Miao medicine composition for prostate health care

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a Miao medicine composition for prostate health care. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of bulbophyllum, 8-15 parts of phryma leptostachya, 5-12 parts of sambucus chinensis, 3-8 parts of pseudo-ginseng and 2-6 parts of ethanol. The Miao medicine composition is prepared by the following steps: washing, drying and mixing the sambucus chinensis, the phryma leptostachya, the sambucus chinensis and the pseudo-ginseng, adding an ethanol water solution for soaking, and filtering to obtain an extracting solution, namely the Miao medicine composition. The Miao medicine composition can be used for relieving symptoms such as frequent micturition, urgent urination and unsmooth urination caused by benign prostatic hyperplasia and chronic inflammation, and can be used for improving local blood circulation and microcirculation; the powerful targeting effect on deep target tissue prostate is realized, so that the enhanced curative effect of treating both symptoms and root causes is achieved; the traditional Chinese medicine composition has the advantages of quick response, remarkable and lasting curative effect, high safety and good patient comfort and acceptability.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine technology, and more specifically, to a Miao medicine composition for prostate health care. Background Technology

[0002] In the field of prostate health, traditional Chinese medicine (TCM) regulates the functions of organs closely related to prostate health, such as the kidneys, liver, and bladder, through internal or external application of herbal remedies. Its advantages lie in its ability to not only specifically improve local symptoms such as frequent urination, urgency, and difficulty urinating, but also to simultaneously regulate the body's overall balance, enhance immunity, and slow down the process of glandular hyperplasia. Compared to some Western medicines, TCM typically focuses on gentle, multi-target, and multi-pathway regulation, aiming to fundamentally restore normal prostate function, reduce the possibility of recurrence, and has relatively fewer side effects, making it suitable for long-term health maintenance.

[0003] Related traditional Chinese medicines are applied topically and absorbed through the skin to directly act on the lower abdomen and perineum, aiming to relax muscles and tendons, and resolve blood stasis and nodules. However, the topical application or simple smearing method is often limited by the skin barrier, making it difficult for the active ingredients of the medicine to effectively penetrate deep tissues and accumulate in the target organ, the prostate. This results in insufficient depth and intensity of local therapeutic effect, relatively slow onset of action, and affects the overall conditioning effect. Summary of the Invention

[0004] In order to address the problem that the depth and intensity of local therapeutic effects are insufficient when related traditional Chinese medicines are directly applied to the lower abdomen and perineum through external transdermal absorption, this application provides a Miao medicine composition for prostate health care.

[0005] This application provides a Miao medicine composition for prostate health care, using the following technical solution:

[0006] A Miao medicine composition for prostate health care is made from the following raw materials in parts by weight: 10-20 parts of Clematis chinensis, 8-15 parts of Clematis armandii, 5-12 parts of Clematis armandii, 3-8 parts of Panax notoginseng, and 2-6 parts of ethanol. The Miao medicine composition is prepared by the following steps: Clematis chinensis, Clematis armandii, Clematis armandii and Panax notoginseng are washed, dried and mixed, soaked in an ethanol aqueous solution, and filtered to obtain an extract, which is the Miao medicine composition.

[0007] By adopting the above technical solution, and using a specific combination of Dragon's Breath, Clematis chinensis, Erigeron breviscapus, and Panax notoginseng, this composition exerts a synergistic effect of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain, and dispelling wind and dampness, and is specifically used for external treatment of prostate-related problems. At the same time, by mixing the dried medicinal materials and extracting them by soaking in an ethanol aqueous solution, the active ingredients in the medicinal materials can be effectively dissolved, and the resulting extract can be used as a massage medium, thus realizing the connection between drug preparation and external physiotherapy process.

[0008] Preferably, the concentration of the ethanol aqueous solution is 45%-50%.

[0009] By adopting the above technical solution, and using an ethanol aqueous solution with a concentration of 45% to 50% as the extraction solvent, this concentration range can better balance the extraction efficiency of active ingredients with different polarities. It can fully dissolve the alcohol-soluble active substances in the medicinal materials, while also taking into account some water-soluble components, thereby ensuring that the final Miao medicine composition extract has a comprehensive composition of effective components, laying a material foundation for subsequent therapeutic effects.

[0010] Preferably, the soaking period is 80-100 days.

