170 results about "Anti allergy" patented technology

The invention belongs to the technical field of biological medicines, and discloses a probiotic and prebiotic composition for improving intestinal microecology and assisting in resisting food allergy, and the composition comprises bifidobacterium longum and oligosaccharide in a mass ratio of (1-3): (1-3). The probiotic and oligosaccharide composition provided by the invention is clear in mechanism and wide in application range, and the effect of relieving food anaphylactic reaction is achieved by enhancing intestinal barriers and regulating intestinal flora. And under the participation of the oligosaccharide, the anti-allergic effect of the probiotics is obviously enhanced. The invention can solve the problem that the existing anti-allergic medicine treats both symptoms and root causes, simplifies the composition, defines the action mechanism of the composition, and expands the range of applicable people.

The invention discloses a lactobacillus rhamnosus strain with antiallergic activity and a preparation method thereof, the strain is lactobacillus rhamnosus Lrn-PG-06, the classification name of the strain is Lactobacillus rhamnosus, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.3077, the preservation time is March 21, 2024, the preservation unit is China General Microbiological Culture Collection Center, the preservation number is CGMCC No.3077, and the preservation number is CGMCC No.3077. The address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The lactobacillus rhamnosus Lrn-PG-06 strain is high in acid resistance, alkali resistance and cholate resistance, high in simulated gastrointestinal fluid resistance and high in oxidation resistance, has the advantage of resisting allergy, and solves the problems that at present, allergic diseases are mainly treated by drugs or are prevented from being in contact with allergens in the environment and food, but due to the fact that the drugs are large in toxic and side effects, the allergens cannot be in contact with the allergens in the environment and food. And allergens causing anaphylaxis are difficult to determine, so that allergic diseases are difficult to treat or prevent.

The invention belongs to the technical field of preparation of probiotics, and provides a bacterial strain with anti-allergic and immunity-improving effects and application of the bacterial strain. According to the method, a three-layer physical self-assembly structure is adopted, and polysaccharide-polyphenol layer-by-layer self-assembly coating treatment, lipid insertion layer treatment and calcium ion crosslinking protection coating treatment are sequentially carried out. And mannan oligosaccharide MOS and / or galactooligosaccharide GOS are / is mixed in the chitosan layer in a ratio of 0.05-0.15% w / v, and the surface sugar ligand density reaches 4-8 [mu] g per 10 CFU. The coating is constructed under the condition that the pH value is 5.4-5.8; the thickness of the lipid layer is 20-80 nm when the pH value is 5.6-6.2; the cross-linked layer is treated at the pH of 6.0-6.5, so that the gastric acid environment is stable for 2 hours, and the gastric acid is controllably released in intestinal juice for 2-4 hours. The prepared strain has the total thickness of 220-900 nm, the outermost layer coverage rate is larger than or equal to 85%, the gastric juice survival rate is remarkably improved, the strain can be prepared into an oral preparation to be used for preventing and relieving allergic diseases, the viable count of each dose is 1 * 10 <-1 > * 10 <-1 > CFU, and the process is mild and suitable for industrial production.

The invention provides a probiotic composition as well as a preparation method and application thereof. The composition is prepared from lactobacillus rhamnosus GG, lactobacillus acidophilus NCFM, an anti-IL-4R alpha monoclonal antibody, an inulin-beta-glucan compound and sodium alginate-chitosan microspheres. The composition regulates immune balance through a specific probiotic strain, blocks an IL-4 / IL-13 signal channel in combination with an anti-IL-4R alpha monoclonal antibody, and improves viable bacterium stability and bioavailability through a microsphere delivery technology. The probiotic composition shows a remarkable anti-allergic effect in an atopic dermatitis mouse model, and can reduce the serum IgE level, reduce the skin inflammatory response and reduce the STAT6 phosphorylation level. The probiotic composition disclosed by the invention has a wide application prospect in the aspect of treating atopic dermatitis and other immune-related diseases.

