 8 times the amount of deionized water is added for steam distillation. The distillation temperature is controlled at 100 °C for 6 hours, and the distillate is cooled to 4 °C by a three-stage condenser and then collected. After standing and separating layers, the upper oil phase is taken, dehydrated with anhydrous sodium sulfate, and the clarified volatile oil is obtained for standby.

[0019] In a preferred embodiment, in step S4, the lycopodium clavatum raw material is crushed to a particle size of 20 mesh and then put into a multi-functional extraction tank. 10 times the amount of 70% ethanol solution is added, the reflux temperature is set at 78 °C, and the extraction time for each time is 2 hours. The extraction operation is repeated three times. The combined extract is removed of impurities by a tubular centrifuge and then transferred to a vacuum concentration tank. It is concentrated under the conditions of a temperature of 60 °C and a vacuum degree of -0.08 MPa, and finally a brownish paste is obtained.

[0020] In a preferred embodiment, in step S5, clove oil and β-cyclodextrin are accurately weighed in a mass ratio of 1:3 and placed in a constant temperature magnetic stirrer. The temperature is set at 50 °C, the stirring speed is 600 revolutions per minute, and the molecular inclusion is completed after reacting for 2 hours. After the reaction solution is processed by a high-pressure homogenizer to form a uniform emulsion, it is dried by a centrifugal spray drying tower. The inlet air temperature is set at 180 °C and the outlet air temperature is set at 85 °C, and the microcapsule powder is collected.

[0021] In a preferred embodiment, in step S6, the hydrophilic polymer gel matrix and sodium carboxymethylcellulose are pre-screened through a 80-mesh sieve and mixed with deionized water in a constant temperature stirring tank. The system temperature is maintained at 50 °C, and stirring is continued at a speed of 400 revolutions per minute for 1.5 hours to complete sufficient swelling. Subsequently, glycerol and sodium alginate are added in sequence, the stirring speed is adjusted to 800 revolutions per minute, and stirring is continued for 40 minutes to form a uniform translucent colloid.

[0022] In a preferred embodiment, in step S7, nitrogen is introduced in advance to displace the air in a closed planetary mixer. After stabilizing the temperature of the gel matrix at 40 °C, the traditional Chinese medicine extract and the nano powder are added in three gradients. For the first time, 30% of the powder is added and mixed at a low speed of 300 revolutions per minute for 15 minutes. The subsequent two times are mixed at a high speed of 600 revolutions per minute respectively, and the total duration is controlled at 30 minutes. Finally, a bubble-free homogeneous drug-containing gel is obtained.

[0023] In a preferred embodiment, in step S8, a servo-controlled coating unit is used for operation. The doctor blade gap is set at 0.35 mm, and the web running speed is 2 m / min. The medicated gel is continuously coated on a medical non-woven fabric substrate with a grammage of 45 g / m², and the coating thickness is monitored in the range of 0.25 - 0.35 mm by a real-time laser thickness gauge. Immediately after coating, a release paper is laminated, and it is sent into a hot air circulation drying oven. The oven temperature is set at 40 °C, the wind speed is 2 m / s, and the curing time is 90 minutes.

[0024] In a preferred embodiment, in step S9, the formed patch passes through a cobalt-60 irradiation sterilization chamber via a conveyor belt. The irradiation dose is set at 10 kGy, and the conveyor belt speed is 0.5 m / s to ensure uniform absorption dose of the product. After sterilization, it is sealed and packaged with an aluminum foil composite film, and left standing in an equilibrium chamber at a temperature of 25 °C and a relative humidity of 30% for 24 hours to stabilize the water content of the patch in the range of 4.5% - 5.5%. After passing the quality inspection, it is packed and stored.