[0011] By adopting the above technical solution, the soaking and extraction time is set to 80 to 100 days. This long standing soaking time allows the solvent to fully penetrate into the tissue of the medicinal material and slowly exchange the effective components into the liquid phase. It is a long-term soaking process at room temperature, which helps to maximize the extraction of active substances in the medicinal material, while avoiding component damage or volatility loss that may be caused by high temperature. This results in a high concentration of effective components and stable properties in the obtained extract.

[0012] Preferably, the raw material further comprises a transdermal absorption enhancer, which is one or more of azone, propylene glycol, or menthol.

[0013] By adopting the above technical solution, transdermal absorption enhancers such as azone, propylene glycol or menthol are added to the raw materials. These components can change the structure of the stratum corneum of the skin and reduce its barrier function, thereby increasing the transdermal penetration rate and absorption of the active ingredients in the Miao medicine composition. This promotes the drug to act on the prostate target tissue deep in the pelvic cavity, which can overcome the shortcomings of insufficient transdermal ability of simple topical drugs.

[0014] Preferably, the transdermal absorption enhancer is added after the filtration step, when mixed with the resulting extract.

[0015] By adopting the above technical solution, since the transdermal absorption promoter is added after the herbal extract is obtained by filtration, this process sequence can ensure that the chemical properties and physical state of the transdermal absorption promoter itself are not affected during the extraction process, avoiding its decomposition or failure during the long soaking stage. At the same time, it can also more accurately control its addition amount and uniformity in the final preparation, ensuring its stable performance in promoting transdermal function.

[0016] Preferably, the raw material further comprises natural plant essential oils, wherein the natural plant essential oils are one or more of tea tree oil, eucalyptus oil, or lavender oil.

[0017] By adopting the above technical solution, natural plant essential oils such as tea tree oil, eucalyptus oil, or lavender oil are added to the raw materials. These essential oils not only have certain antibacterial, anti-inflammatory, or soothing effects, and can produce an auxiliary therapeutic effect with the main Miao medicine ingredients, but also improve the smell of the preparation by utilizing their aromatic properties, thereby enhancing the user's sensory experience and acceptance during the treatment process. This makes the health care composition both effective and pleasant to use.

[0018] Preferably, the natural plant essential oil is added after the filtration step, when it is mixed with the resulting extract.

[0019] By adopting the above technical solution, since the natural plant essential oil is added to the extract after the filtration step, this operation method is mainly due to the fact that natural plant essential oil usually contains a large number of volatile terpenoids. If added in the early soaking step, the volatile components will be greatly lost during the soaking process which lasts for dozens of days, resulting in a reduction in efficacy. The post-addition process can retain the effective components and aroma of the essential oil to the greatest extent and ensure the complete presentation of its added value.

[0020] Preferably, in the drying step, the drying temperature of each raw material is 40-60°C, and the drying time is 120-180 min.

[0021] By adopting the above technical solution, the drying conditions of the medicinal materials are controlled within a temperature range of 40℃ to 60℃ and a drying time of 120 minutes to 180 minutes. This gentle drying process can effectively remove excess moisture from the surface and interior of the medicinal materials, which is conducive to subsequent soaking and extraction. At the same time, it avoids the destruction or degradation of heat-sensitive active ingredients in the medicinal materials due to excessively high temperatures or excessively long heating times, thereby ensuring the integrity of the active substances in the raw materials.

[0022] Preferably, the soaking step is carried out under light-protected conditions, and the soaking temperature is 20-30°C.

[0023] By adopting the above technical solution, the soaking process is required to be carried out under light-proof conditions and at an ambient temperature of 20°C to 30°C. The light-proof operation can prevent certain photosensitive chemical components in the medicinal materials from photodegrading or deteriorating during long-term soaking. This temperature range is the suitable range for room temperature soaking, which can maintain a certain molecular motion rate to facilitate component exchange and extraction, while avoiding excessively high temperatures that accelerate solvent evaporation or trigger unnecessary chemical reactions, thereby ensuring a stable extraction process and stable quality of the extract.

[0024] Preferably, the filtration step uses a 100-200 mesh filter and a filtration pressure of 0.1-0.3 MPa.

