Traditional Chinese medicine composition for treating bone fracture and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating bone fracture and a preparation method thereof. In the traditional Chinese medicine composition, angelica sinensis and ligusticum wallichii are used as monarch drugs for dispelling wind and eliminating dampness and eliminating cold to stop pain, notopterygium root, radix angelicae pubescentis, cassia twig and frankincense are used as ministerial drugs for assisting the monarch drugs to play roles and enhancing the curative effect of the monarch drugs, lycopodium clavatum, codonopsis pilosula and atractylodes macrocephala are used as adjuvant drugs for promoting blood circulation to remove blood stasis, promoting qi circulation to relieve pain and tonifying spleen to excrete dampness, and liquorice is used as a conductant drug for reconciling the drugs. All the components in the formula have a synergistic effect, so that the traditional Chinese medicine composition has the effects of dispelling wind and eliminating dampness, eliminating cold to stop pain and invigorating spleen and replenishing qi, and is used for treating bone fracture diseases.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and relates to a traditional Chinese medicine composition for treating bone injuries and its preparation method. Background Technology

[0002] In Traditional Chinese Medicine (TCM) clinical practice, common bone and joint injuries are mainly classified into five categories: fractures, joint diseases, soft tissue injuries, spinal diseases, and bone tumors. The main symptoms are swelling and pain. Western medicine often uses surgery, but postoperative complications are common. Drug treatment mainly uses analgesics and anti-inflammatory drugs, but these have limitations such as drug dependence and gastrointestinal reactions.

[0003] The causes of orthopedic diseases are nothing more than internal and external factors. Internal factors are mostly due to spleen and stomach weakness, liver and kidney deficiency, and lack of nourishment for tendons and bones. External factors are mostly due to external forces such as falls, which lead to local blood stasis and meridian blockage.

[0004] The pathogenesis of bone and joint injuries is quite complex. In clinical practice, we must not stick to conventional methods. We should pay attention to the unique syndrome differentiation and treatment and holistic concept of traditional Chinese medicine, and optimize the combination of herbs. Summary of the Invention

[0005] In view of this, the present invention provides a traditional Chinese medicine composition for treating bone injuries and a method for preparing the same.

[0006] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating bone injuries, the composition comprising the following components in parts by weight: 25-35 parts Angelica sinensis, 25-35 parts Ligusticum chuanxiong, 10-15 parts Notopterygium incisum, 10-15 parts Angelica pubescens, 10-20 parts Cinnamomum cassia, 10-20 parts Boswellia carterii, 15-25 parts Lycopodium clavatum, 10-20 parts Codonopsis pilosula, 10-15 parts Atractylodes macrocephala, and 4-8 parts Glycyrrhiza uralensis.

[0007] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 30 parts Angelica sinensis, 30 parts Ligusticum chuanxiong, 12 parts Notopterygium incisum, 12 parts Angelica pubescens, 15 parts Cinnamomum cassia, 15 parts Boswellia carterii, 20 parts Lycopodium clavatum, 15 parts Codonopsis pilosula, 12 parts Atractylodes macrocephala, and 6 parts Glycyrrhiza uralensis.

[0008] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 25 parts Angelica sinensis, 35 parts Ligusticum chuanxiong, 10 parts Notopterygium incisum, 15 parts Angelica pubescens, 10 parts Cinnamomum cassia, 10 parts Boswellia carterii, 25 parts Lycopodium clavatum, 20 parts Codonopsis pilosula, 10 parts Atractylodes macrocephala, and 4 parts Glycyrrhiza uralensis.

[0009] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 35 parts Angelica sinensis, 25 parts Ligusticum chuanxiong, 15 parts Notopterygium incisum, 10 parts Angelica pubescens, 20 parts Cinnamomum cassia, 20 parts Boswellia carterii, 15 parts Lycopodium clavatum, 10 parts Codonopsis pilosula, 15 parts Atractylodes macrocephala, and 8 parts Glycyrrhiza uralensis.

