133 results about "Nasal polyps" patented technology

In some aspects, the present invention provides methods treating a subject in need of treatment for chronic rhinosinusitis or nasal polyposis, the methods comprising administering a complement inhibitor such as a compstatin analog to the subject. In some embodiments, the complement inhibitor is administered intranasally, e.g., in a nasal spray.

CD48, a surface-marker molecule present in eosinophils, is disclosed herein as a key molecule in allergic conditions, particularly in allergic airway inflammations like asthma, allergy and nasal polyposis. CD48 is thus presented as a target molecule in the treatment of said conditions. In addition, diagnostic methods, and a kit for the diagnosis of allergic inflammatory conditions are described, based on the detection of CD48 expression.

An inflammation-relieving Chinese medicine for treating allergic rhinitis, allergic dermatitis, nasal polyp, pyogenic tympanitis, pyogenic skin infection, etc is prepared from streptomycin, chloromycetin, hydrocortisone, and 6 Chinese-medicinal materials including astragalus root, cotis root, honeysuckle flower, etc.

The present invention relates generally to the use of recombinant human CC10 (rhCC10), also known as recombinant human uteroglobin, for use as a therapeutic in the treatment of nasal rhinitis, nasal sinusitis, chronic rhinosinusitis, and nasal polyposis. More particularly, the invention provides methods, including broadly the critical dosage ranges of rhCC10 and intranasal route of administration, which may be administered to safely and effectively treat the aforementioned conditions. The invention further provides a composition useful in administering rhCC10 to humans.

The invention relates generally to methods and compositions for treating sinusitis, asthma, or polyps. The invention also relates to methods and compositions for treating nasal polyps.

The present invention provides miRNA biomarkers useful for diagnosis, prognosis, and / or treatment of airway diseases such as asthma, asthma exacerbation and nasal polyps.

The invention belongs to the technical field of drugs, and particularly relates to a drug for treating acute or chronic rhinitis. The drug is characterized by being prepared from the following raw materials in parts by weight: 20-30 parts of cocklebur fruits, 10-14 parts of radix angelicae, 8-10 parts of flower bud of lily magnolia, 8-10 parts of borneol, 7-9 parts of menthol, 5-7 parts of sesame oil and 3-5 parts of fructus forsythia. The drug has the effects of dispelling wind and clearing dampness, improving symptoms, clearing away heat and relieving swelling, dispersing stasis, relieving pain, moisturizing mucosa, shrinking polyp, and the like, is mainly used for treating chronic rhinitis, atrophic rhinitis, nasal polyp and the like. The drug is strong in adaptation, short in course of treatment, good in effect, capable of relieving untoward effect of a patient, especially convenient and effective for treating a child patient.

The invention provides a non-tobacco snuff for treating the rhinitis and nasal polyps, and a preparation method thereof. The components of the non-tobacco snuff comprise Coffonrose Hibiscus Leaf, American ginseng, dahurian angelica root, Herba Centipedae, mint, lily magnolia, Nodus Nelumbinis Rhizomatis Charcoal, dried alum, Rubia cordifolia, borneol and borax. The preparation method comprises the following steps: respectively choosing Coffonrose Hibiscus Leaf, American ginseng or Radix Ginseng, dahurian angelica root, Herba Centipedae, mint, lily magnolia, Nodus Nelumbinis Rhizomatis Charcoal, dried alum, Rubia cordifolia; drying at a low temperature of 60DEG C to the water content of 5% or less; carrying out superfine crushing; respectively grinding borneol and borax, and sieving by a 200 mesh sieve; and mixing the above raw materials, uniformly stirring, and filling the obtained mixture to a bottle. The preparation method has the advantages of simplicity, easy operation and low preparation cost, and the produced non-tobacco snuff has the advantages of good effect, no toxic side effects, and very convenient use.