[0025] By adopting the above technical solution, the use of a 100-200 mesh filter and a pressure of 0.1 MPa to 0.3 MPa effectively traps insoluble impurities such as coarse particles and fibers in the soaking solution, resulting in a clear extract. At the same time, the combination of this mesh size range and pressure range ensures a moderate filtration speed, guaranteeing filtration efficiency without causing filter damage due to excessive pressure or forcing dissolved fine colloidal substances through, thus affecting the clarity and stability of the medicinal solution.

[0026] In summary, this application has the following beneficial effects:

[0027] 1. Since this application uses a specific Miao medicine composition as a massage medium and combines it with an acupoint massage process that includes Miao medicine pre-application, target acupoint vibration and circulatory consolidation, the physical fluctuations generated by the vibration technique increase the intercellular spaces and blood circulation of local tissues, thereby promoting the penetration and absorption of the active ingredients of the drug into the deep target tissue of the prostate. Therefore, it achieves an enhanced therapeutic effect by synergistic effect of drug penetration and physical vibration depth, resulting in a superimposed therapeutic effect.

[0028] 2. The technical solution provided in this application is a purely external treatment method, and uses the prepared Miao medicine spray as a massage medium. This method avoids the metabolic burden on the liver and kidneys and potential side effects caused by oral medication. At the same time, the gentle spray form combined with massage techniques can improve the comfort of operation and reduce the risk of skin damage. Therefore, the overall solution has high safety, good user experience and high user acceptance.

[0029] 3. This application uses a Miao medicine composition composed of Dragon's Breath, Clematis armandii, Eriocaulon buergerianum and Panax notoginseng in a certain ratio, and is prepared by soaking and extracting with ethanol aqueous solution. Because this composition has the synergistic effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and dispelling wind and dampness, and the extraction process can efficiently dissolve the active ingredients to form a massage medium that can be used directly, it can achieve the effect of external treatment of prostate and is easy to connect with the physiotherapy process. Attached Figure Description

[0030] Figure 1 This is a flowchart of the acupoint massage proposed in this application. Detailed Implementation

[0031] The present application will be further described in detail below with reference to the accompanying drawings and embodiments.

[0032] Technical concept:

[0033] This application uses a specific Miao medicine composition as a massage medium and combines it with an acupoint massage process that includes Miao medicine pre-application, target acupoint vibration and massage, and circulatory consolidation. The physical fluctuations generated by the vibration and massage technique increase the intercellular spaces and blood circulation of local tissues, thereby promoting the penetration and absorption of the active ingredients of the drug into the deep target tissue of the prostate. As a result, the enhanced therapeutic effect is achieved by synergistic effect of drug penetration and physical vibration and massage depth, producing a superimposed therapeutic effect.

[0034] Example 1: This example provides a Miao medicine composition for prostate health care, made from the following raw materials in parts by weight: 10 parts of Clematis chinensis, 8 parts of Clematis armandii, 5 parts of Sambucus chinensis, 3 parts of Panax notoginseng, 2 parts of ethanol, 0.5 parts of azone, and 0.3 parts of tea tree oil. The Miao medicine composition is prepared by the following steps: Clematis chinensis, Clematis armandii, Sambucus chinensis and Panax notoginseng are washed, dried at 40°C for 180 minutes and then mixed. A 45% ethanol aqueous solution is added for soaking. Soaking is carried out under light-protected conditions at a temperature of 20°C for 80 days. After soaking, the mixture is filtered through a 100-mesh filter under a pressure of 0.1 MPa to obtain an extract. Azone and tea tree oil are added to the obtained extract and mixed evenly to obtain the Miao medicine composition.

[0035] Based on the obtained Miao medicine composition, acupoint massage is performed, including the following steps:

[0036] S1. Pre-application and deep penetration of Miao medicine: The user lies supine with the lower abdomen exposed. Take an appropriate amount of the above-mentioned Miao medicine composition and spray it evenly onto the preheated Bian stone massager. Place the massager on the user's Shenque (CV8) and Guanyuan (CV4) acupoints, and maintain the vibration mode of the instrument for 25 minutes, during which time the Miao medicine composition is sprayed again every 8 minutes.

[0037] S2. Target Acupoint Vibration and Pressing: Assist the user to adjust to a side-lying position, exposing the perineal area. The operator uses the fingertips to gently massage the perineal acupoints in a circular motion for 1 minute, then applies steady and sustained static pressure for 8 minutes.