[0010] In a second aspect, the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating bone injuries, comprising the following steps: weighing the raw materials according to the above-mentioned weight parts, mixing them, adding purified water at a ratio of 1:8-10, soaking for 30 minutes, decocting 2-3 times, each time decocting for 0.5-1.5 hours, concentrating, and obtaining the traditional Chinese medicine composition.

[0011] In some embodiments of the present invention, the preparation method of the traditional Chinese medicine composition for treating bone injuries includes the following steps: weighing the raw materials according to the above-mentioned weight parts, mixing them, adding purified water at a ratio of 1:8, soaking for 30 minutes, decocting twice, each time for 1 hour, concentrating, and obtaining the traditional Chinese medicine composition.

[0012] A third aspect of the present invention provides a traditional Chinese medicine preparation of a traditional Chinese medicine composition for treating bone injuries, characterized in that the traditional Chinese medicine preparation is made from the above-mentioned traditional Chinese medicine composition for treating bone injuries.

[0013] Furthermore, the traditional Chinese medicine preparation also includes pharmaceutically acceptable excipients. The dosage form of the traditional Chinese medicine preparation is granules, pills, capsules, tablets, powders, or oral liquids.

[0014] A fourth aspect of the present invention provides the use of the traditional Chinese medicine composition for treating bone injuries in the preparation of a medicament for the prevention or treatment of bone injury diseases.

[0015] Furthermore, the bone injury disease is a fracture or soft tissue injury.

[0016] The beneficial effects of the traditional Chinese medicine composition for treating bone injuries of this invention are as follows: In this invention's herbal composition, Angelica sinensis and Ligusticum chuanxiong dispel wind and dampness, disperse cold and relieve pain, serving as the principal herbs. Notopterygium incisum, Angelica pubescens, Cinnamomum cassia, and Boswellia carterii serve as the assistant herbs, assisting the principal herbs in their effects and enhancing their efficacy. Lycopodium clavatum, Codonopsis pilosula, and Atractylodes macrocephala invigorate blood circulation, remove blood stasis, promote qi circulation, relieve pain, strengthen the spleen, and eliminate dampness, serving as the adjuvant herbs. Glycyrrhiza uralensis serves as the guiding herb, harmonizing the effects of all the herbs. The synergistic effect among the components of this formula enables the herbal composition of this invention to dispel wind and dampness, disperse cold and relieve pain, strengthen the spleen and replenish qi, and is used to treat bone and joint injuries.

[0017] The herbal composition of this invention significantly reduces whole blood viscosity (high shear and low shear) and plasma specific viscosity in rats with bone injuries, and significantly increases bone calcium content, thus having a positive therapeutic effect on bone injuries.

[0018] The herbal composition of this invention significantly reduces the injury index score and has a positive therapeutic effect on soft tissue injuries. Attached Figure Description

[0019] Figure 1 For comparison of low-shear 10 / S whole blood viscosity, compared with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01.

[0020] Figure 2 For the comparison of high-shear 200 / S whole blood viscosity with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01.

[0021] Figure 3 For comparison of plasma viscosity, compared with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01.

[0022] Figure 4 For comparison of bone calcium content, compared with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01.

[0023] Figure 5 For comparison of injury index scores, compared with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01. Detailed Implementation

[0024] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0025] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be readily apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0026] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0027] Unless otherwise specified, the technical solutions described in this invention are all conventional solutions in the field, and the reagents or raw materials used are all purchased from commercial channels or are publicly available unless otherwise specified.

[0028] Example 1: A traditional Chinese medicine composition for treating bone injuries Angelica sinensis 30 parts, Ligusticum chuanxiong 30 parts, Notopterygium incisum 12 parts, Angelica pubescens 12 parts, Cinnamomum cassia 15 parts, Boswellia carterii 15 parts, Lycopodium clavatum 20 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 12 parts, Glycyrrhiza uralensis 6 parts.

