97 results about "Anti allergy" patented technology

The invention belongs to the technical field of preparation of probiotics, and provides a bacterial strain with anti-allergic and immunity-improving effects and application of the bacterial strain. According to the method, a three-layer physical self-assembly structure is adopted, and polysaccharide-polyphenol layer-by-layer self-assembly coating treatment, lipid insertion layer treatment and calcium ion crosslinking protection coating treatment are sequentially carried out. And mannan oligosaccharide MOS and / or galactooligosaccharide GOS are / is mixed in the chitosan layer in a ratio of 0.05-0.15% w / v, and the surface sugar ligand density reaches 4-8 [mu] g per 10 CFU. The coating is constructed under the condition that the pH value is 5.4-5.8; the thickness of the lipid layer is 20-80 nm when the pH value is 5.6-6.2; the cross-linked layer is treated at the pH of 6.0-6.5, so that the gastric acid environment is stable for 2 hours, and the gastric acid is controllably released in intestinal juice for 2-4 hours. The prepared strain has the total thickness of 220-900 nm, the outermost layer coverage rate is larger than or equal to 85%, the gastric juice survival rate is remarkably improved, the strain can be prepared into an oral preparation to be used for preventing and relieving allergic diseases, the viable count of each dose is 1 * 10 <-1 > * 10 <-1 > CFU, and the process is mild and suitable for industrial production.

The invention belongs to the technical field of traditional Chinese medicines, mainly relates to a preparation method of herbal ointment, and in particular relates to a preparation method and application of specific endowment herbal ointment. The formula disclosed by the invention comprises herbal fermentation liquor, herbal enzymatic hydrolysate and herbal extracting liquor, wherein the herbal fermentation liquor is obtained by fermenting mint, purple perilla, chrysanthemum, radix angelicae and pericarpium citri reticulatae through probiotics and then filtering; the herbal enzymatic hydrolysate is obtained by performing enzymolysis and extraction on semen armeniacae amarae and poria cocos; the herbal extracting solution is obtained by extracting smoked plum, lily and liquorice with water. The herbal ointment prepared by the invention has the effects of resisting allergy, relieving itching, diminishing swelling and relieving eczema and rhinitis.

We provide fibers using microcapsule technology. [Solution] The fiber 5 comprises a mixture of phase-change microcapsules 1, functional microcapsules 2, and a substrate. The mixture of phase-change microcapsules, functional microcapsules, and substrate comprises the phase-change microcapsules comprising a phase-change core material and a phase-change wall material coated on the phase-change core material. The phase-change core material comprises any one or any combination of organic PCM material, inorganic PCM material, or bio-based PCM material. The functional microcapsules comprise a functional core material and a functional wall material coated on the functional core material. The functional core material comprises any one or any combination of anti-mite aid, anti-fungal aid, antibacterial and anti-fungal aid, deodorizing aid, moisturizing aid, or anti-allergy aid. The fiber integrates multiple functions, such as cooling sensation, anti-mite, anti-fungal, deodorizing and disinfecting, moisturizing, and anti-allergy. The fiber can meet the needs of use in various environments, satisfy users' demands for diverse textile functions, and improve practicality.

The invention discloses a signal acquisition system of a self-adaptive film electrode patch for heart diseases, and relates to the technical field of medical instruments, the signal acquisition system comprises a flexible substrate, a nano electrode wire, an electrode patch and a circuit module; a bonding layer is arranged on the bottom surface of the flexible substrate, an anti-allergic medicine is distributed in the bonding layer, and the flexible substrate is used for being attached to the skin surface through the bonding layer; the plurality of nano electrode wires are distributed on the bonding layer of the flexible substrate, one ends of the plurality of nano electrode wires are respectively arranged at the detection points, the other ends of the plurality of electrode wires are connected with the circuit module, and the circuit module is used for outputting electric signals collected by the electrode paste; the electrode patch comprises a flexible conductive base layer and a contact layer, a printed circuit is arranged on one side of the flexible conductive base layer, the contact layer is attached to the printed circuit, the other side of the flexible conductive base layer is used for being bonded to a flexible substrate and located at a detection point, and the flexible conductive base layer is conducted with the nano electrode wire; the collection system is simple to operate, and solves the problems that an existing lead wire is easy to wind, the surgical field is affected, and skin allergy is caused by patch. The method has high use value and popularization value.

