261results about How to "Increase injection volume" patented technology

The present invention provides methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2, NF-AT3, calcineurin, MCIP, and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of many of these factors or the pathways mediated by these factors has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides a link between these factors and the pathways they mediate through a family of non-voltage gated channels called TRP channels. The present invention further demonstrates that inhibitors of TRP channels can inhibit or treat heart failure and cardiac hypertrophy.

The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac hypertrophy. Surprisingly, the present invention demonstrates that HDAC inhibitors inhibit cardiac hypertrophy by inhibiting fetal cardiac gene expression and interfering with sarcomeric organization.

A liquid ejection device of the invention is constructed to eject a liquid to an ejection object. The liquid ejection device has a dot data generator configured to generate dot data from given image data, where the dot data represents a dot creation state in each pixel set on the ejection object. The liquid ejection device also has a liquid ejector equipped with a nozzle array including multiple nozzles aligned in a specific direction substantially perpendicular to a scanning direction. The liquid ejector makes multiple scans of the nozzle array in the scanning direction in a common printing area according to the generated dot data and ejects the liquid to the ejection object to create dots. The dot data generator has a specific print mode that generates corrective dot data by skipping a virtual dot array created by one scan from a group of dot arrays to be created by the multiple scans of the nozzle array, in order to prevent a potential contact with a dot array to be created by another scan. This arrangement desirably prevents unevenness of liquid ejection caused by a meandering scan of at least either the liquid ejector or the ejection object.

The invention relates to a method for electrolyte-injecting a battery, which comprises the steps that: a battery shell is vacuumized; then non-aqueous electrolyte is injected into the battery shell by a filling machine; after a first electrolyte-injection is finished, the electrolyte content of the first electrolyte-injection is above 60 percent of the total weight of the electrolyte injected; the battery shell is sealed to carry out centrifugal sinking; then the seal is taken to vacuumize; a second electrolyte-injection is carried out; the electrolyte content of the second electrolyte-injection is the content which injects the battery shell full. By using the method of the second electrolyte injection, the invention largely enhances the electrolyte injection volume, which enhances by 15 percent-25 percent of the electrolyte injection volume compared with the prior art.

The invention discloses a high-efficiency superfine spherical metal powder preparation device, which comprises a shell, a crucible and a powder collecting area, and is characterized in that the crucible is in a circular structure that the inside and the outside are nested, the bottom of the inner accommodating cavity of the crucible and the bottom of the outer accommodating cavity of the crucible are provided with central holes which are through; a space used for flowing molten metal is arranged between the bottom of the inner accommodating cavity and the bottom of the outer accommodating cavity; a tabletting is arranged above the central hole of the inner accommodating cavity, and a drive rod contacts with the tabletting; the central hole bottom of the outer accommodating cavity is provided with a gasket with a hole; the powder collecting area comprises a catch tray and a rotating disk, wherein the catch tray is arranged on the bottom of the shell and the rotating disk is arranged above the catch tray and is connected with a motor. The invention further discloses a method of preparing the superfine spherical metal powder, the method mainly combines a pulse microcellular injection method and a centrifugal atomization method, and the superfine spherical metal powder meeting the usage requirements that the grain size distribution range is narrow, the sphericity is high, the spreadability and the mobility are good, and the production efficiency is high can be prepared.

The invention relates to a two-stage oxygen supply dry slag removal pressurized gas flow bed gasification furnace, comprising a cylinder-shaped pressure-bearing case, a gasification chamber arranged in the cylinder-shaped pressure-bearing case, a synthesis gas cooling chamber, a mechanical slag crusher and a slag locking tank; wherein the gasification chamber and the synthesis gas cooling chamberare respectively arranged at the upper part and the lower part in the cylinder-shaped pressure-bearing case, the mechanical slag crusher is arranged below the bottom of the gasification furnace, and the slag locking tank is arranged below the mechanical slag crusher. The invention adopts two-stage oxygen supply temperature control technology and water vapour temperature control technology, and reasonable dry slag removal structure and necessary automatic control means are combined, solid slag removal of China 'double-high' coal large-scale pressurized gas flow bed gasification is realized, and the invention is especially applicable to 'double-high' coals with high ash content (25-27%) and high ash melting point (FT is more than 1400 DEG C), and handing capacity of single day can reach about 2000t/d.

