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Polycinnamic alcohol production formula and its preparation process

A preparation process, lauromacrogol technology, applied in the field of lauromacrogol production prescription and its preparation process, can solve the problems that have not been reported, and achieve the effect of simplifying the operation

Active Publication Date: 2006-04-26
SHAANXI TIANYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, there are no reports on the control methods for the end point of the product reaction.

Method used

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  • Polycinnamic alcohol production formula and its preparation process
  • Polycinnamic alcohol production formula and its preparation process
  • Polycinnamic alcohol production formula and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] In the reaction of synthetic lauromacrogol bulk drug,

[0054] 1. Specifications and standards of chemical raw materials:

[0055] lauryl alcohol chemically pure

[0056] Ethylene oxide chemically pure

[0057] Solid Sodium Hydroxide Chemically Pure

[0058] Acetic acid chemically pure

[0059] 2. Preparation route and related technical parameters:

[0060]

[0061] Feed Ratio Molecular Ratio Lauryl Alcohol: Ethylene Oxide = 1:9

[0062] Weight ratio lauryl alcohol: ethylene oxide = 1: 1.95 ~ 2.13 parts

[0063] The consumption of catalyzer solid sodium hydroxide: 0.1% (W / W, according to total feeding amount)

[0064] Namely: 0.00295~0.00313 copies

[0065] 3. Detailed chemical reaction formula and reaction conditions

[0066]

[0067] Heating, raising the temperature to 135-150°C, feeding ethylene oxide

[0068] The pressure is kept at 0.15~0.20MPa

[0069] The temperature is controlled at 140~155℃

[0070] Reacti...

Embodiment 2

[0092] In the reaction of synthetic lauromacrogol bulk drug,

[0093] 1. Specifications and standards of chemical raw materials:

[0094] lauryl alcohol chemically pure

[0095] Ethylene oxide chemically pure

[0096] Solid Sodium Hydroxide Chemically Pure

[0097] Acetic acid chemically pure

[0098] 2. Preparation route and related technical parameters:

[0099]

[0100] Feed Ratio Molecular Ratio Lauryl Alcohol: Ethylene Oxide = 1:9

[0101] Weight ratio lauryl alcohol: ethylene oxide = 1:2 parts

[0102] The consumption of catalyzer solid sodium hydroxide: 0.1% (W / W, according to total feeding amount)

[0103] That is: 0.003 copies

[0104] 3. Detailed chemical reaction formula and reaction conditions

[0105]

[0106] Heating, raising the temperature to 135°C, feeding ethylene oxide

[0107] The pressure is maintained at 0.18MPa

[0108] Temperature controlled at 150°C

[0109] Reaction end point control Reactant...

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PUM

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Abstract

The present invention relates to chemical medicine preparation, and is the preparation process of lauromacrogol. The preparation process of the present invention adopts NaOH as catalyst to simplify operation and control of heavy metal content, HAC for neutralization in mild reaction condition to avoid oxidation of phosphoric acid at high temperature, and cloud point measuring method to control polymerization end point. Therefore, the synthesis process of the present invention is reasonable and can ensure stable quality of medicine material product.

Description

1. Technical field: [0001] The invention relates to a prescription for producing lauromacrogol in a series of pharmaceutical and chemical products and a preparation process thereof. 2. Background technology: [0002] Currently, liver disease ranks second in the mortality rate of malignant diseases, with at least 300,000 newly discovered patients and 110,000 liver disease patients dying each year. There are no less than 3 million patients with liver cancer and severe liver cirrhosis in the country, and about one-third of patients will develop esophageal varices; there are about 250,000 patients with esophageal varices, which are caused by gastric cancer, esophageal cancer and portal hypertension. There are about 300,000 people with gastrointestinal bleeding, and about 500,000 patients with gastric bleeding caused by other reasons. [0003] In response to the rapid increase in the incidence of gastrointestinal hemorrhage, hospitals in various provinces, municipalities, and au...

Claims

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Application Information

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IPC IPC(8): C07C43/13C07C41/03C08G65/08
Inventor 杨军营
Owner SHAANXI TIANYU PHARMA
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