The invention belongs to the technical field of biological medicines, and particularly relates to application of quercetin combined with curcumin in preparation of an anti-allergic reaction medicine. Through a large number of researches, the inventor finds that combined administration of quercetin and curcumin with a specific concentration can effectively inhibit mast cell degranulation, and the inhibition rate of mast cell degranulation reaches 90% or more, so that I-type anaphylaxis mediated by immune globulin E is inhibited, especially systemic anaphylaxis, and the curative effect is good. The compound can be used for preparing anti-anaphylaxis drugs. The drug combination scheme provided by the invention has important significance and wide application prospect in drugs for treating or preventing anaphylactic reactions.

The invention belongs to the technical field of food engineering, and particularly relates to an anti-allergic special medical infant milk protein partial hydrolysis formula food composition, a preparation method and application. According to the infant milk protein partial hydrolysis formula food composition for the special medical purpose, the mass ratio of the 2 '-fucosyllactose to the lactobacillus acidophilus NCFM to the bifidobacterium animalis Bi-07 is (150-200): (5-10): (2-8). The partially hydrolyzed formula food composition provided by the invention can prevent respiratory tract infection and maintain the natural defense capability of children; the infant health is promoted; the method helps infants to establish healthy intestinal microflora, which is crucial to immune system and cognitive development.

The invention relates to the technical field of cosmetics, in particular to a composition with a blackhead removing effect and application of the composition in the cosmetics, mandelic acid and salicylic acid in the composition can permeate deep pores to dissolve grease and cutin so as to achieve the effect of reducing formation of blackheads, tea tree essential oil can remove bacteria and dirt in the pores, and therefore the blackhead removing effect is achieved. Antibacterial and anti-inflammation effects can be realized on the basis of removing blackheads, pricking pain caused by skin allergy can be relieved by adding carboxymethyl yeast glucan, and moisturizing effects can be realized; the herba portulacae extract has the effects of resisting inflammation, resisting allergy and enhancing the skin immune function, when the herba portulacae extract is used in the composition with the blackhead removing effect, the effect of accelerating skin recovery can be achieved, and the D-panthenol has the effect of rapidly permeating into the skin cuticle and can stimulate the growth of epidermal cells so as to accelerate skin barrier repair after blackhead removing. And the chitosan-based gel is combined, so that the probability that the skin is irritated and allergic can be reduced.

The invention relates to a traditional Chinese medicine composition for preventing and treating liver rupture syndrome of broiler breeders and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 50-200 parts of silybum marianum, 50-200 parts of schisandra chinensis, 50-200 parts of gentiana macrophylla, 50-200 parts of andrographis paniculata, 50-200 parts of radix paeoniae alba, 50-200 parts of oldenlandia diffusa, 50-200 parts of folium isatidis and 50-200 parts of patrinia. The traditional Chinese medicine composition has the effects of resisting endotoxin, inflammation, allergy and liver injury and the like, and effectively prevents and treats the liver rupture syndrome of the broiler breeders.

The invention belongs to the technical field of traditional Chinese medicines, mainly relates to a preparation method of herbal ointment, and in particular relates to a preparation method and application of specific endowment herbal ointment. The formula disclosed by the invention comprises herbal fermentation liquor, herbal enzymatic hydrolysate and herbal extracting liquor, wherein the herbal fermentation liquor is obtained by fermenting mint, purple perilla, chrysanthemum, radix angelicae and pericarpium citri reticulatae through probiotics and then filtering; the herbal enzymatic hydrolysate is obtained by performing enzymolysis and extraction on semen armeniacae amarae and poria cocos; the herbal extracting solution is obtained by extracting smoked plum, lily and liquorice with water. The herbal ointment prepared by the invention has the effects of resisting allergy, relieving itching, diminishing swelling and relieving eczema and rhinitis.