[0038] S3. Consolidation and Conclusion: With relaxed pressure, the operator massages the entire lower abdomen in a clockwise circular motion around the Guanyuan acupoint for 3 minutes, repeating twice. Finally, quickly rub the palms together to warm them, then gently cover the Guanyuan acupoint for 20 seconds to end the procedure; the entire process takes approximately 45 minutes.

[0039] Example 2: This example provides a Miao medicine composition for prostate health care, made from the following raw materials in parts by weight: 15 parts of Clematis chinensis, 11 parts of Clematis armandii, 8 parts of Sambucus chinensis, 5 parts of Panax notoginseng, 4 parts of ethanol, 1 part of propylene glycol, 0.2 parts of menthol, and 0.5 parts of lavender oil. The Miao medicine composition is prepared by the following steps: Clematis chinensis, Clematis armandii, Sambucus chinensis, and Panax notoginseng are washed, dried at 50°C for 150 minutes, mixed, and soaked in a 47% ethanol aqueous solution. The soaking is carried out under light-protected conditions at a temperature of 25°C for 90 days. After soaking, the solution is filtered through a 150-mesh filter at a pressure of 0.2 MPa to obtain an extract. Propylene glycol, menthol, and lavender oil are added to the obtained extract and mixed evenly to obtain the Miao medicine composition.

[0040] Based on the obtained Miao medicine composition, acupoint massage is performed, including the following steps:

[0041] S1. Pre-application and deep penetration of Miao medicine: The user lies supine with the lower abdomen exposed. Take an appropriate amount of the above-mentioned Miao medicine composition and spray it evenly onto the preheated Bian stone massager. Place the massager on the user's Shenque (CV8) and Guanyuan (CV4) acupoints, and maintain the vibration mode of the instrument for 30 minutes, during which time the Miao medicine composition is sprayed again every 10 minutes.

[0042] S2. Target Acupoint Vibration and Pressing: Assist the user to adjust to a side-lying position, exposing the perineal area. The operator uses the fingertips to gently massage the perineal acupoint in a circular motion for 1 minute, then applies steady and sustained static pressure for 10 minutes.

[0043] S3. Consolidation and Conclusion: With relaxed pressure, the operator massages the entire lower abdomen in a clockwise circular motion around the Guanyuan acupoint for 2 minutes, repeating this three times. Finally, quickly rub the palms together to warm them, then gently cover the Guanyuan acupoint for 30 seconds to end the procedure. The entire procedure takes approximately 55 minutes.

[0044] Example 3: This example provides a Miao medicine composition for prostate health care, made from the following raw materials in parts by weight: 20 parts of Clematis chinensis, 15 parts of Clematis armandii, 12 parts of Aconitum carmichaelii, 8 parts of Panax notoginseng, and 6 parts of ethanol. The Miao medicine composition is prepared by the following steps: Clematis chinensis, Clematis armandii, Aconitum carmichaelii, and Panax notoginseng are washed, dried at 60°C for 120 minutes, mixed, and soaked in a 50% ethanol aqueous solution. The soaking is carried out under light-protected conditions at a temperature of 30°C for 100 days. After soaking, the mixture is filtered through a 200-mesh filter at a pressure of 0.3 MPa to obtain the extract, which is the Miao medicine composition.

[0045] Based on the obtained Miao medicine composition, acupoint massage is performed, including the following steps:

[0046] S1. Pre-application and deep penetration of Miao medicine: The user lies supine with the lower abdomen exposed. Take an appropriate amount of the above-mentioned Miao medicine composition and spray it evenly onto the preheated Bian stone massager. Place the massager on the user's Shenque (CV8) and Guanyuan (CV4) acupoints, and maintain the vibration mode of the instrument for 35 minutes, during which time the Miao medicine composition is sprayed again every 12 minutes.

[0047] S2. Target Acupoint Vibration and Pressing: Assist the user to adjust to a side-lying position, exposing the perineal area. The operator uses the fingertips to gently massage the perineal acupoints in a circular motion for 1 minute, then applies steady and sustained static pressure for 12 minutes.

[0048] S3. Consolidation and Conclusion: With relaxed pressure, the operator massages the entire lower abdomen in a clockwise circular motion around the Guanyuan acupoint for 4 minutes, repeating this once. Finally, quickly rub the palms together to warm them, then gently cover the Guanyuan acupoint for 40 seconds to end the procedure. The entire procedure takes approximately 60 minutes.

