Application of lauromacrogol and methotrexate in preparation of medicine for treating cesarean scar pregnancy

Abstract

The invention provides application of lauromacrogol and methotrexate in preparation of a medicine for treating cesarean scar pregnancy. The method comprises the following steps: inserting needle fromthe posterior fornix of uterus under ultrasonic guidance, enabling puncture needle to directly reach the gestational sac, extracting gestational sac fluid, and inactivating with lauromacrogol to causequick inactivation of the embryo; injecting methotrexate into the gestational sac and multiple surrounding points thereof. By virtue of drug combination, trophocyte necrocytosis can be effectively accelerated, trophoderm peel is facilitated, and HCG (Human Chorionic Gonadotropin) of blood is rapidly lowered. Additionally, multi-point injection is performed in a blood flow richness region of a peripheral muscle layer of the incision with the lauromacrogol, peripheral flow of the trophoderm is effectively blocked, the blood flow of the gestation sac and peripheral muscle layer is obviously reduced, the HCG of the blood is further lowered, and massive haemorrhage of uterine curettage, incision hematoma, perforation of uterus and other complications under ultrasonic guidance are obviously reduced.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to the application of lauromacrogol and methotrexate in the preparation of medicines for treating cesarean scar pregnancy. Background technique [0002] Uterine scar pregnancy after cesarean section (cesarean scar pregnancy, CSP) refers to a type of ectopic pregnancy in which the fertilized egg implants in the scar of the uterine incision of the previous cesarean section. It is a time-limited definition and is limited to early pregnancy (≤12 weeks); CSP in the second trimester after 12 weeks of pregnancy is diagnosed as "intrauterine pregnancy, uterine scar pregnancy after cesarean section, placenta accreta". If there is placenta previa, it is diagnosed as "intrauterine pregnancy, Uterine scar pregnancy after cesarean section, placenta accreta, and placenta previa state", and in the second and third trimesters, it will be placenta accreta and placenta previa, which is t...

AI Technical Summary

Problems solved by technology

(2) Early pregnancy CS patients who are unwilling or unsuitable for surgical treatment

5. There are also ultrasound-guided local injections (25-50 mg) into the gestational sac, or systemic single-dose injections of MTX (50 mg / m 2 ) and other programs to treat CSP, the research results show that no matter MTX alone or combined with UAE, the treatment of CSP has a certain effect, but the total treatment time is long, and there is a possibility of treatment failure, and the success rate is 71% to 83%.

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