[0029] Weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:8, soak for 30 minutes, decoct twice, each time for 1 hour, concentrate, and obtain the Chinese herbal composition.

[0030] Example 2: A traditional Chinese medicine composition for treating bone injuries Angelica sinensis 25 parts, Ligusticum chuanxiong 35 parts, Notopterygium incisum 10 parts, Angelica pubescens 15 parts, Cinnamomum cassia 10 parts, Boswellia carterii 10 parts, Lycopodium clavatum 25 parts, Codonopsis pilosula 20 parts, Atractylodes macrocephala 10 parts, Glycyrrhiza uralensis 4 parts.

[0031] Weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:10, soak for 30 minutes, decoct twice, each time for 1.5 hours, concentrate, and obtain the Chinese herbal composition.

[0032] Example 3: A traditional Chinese medicine composition for treating bone injuries Angelica sinensis 35 parts, Ligusticum chuanxiong 25 parts, Notopterygium incisum 15 parts, Angelica pubescens 10 parts, Cinnamomum cassia 20 parts, Boswellia carterii 20 parts, Lycopodium clavatum 15 parts, Codonopsis pilosula 10 parts, Atractylodes macrocephala 15 parts, Glycyrrhiza uralensis 8 parts.

[0033] Weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:9, soak for 30 minutes, decoct 3 times, each time for 0.5 hours, concentrate, and obtain the Chinese herbal composition.

[0034] Example 4: A traditional Chinese medicine composition for treating bone injuries Angelica sinensis 30 parts, Ligusticum chuanxiong 25 parts, Notopterygium incisum 15 parts, Angelica pubescens 10 parts, Cinnamomum cassia 10 parts, Boswellia carterii 15 parts, Lycopodium clavatum 20 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 15 parts, Glycyrrhiza uralensis 8 parts.

[0035] Weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:8, soak for 30 minutes, decoct twice, each time for 1 hour, concentrate, and obtain the Chinese herbal composition.

[0036] Example 5: A traditional Chinese medicine composition for treating bone injuries Angelica sinensis 35 parts, Ligusticum chuanxiong 35 parts, Notopterygium incisum 12 parts, Angelica pubescens 15 parts, Cinnamomum cassia 20 parts, Boswellia carterii 10 parts, Lycopodium clavatum 15 parts, Codonopsis pilosula 20 parts, Atractylodes macrocephala 12 parts, Glycyrrhiza uralensis 6 parts.

[0037] Weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:9, soak for 30 minutes, decoct twice, each time for 1.5 hours, concentrate, and obtain the Chinese herbal composition.

[0038] Example 6: A traditional Chinese medicine composition for treating bone injuries Angelica sinensis 25 parts, Ligusticum chuanxiong 35 parts, Notopterygium incisum 10 parts, Angelica pubescens 12 parts, Cinnamomum cassia 15 parts, Boswellia carterii 20 parts, Lycopodium clavatum 25 parts, Codonopsis pilosula 10 parts, Atractylodes macrocephala 10 parts, Glycyrrhiza uralensis 4 parts.

[0039] Weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:10, soak for 30 minutes, decoct 3 times, each time for 1 hour, concentrate, and obtain the Chinese herbal composition.

[0040] Comparative Example 1 Angelica sinensis 30 parts, Notopterygium incisum 12 parts, Angelica pubescens 12 parts, Cinnamomum cassia 15 parts, Boswellia carterii 15 parts, Lycopodium clavatum 20 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 12 parts, Glycyrrhiza uralensis 6 parts.

[0041] Compared with Example 1, the difference is that it does not contain Ligusticum chuanxiong, while the other components and dosages remain the same.

[0042] The preparation method is the same as in Example 1.

[0043] Comparative Example 2 30 parts of Ligusticum chuanxiong, 12 parts of Notopterygium incisum, 12 parts of Angelica pubescens, 15 parts of Cinnamomum cassia, 15 parts of Boswellia carterii, 20 parts of Lycopodium clavatum, 15 parts of Codonopsis pilosula, 12 parts of Atractylodes macrocephala, and 6 parts of Glycyrrhiza uralensis.