[0025] In summary, due to the adoption of the above technical solutions, the beneficial effects of the present invention are as follows:

[0026] 1. In the present invention, through the organic integration of traditional Chinese medicine theory and modern preparation technology, a multi-dimensional synergistic effect is achieved. The core lies in constructing a dynamic action system of "warming and dredging - penetrating and dispersing - sustained release": The monarch drugs Notopterygium incisum and Clematis chinensis play the main effect of dispelling wind and dampness, and cooperate with the collaterals dredging network formed by Angelica pubescens and Ligusticum chuanxiong to deeply dissolve the cold-damp blockage in joints; the warming meridian properties of Cinnamomum cassia and Artemisia argyi can activate local microcirculation, and the bidirectional penetration effect of Lycopodium clavatum and Speranskia tuberculata enhances the penetration of drug efficacy into deep tissues. The innovatively introduced capsaicin and clove oil form an alternating cold and heat stimulation, which not only promotes capillary dilation to accelerate drug absorption but also relieves the hot burning discomfort of traditional plasters through a cooling effect, achieving a balanced improvement in treatment comfort.

[0027] 2. In the present invention, through the triple technologies of nano-powder drug loading, microcapsule controlled release, and gel sustained release, a gradient release of drug components is achieved. The quick-acting components such as Notopterygium incisum and Clematis chinensis are rapidly released in the first 2 hours to relieve pain, the collaterals dredging substances such as Angelica pubescens and Ligusticum chuanxiong are continuously released in the middle period of 4 - 6 hours to improve circulation, and the long-term conditioning is maintained by components such as Gentiana macrophylla and Speranskia tuberculata for more than 8 hours in the later period. The hydrophilic gel matrix is combined with the natural tea tree oil anti-corrosion system, which not only maintains skin breathability to reduce the risk of allergy but also avoids the stuffy disadvantages of traditional rubber patches through humidity regulation, making the treatment process have the dual advantages of deep repair and comfortable body feeling. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the process principle of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0029] To make the objectives, technical solutions and advantages of the present invention more clear and understandable, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0030] Embodiment:

[0031] Referring to Figure 1 , a preparation method of a health-care medicated patch for dispelling wind and removing dampness, the health-care medicated patch for dispelling wind and removing dampness includes:

[0032] Group of traditional Chinese medicine extracts:

[0033] 6 parts by weight of Notopterygium incisum extract; 5 parts by weight of Clematis chinensis extract; 5 parts by weight of Angelica pubescens ultrafine powder; 4 parts by weight of Ligusticum wallichii nanopowder; 4 parts by weight of volatile oil of Cinnamomum cassia; 3 parts by weight of essential oil of Artemisia argyi; 5 parts by weight of alcohol extract of Lycopodium clavatum; 5 parts by weight of water extract of Speranskia tuberculata; 3 parts by weight of alkaloids of Gentiana macrophylla;

[0034] Modern synergistic group:

[0035] 2 parts by weight of microcapsules of clove oil; 0.5 part by weight of sustained-release microparticles of capsaicin; 1.5 parts by weight of β-cyclodextrin inclusion complex of menthol; 1 part by weight of azone (penetration enhancer); 2 parts by weight of tea tree oil (natural preservative) Matrix group:

[0036] 25 parts by weight of hydrophilic polymer gel matrix; 8 parts by weight of glycerol (humectant); 6 parts by weight of sodium carboxymethylcellulose; 4 parts by weight of sodium alginate; 3 parts by weight of deionized water.

[0037] A preparation method of a health-care medicated patch for dispelling wind and removing dampness includes the following steps:

[0038] S1: Put Notopterygium incisum and Clematis chinensis into a supercritical CO2 extraction device, set the pressure at 25 MPa and the temperature at 45 °C, separate the fat-soluble extract and concentrate it to a relative density of 1.15;

[0039] S2: Process Angelica pubescens with an ultrafine pulverizer until D90 < 10 μm, and prepare 200 - 400 nm nanopowder of Ligusticum wallichii using a nano pulverizer;