This invention belongs to the field of anti-allergy functional food technology, specifically relating to an anti-allergy composition containing inactivated Akkermansia myxophilus. Existing anti-allergy drugs have side effects. The composition of this invention contains inactivated Akkermansia myxophilus, quercetin, vitamin C, and zinc. This invention can improve allergic rhinitis, alleviate eczema symptoms, and improve allergic constitution by regulating immune balance and inhibiting histamine release. The composition of this invention is stable at room temperature and can be formulated into powder or chewable tablets.

The invention discloses an oral care composition and application thereof. The oral care composition disclosed by the invention is prepared from guaiazulene, allantoin and dipotassium glycyrrhizinate. According to the oral care composition disclosed by the invention, guaiazulene, allantoin and dipotassium glycyrrhizinate are organically combined, so that gingival bleeding can be effectively relieved, gingival inflammation can be relieved, and uncomfortable symptoms such as red and swollen gingiva and pain can be eliminated; the three components can synergistically promote oral mucosa repair, enhance anti-inflammatory and anti-allergic effects, comprehensively nurse oral health, and can be prepared into various oral care products.

The present application relates to the application of an acidic goat milk oligosaccharide composition in the preparation of an anti-allergy drug or food, the composition comprising 24 acidic sugar chains 24SMAOs, among which, according to the classification of sialic acid structure, 12 Neu5Ac modified sialylation sugar chains, 10 Neu5Gc modified sialylation sugar chains and 2 sialylation sugar chains modified by both Neu5Ac and Neu5Gc, according to the classification of sialic acid connection mode, 11 alpha2,3 connected sialic acid sugar chains, 10 alpha2,6 connected sialic acid sugar chains and 3 sialic acid sugar chains connected by both alpha2,3 and alpha2,6. The composition belongs to a natural anti-allergy substance, has safety and effectiveness, and realizes excellent anti-allergy performance.

A use of extracts of roselle seeds for preparing a composition of antioxidant, anti-inflammation, anti-UVB, anti-allergy, whitening, moisturizing, and anti-wrinkle, wherein the extracts of the roselle seeds comprise lauric, palmitic, linoleic, oleic, or stearic acids; and a method for preparing the extracts of the roselle seeds comprises steps of: steeping of: extracting a weight ratio of the 12:1 to 20:1 roselle seeds and an ethanol solution with a concentration of 75 to 95%; and steeping the roselle seeds in the ethanol solution to obtain a suspension; and extraction of: the suspension being engaged in an extraction of a continuous and rapid oscillation with an ultrasonic energy with a total energy of 200 to 500W, wherein 1 to 3 hours of the oscillation is one cycle, and a total number of 3 to 5 cycles is lasted, in order to obtain roselle seed crude extracts.

The invention relates to the technical field of microorganisms, in particular to a yeast metagen with an anti-allergic effect as well as a preparation method and application of the yeast metagen. According to the invention, the metabolite is an inactivated saccharomyces boulardii strain and a fermentation metabolite thereof, wherein the preservation number of the saccharomyces boulardii strain is CCTCC (China Center for Type Culture Collection) NO: M 20251803. The metagen can be used for remarkably reducing the total IgE (Immunoglobulin E) level of serum and relieving anaphylactic reaction by adjusting the balance of Th1 / Th2, Th17 and Treg immune cells. Therefore, the metabiotics disclosed by the invention have a wide application prospect in preparation of foods, medicines or health-care products for relieving allergic symptoms.