[0044] Compared with Example 1, the difference is that it does not contain Angelica sinensis, while the other components and their amounts remain the same.

[0045] The preparation method is the same as in Example 1.

[0046] Comparative Example 3 Angelica sinensis 30 parts, Ligusticum chuanxiong 30 parts, Angelica pubescens 12 parts, Boswellia carterii 15 parts, Lycopodium clavatum 20 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 12 parts, Glycyrrhiza uralensis 6 parts.

[0047] Compared with Example 1, the difference is that it does not contain Notopterygium root or cinnamon twig, while the other components and dosages remain the same.

[0048] The preparation method is the same as in Example 1.

[0049] Comparative Example 4 Angelica sinensis 30 parts, Ligusticum chuanxiong 30 parts, Notopterygium incisum 12 parts, Saposhnikovia divaricata 12 parts, Cinnamomum cassia 15 parts, Commiphora myrrha 15 parts, Lycopodium clavatum 20 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 12 parts, Glycyrrhiza uralensis 6 parts.

[0050] Compared with Example 1, the difference is that Saposhnikovia divaricata is used instead of Angelica pubescens, and Myrrh is used instead of Boswellia carterii, while the other components and dosages remain unchanged.

[0051] The preparation method is the same as in Example 1.

[0052] Study on the effects of the traditional Chinese medicine composition of this invention on a rat model of bone injury 1. Experimental Methods Fifty-four SPF-grade male SD rats, weighing 180-220g, were randomly selected as the normal control group (n=6) and the remaining rats as the model group (n=6).

[0053] In the model group, rats underwent a closed artificial fracture manually induced in the lower third of their left calf under light ether anesthesia. The fractures were not fixed post-surgery, and the rats were divided into groups and administered medication starting from the day of surgery.

[0054] After modeling, the rats were randomly divided into four groups: model control group, experimental group 1, experimental group 2, experimental group 3, control group 1, control group 2, control group 3, and control group 4, with 6 rats in each group.

[0055] The experimental groups and gavage protocols are shown in Table 1.

[0056] Table 1. Gavage regimens for each group of rats Each group was administered the medication by gavage once daily for 15 consecutive days.

[0057] 2. Detection indicators 2.1 X-ray examination X-ray images of the affected limb (50KV, 50mA, 0.08s) were taken 15 days after drug administration for examination.

[0058] 2.2 Measurement of whole blood viscosity and plasma viscosity After X-rays were taken on day 15, rats in each group were anesthetized with 1 g / kg urethane, and blood was collected from the abdominal aorta. Whole blood viscosity and plasma viscosity were measured using a cone-plate viscometer.

[0059] 2.3 Determination of bone calcium content Take a specimen from the fracture site, dry it, digest it with 0.1g of digestive solution (perchloric acid: concentrated nitric acid = 3:1), make up to 10ml with deionized water, and determine the bone calcium content using an atomic absorption spectrophotometer.

[0060] 3. Statistical Methods Data processing was performed using GraphPad Prism 8.0 software, with the measurement data presented in... ±s indicates that statistical differences between groups were compared using one-way ANOVA, and P<0.05 indicates that the difference was statistically significant.

[0061] 4. Experimental Results 4.1 X-ray examination results On day 15 post-fracture, the fracture line was blurred in the control rats, and a small amount of external callus was observed. In experimental groups 1, 2, and 3, the fracture line was blurred, and a large amount of external callus was observed. The number of external callus in experimental groups 1, 2, and 3 was greater than that in control groups 1-4.

[0062] 4.2 Effects on whole blood viscosity and plasma viscosity in rats Table 2 Results of whole blood viscosity and plasma viscosity in each group Note: Compared with the normal control group, & P < 0.05 && P < 0.01; Compared with the model control group, P < 0.05 P < 0.01; Compared with Experiment 1, # P < 0.05 ## P < 0.01.