[0040] S3: Extract the volatile oil from Cinnamomum cassia and Artemisia argyi by steam distillation, and collect the essential oil components after condensation for standby;

[0041] S4: Reflux and extract Lycopodium clavatum three times with 70% ethanol, combine the extracts and concentrate them under reduced pressure to an alcohol-free extract;

[0042] S5: Mix clove oil and β-cyclodextrin in a molar ratio of 1:3, stir and include them at a constant temperature of 50 °C for 2 hours with magnetic stirring, and then spray-dry to prepare microcapsules;

[0043] S6: Swell the hydrophilic polymer gel matrix and sodium carboxymethylcellulose at 50 °C for 1.5 hours, add glycerol, sodium alginate and deionized water, and stir evenly to form a gel.

[0044] S7: Under nitrogen protection, add the traditional Chinese medicine extract, nano powder and capsaicin sustained-release microparticles in sequence, and mix the medicine in gradient with a three-way planetary mixer for 30 minutes.

[0045] S8: Use a precision coater to evenly coat the drug-containing gel on the breathable non-woven fabric, laminate the anti-stick release paper, and then dry and cure it by hot air circulation at 40 °C.

[0046] S9: The finished product is sterilized by cobalt-60 irradiation, then sealed and packaged, balanced in an environment with humidity < 30% for 24 hours, and stored in the warehouse after the transdermal absorption rate is tested and meets the standard.

[0047] In step S1, use a supercritical CO2 extraction device to process the raw materials of Notopterygium incisum and Clematis chinensis. Set the extraction pressure at 25 MPa, and keep the system temperature at 45 °C. Operate continuously for 150 minutes under constant dynamic extraction conditions to ensure the full release of active ingredients. After the extraction is completed, recover the extract through a two-stage separator, and concentrate it under reduced pressure in a water bath at 60 °C using a rotary evaporator to finally obtain a concentrated solution with a relative density of 1.15.

[0048] In step S2, when the raw material of Angelica pubescens is processed by an ultrafine pulverizer, a zirconia ceramic grinding disc is selected for three-stage pulverization. After initially coarsely pulverizing to 100 mesh, control the final particle size of the finished product through an air classification system to ensure that more than 90% of the particles are less than 10 microns. Ligusticum chuanxiong is processed by a high-energy nano pulverizer, and cyclic pulverization is carried out under the protection of liquid nitrogen at low temperature. Set the rotation speed at 2800 revolutions per minute and the pulverization time at 120 minutes to make the particle size stable within the range of 200 - 400 nanometers.

[0049] In step S3, put the raw materials of Cinnamomum cassia and Artemisia argyi into the distillation kettle at a ratio of 1:1, add 8 times the amount of deionized water for steam distillation. Control the distillation temperature at 100 °C for 6 hours, and collect the distillate after cooling it to 4 °C through a three-stage condenser. After standing and separating layers, take the upper oil phase and dehydrate it with anhydrous sodium sulfate to obtain a clear volatile oil for standby.

[0050] In step S4, after the raw material of Lycopodium clavatum is crushed to a particle size of 20 mesh, put it into a multi-functional extraction tank. Add 10 times the amount of 70% ethanol solution, set the reflux temperature at 78 °C, and each extraction time at 2 hours. Repeat the extraction operation three times. Combine the extraction solutions, remove impurities through a tubular centrifuge, and then transfer them to a vacuum concentration tank. Concentrate under the conditions of a temperature of 60 °C and a vacuum degree of -0.08 MPa to finally obtain a brownish-black extract.

[0051] In step S5, clove oil and β-cyclodextrin are accurately weighed according to a mass ratio of 1:3 and placed in a constant-temperature magnetic stirrer. The temperature is set at 50 °C, the stirring speed is 600 revolutions per minute, and the reaction continues for 2 hours to complete molecular inclusion. After the reaction solution is processed by a high-pressure homogenizer to form a uniform emulsion, it is dried through a centrifugal spray drying tower. The inlet air temperature is set at 180 °C and the outlet air temperature is 85 °C, and the microcapsule powder is collected.