[0049] Comparative Example 1: This comparative example refers to the content of Example 1, except that the same Miao medicine composition is used for external application and acupoint massage, and the rest of the content is the same as Example 1.

[0050] Comparative Example 2: This comparative example is the same as that in Example 1, except that ordinary massage oil is used and only acupoint massage is performed, without using the Miao medicine composition. The rest of the contents are the same as those in Example 1.

[0051] Performance testing

[0052] Study participants: Patients with benign prostatic hyperplasia and chronic inflammation, aged 45-75 years, were selected; and they were grouped according to different subsequent implementation plans, as follows:

[0053] Example 1 group: The scheme of Example 1 is adopted, that is, using a Miao medicine composition with a specific formula and combined with a complete acupoint massage process.

[0054] Comparative Example 1: The same Miao medicine composition as the experimental group was used for external application, but without acupoint massage.

[0055] Comparative Group 2: The Comparative Group 2 scheme was adopted, which used ordinary massage oil and the same acupoint massage procedure as the experimental group.

[0056] Symptom improvement assessment: The International Prostate Symptom Scale (IPSS, 0-35 points) was used. A trained physician conducted face-to-face interviews with patients before treatment, 2 weeks after treatment, 4 weeks after treatment, and at the 8-week follow-up, recording the scores. The scoring included 7 items, such as urinary incompleteness, urination interval, and weak urine stream, with each item scored from 0 to 5 points. The improvement rate after 4 weeks of treatment was calculated as follows: Improvement rate = (Pre-treatment score - 4-week post-treatment score) / Pre-treatment score × 100%

[0057] Table 1: IPSS Scoring Statistics Table

[0058]

[0059] Based on the data in Table 1, the improvement rates of IPSS scores for each group after 4 weeks are as follows: Example 1 group: 62.3%; Comparative Example 1 group: 26.7%; Comparative Example 2 group: 27.5%.

[0060] Urinary function testing: A urodynamic analyzer was used to measure the maximum urinary flow rate (Qmax). Patients were required to have a bladder filling volume of 150–400 mL, and the average of two measurements was taken. Post-void residual urine volume (PVR) was measured using ultrasound, and bladder emptying efficiency was calculated: Emptying efficiency = [(void volume) / (void volume + residual urine volume)] × 100%. All measurements were performed by the same sonographer before treatment and 4 weeks after treatment.

[0061] Table 2: Comparison of Urinary Function Test Data

[0062]

[0063] Inflammatory marker detection: Fasting venous blood (5 mL) was collected from patients before treatment and 4 weeks after treatment. Serum was separated, and serum PSA and C-reactive protein were detected using chemiluminescent immunoassay. Simultaneously, prostatic fluid was collected, smeared, stained with Wright's stain, and the number of white blood cells was counted under oil immersion. The average value of 5 fields of view was taken. The reduction rate of each indicator was calculated as follows: Reduction rate = (Pre-treatment value - Post-treatment value) / Pre-treatment value × 100%.

[0064] Table 3: Comparison of Inflammatory Marker Detection Data

[0065]

[0066] Drug penetration depth detection: A porcine skin model was established using the in vitro Franz diffusion cell method. Fluorescently labeled Miao medicine compositions were applied to the skin either as a simple external application or as an external application combined with vibration massage (frequency 100 Hz, amplitude 2 mm). Six hours after administration, frozen sections of skin tissue were collected, and the fluorescence intensity at different skin layers was observed and measured under a laser confocal microscope to calculate the penetration rate. Separately, male SD rats were anesthetized, and the prostate region was exposed. Fluorescently labeled substances were applied externally to the corresponding area on the lower abdomen. These rats were also divided into a simple external application group and a vibration massage group. Six hours later, prostate tissue homogenates were collected, and the drug concentration was measured using a fluorescence spectrophotometer to calculate the penetration enhancement factor.

[0067] Table 4: Comparison Table of Drug Penetration Depth Detection Data

[0068]

[0069] Onset time comparison test: Each patient was given a symptom diary card and asked to record changes in symptoms such as urinary frequency, urgency, nocturia, and pain daily starting from the first day of treatment, and to mark the specific date on which they first felt a significant reduction in symptoms. The researchers summarized and calculated the average onset time (in days) for each symptom in each group. Significant symptom reduction was defined as: a ≥50% improvement in symptoms as assessed by the patient compared to before treatment.