[0063] The results are shown in Table 2. Figures 1-3 .

[0064] Compared with the normal control group, the whole blood viscosity (high shear and low shear) and plasma specific viscosity of the rats in the model control group were significantly increased.

[0065] Compared with the model control group, the whole blood viscosity (high shear and low shear) and plasma specific viscosity of rats in experimental groups 1, 2 and 3 were significantly reduced.

[0066] Compared with control groups 1-4, experimental groups 1, 2, and 3 showed significant differences in reducing whole blood viscosity (high shear and low shear) and plasma specific viscosity.

[0067] 4.3 Effects on bone calcium content in rats See results Figure 4 .

[0068] Compared with the model control group, the bone calcium content of rats in experimental groups 1, 2 and 3 was significantly increased.

[0069] Compared with control groups 1-4, experimental groups 1, 2, and 3 showed significant differences in increasing bone calcium content.

[0070] The herbal composition of this invention significantly reduces whole blood viscosity (high shear and low shear) and plasma specific viscosity in rats with bone injuries, and increases bone calcium content, thus having a positive therapeutic effect on bone injuries.

[0071] Comparative Example 1's herbal composition did not contain Ligusticum chuanxiong; Comparative Example 2's herbal composition did not contain Angelica sinensis; Comparative Example 3's herbal composition did not contain Notopterygium incisum or Cinnamomum cassia; Comparative Example 4's herbal composition used Saposhnikovia divaricata instead of Angelica pubescens and Myrrh instead of Boswellia carterii. Compared with the control groups 1-4, the improvement effects of each indicator in experimental groups 1, 2, and 3 were more significant. Animal experimental results proved that the components of the herbal composition of this invention are indispensable and have a synergistic effect in the treatment of bone injuries.

[0072] Study on the effects of the traditional Chinese medicine composition of this invention on a rat model of soft tissue injury 1. Experimental Methods Twenty-four SPF-grade SD rats, weighing 180-220g, were randomly selected as the normal control group (n=6) and the remaining rats as the model group (n=6).

[0073] Twenty-four hours before the experiment, the rats in the model group had their hair removed from their right hind leg with 10% sodium sulfide solution. The location was identified and marked. After anesthetizing with ether, two hemostatic forceps were clamped onto the marked point of the rat for 50 seconds to cause soft tissue injury.

[0074] After modeling, the rats were randomly divided into a model control group, Example 1 group, and Example 2 group, with 6 rats in each group. Example 1 and Example 2 groups were administered the herbal compositions of Example 1 and Example 2 by gavage at a dose of 21.5 g / kg (based on crude drug). The normal control group and the model control group were administered an equal volume of distilled water by gavage.

[0075] Administer once daily for 8 consecutive days.

[0076] 2. Damage Index Score 0 points: Complete recovery, the tissue is the same as normal tissue; 1 point: No bleeding foci on the surface, but occasional sagittal hemorrhage or ecchymosis foci are seen when the soft tissue is cut open; 2 points: Areas of bleeding, ecchymosis, and edema smaller than 0.5 cm are visible on the surface; 3 points: Bleeding, ecchymosis and edema areas larger than 1 cm are seen on the surface.

[0077] 3. Statistical Methods Data processing was performed using GraphPad Prism 8.0 software, with the measurement data presented in... ±s indicates that statistical differences between groups were compared using one-way ANOVA, and P<0.05 indicates that the difference was statistically significant.

[0078] 4. Experimental Results See results Figure 5 .

[0079] Compared with the normal control group, the damage index score of rats in the model control group was significantly increased.

[0080] Compared with the model control group, the damage index scores of rats in experimental groups 1, 2 and 3 were significantly reduced.

[0081] The herbal composition of this invention significantly reduces the injury index score and has a positive therapeutic effect on soft tissue injuries.

