The invention discloses health care wine preventing and curing rheumatism and rheumatoid. The health care wine is prepared from the following raw materials of, in parts by weight, 450-550 parts of fresh honey bee pupae, 80-120 parts of honey, 10-30 parts of roots of bidentate achyranthes, 10-30 parts of prepared radix rehmanniae, 15-40 parts of radix ophiopogonis, 10-28 parts of rhizoma polygonati, 15-35 parts of dried radix rehmanniae and 10-30 parts of cortex lycii radicis. The invention further discloses a preparation method of the health care wine preventing and curing rheumatism and rheumatoid. The health care wine is clear and transparent, fragrant and mild, rich in bouquet, and soft and sweet in taste, has the efficacy of tonifying the liver and kidneys, nourishing the blood to expel wind and dampness, promoting blood circulation to remove blood stasis and activating meridians to stop pain, can promote circulation of blood and postpone ageing, and meanwhile, has the outstandingeffects of symptom improvement and treatment on rheumatism and rheumatoid, and the health care wine has the characteristics that the curative effect is accurate, the treatment time is short, no toxicand side effect is caused, the health care wine is healthy and nutrient, safe and reliable, and beneficial for health if being taken for a long term.