[0070] Table 5: Comparison of Onset Time Test Data

[0071]

[0072] Durability of treatment efficacy monitoring: After treatment, patients were followed up regularly, and symptom recurrence was assessed at 4, 8, and 12 weeks post-treatment. Recurrence was defined as: IPSS score returning to more than 80% of pre-treatment level, or the patient requiring additional treatment due to worsening symptoms. The cumulative recurrence rate was calculated for each group.

[0073] Table 6: Comparison of Durability of Therapeutic Effect Data

[0074]

[0075] Safety assessment: During treatment, patients were closely monitored and any adverse reactions, including skin irritation, allergic reactions, and general malaise, were recorded and graded according to the CTCAE 5.0 criteria. Fasting venous blood samples were collected from all patients before and after treatment to measure liver function (ALT, AST) and kidney function (Cr, BUN) to evaluate the impact on the liver and kidneys.

[0076] Table 7: Comparison of Safety Assessment and Testing Data

[0077]

[0078] Microcirculation improvement rate detection: Using laser Doppler flowmeter, local blood flow (perfusion units PU) and microvascular density (number of vessels per square centimeter) were measured in the Guanyuan acupoint area of ​​the lower abdomen before treatment and 4 weeks after treatment. Each site was measured three times and the average value was taken to calculate the percentage increase before and after treatment.

[0079] Table 8: Comparison of Microcirculation Improvement Rate Detection Data

[0080]

[0081] Prostate tissue pathological improvement detection: A rat model of benign prostatic hyperplasia with inflammation was established (castrated rats injected with testosterone propionate + Escherichia coli). The rats were randomly divided into three groups, receiving the corresponding interventions of Example 1, Comparative Example 1, and Comparative Example 2, respectively (dosage calculated based on body surface area), for 14 consecutive days. After sacrifice, prostate tissue was collected, fixed in 4% paraformaldehyde, embedded in paraffin, sectioned, stained with hematoxylin and eosin (HE), and the degree of interstitial edema and inflammatory cell infiltration was observed under a light microscope. A double-blind semi-quantitative scoring system (0–4 points) was used to calculate the reduction rate in each group.

[0082] Table 9: Comparison of Prostate Tissue Pathological Improvement Detection Data

[0083]

[0084] User experience survey: After treatment, a self-made satisfaction questionnaire was used, with a 10-point scale, where 1 point is very dissatisfied and 10 points is very satisfied. Patients were surveyed, including three dimensions: operation comfort, temperature sensation, and overall satisfaction. At the same time, the number of times the operator was trained and the time it took for the patient to become proficient in self-operation were recorded. The within-group correlation coefficient (ICC) was used to assess the consistency of process standardization among different operators.

[0085] Table 10: Statistical Table of User Experience Survey Data

[0086]

[0087] Economic Benefit Analysis: Cost calculation includes the cost of medicinal materials, massage oil, wear and tear of the Bianstone instrument, and operator hourly wages (calculated based on the local average wage). The efficacy indicator is the effectiveness rate after 4 weeks of treatment (IPSS improvement ≥ 50% is defined as effective). Effectiveness-cost ratio = Effectiveness percentage / Total cost over 4 weeks (unit: % / yuan). A higher ratio indicates better cost-effectiveness.

[0088] Table 11: Economic Benefit Comparison Table

[0089]

[0090] Example Conclusion:

[0091] Based on the results of Example 1, Comparative Example 1, and Comparative Example 2, and in conjunction with Table 1, it can be seen that the improvement rate of IPSS score in Example 1 after 4 weeks of treatment reached 62.3%, which was much higher than that in Comparative Example 1 and Comparative Example 2. This indicates that the combination of Miao medicine and acupoint massage has a synergistic effect in improving prostate symptoms.

[0092] Combining Example 1 and Comparative Example 1 and Comparative Example 2, and referring to Table 2, it can be seen that Example 1 is superior to the two comparative example groups in terms of increased maximum urinary flow rate, reduced residual urine volume, and improved bladder emptying efficiency, indicating that this comprehensive approach can more effectively improve the patient's urinary function.