The invention relates to a traditional Chinese medicine composition for treating rhinitis. The traditional Chinese medicine composition is mainly prepared from the following crude drugs: cantharides, rhizoma typhonii, pinellia ternate, bulb of thunberg fritillary, scolopendra, asarum, centipeda minima, sangusis draconis, borneol and musk in a processing manner according to certain parts by weight. The traditional Chinese medicine composition has a good curative effect on treatment of acute rhinitis, chronic rhinitis, adenoidal hypertrophy, nasal polyp, anaphylactic rhinitis and nasosinusitis, and is quick to take effect, short in curative effect, small in side effect, and fewer in used crude drug variety, the recovery rate can be up to 86%, the effective rate can be up to over 97.8%, and the cost is saved. The traditional Chinese medicine composition can be prepared into external paste, such as patches, water aqua, spray or an ointment and the like, and is more convenient to use and carry, and the availability and the curative effect of the composition are further improved.

An antibacterial traditional Chinese medicinal oil component for external use and its application for treating rhinitis, comprising a mixed herbal oil formed by superimposing functional oil and base oil components; taking a sufficient amount of Xinyi flower 2-5%, Xanthium 2-5%, Angelica dahurica 1 ~4%, peppermint 2~6%, thyme 1~3%, lavender 2~3%, juniper 1~2%, tea tree oil 1~3%, and the balance is base oil, stir evenly, and pack 5ml to 30ml Store in ceramic or opaque glass bottles. The invention mainly uses magnolia flower, cocklebur, angelica dahurica, peppermint, thyme, juniper, lavender and tea tree oil as main ingredients for external use, adds base oil, and is formed by reasonable matching to form compatibility. It is a pure natural plant formula, which avoids the harm of western medicine to the human body, makes the medicine go directly to the focus, and is safe and reliable in clinical application. This invention is suitable for treating allergic rhinitis, sinusitis, nasal polyps, and hypertrophy of the nasal cavity. Healed from rhinitis.

The invention relates to pure traditional Chinese medicine rhinitis paste for treating allergic rhinitis, nasosinusitis and nasal polyp. The pure traditional Chinese medicine rhinitis paste is composed of the following raw materials: bear gall powder, leech, xanthium sibiricum, flos magnoliae liliflorae, centipeda minima, divaricate saposhnikovia root, isatis root, liquorice, notopterygium root, asarum, ligusticum wallichii, fructus forsythiae, kalimeris, lalang grass rhizome, madder, artificial musk, combined spicebush root, chrysanthemum, sulforaphane, folium artemisiae argyi, scutellaria baicalensis, rhizoma acori graminei, angelica dahurica, houttuynia, cassia twig, herba cepbalanoplosis segeti, radix platycodonis, bear gall powder, folium perillae, climbing groundsel herb, rhizoma polygoni cuspidati, fructus liquidambaris, tetrapanax papyriferus, burdock roots, herba schizonepetae, fructus viticis, folium mori, cassia twigs, fructus gleditsiae, menthol and rosemary oil. The pure traditional Chinese medicine rhinitis paste has the advantages that nasal obstruction and headache, brain distension and other symptoms caused by nasal obstruction can be rapidly relieved, purulent nasal mucus can be reduced, the olfactory function is improved and recovered, the curative effect is remarkable, allergic rhinitis, nasosinusitis and nasal polyp are effectively treated, pain and risks of surgical treatment can be avoided, and good medical benefits and social benefits are achieved.

The invention discloses a method for establishing an eosinophilic granulocyte proportion model by utilizing a nasal polyp pathological picture, and the method comprises the following steps: preparingdata, manufacturing nasal polyp into a slide, scanning by using a digital pathological instrument to obtain a WSI picture, and cutting the WSI picture to obtain small pathological pictures; dividing all the small pathological pictures into training set data and test set data according to a set proportion; establishing the eosinophilic granulocyte proportion model; performing training on an ImageNet data set by adopting an Inception V3 model to obtain model parameters, removing the last full connection layer FC of the model, adding a full connection layer FC, wherein only one neuron is arranged in the full connection layer FC, and no activation function is adopted; setting a loss function to employ a mean square error MSE, and setting a learning rate lr. The method is applied to a chronicnasosinusitis nasal polyp pathological auxiliary diagnosis system, and the eosinophilic granulocyte proportion on a pathological picture is rapidly and accurately obtained through learning and training.

