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Anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition for skin and preparation method of anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition

A composition and anti-allergic technology, applied in the directions of drug combinations, skin diseases, pharmaceutical formulations, etc., can solve the problems such as undiscovered Radix chinensis oil preparations, and achieve the effects of improving biocompatibility, increasing compliance, and fast absorption

Inactive Publication Date: 2021-06-22
福建宸润生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, it has not been found that a certain simple formula of litsea cubeba oil preparation has excellent anti-allergic, anti-itching and anti-inflammatory effects

Method used

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  • Anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition for skin and preparation method of anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition
  • Anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition for skin and preparation method of anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription composition: Litsea cubeba oil 6g, lauromacrogol 1.5g, stearic acid 30g, glycerin 10g, glyceryl stearate 7g, urea 2.5g, anhydrous potassium carbonate 1.3g, triethanolamine 0.4g, paraben B 0.04 g of ester, 100 g of pure water.

[0025] Preparation method: take lauromacrogol, stearic acid, glyceryl monostearate and litsea cubeba oil and heat them to 65°C, stir well to obtain the oil phase; take urea, glycerin, triethanolamine, anhydrous potassium carbonate, nitric acid Ethyl parkinate and purified water are heated to 65°C and melted to obtain a water phase; add the oil phase to the water phase, stir and emulsify at 65°C for 10-30 minutes to obtain the product.

Embodiment 2

[0027] Prescription composition: Litsea cubeba oil 6g, lauromacrogol 1.8g, stearic acid 31g, glycerin 9g, glyceryl stearate 6g, urea 2.5g, anhydrous potassium carbonate 1.4g, triethanolamine 0.4g, paraben B 0.04 g of ester, 100 g of pure water.

[0028] Preparation method: take lauromacrogol, stearic acid, glyceryl monostearate and litsea cubeba oil and heat them to 60°C, stir well to obtain the oil phase; take urea, glycerin, triethanolamine, anhydrous potassium carbonate, nitric acid Ethyl parkinate and purified water are heated to 70°C and melted to obtain the water phase; the oil phase is added to the water phase, stirred and emulsified at 65°C for 10-30min to obtain the product.

Embodiment 3

[0030] Prescription composition: Litsea cubeba oil 7g, lauromacrogol 1.8g, stearic acid 30g, glycerin 10g, glyceryl stearate 6.5g, urea 2.8g, anhydrous potassium carbonate 1.4g, triethanolamine 0.4g, paraben 0.03 g of ethyl ester and 100 g of pure water.

[0031] Preparation method: take lauromacrogol, stearic acid, glyceryl monostearate and litsea cubeba oil and heat them to 65°C, stir well to obtain the oil phase; take urea, glycerin, triethanolamine, anhydrous potassium carbonate, nitric acid Ethyl parkinate and purified water are heated to 65°C and melted to obtain a water phase; add the oil phase to the water phase, stir and emulsify at 65°C for 10-30 minutes to obtain the product.

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to an anti-allergic, itching-relieving and anti-inflammatory pharmaceutical composition for skin and a preparation method thereof. The pharmaceutical composition comprises the following parts in percentage by weight: 1%-10% of litsea cubeba oil and 0.5%-5% of lauromacrogol, is derived from plants, is soft in smell and special in effect, has the characteristics of quicker absorption, good curative effect, convenience in use, no sticky feeling on skin during use, no irritation, safety, no toxic or side effect and the like, and increases the medication compliance of patients.

Description

technical field [0001] The invention relates to a skin anti-allergic, anti-itch and anti-inflammatory pharmaceutical composition and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Eczema is the most common disease in dermatology, and various types of eczema can account for 20% of dermatology outpatient visits. Generally, the onset of eczema is more common in the face, behind the ears, flexor sides of the limbs, hands, etc., and is in a state of symmetrical distribution. Eczema is divided into children's eczema and adult eczema, and the incidence of infant eczema is more than 70%. The etiology of eczema is generally more complex, allergies, external stimuli, friction, sun exposure and other reasons can form eczema. Eczema is a chronic relapsing disease that can last for months, years or even decades. The most notable symptom is severe itching, which can significantly affect the patient's study, work and l...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/06A61K47/14A61K47/12A61K47/18A61K47/02A61P17/00A61P37/08A61P17/04A61K31/77
CPCA61K9/06A61K31/77A61K36/54A61K47/02A61K47/12A61K47/14A61K47/18A61P17/00A61P17/04A61P37/08A61K2300/00
Inventor 密夫山徐伟杨英祥陈三妹刘明峰
Owner 福建宸润生物科技有限公司
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