Efficient painless drug for treating local tumor ablation

A technology for the treatment of drugs and tumors, used in anti-tumor drugs, drug combinations, drug delivery, etc., can solve problems such as poor overall efficacy, achieve complete tumor inactivation, improve compliance, and reduce pain response effects.

Inactive Publication Date: 2013-07-10
FUJIAN MEDICAL UNIV UNION HOSPITAL
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In some studies, intratumoral injection of lauromacrogol injection has a certain effect on the treatment of uterine fibroids, but the overall

Method used

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  • Efficient painless drug for treating local tumor ablation
  • Efficient painless drug for treating local tumor ablation
  • Efficient painless drug for treating local tumor ablation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] 1. Preparation of mixed injection medicine

[0013] Under sterile conditions, accurately absorb absolute ethanol and lauromacrogol, and mix them thoroughly at a volume ratio of 19 / 1 (V / V) to obtain a mixed injection (that is, 95% ethanol by volume + 5% polyol by volume). cinnamyl alcohol mixture), and stored at 4°C for later use.

[0014] 2. Drug analgesic test

[0015] Take 32 Kunming mice, weighing 18-22 g, half male and half male, and randomly divide them into 4 groups: normal saline control group (A), 2% lidocaine control group (B), lauromacrogol injection group ( C), 95% ethanol + 5% lauromacrogol mixture group (D). 10 μl of the above-mentioned corresponding drugs were subcutaneously injected into the foot pad of the left hind limb of the mice with a micro-injector, and 10 μl of 1% formalin was injected again along the needle track 5 minutes later, the pain response of the mice was observed for 2 minutes, and the score was calculated. 3 points for licking, bitin...

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Abstract

The invention discloses an efficient painless drug for treating local tumor ablation. The efficient painless drug is mixed solution of absolute ethyl alcohol and lauromacrogol, wherein the ratio of lauromacrogol is 0.1-99.9%, and the ratio of absolute ethyl alcohol is 99.9%-0.1% according to the volume fraction. The efficient painless drug for treating local tumor ablation, which is injected into local tumor under guide of an ultrasonic imaging technique, is the mixed solution of absolute ethyl alcohol and lauromacrogol according to the volume ratio of 19/1 to 99/1; and volume ratio of absolute ethyl alcohol to lauromacrogol preferably is 99/1 or 19/1; the efficient painless drug for treating local tumor ablation is applied to preparation of the drug for treating ablation by being injected to the tumor under guide of the ultrasonic imaging technique; the sufferer has no adverse reaction such as pain in an operation; and the postoperation color Doppler ultrasonic review finds out that the tumor echo is increased, blood flow signals are obviously reduced, and the indexes of a part of patients with rising alpha fetal protein are obviously reduced by review.

Description

technical field [0001] The invention relates to a drug for local ablation of tumors, which uses absolute ethanol to directly kill tumors and lauromacrogol to destroy tumor blood vessels and induce local immune responses to achieve multi-channel anti-tumor effects, and has no adverse reactions such as pain during the injection process, and is highly effective. Painless anti-tumor advantage. Background technique [0002] Tumor chemical ablation has the advantages of simple operation, mild adverse reactions, and low cost, among which percutaneous ethanol injection (PEI) is the most representative. The main mechanism of PEI treatment is that high-concentration ethanol is injected into the tumor to cause rapid dehydration of tumor cells, protein coagulation, denaturation and necrosis of cancer cells. However, due to the uneven diffusion of the drug after intratumoral injection of pure anhydrous ethanol, multiple injections are required, and some large tumors are difficult to be ...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61K9/08A61P35/00A61K31/045
Inventor 陈志奎林礼务薛恩生何以敉曲振鹏
Owner FUJIAN MEDICAL UNIV UNION HOSPITAL
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