A Chinese medicine in the form of tablet for treating enteritis, colitis, bacterial dysentery, and nasosinusitis is prepared from green chiretta, senecio, pregelatinized starch, microcrystal cellulose, and dissolved-in-stomach coating powder. Its advantage are high curative effect and stability, long effective period up to 3 years, and low cost.

The invention discloses a traditional Chinese medicine liquid preparation for treating rhinitis and a preparation method thereof. The liquid preparation comprises 500 to 800 parts of main liquid preparation, and several parts of auxiliary components and rice vinegar; wherein the main liquid preparation is prepared by decocting main medicinal raw materials such as radix bupleuri, balloonflower root, herba schizonepetae, coptidis rhizoma, and centipede with water, and the auxiliary components comprise a scallion liquid, a garlic liquid, borneol, and ethanol. The liquid preparation is mainly used to treat rhinitis, nasosinusitis, and nasal polyp, and has the advantages of little using amount, user-friendliness, direct act on nasal mucosa, improvement on the blood circulation of nasal mucosa, rapid absorption, prominent curative effect, no side effect, and no drug resistance. The clinical observation results have shown that the cure rate of 2900 clinical treatments on rhinitis, nasosinusitis, and nasal polyp can reach 84% to 85%.

The invention discloses Chinese medicinal herb for treating rhinitis. The Chinese medicinal herb consists of the following five kinds of medical materials in parts by weight: 10 parts of herba centipedae, 9 parts of eritrichium pedumculare, 9 parts of centipeda minima, 12 parts of myriogyne minuta and 20 parts of small centipeda herb, the medical materials are boiled and refined by an indigenous method, and the ointment is obtained. The ointment is externally applied at the nasal cavity, the effect is obviously taken in the same day, and when the ointment is continuously used for 2 to 4 times, acute rhinitis, chronic rhinitis, nasal turbinate hypertrophy, nasal polyp, allergic rhinitis, sinusitis, atrophic rhinitis and the like can be fundamentally treated. The Chinese medicinal herb has the advantages that the clinical practical application effect is good, many rhinitis patients are cured, recrudesce cannot occur in two years, and the Chinese medicinal herb is very popular in wide patients.

The invention provides a pyrazolothiazole compound of the formula [I], or a pharmaceutically acceptable salt thereof:The compound of the invention has JAK1 inhibitory activity, and thus, immunosuppressive effect, anti-inflammatory effect and anti-proliferative effect, and is useful in the treatment of the diseases, for example, rheumatoid arthritis, inflammatory bowel disease, psoriasis and vasculitis, bronchial asthma, chronic obstructive pulmonary disease and eosinophilic sinusitis, nasal polyp.

The invention provides a kit for detecting chronic sinusitis with a nasal polyp subtype, and application of a CST1 gene as a biomarker. The kit comprises specific primers of the CST1 gene. As the biomarker, the CST1 gene can be used for preparing products for detecting the chronic sinusitis with the nasal polyp subtype. The kit provided by the invention screens by using proteomics and transcriptomics methods and adopts the CST1 gene as the biomarker, so that a method for detecting the chronic sinusitis with the nasal polyp subtype by using the kit is realized, and the nasal polyp subtype can be quickly identified; furthermore, compared with the traditional pathological detection method, the kit is shorter in time consumption; the kit can be used for rapidly detecting samples on a large scale at the same time, thus lowering labor cost and medical cost. More importantly, the kit can comprehensively reflect the histopathological features.