[0082] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating bone injuries, characterized in that, The traditional Chinese medicine composition for treating bone injuries comprises the following components in parts by weight: Angelica sinensis 25-35 parts, Ligusticum chuanxiong 25-35 parts, Notopterygium incisum 10-15 parts, Angelica pubescens 10-15 parts, Cinnamomum cassia 10-20 parts, Boswellia carterii 10-20 parts, Lycopodium clavatum 15-25 parts, Codonopsis pilosula 10-20 parts, Atractylodes macrocephala 10-15 parts, and Glycyrrhiza uralensis 4-8 parts.

2. The traditional Chinese medicine composition for treating bone injuries according to claim 1, characterized in that, The traditional Chinese medicine composition for treating bone injuries comprises the following components in parts by weight: Angelica sinensis 30 parts, Ligusticum chuanxiong 30 parts, Notopterygium incisum 12 parts, Angelica pubescens 12 parts, Cinnamomum cassia 15 parts, Boswellia carterii 15 parts, Lycopodium clavatum 20 parts, Codonopsis pilosula 15 parts, Atractylodes macrocephala 12 parts, and Glycyrrhiza uralensis 6 parts.

3. The traditional Chinese medicine composition for treating bone injuries according to claim 1, characterized in that, The traditional Chinese medicine composition for treating bone injuries comprises the following components in parts by weight: Angelica sinensis 25 parts, Ligusticum chuanxiong 35 parts, Notopterygium incisum 10 parts, Angelica pubescens 15 parts, Cinnamomum cassia 10 parts, Boswellia carterii 10 parts, Lycopodium clavatum 25 parts, Codonopsis pilosula 20 parts, Atractylodes macrocephala 10 parts, and Glycyrrhiza uralensis 4 parts.

4. The traditional Chinese medicine composition for treating bone injuries according to claim 1, characterized in that, The traditional Chinese medicine composition for treating bone injuries comprises the following components in parts by weight: Angelica sinensis 35 parts, Ligusticum chuanxiong 25 parts, Notopterygium incisum 15 parts, Angelica pubescens 10 parts, Cinnamomum cassia 20 parts, Boswellia carterii 20 parts, Lycopodium clavatum 15 parts, Codonopsis pilosula 10 parts, Atractylodes macrocephala 15 parts, and Glycyrrhiza uralensis 8 parts.

5. The method for preparing the traditional Chinese medicine composition for treating bone injuries according to any one of claims 1-4, characterized in that, The preparation method includes the following steps: weigh the raw materials according to the above weight proportions, mix them, add purified water at a drug-liquid ratio of 1:8-10, soak for 30 minutes, decoct 2-3 times, each time for 0.5-1.5 hours, concentrate, and obtain the traditional Chinese medicine composition.

6. The method for preparing the traditional Chinese medicine composition for treating bone injuries according to claim 5, characterized in that, The preparation method includes the following steps: weigh the raw materials according to the above weight proportions, mix them, add purified water at a ratio of 1:8, soak for 30 minutes, decoct twice, each time for 1 hour, concentrate, and obtain the traditional Chinese medicine composition.

7. A traditional Chinese medicine preparation comprising a traditional Chinese medicine composition for treating bone injuries, characterized in that, The traditional Chinese medicine preparation is made from the traditional Chinese medicine composition for treating bone injuries as described in any one of claims 1-4.

8. The traditional Chinese medicine preparation of the traditional Chinese medicine composition for treating bone injuries according to claim 7, characterized in that, The traditional Chinese medicine preparation also includes pharmaceutically acceptable excipients, and the dosage form of the traditional Chinese medicine preparation is granules, pills, capsules, tablets, powders or oral liquids.

9. The use of the traditional Chinese medicine composition for treating bone injuries according to any one of claims 1-4 in the preparation of a medicine for preventing or treating bone injuries.

10. The use according to claim 9, characterized in that, The bone injury refers to a fracture caused by disease or a soft tissue injury.

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