The invention belongs to the technical field of pipeline leakage detection, in particular to a heat supply pipeline leakage detection system based on infrasound waves and a reference point. The heat supply pipeline leakage detection system comprises a center control system, an upstream acoustic wave monitoring device, a downstream acoustic wave monitoring device and an acoustic source device. Thedistance between the upstream acoustic wave monitoring device and the downstream acoustic wave monitoring device is fixed. The acoustic source device is located on a pipeline between the upstream acoustic wave monitoring device and the downstream acoustic wave monitoring device, and the distance between the acoustic source device and the upstream acoustic wave monitoring device is fixed. The upstream acoustic wave monitoring device, the downstream acoustic wave monitoring device and the acoustic source device are all connected with the center control system through wired network or wireless network for two-way data communication. According to the heat supply pipeline leakage detection system based on the infrasound waves and the reference point, the velocity of acoustic wave propagation inthe pipeline can be measured online by detecting an acoustic wave signal emitted from the reference point, when a pipeline leakage accident occurs, the calculation accuracy of a leakage location canbe significantly improved by calculating the leakage location at the acoustic wave transmission velocity, and the site survey workload of maintenance personnel is greatly reduced.