The invention belongs to the field of traditional Chinese medicine and particularly relates to a traditional Chinese medicine for treating rhinitis and a preparation method thereof. The traditional Chinese medicine comprises fructus xanthii, rhizoma chuanxiong, flos magnoliae, radix angelicae dahuricae, ovateleaf holly bark, Calvatia gigantea fruiting body, radix trichosanthis, fructus piperis longi, cortex phellodendri, honeysuckle flower bud, radix scutellariae, Euphorbia kansui root, fructus gleditsiae, semen brassicae, fructus bruceae, rhizoma corydalis, indigo naturalis, herba ecliptae and asarum. The traditional Chinese medicine is prepared by processes such as soaking and decocting. The traditional Chinese medicine materials of the traditional Chinese medicine directly act on nose lesions and are capable of expelling and eliminating pus, fast removing nose lesion inflammation and radically curing various rhinitis, and the traditional Chinese medicine is convenient, efficient, short in treatment cycle, low in relapse rate and free of side effects and dependency. Clinical practice of the traditional Chinese medicine on over ten thousand people shows that the traditional Chinese medicine is definite in curative effect on allergic rhinitis, nasosinusitis, paranasal sinusitis, nasal polyp, acute and chronic rhinitis and turbinate hypertrophy, low in cost, good in effect, lowin use amount and free of side effects.

A traditional Chinese medicine composition for treating rhinitis and a preparation method thereof. The invention belongs to the technical field of traditional Chinese medicines and provides the traditional Chinese medicine composition for treating rhinitis, which is quick to act, short in treatment course, good in effects, low in toxic and side effects, not liable to cause relapse and low in cost, and the preparation method thereof. The traditional Chinese medicine composition includes, by weight, 120-180 parts of centipeda minima, 20-40 parts of flos magnolia, 10-30 parts of radix angelicae dahuricae, 20-30 parts of fructus xanthii, 3-5 parts of divaricate saposhnikovia roots, 3-8 parts of borneol and 0.01-0.05 parts of halite violaceous. The traditional Chinese medicine composition is quick to act, short in treatment course, low in toxic and side effects, not liable to cause relapse and low in cost, has excellent treatment effects on chronic simple rhinitis, chronic hypertrophic rhinitis, chronic paranasal sinusitis, allergic rhinitis and nasal polyp, and is more than 95% in effective rate and more than 75% in curative rate.

The invention discloses a medicament for treating nasal polyp, nasosinusitis and acute and chronic rhinitis, which is mainly prepared from pangolin scales, tall gastrodia tuber, weeping forsythia, golden thread and figwort root according to a weight ratio. The medicament has the effects of clearing heat and purging intense heat, resisting bacteria, diminishing inflammation and cooling blood, has good curative effect on the nasal polyp, the nasosinusitis and the acute and chronic rhinitis and rhinitis and nasal obstruction, and has high cure rate.