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis, which is prepared from the following raw materials in parts by weight: 6 to 30 parts of folium mori, 6 to 30 parts of flos chrysanthemi, 1 to 9 parts of radix ginseng, 10 to 30 parts of fructus ziziphi jujubae, 3 to 10 parts of rhizoma zingiberis recens, 3 to 10 parts of liquorice root, 10 to 30 parts of radix astragali seu hedysari, 3 to 12 parts of radix angelicae sinensis, 6 to 15 parts of radix ophiopogonis, 1 to 6 parts of radix puerariae, 3 to 12 parts of radix angelicae dahuricae, 3 to 9 parts of herba menthae and 3 to 10 parts of radix platycodonis. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) respectively taking the raw materials in parts by weight, and adding water to soak for 1 hour; step 2) adding water and decocting twice, adding 400-900 parts by volume of water each time, boiling and decocting with strong fire for the first time, adding water and boiling with slow fire for the second time, and combining decoctions; and (3) adding pharmaceutically acceptable medicinal auxiliary agents according to a conventional process to prepare clinically acceptable granules, pills, tablets, powder or capsules. The traditional Chinese medicine composition has the effects of resisting allergy, inflammation and bacteria and the like, and can relieve the symptoms of nasal obstruction, running nose, sneezing and the like of allergic rhinitis patients.

The invention relates to the field of anti-allergic compositions, and discloses an immunoregulation anti-allergic compound powder based on non-active yeast and probiotics, and the immunoregulation anti-allergic compound powder comprises the following components in parts by mass: 15-30 parts of non-active yeast powder, 10-25 parts of a probiotic composition, 40-55 parts of a prebiotic composition, 4-6 parts of fucoidin, 0.5-1.5 parts of N-acetylneuraminic acid, and 5-10 parts of an auxiliary material; wherein the prebiotic composition is prepared from resistant dextrin, stachyose, fructo-oligosaccharide and galactooligosaccharide; the auxiliary materials comprise at least two of anhydrous dextrose, acerola cherry powder, elderberry powder, sorbitol and yeast beta-glucan. Through the coupling design of low-temperature mixing and a step-by-step embedding process, the mobility of the powder is maintained, and meanwhile, the activity of thermosensitive components is kept. Compared with a conventional high-temperature mixing or disordered adding process, the problems of component damage and function loss caused by a heat effect or mechanical shearing are solved.

We provide fibers using microcapsule technology. [Solution] The fiber 5 comprises a mixture of phase-change microcapsules 1, functional microcapsules 2, and a substrate. The mixture of phase-change microcapsules, functional microcapsules, and substrate comprises the phase-change microcapsules comprising a phase-change core material and a phase-change wall material coated on the phase-change core material. The phase-change core material comprises any one or any combination of organic PCM material, inorganic PCM material, or bio-based PCM material. The functional microcapsules comprise a functional core material and a functional wall material coated on the functional core material. The functional core material comprises any one or any combination of anti-mite aid, anti-fungal aid, antibacterial and anti-fungal aid, deodorizing aid, moisturizing aid, or anti-allergy aid. The fiber integrates multiple functions, such as cooling sensation, anti-mite, anti-fungal, deodorizing and disinfecting, moisturizing, and anti-allergy. The fiber can meet the needs of use in various environments, satisfy users' demands for diverse textile functions, and improve practicality.

The invention discloses a composition and application thereof, and the composition comprises synephrine or a pharmaceutically acceptable salt thereof, and further comprises naringin, neohesperidin and / or hesperidin. The composition prepared by compounding the synephrine or the pharmaceutically acceptable salt thereof with the naringin, the neohesperidin and / or the hesperidin has the effects of relieving, repairing, resisting wrinkles, easing pain, relieving itching or resisting allergy when being used as a functional component of a skin care product; when being used as a functional component of a scalp care product, the shampoo has the effects of removing dandruff, removing oil, relieving itching or preventing alopecia.

The invention discloses a signal acquisition system of a self-adaptive film electrode patch for heart diseases, and relates to the technical field of medical instruments, the signal acquisition system comprises a flexible substrate, a nano electrode wire, an electrode patch and a circuit module; a bonding layer is arranged on the bottom surface of the flexible substrate, an anti-allergic medicine is distributed in the bonding layer, and the flexible substrate is used for being attached to the skin surface through the bonding layer; the plurality of nano electrode wires are distributed on the bonding layer of the flexible substrate, one ends of the plurality of nano electrode wires are respectively arranged at the detection points, the other ends of the plurality of electrode wires are connected with the circuit module, and the circuit module is used for outputting electric signals collected by the electrode paste; the electrode patch comprises a flexible conductive base layer and a contact layer, a printed circuit is arranged on one side of the flexible conductive base layer, the contact layer is attached to the printed circuit, the other side of the flexible conductive base layer is used for being bonded to a flexible substrate and located at a detection point, and the flexible conductive base layer is conducted with the nano electrode wire; the collection system is simple to operate, and solves the problems that an existing lead wire is easy to wind, the surgical field is affected, and skin allergy is caused by patch. The method has high use value and popularization value.