[0093] Based on the results of Example 1 and Comparative Examples 1 and 2, and in conjunction with Table 3, it can be seen that Example 1 showed a higher reduction rate in inflammatory markers such as prostatic fluid white blood cell count, serum PSA, and CRP than the two comparative examples, demonstrating that the regimen has a high anti-inflammatory effect.

[0094] As can be seen from the combination of Example 1 and Comparative Example 1 and Table 4, compared with topical application alone, combining it with vibration massage can increase the efficiency of drug penetration into subcutaneous tissue by about 6 times and the efficiency of penetration into the simulated prostate area by up to 9 times, which provides evidence that combining it with acupoint massage can improve the therapeutic effect.

[0095] Combining Example 1 and Comparative Example 1 and Comparative Example 2, and referring to Table 5, it can be seen that the average onset time of key symptoms such as urinary frequency, urgency, reduced nocturia, and pain relief in Example 1 is shorter than that in the two comparative example groups, indicating that the comprehensive regimen has a faster onset of action.

[0096] Combining the results of Example 1 and Comparative Example 1 and Comparative Example 2, and referring to Table 6, it can be seen that the cumulative relapse rate of Example 1 was only 23.3% 12 weeks after the end of treatment, which was much lower than 80.0% and 83.3% of the two comparative example groups, proving that the efficacy of this regimen is more durable.

[0097] Based on the comparison of Example 1 and Comparative Examples 1 and 2, and in conjunction with Table 7, it can be seen that the total incidence of adverse reactions in Example 1 was lower than that in Comparative Examples 1 and 2, indicating that the combination of Miao medicine and gentle acupoint massage is safe and even superior to single therapy.

[0098] Combining the results of Example 1 and Comparative Example 1 and Comparative Example 2, and referring to Table 10, it can be seen that the patient scores of Example 1 in terms of operational comfort, warmth sensation, and overall satisfaction were higher than those of the two comparative example groups, indicating that the comprehensive solution has a better user experience and acceptance.

[0099] Based on the comparison of Example 1 group with conventional Western medicine treatment, traditional Chinese medicine alone, and other physiotherapy methods, and in conjunction with Table 11, it can be seen that the efficacy-cost ratio of Example 1 is higher than that of other control groups, indicating that the combination of Miao medicine composition and acupoint massage has high economic benefits and cost-effectiveness.

[0100] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A Miao medicine composition for prostate health care, characterized in that, It is made from the following raw materials in parts by weight: 10-20 parts of Clematis chinensis, 8-15 parts of Clematis armandii, 5-12 parts of Clematis armandii, 3-8 parts of Panax notoginseng, and 2-6 parts of ethanol; and the Miao medicine composition is prepared by the following steps: Clematis chinensis, Clematis armandii, Clematis armandii and Panax notoginseng are washed, dried and mixed, soaked in an ethanol aqueous solution, filtered to obtain an extract, and the Miao medicine composition is obtained.

2. The Miao medicine composition for prostate health care according to claim 1, characterized in that, The concentration of the ethanol aqueous solution is 45%-50%.

3. The Miao medicine composition for prostate health care according to claim 1, characterized in that, The soaking period is 80-100 days.

4. The Miao medicine composition for prostate health care according to claim 1, characterized in that, The raw material also includes a transdermal absorption enhancer, which is one or more of azone, propylene glycol, or menthol.

5. A Miao medicine composition for prostate health care according to claim 4, characterized in that, The transdermal absorption enhancer is added after the filtration step when mixed with the resulting extract.

6. A Miao medicine composition for prostate health care according to claim 1, characterized in that, The raw materials also include natural plant essential oils, which are one or more of tea tree oil, eucalyptus oil, or lavender oil.

7. A Miao medicine composition for prostate health care according to claim 6, characterized in that, The natural plant essential oil is added after the filtration step and when mixed with the resulting extract.

8. A Miao medicine composition for prostate health care according to claim 1, characterized in that, In the drying step, the drying temperature of each raw material is 40-60℃, and the drying time is 120-180 min.

9. A Miao medicine composition for prostate health care according to claim 1, characterized in that, The soaking step is carried out under light-protected conditions, and the soaking temperature is 20-30℃.

10. A Miao medicine composition for prostate health care according to claim 1, characterized in that, The filtration step uses a 100-200 mesh filter screen and a filtration pressure of 0.1-0.3 MPa.

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