The invention relates to a traditional Chinese medicine preparation for nursing patients suffering from rhinitis and a preparation method thereof. Effective constituents of the traditional Chinese medicine preparation comprise asarum, magnolia delavayi, corn silk, pothos chinensis, cocklebur, lily magnolia, grass-leaved sweetflag rhizome, perilla root, soda-apple night-shade herb, cowry shell, balloonflower root, torpedograss root and rhizome, passionflower, otolhum pseudoscinaenae, bunge corydalis herb and aneurolepidium root. The traditional Chinese medicine preparation is a pure Chinese herbal medicine, is prepared by the advanced pharmaceutical technology, has effects of dispelling wind and facilitating lung, dredging acupoint and diminishing inflammation, and dispelling the wind and bringing down a fever, has obvious effects of treating allergic rhinitis, chronic rhinitis, atrophic rhinitis, nasosinusitis, nasal polyp and acute or chronic paranasal sinusitis, has a short treatment course, produces effects fast, is safe and nontoxic and has total rhinitis treatment efficiency more than 90%.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine tablet for treating nasal polyp and a preparation method thereof. The tablet is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 10-15 parts of rhizoma atractylodis, 15-20 parts of radix angelicae, 10-15 parts of fructus mume, 10-15 parts of fructus schizandrae, 8-10 parts of Chinese honeylocust fruits, 4-6 parts of alum, 8-10 parts of castor beans, 1-3 parts of borneol, 6-8 parts of bombyx batryticatus, 1-3 parts of asarum, 15-20 parts of clove, 15-20 parts of abrotani herba, 6-8 parts of cortex phellodendri, 8-10 parts of nodus nelumbinis rhizomatis charcoal, 8-10 parts of caulis akebiae, 8-10 parts of muskmelon pedicel, 8-10 parts of radix curcumae, 8-10 parts of radix scutellariae, 10-15 parts of cape jasmine, 10-15 parts of flos magnoliae, 10-15 parts of rhizoma cimicifugae, 10-15 parts of folium eriobotryae, 8-10 parts of rhizoma anemarrhenae, 6-8 parts of fritillaria bulb and 10-15 parts of licorice root. The traditional Chinese medicine can be used for removing slough, promoting growth of tissue regeneration, nourishing yin and lung, clearing heat, removing toxicity, suppressing hyperactive liver for descending adverse qi, astringing and stopping bleeding, can be used for treating both symptoms and root cause of nasal polyp with quick response, and can effectively relieve pain of patients.

The invention discloses a composition for treating ulcerative colitis. The composition comprises, by weight, 3-8 parts of astilboides tabularis, 4-9 parts of peach kernel powder, 3-12 parts of caulis spatholobi, 15-60 parts of gynura segetum, 10-25 parts of psychotria calocarpa kurz, 9-15 parts of paleaceous knotweed rhizome, 6-15 parts of sea-buckthorn, 3-9 parts of bitter gourd, 1-3 parts of cuttlebone, 0.4-1 part of mirabilite, 0.6-1.5 parts of fructus amomi, 3-9 parts of carrots, 5-15 parts of liquorice and 0.2-0.6 part of betel nuts. The composition conforms to the principle of traditional Chinese medicine symptom distinguishing treatment of traditional Chinese doctors, the treatment effect is comprehensive, the medicine effect is lasting, and the composition is an ulcerative colitis prescription treating both symptoms and root causes; the selected traditional Chinese medicine materials have the effects of removing polyps and resolving hard lumps. The composition is used for various polyps such as a nasal polyp, a polyp of a vocal cord, a gastrointestinal polyp, gastric ulcer and uterus colpo-polyp clinically, and all the effects are good. The composition is an ideal medicine for treating ulcerative colitis.

The invention discloses a nasal polyp pathological section analysis method and system and a readable storage medium, and the method comprises the steps: collecting the pathological image information of an entity section under a microscope in real time through an image collector, and transmitting the information to a processor; the processor is used for performing effective area detection on all cells on the nasal polyp pathological image, removing an epithelium area, a blood vessel area and a gland area in the current visual field, and then counting the number of plasma cells, neutrophils, eosinophils and lymphocytes in the current visual field; counting the sum of the four types of inflammatory cells as the total number of inflammatory cells in the current view; and then calculating the percentage of plasma cells, neutrophil cells, eosinophil cells and lymphocytes, finally judging the nasal polyp inflammation type of the current slice patient according to the number and proportion of the four types of inflammatory cells under the random 10 high-power lens visual fields and hot spot visual fields in the current slide, and finally storing the statistical result. The invention is helpful for individualized diagnosis and treatment and prognosis improvement of nasosinusitis patients.

