The invention relates to the technical field of
medicine, and particularly discloses a foam hardening agent for treating low-flow-rate
vascular malformation and a preparation method thereof, the foam hardening agent comprises a
drug conjugate, a stabilizer, a water-soluble
enhancer, foaming gas and an injection
solvent; according to the
drug conjugate, citric anhydride is bridged with
lauromacrogol and
bleomycin to form a covalent structure, so that the problems of non-uniform
drug distribution and poor synergism during physical mixing are solved. The preparation method comprises the following steps: synthesizing a conjugate through esterification and amidation reactions, mixing the conjugate with auxiliary materials, and foaming through a Tesari method. The two drugs are bridged through the citric anhydride to form a conjugate which can be synergistically slowly released in a focus microenvironment, the
curative effect is remarkably improved, meanwhile, the single drug dosage and toxic and side effects are reduced, and the foam preparation is high in stability, clear in development and suitable for precise
interventional therapy guided by color
ultrasound.