The invention provides a traditional Chinese medicine composition for treating male hormone alopecia. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1.5-3 parts of prepared polygonum multiflorum, 1.5-3 parts of scalded rhizoma drynariae, 0.5-1.5 parts of liquorice tablets, 2.5-3 parts of raw cacumen biotae, 2.5-3 parts of salvia miltiorrhiza, 1.5-3 parts of angelica sinensis and 1-2 parts of ligusticum chuanxiong hort. The traditional Chinese medicine composition is obtained by soaking in cold water for 20-30 minutes, decocting and concentrating. The traditional Chinese medicinal materials capable of activating blood circulation, removing blood stasis, nourishing essence and blood and resisting inflammation and allergy are adopted as raw materials, so that the traditional Chinese medicinal composition has multiple effects of activating blood circulation, improving blood circulation and nourishing hair follicles, and the alopecia is cured from the perspective of permanent cure; the traditional Chinese medicines synergistically exert a curative effect, so that the traditional Chinese medicine can nourish hair, prevent alopecia, diminish inflammation and moisten skin.

The application discloses an anti-nasal allergy gel production optimization method based on data analysis, and particularly relates to the field of resource allocation and production optimization, and is used for solving the problem that the response to regional and seasonal demand changes in the existing anti-allergy gel production process is lagging behind, and the raw material supply constraint and the production line switching cost are difficult to balance. The method collects raw material supply chain data, market sales records and environmental allergen time series data, constructs a unified space-time correlation data basis, predicts the anti-allergy response intensity in the future production cycle by using a recurrent neural network, and forms product dosage form preference weights based on association rule mining. On this basis, combined with the raw material inventory and the delivery cycle constraint, a plurality of executable candidate production schemes are generated, and further, the schemes are selected according to the real-time state of the production line and the switching cost, so as to realize the fine configuration and efficient execution of the anti-nasal allergy gel production process.

The invention provides anti-allergic toothpaste containing core-shell structure bioactive glass. The anti-allergic toothpaste comprises the following components in percentage by weight: 15-30% of a friction agent, 10-25% of a humectant, 0.5-2% of an adhesive, 0.1-1% of a sweetening agent, 0.1-0.5% of a preservative, 0.5-2% of essence, 1-20% of core-shell structure bioactive glass and the balance of glycerol. A shell of the core-shell structure bioactive glass is boron-containing boron-series bioactive glass, and an inner core of the core-shell structure bioactive glass is silicon-based bioactive glass. Boron-based bioactive glass and silicon-based bioactive glass with different properties are combined to form a core-shell structure, so that the problem that the activity and degradation resistance of the existing bioactive glass are difficult to balance when the existing bioactive glass is applied to anti-allergic toothpaste is solved, and the anti-allergic effect and storage stability of the toothpaste are improved.

Disclosed is a pharmaceutical composition in dry powder form for intranasal administration, comprising an anti-anaphylactic adrenergic receptor agonist in the form of dry powder for intranasal administration, the composition comprising solid particles of the active agent in combination with at least one functional additive, and solid particles of an inert carrier.

To provide an intestinal disorder controlling agent, an antiallergic agent, an immunopotentiator and an intestinal adhesion improver of lactic acid bacteria, safely ingestible, inexpensively available and excellent in intestinal adhesion improving action of lactic acid bacteria.SOLUTION: The agent of the present invention contains a flower extract. The flower is a flower of Lythraceae, Asteraceae, Fabaceae, Rosaceae or Iridaceae, and is particularly preferably at least one selected from the group consisting of safflower, pomegranate, kudzu, cherry, chrysanthemum, saffron, peach and rose.SELECTED DRAWING: Figure 1

The invention discloses a special cleaning agent used in cooperation with tooth brushing and a preparation method thereof, and belongs to the field of tooth cleaning. The toothpaste is prepared from the following components in an equal amount of deionized water: 8.8.6 to 17.8 percent of a surfactant, 5.3 to 11.1 percent of a sterilizing agent, 2.4 to 9.7 percent of an enzyme preparation, 3.6 to 7.9 percent of an anti-allergic agent, 2.3 to 6.7 percent of a flavoring agent, 1.3 to 5.9 percent of a thickening agent, 14.2 to 28.9 percent of a humectant, 3.7 to 4.8 percent of a radix scutellariae extract, 1.3 to 5.6 percent of a coloring agent, 3.5 to 11.5 percent of essence, 0.2 to 0.9 percent of vitamin, 1.5 to 4.9 percent of a foaming agent and 1.5 to 9.9 percent of an emulsifying agent. The special cleaning agent for tooth brushing and the preparation method thereof have the beneficial effects that the special cleaning agent for tooth brushing and the preparation method thereof are provided.