[0052] In step S6, the hydrophilic polymer gel matrix and sodium carboxymethylcellulose are pre-screened through a 80-mesh sieve and mixed with deionized water in a constant-temperature stirring tank. The system temperature is maintained at 50 °C, and stirring continues at a speed of 400 revolutions per minute for 1.5 hours to complete sufficient swelling. Subsequently, glycerol and sodium alginate are added in sequence, the stirring speed is adjusted to 800 revolutions per minute, and stirring continues for 40 minutes to form a uniform translucent colloid.

[0053] In step S7, nitrogen is pre-introduced into a closed planetary mixer to displace the air. After stabilizing the temperature of the gel matrix at 40 °C, the traditional Chinese medicine extract and nano powder are added in three gradient steps. 30% of the powder is added for the first time and mixed at a low speed of 300 revolutions per minute for 15 minutes. The subsequent two times are mixed at a high speed of 600 revolutions per minute, and the total duration is controlled at 30 minutes to finally obtain a bubble-free homogeneous drug-containing gel.

[0054] In step S8, a servo-controlled coating unit is used for operation. The blade gap is set at 0.35 mm and the tape running speed is 2 m / min. The drug-containing gel is continuously coated on a medical non-woven fabric substrate with a grammage of 45 g / m², and the coating thickness is monitored by a real-time laser thickness gauge in the range of 0.25 - 0.35 mm. After coating, a release paper is immediately laminated and sent into a hot air circulation drying oven. The oven temperature is set at 40 °C, the wind speed is 2 m / s, and the curing time is 90 minutes.

[0055] In step S9, the formed patch passes through a cobalt-60 irradiation sterilization chamber by a conveyor belt. The irradiation dose is set at 10 kGy and the conveyor belt speed is 0.5 m / s to ensure uniform absorption dose of the product. After sterilization, it is sealed and packaged with an aluminum foil composite film, and left standing in a balance chamber at a temperature of 25 °C and a relative humidity of 30% for 24 hours to stabilize the water content of the patch in the range of 4.5% - 5.5%. After passing the quality inspection, it is packed and stored.

[0056] It can be seen from the above that:

[0057] In the present invention, a multi-dimensional synergistic effect is achieved through the organic integration of traditional Chinese medicine theory and modern preparation technology. The core lies in the construction of a dynamic action system of "warming-drying-dispersing-slow release": the main medicines Qianghuo and Weilingxian play the main effect of dispelling wind and dampness, and cooperate with the network of meridians formed by Duhuo and Chuanxiong to deeply resolve the blockage of cold and dampness in the joints; the warming properties of cinnamon twigs and mugwort leaves can activate local microcirculation, while the two-way penetration effect of smilax glabra and radix peony root enhances the penetration of the drug into deep tissues. The innovatively introduced capsaicin and clove oil form alternating hot and cold stimulation, which not only promotes capillary dilation and accelerates drug absorption, but also relieves the discomfort of heat burning of traditional plasters through the cooling effect, achieving a balanced improvement in treatment comfort.

[0058] In the present invention, the gradient release of drug ingredients is achieved through the triple technology of nanopowder drug loading, microcapsule controlled release and gel sustained release. In the first 2 hours, quick-acting ingredients such as Notopterygium and Clematis are quickly released to relieve pain. In the middle 4-6 hours, the meridian-draining substances such as Angelica dahurica and Chuanxiong are continuously released to improve circulation. In the later period, for more than 8 hours, ingredients such as Gentiana macrophylla and Radix Angelicae Pubescentis are used to maintain long-term conditioning. The hydrophilic gel matrix is combined with the natural preservative system of tea tree oil to maintain the breathability of the skin and reduce the risk of allergies, and to avoid the stuffiness of traditional rubber patches through humidity regulation, so that the treatment process has the dual advantages of deep repair and somatic comfort.