The invention relates to a blast furnace first slag experiment method and a first slag experimental furnace which solves the problem that the current experiment method can not well guide the optimization of furnace material structure for first slag can not be acquired. The first slag experimental furnace comprises an electric furnace and an air distribution cabinet, wherein the electric furnace is provided with a hearth pipe; a graphite crucible positioned on a graphite base is arranged in the hearth pipe; the upper end of the graphite crucible is provided with a center press rod, and the upper end of the center press rod penetrates through the hearth pipe and is provided with an inserted thermocouple; a material surface load readjusting device is arranged on the center press rod; the upper end of the hearth pipe is provided with an upper cover, an exhaust opening and a displacement sensor, and the lower end is provided with a material receiving box and communicated with the air distribution cabinet by a reducing gas inlet; and a pressure difference transmitter is arranged on a connecting pipeline of the reducing gas inlet and the air distribution cabinet. The experiment method obtains first slag by simulating the blast furnace condition through the first slag furnace, records all detecting data on line and carries out chemical analysis and microscopic detection on the first slag, thereby having important guide significance for optimizing the furnace material structure.

An apparatus includes a transformation table acquiring unit, a blood-flow information acquisition unit and a blood-flow image generating unit. The transformation table acquiring unit obtains a transformation table for transforming unspecified information representing a concentration of a contrast medium in a myocardium into an unspecified blood flow value image based on a CT image acquired in a concentration transition period. The blood-flow information acquisition unit obtains information representing the concentration of the contrast medium based on a CT image acquired during a constant concentration period. The blood-flow image generating unit generates a blood flow value image based on the information representing the concentration of the contrast medium according to the transformation table.

The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.

The invention belongs to the field of environmental monitoring, and discloses an instrument capable of automatically measuring the content of organic matters in surface water and sewage, in particular to an automatic instrument for measuring the content of total organic carbon (TOC) in water, and can realize full-automatic measurement process and meet the national requirements for measurement technical indexes. The infrared TOC analyzer consists of a total carbon measuring system, an inorganic carbon measuring system, a data processing system and a control system, wherein, the control system controls the processes of the total carbon measuring system and the inorganic carbon measuring system and transmits output signals to the data processing system; the total carbon measuring system comprises an automatic sample injection unit, a heating-burning unit and an optical measurement unit; and the inorganic carbon measuring system comprises an acidification unit, a pre-purge unit and an optical measurement unit. By adopting the infrared TOC analyzer, the problem of low temperature in the traditional heating method is solved during the TOC measurement process so that the burning temperature is improved to 1200 DEG C, thus a water sample can be more fully burned and the measurement accuracy is improved; and meanwhile the problems such as a small quantity of the water samples, thermal radiation interference and TOC-COD (chemical oxygen demand) integrated measurement are solved. Therefore, the infrared TOC analyzer is applicable to measuring the content of the TOC in various types of water in the environmental monitoring field and other fields.

The invention discloses a mass spectrum ionization source and belongs to the technical field of mass spectrum ion sources. The mass spectrum ionization source is designed in order to solve the problems that the detection range of an existing ion source ionization source is limited and ionization efficiency is low. The mass spectrum ionization source comprises a sample injection device, a repelling electrode and a dielectric barrier discharge device; liquid or gas samples enter a tee nozzle through a sample injection tube of the sample injection device, and the liquid samples with solvent removed are sprayed out from the lead-out end of the tee nozzle along with carrier gas or the gas samples are sprayed out from the lead-out end of the tee nozzle; reaction gas enters an insulation dielectric cavity through a gas guide tube of the dielectric barrier discharge device, and low-temperature plasma is generated under the action of a discharge electrode and sprayed out from the lead-out end of the insulation dielectric cavity; the low-temperature plasma and the liquid or gas samples converge on a mass spectrum opening in a backflow mode, ionized sample molecules are formed, and the molecules converge to the mass spectrum opening under the action of the repelling electrode. According to the mass spectrum ionization source, not only is the detection range of the ionization source widened, but also the ionization efficiency and the detection sensitivity of an instrument are improved.