The invention relates to the technical field of pet skin care products, and particularly discloses a universal skin care nutritional supplement for dogs and cats, capable of removing dampness, relieving itching and resisting allergy and a preparation method of the universal skin care nutritional supplement. The invention relates to a general skin care nutritional supplement for dogs and cats with effects of removing dampness, relieving itching and resisting allergy. The nutritional supplement is prepared from the following raw material components in parts by weight: 10 to 20 parts of a dampness removing component, 15 to 20 parts of a moisturizing component, 28 to 34 parts of an itching-relieving and anti-inflammatory component, 1 to 1.5 parts of vitamins, 20 to 25 parts of seasoning powder and 8 to 12 parts of a filling agent, the dehumidifying component comprises rhizoma atractylodis and poria cocos; the moisturizing component comprises angelica sinensis, sea-buckthorn and fish oil. All the raw materials are scientifically proportioned and have a synergistic effect, the five core effects of dehumidification, itching relieving, allergy resistance, inflammation resistance and moisturizing and repairing are fully covered, and the limitation that an existing product is single in effect is overcome.

The present invention relates to an aqueous pharmaceutical composition for injection comprising doxylamine or a physiologically acceptable salt thereof wherein the concentration of doxylamine is in the range of from 5 mg / ml to 25 mg / ml, based on the weight of doxylamine free base and based on the total volume of the composition; wherein the pH value of the composition is in the range of 6.0 to 7.0. The pharmaceutical composition disclosed by the invention has the effects and effects of sedation, hypnosis, histamine resistance, choline resistance, allergy resistance and the like.

The application discloses a astragaloside IV-gallic acid combination, a nose temperature-sensitive gel and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The astragaloside IV-gallic acid combination is obtained by the reaction of a hydroxyl group in an astragaloside IV molecule and a carboxyl group in a gallic acid molecule. The astragaloside IV-gallic acid combination has good water solubility, can realize the spatiotemporal co-delivery of the astragaloside IV and the gallic acid, and is convenient for playing the synergistic anti-allergy effect of the two. The astragaloside IV-gallic acid combination is further used to prepare the nose temperature-sensitive gel. The nose temperature-sensitive gel is a free-flowing liquid at room temperature of about 25 DEG C, becomes a solid-like gel after being adsorbed on the nasal mucosa, can prolong the release time of the drug, has good nasal mucosa adhesion, and prolongs the residence time of the drug in the nasal cavity.

The invention discloses a whey protein source peptide with hyaluronidase inhibitory activity. The whey protein source peptide is characterized in that the sequence of the whey protein source peptide is amino terminal-GGVSLPEW-carboxyl terminal. The peptide has the advantages of no toxicity, no sensitization and the like, has a remarkable inhibition effect on hyaluronidase, and can be used for developing functional foods or medicines with anti-allergic characteristics.

The invention relates to chitosan-containing nasal anti-allergic powder and a preparation method thereof, belongs to the technical field of medicines, and solves the problem that a barrier film formed by an existing nasal anti-allergic product is relatively short in residence time in a nasal cavity. The nasal antiallergic powder is prepared from modified chitosan containing-NH3 < + >, carboxymethyl chitosan, a soothing agent and a preservative, the anti-allergic powder for the nose is prepared from the following components in parts by weight: 30 to 70 parts of modified chitosan containing-NH < 3 + >, 30 to 50 parts of carboxymethyl chitosan, 0.1 to 2 parts of a soothing agent and 0.0001 to 0.1 part of a preservative. The nasal antiallergic powder can stay in a nasal cavity for a long time, and can instantly expand to form a film when being in contact with the moist nasal cavity.