This invention belongs to the field of anti-allergy functional food technology, specifically relating to an anti-allergy composition containing inactivated Akkermansia myxophilus. Existing anti-allergy drugs have side effects. The composition of this invention contains inactivated Akkermansia myxophilus, quercetin, vitamin C, and zinc. This invention can improve allergic rhinitis, alleviate eczema symptoms, and improve allergic constitution by regulating immune balance and inhibiting histamine release. The composition of this invention is stable at room temperature and can be formulated into powder or chewable tablets.

The invention discloses an oral care composition and application thereof. The oral care composition disclosed by the invention is prepared from guaiazulene, allantoin and dipotassium glycyrrhizinate. According to the oral care composition disclosed by the invention, guaiazulene, allantoin and dipotassium glycyrrhizinate are organically combined, so that gingival bleeding can be effectively relieved, gingival inflammation can be relieved, and uncomfortable symptoms such as red and swollen gingiva and pain can be eliminated; the three components can synergistically promote oral mucosa repair, enhance anti-inflammatory and anti-allergic effects, comprehensively nurse oral health, and can be prepared into various oral care products.

A plant lactobacillus JN9, a preparation, a probiotic composition and its use. The present application obtains a new plant lactobacillus JN9 through screening, and the deposit number is: CCTCC NO: M 20241647. Through the basic characteristic analysis (growth curve, acid resistance, bile salt resistance, gastrointestinal fluid resistance), safety evaluation (antibiotic sensitivity, hemolytic ability, toxin production ability, cytotoxicity, ability to produce bioamines), adhesion evaluation, GABA production evaluation, alcohol tolerance and acetaldehyde dehydrogenase production ability evaluation of the strain, it is found that it is a safe strain with excellent GABA production performance, high alcohol tolerance and high acetaldehyde dehydrogenase enzyme activity. It can be used to improve mood such as relieving stress, anti-depression and improving the body's sleep quality, lowering blood pressure, anti-diabetes, anti-cancer, anti-oxidation, anti-inflammatory, anti-microbial, anti-allergic, and enhancing alcohol tolerance during drinking and relieving discomfort after drinking.

The invention discloses a substance with anti-allergic activity and application thereof, the substance with anti-allergic activity is a bitter receptor stimulant, and the bitter receptor stimulant is selected from at least one of denatonium benzoate, difenidol and quinine. The compound can reduce the expression level of IgE in serum, inhibit mast cell degranulation and regulate and control expression of cytokines at the downstream of Th1, Th2 and Dc cells, so that allergy is prevented and allergic symptoms are relieved, and the compound can be used for preparing medicines, health foods, functional foods and dietary supplements for preventing and relieving food allergy.

The present application relates to the application of an acidic goat milk oligosaccharide composition in the preparation of an anti-allergy drug or food, the composition comprising 24 acidic sugar chains 24SMAOs, among which, according to the classification of sialic acid structure, 12 Neu5Ac modified sialylation sugar chains, 10 Neu5Gc modified sialylation sugar chains and 2 sialylation sugar chains modified by both Neu5Ac and Neu5Gc, according to the classification of sialic acid connection mode, 11 alpha2,3 connected sialic acid sugar chains, 10 alpha2,6 connected sialic acid sugar chains and 3 sialic acid sugar chains connected by both alpha2,3 and alpha2,6. The composition belongs to a natural anti-allergy substance, has safety and effectiveness, and realizes excellent anti-allergy performance.

The present invention provides antibodies that bind to peanut allergens, in particular antibodies that bind to Ara h 2 and Ara h 3 or Ara h 6. The present invention also provides compositions and kits comprising different antibodies that bind to different non-overlapping epitopes of Ara h 2 and multispecific antibodies that bind to different non-overlapping epitopes of Ara h 2. In addition, the invention also relates to application of the antibodies, the compositions and the kits, for example, the application for preventing or treating peanut allergy.