The invention discloses a downhole low-frequency hydraulic pulsation coupled hydraulic ultrasound generation system applied to injection augmentation of low-permeability reservoirs. The system comprises a low-frequency hydraulic pulsation generation part and a hydraulic ultrasound generation part, wherein the low-frequency hydraulic pulsation generation part mainly comprises a frustum-shaped cylinder assembly, a compound frustum-shaped piston matched with the frustum-shaped cylinder assembly, a returning spring and the like; the cylinder body, the piston and the returning spring form a hydraulic reciprocating vibration system for generating low-frequency hydraulic pulsation in water injection process of a water injection well; the hydraulic ultrasound generation part comprises a flowing channel nozzle and a vibrating reed and is used for generating ultrasound under hydraulic action of the injected water flow and applying the ultrasound to the reservoirs; the hydraulic ultrasound is capable of removing blockage of reservoirs close to the well wall; the low-frequency hydraulic pulsation is capable of effectively improving permeability of the reservoirs, reducing the surrounding flow of the injected water, improving the volumetric sweep efficiency and augmenting injection and assisting for increasing recovery ratio; the system is capable of outputting low-frequency hydraulic pulsation and hydraulic ultrasound of a hydraulic driving manner based on operation displacement range of the low-permeability water injection well, integrally augmenting injection and improving the recovery ratio.

The invention relates to a preparation method of a lithium ion battery, which comprises the steps that a polar core is arranged in the casing body of a battery after being formed by a positive pole, a negative pole and a diaphragm, and then injected into the electrolytic solution to form a semi-finished lithium ion battery, after the semi-finished lithium ion battery is formed and exhausted, the liquid-injection port of the casing body of the battery is sealed; wherein, the method also comprises the steps that the formed semi-finished lithium ion battery is arranged before the exhaustion. According to the method provided by the invention, the gas generated inside the battery can be adequately absorbed and exhausted through putting the semi-finished lithium ion battery for a time interval between the formation and the exhaustion process of the semi-finished lithium ion battery, therefore, the leakage phenomenon of a considerable amount of gas and the electrolytic solution generated during the exhausting process can be effectively avoided, to ensure that the actual injection amount of the electrolytic solution of the battery is increased; thereby, the capacitance and the cycle performance of the battery is enhanced.

The present invention provides for methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2 and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of class II HDAC's has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides the link between MEF-2 and class II HDAC's, a kinase known as PKD. The present invention further demonstrates that inhibitors of PKD inhibit cardiac hypertrophy and heart disease by inhibiting, in part, the fetal cardiac gene expression and cellular reorganization that occurs when MEF-2 dependent transcription is inhibited.

The invention provides a light-emitting diode and a manufacturing method thereof. The light-emitting diode sequentially comprises a substrate, a semiconductor layer and a transparent conducting layer. The light-emitting diode also comprises a first electrode and a second electrode. The first electrode is electrically connected with the semiconductor layer, and the second electrode is electrically connected with the transparent conducting layer; the upper surface of the substrate is provided with a plurality of bulges, and grooves are formed among the bulges; the semiconductor layer comprises a groove semiconductor layer positioned over the grooves and a bulge semiconductor layer positioned over the bulges; and the transparent conducting layer is positioned above the semiconductor layer for providing current for the groove semiconductor layer. In the light-emitting diode, the current mainly passes through the groove semiconductor layer with less lattice defects and only a little current passes through the bulge semiconductor layer with more lattice defects so as to greatly reduce the occurrence probability of the nonradiative recombination and improve the lighting efficiency of the light-emitting diode.

The invention relates to a semisolid injection molding machine with multi-station injection. The semisolid injection molding machine with multi-station injection comprises an injection mold and semisolid injection mechanisms. An injection mold cavity and injection sprues communicating mutually are arranged on the injection mold; two or more than two sets of semisolid injection mechanisms are arranged; two or more than two injection sprues are arranged corresponding to the semisolid injection mechanisms; the injection sprues communicate with the injection mold cavity through different injectionrunners; and the semisolid injection mechanisms communicate with the corresponding injection sprues. According to the semisolid injection molding machine with multi-station injection provided by theinvention, semisolid magnesium alloy is injected through the two sets of semisolid injection mechanisms, so that the injection volume is effectively increased, and the flow length ratio is reduced; and the structure is suitable for the occasions requiring producing thin-wall or thick-wall magnesium alloy products with high production quality and large flow length ratio.