The present invention discloses a device for cleaning nasal polyps. The device comprises a machine body, an air draft mechanism is arranged in the machine body, a driving mechanism is further arrangedin the machine body, an auxiliary mechanism is arranged in the machine body, and the driving mechanism comprises a driving cavity formed in the machine body. The device is simple in structure and convenient to operate. When the device is normally used, a patient firstly places a nasal polyp box in the device, then presses a button to adjust which nasal cavity needs to be cleaned, fixes the deviceto the head through a rubber rope after preparation work is completed, meanwhile, bites the device with the mouth, then stretches a telescopic rod into the nasal polyps in the nasal cavity to clamp and crush the nasal polyps, then uses the air draft mechanism to extract out the crushed nasal polyps and places the nasal polyps in the nasal polyp box. The device saves operation treatment time of adoctor on a patient, improves treatment efficiency and reduces labor intensity of the doctor.

The invention discloses Chinese medicinal lotus node powder for treating rhinopolypus, which is mainly researched for solving the problems of poor treatment effect and low curative rate existing in the conventional medicament for treating rhinopolypus. The Chinese medicinal lotus node powder is prepared by preparing 30g of continuous nodus nelumbinis rhizomatis charcoal, 15g of sal ammoniac, 5g of dried alum and 5g of borneol, drying the lotus node on a tile and grinding the other medicaments into fine powder, and is stored in a bottle; and 0.2g of the Chinese medicinal lotus node powder is blown onto rhinopolypus every time, and is applied for 5-6 times every day till rhinopolypus is healed. The Chinese medicinal borax-realgar powder has the advantages of effective rate of over 95 percent on rhinopolypus, curative rate of over 80 percent and freeness from toxic and side effects.

The invention relates to the field of nasal polyp and prognostic testing thereof, in particular to application of a flora abundance testing sample to preparing nasal polyp and a prognostic testing agent thereof. By comparing the differences of the compositions and structures of paranasal sinus microorganisms between CRSwNP and a healthy contrast, especially evaluating the relationship between thecompositions of the paranasal sinus microorganisms and the inflammation type, whether the composition of a certain paranasal sinus microorganism is related to the postoperative polyp relapse of a CRSwNP patient, and the synergistic prediction value of inflammation cells and different bacteria on the polyp relapse is further evaluated.

The invention discloses medical wine as well as a preparation method and applications of the medical wine. The medical wine is prepared from the following medicinal materials in parts by weight: 40-60 parts of houttuynia cordata roots, 40-60 parts of folium ainsliaeae triflorae, 40-60 parts of roughhaired holly root, and 40-60 parts of fresh ginger. The medical wine is prepared through pretreatment, fermentation and soaking. The preparation method comprises the steps of pretreatment, fermentation and soaking. The preparation method specifically comprises the following steps: regulating the water contents of the raw materials to be 30-40 % for later use; weighing the medicinal materials according to the weight parts in the prescription, mixing the medicinal materials, and carrying out natural fermentation for 5-10 days at the temperature of 33-36 DEG C and the humidity of 35-50 %, thus obtaining a fermentation material a; adding the fermentation material a into baijiu with the weight being 3-7 times of the total weight of the raw medicinal materials, and carrying out soaking for 10-30 days, thus obtaining the target material, namely, the medical wine. The applications refer to the applications of the medical wine in preparing medicines for realizing treatment and / or adjuvant treatment on cancer, tumor, gout, headache, rhinitis, nasal polyp and spur. The medical wine has the advantages that the curative effects are safe and reliable, the toxic and side effects are low, etc.

The invention relates to Chinese medicine realgar sal ammoniac powder for treating nasal polyp, which is developed by mainly solving the problems of poor curative effect and low cure rate of the conventional medicine for treating the nasal polyp. 15 grams of realgar, 15 grams of sal ammoniac, 15 grams of centipeda minima and 6 grams of borneol are taken, dried by a fire and ground into fine powder; 0.2 gram of the medicine is blown on the nasal polyp at each time; and the medicine is applied for 5 to 6 times every day until the nasal polyp is cured. The Chinese medicine realgar sal ammoniac powder for treating the nasal polyp has the advantages that: effective rate of treating the nasal polyp is over 95 percent; cure rate is over 80 percent; and no toxic or side effect exists.