[0059] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the term "comprise" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0060] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A preparation method of a health care medicated plaster for dispelling wind and removing dampness, characterized in that: The preparation method includes the following steps: S1: Put Notopterygii Rhizoma and Clematidis Radix into a supercritical CO2 extraction device, set the pressure at 25 MPa and the temperature at 45 °C, separate the fat-soluble extract and concentrate it to a relative density of 1.15; S2: Angelicae Pubescentis Radix is processed by an ultrafine pulverizer until D90 < 10 μm, and Chuanxiong Rhizoma is prepared into 200 - 400 nm nano-powder by a nano pulverizer; S3: Ramulus Cinnamomi and Folium Artemisiae Argyi are subjected to steam distillation to extract volatile oils, and the essential oil components are collected after condensation for standby; S4: Lycopodiellae Herba is refluxed and extracted three times with 70% ethanol, and the combined extract is concentrated under reduced pressure to an alcohol-free extract; S5: Clove oil and β-cyclodextrin are mixed at a molar ratio of 1:3, magnetically stirred at a constant temperature of 50 °C for 2 hours, and then spray-dried to prepare microcapsules; S6: The hydrophilic polymer gel matrix and sodium carboxymethylcellulose are swollen at 50 °C for 1.5 hours, and glycerol, sodium alginate and deionized water are added and stirred evenly to form a gel; S7: Under nitrogen protection, the traditional Chinese medicine extract, nano-powder and capsaicin sustained-release microparticles are added in sequence, and a three-way planetary mixer is used to mix the medicine in a gradient manner for 30 minutes; S8: The drug-containing gel is evenly coated on the breathable non-woven fabric by a precision coater, and after laminating with a non-stick release paper, it is dried and cured by hot air circulation at 40 °C; S9: The finished product is sterilized by cobalt-60 irradiation and then sealed and packaged, balanced in an environment with a humidity < 30% for 24 hours, and stored in the warehouse after the transdermal absorption rate is detected to meet the standard.

2. The preparation method of a health medicated plaster for dispelling wind and removing dampness as claimed in claim 1, wherein: In step S1, the raw materials of Notopterygii Rhizoma and Clematidis Radix are processed by a supercritical CO2 extraction device, the extraction pressure is set at 25 MPa, and the system temperature is maintained at 45 °C; under constant dynamic extraction conditions, it runs continuously for 150 minutes to ensure the full release of active ingredients; after extraction, the extract is recovered by a two-stage separator, and concentrated under reduced pressure in a water bath at 60 °C using a rotary evaporator to finally obtain a concentrated solution with a relative density of 1.

15.

3. The preparation method of a health medicated plaster for dispelling wind and removing dampness as described in claim 1, characterized in that: In step S2, when the raw material of Angelicae Pubescentis Radix is processed by an ultrafine pulverizer, a zirconia ceramic grinding disc is selected for three-stage pulverization. After the initial coarse pulverization to 100 meshes, the final particle size of the finished product is controlled by an air classification system to ensure that more than 90% of the particles are less than 10 microns; Chuanxiong Rhizoma is processed by a high-energy nano pulverizer, and cyclic pulverization is carried out under the protection of liquid nitrogen at low temperature. The rotation speed is set at 2800 revolutions per minute and the pulverization time is 120 minutes to make the particle size stable in the range of 200 - 400 nm.

4. The preparation method of a health medicated plaster for dispelling wind and removing dampness according to claim 1, characterized in that: In step S3, the raw materials of Ramulus Cinnamomi and Folium Artemisiae Argyi are put into the distillation kettle at a ratio of 1:1, and 8 times the amount of deionized water is added for steam distillation; the distillation temperature is controlled at 100 °C for 6 hours, and the distillate is cooled to 4 °C by a three-stage condenser and then collected; after standing and separating, the upper oil phase is taken and dehydrated with anhydrous sodium sulfate to obtain clarified volatile oil for standby.