A use of extracts of roselle seeds for preparing a composition of antioxidant, anti-inflammation, anti-UVB, anti-allergy, whitening, moisturizing, and anti-wrinkle, wherein the extracts of the roselle seeds comprise lauric, palmitic, linoleic, oleic, or stearic acids; and a method for preparing the extracts of the roselle seeds comprises steps of: steeping of: extracting a weight ratio of the 12:1 to 20:1 roselle seeds and an ethanol solution with a concentration of 75 to 95%; and steeping the roselle seeds in the ethanol solution to obtain a suspension; and extraction of: the suspension being engaged in an extraction of a continuous and rapid oscillation with an ultrasonic energy with a total energy of 200 to 500W, wherein 1 to 3 hours of the oscillation is one cycle, and a total number of 3 to 5 cycles is lasted, in order to obtain roselle seed crude extracts.

The invention provides a topical spray for treating myiasis on livestock wounds and a preparation method thereof, belonging to the technical field of veterinary drug preparations. The topical spray comprises, by volume, an insecticidal active component: 2-4 parts of diazinon; 0.5-1 parts of wormwood oil; 2-3 parts of peppermint oil; a solvent carrier component: 50-70 parts of xylene; 30-50 parts of diesel; and an emulsifier component: 2-8 parts of emulsifier. In the present invention, the diazinon is an organophosphorus insecticide and acaricide, and has a good killing effect on various mites, flies, lice, and ticks; the wormwood oil has the effects of anti-allergy, anti-inflammatory, blood-activating, antibacterial, antiviral, analgesic, immunity-enhancing, and antioxidant; and the peppermint oil has the effects of anti-inflammatory, analgesic, antibacterial, antiviral, and penetration-promoting. The diazinon is used in combination with the wormwood oil and the peppermint oil to enhance the insecticidal effect of the diazinon. Meanwhile, the wormwood oil and the peppermint oil can reduce the irritation of the diazinon to animal skin.

The invention relates to the technical field of microorganisms, in particular to a yeast metagen with an anti-allergic effect as well as a preparation method and application of the yeast metagen. According to the invention, the metabolite is an inactivated saccharomyces boulardii strain and a fermentation metabolite thereof, wherein the preservation number of the saccharomyces boulardii strain is CCTCC (China Center for Type Culture Collection) NO: M 20251803. The metagen can be used for remarkably reducing the total IgE (Immunoglobulin E) level of serum and relieving anaphylactic reaction by adjusting the balance of Th1 / Th2, Th17 and Treg immune cells. Therefore, the metabiotics disclosed by the invention have a wide application prospect in preparation of foods, medicines or health-care products for relieving allergic symptoms.

The invention belongs to the technical field of genetic engineering, and particularly relates to truncated tropomyosin, a nucleic acid molecule and application of the truncated tropomyosin. The truncated tropomyosin is based on an alpha-helical structure of tropomyosin, and is obtained by taking glutamic acid (E26) at the 26th site, glutamine (Q51) at the 51st site or glutamic acid (E73) at the 73rd site as a truncation site. By reasonably designing a truncation site and further replacing the secretion signal peptide, the expression quantity of the protein in a recombinant expression system is remarkably improved, the immunogenicity of the protein is effectively reserved, and the protein can be used for precise diagnosis of allergy and development of anti-allergic vaccines.

The invention provides a traditional Chinese medicine composition for treating male hormone alopecia. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1.5-3 parts of prepared polygonum multiflorum, 1.5-3 parts of scalded rhizoma drynariae, 0.5-1.5 parts of liquorice tablets, 2.5-3 parts of raw cacumen biotae, 2.5-3 parts of salvia miltiorrhiza, 1.5-3 parts of angelica sinensis and 1-2 parts of ligusticum chuanxiong hort. The traditional Chinese medicine composition is obtained by soaking in cold water for 20-30 minutes, decocting and concentrating. The traditional Chinese medicinal materials capable of activating blood circulation, removing blood stasis, nourishing essence and blood and resisting inflammation and allergy are adopted as raw materials, so that the traditional Chinese medicinal composition has multiple effects of activating blood circulation, improving blood circulation and nourishing hair follicles, and the alopecia is cured from the perspective of permanent cure; the traditional Chinese medicines synergistically exert a curative effect, so that the traditional Chinese medicine can nourish hair, prevent alopecia, diminish inflammation and moisten skin.

The invention relates to the field of medicines, in particular to application of LKB1 / AMPK pathway-based fucoidan in preparation of anti-type I anaphylaxis medicines. The LKB1 / AMPK pathway is activated by the alginate, so that mast cell degranulation is effectively inhibited, mast cell mediated cell anaphylaxis is further effectively inhibited, and the alginate can be used for preparing anti-anaphylaxis related drugs.

The application discloses an anti-nasal allergy gel production optimization method based on data analysis, and particularly relates to the field of resource allocation and production optimization, and is used for solving the problem that the response to regional and seasonal demand changes in the existing anti-allergy gel production process is lagging behind, and the raw material supply constraint and the production line switching cost are difficult to balance. The method collects raw material supply chain data, market sales records and environmental allergen time series data, constructs a unified space-time correlation data basis, predicts the anti-allergy response intensity in the future production cycle by using a recurrent neural network, and forms product dosage form preference weights based on association rule mining. On this basis, combined with the raw material inventory and the delivery cycle constraint, a plurality of executable candidate production schemes are generated, and further, the schemes are selected according to the real-time state of the production line and the switching cost, so as to realize the fine configuration and efficient execution of the anti-nasal allergy gel production process.

The invention provides application of a stevia rebaudiana extract, and belongs to the technical field of pure natural plant extracts, the stevia rebaudiana extract at least contains phenols, flavones and potassium ions, and when a health care product and / or a composition are given to a subject, at least one of the following components is achieved: antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity and the like. The expression of IRS protein, tyrosine phosphorylation of IRS and the content of GLUT4 protein are increased; bacteria are inhibited, and viruses and allergy are resisted; the intraocular pressure is reduced; the appetite is promoted; the hair loss is prevented or the hair growth is promoted. The application comprises application of the stevia rebaudiana extract in preparation of hair loss preventing or hair growth promoting products. The health-care product containing the stevia rebaudiana extract can prevent or treat type 2 diabetes mellitus, inhibit bacteria or resist viruses or allergy, and can be used as auxiliary food and / or sports food for sub-health people, type 2 diabetes mellitus patients, patients receiving glaucoma treatment, cancer patients, hepatitis patients, overweight people, picky and anorexia children or patients during general disease rehabilitation. The hair loss can be prevented or the hair growth is promoted.

To provide a novel Lacticaseibacillus rhamnosus strain.SOLUTION: The present invention relates to a novel Lacticaseibacillus rhamnosus ICL-46 strain and its use for anti-inflammation, anti-allergy, skin soothing, and skin microorganism regulation. According to one embodiment of the strain, since it has effects of anti-inflammation, anti-allergy, skin immunity enhancement, atopic dermatitis improvement, skin soothing, and skin microorganism regulation, it can be variously applied to cosmetics, pharmaceuticals, foods, and the like.SELECTED DRAWING: Figure 1

The invention provides anti-allergic toothpaste containing core-shell structure bioactive glass. The anti-allergic toothpaste comprises the following components in percentage by weight: 15-30% of a friction agent, 10-25% of a humectant, 0.5-2% of an adhesive, 0.1-1% of a sweetening agent, 0.1-0.5% of a preservative, 0.5-2% of essence, 1-20% of core-shell structure bioactive glass and the balance of glycerol. A shell of the core-shell structure bioactive glass is boron-containing boron-series bioactive glass, and an inner core of the core-shell structure bioactive glass is silicon-based bioactive glass. Boron-based bioactive glass and silicon-based bioactive glass with different properties are combined to form a core-shell structure, so that the problem that the activity and degradation resistance of the existing bioactive glass are difficult to balance when the existing bioactive glass is applied to anti-allergic toothpaste is solved, and the anti-allergic effect and storage stability of the toothpaste are improved.