5. The preparation method of a kind of anti-wind and dehumidifying health medicated patch according to claim 1, characterized in that: In step S4, after the raw material of Lycopodiellae Herba is crushed to a particle size of 20 meshes, it is put into a multi-functional extraction tank; 10 times the amount of 70% ethanol solution is added, the reflux temperature is set at 78 °C, and the extraction time for each time is 2 hours. The extraction operation is repeated three times; the combined extract is removed from impurities by a tubular centrifuge and then transferred to a vacuum concentration tank, and concentrated under the conditions of a temperature of 60 °C and a vacuum degree of -0.08 MPa to finally obtain a brownish paste.

6. The preparation method of a health medicated plaster for dispelling wind and removing dampness as described in claim 1, characterized in that: In step S5, clove oil and β-cyclodextrin are accurately weighed at a mass ratio of 1:3 and placed in a thermostatic magnetic stirrer. The temperature is set at 50 °C, the stirring speed is 600 r / min, and the reaction lasts for 2 hours to complete molecular inclusion. After the reaction solution is processed by a high-pressure homogenizer to form a uniform emulsion, it is dried through a centrifugal spray drying tower. The inlet air temperature is set at 180 °C, the outlet air temperature is 85 °C, and the microcapsule powder is collected.

7. The preparation method of a health medicated plaster for dispelling wind and removing dampness according to claim 1, characterized in that: In step S6, the hydrophilic polymer gel matrix and sodium carboxymethylcellulose are pre-screened through a 80-mesh sieve and mixed with deionized water in a thermostatic stirring tank. The system temperature is maintained at 50 °C, and stirring is continued at a speed of 400 r / min for 1.5 hours to complete sufficient swelling. Subsequently, glycerol and sodium alginate are added in sequence, the stirring speed is adjusted to 800 r / min, and stirring is continued for 40 minutes to form a uniform translucent colloid.

8. The preparation method of a health medicated plaster for dispelling wind and removing dampness as claimed in claim 1, characterized in that: In step S7, in a closed planetary mixer, nitrogen is pre-introduced to displace air. After stabilizing the temperature of the gel matrix at 40 °C, the traditional Chinese medicine extract and nano powder are added in three gradients. For the first time, 30% of the powder is added and mixed at a low speed of 300 r / min for 15 minutes. The subsequent two times are mixed at a high speed of 600 r / min respectively, and the total duration is controlled at 30 minutes to finally obtain a bubble-free homogeneous drug-containing gel.

9. The preparation method of a health care medicated plaster for dispelling wind and removing dampness as claimed in claim 1, characterized in that: In step S8, a servo-controlled coating unit is used for operation. The doctor blade gap is set at 0.35 mm and the web speed is 2 m / min. The drug-containing gel is continuously coated on a medical non-woven fabric substrate with a grammage of 45 g / m², and the coating thickness is monitored by a real-time laser thickness gauge in the range of 0.25 - 0.35 mm. Immediately after coating, a release paper is laminated, and it is sent into a hot air circulation drying oven. The temperature of the oven is set at 40 °C, the wind speed is 2 m / s, and the curing time is 90 minutes.

10. The preparation method of a health care medicated patch for dispelling wind and removing dampness as described in claim 1, characterized in that: In step S9, the formed patch passes through a cobalt-60 irradiation sterilization chamber by a conveyor belt. The irradiation dose is set at 10 kGy, and the conveyor belt speed is 0.5 m / s to ensure uniform absorption dose of the product. After sterilization, it is sealed and packaged with an aluminum foil composite film, and left standing in a balance chamber at a temperature of 25 °C and a relative humidity of 30% for 24 hours to make the water content of the patch stable in the range of 4.5% - 5.5%. After passing the quality inspection, it is packed in boxes for storage.

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