The invention provides a preparation process of an anti-allergic health food, and relates to the technical field of health food preparation. The production process of the anti-allergic health-care food comprises the following steps: preparing the following raw materials: herba cistanche, radix astragali, rhizoma polygonati, a bupleurum chinense leaf extract, a dandelion extract, honey and potassium sorbate, wherein the addition ratio of the bupleurum chinense leaf extract to the dandelion extract is 1: 2; cistanche deserticola, astragalus membranaceus and rhizoma polygonati are mixed, excessive water is added for soaking, reflux extraction and filtration are performed, filtrate is combined, and an extracting solution is obtained. By adding the bupleurum chinense leaf extract and the dandelion extract into an extracting solution of traditional Chinese medicinal materials such as astragalus membranaceus, the ratio of IgG1 / IgG2a can be effectively reduced, namely Th1 type immune response is relatively enhanced, Th2 type response is relatively weakened, allergen-specific IgE antibodies generated by B cells are correspondingly reduced, degranulation reaction and release of inflammatory mediators such as histamine are relieved, and the anti-inflammatory effect is achieved. The anaphylactic reaction is effectively relieved.

The invention discloses an application of N-(4-methoxyphenyl)-4-(4-methoxyphenyl) benzenesulfonamide in preparation of drugs for treating allergic diseases, and belongs to the technical field of biological medicines. The invention discloses a new pharmaceutical application of N-(4-methoxyphenyl)-4-(4-methoxyphenyl) benzenesulfonamide for the first time, and the N-(4-methoxyphenyl)-4-(4-methoxyphenyl) benzenesulfonamide serving as an anti-allergic antagonist can effectively inhibit phospholipase C activity of stimulated cells and mediated calcium mobilization thereof in vitro. And the effective dose of the desloratadine, which is a positive drug, is lower in vivo to generate a comparable anti-allergic effect with the desloratadine. Meanwhile, in animal models of allergic rhinitis and atopic dermatitis, compared with a positive drug desloratadine, the compound can effectively inhibit the pathological progress of diseases at a lower dosage. Therefore, the compound has a definite effect of inhibiting in-vitro and in-vivo anaphylaxis, and can be effectively applied to the development of drugs for treating allergic diseases.

The invention discloses a whey protein source peptide with hyaluronidase inhibitory activity. The whey protein source peptide is characterized in that the sequence of the whey protein source peptide is amino terminal-GVSLPEW-carboxyl terminal. The peptide has the advantages of no toxicity, no sensitization and the like, has a remarkable inhibition effect on hyaluronidase, and can be used for developing functional foods or medicines with anti-allergic characteristics.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a compound in preparation of an anti-allergic medicine. The degranulation inhibition effect is verified through a mast cell in-vitro culture model, the overall anti-allergic activity is verified by combining an animal allergy model, and a series of experiments prove that the compound A33 can inhibit I-type anaphylaxis (such as ear and subcutaneous anaphylaxis) mediated by an IgE antibody. Different from a traditional anti-allergic drug (such as an antihistamine drug), the compound A33 is used for preventing release of media such as TNF-alpha and IL-6 from the source in an anaphylactic reaction starting link that the compound A33 directly inhibits mast cell degranulation in allusion to downstream blocking of an allergic medium, so that the compound A33 is introduced into the field of anti-allergic product research; a new candidate strategy with a clear targeting mechanism and an experimental basis is provided for prevention and / or treatment of allergic diseases, and the application value in anti-allergic drugs, cosmetics or daily chemical products is wide.

Pharmaceutical composition comprising a Pickering oil-in-water emulsion containing an aqueous phase, a vegetable oil phase, and an organomodified phyllosilicate, particularly for its use in increasing TAFA4 production, and possibly for increasing serotonin production, for its use as a cutaneous anti-inflammatory agent and / or wound-healing agent and / or as a cutaneous anti-allergy agent. Figure to be published with the abstract: none.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to application of a compound in preparation of an anti-allergic reaction medicine. The compound provided by the invention can effectively inhibit mast cell degranulation so as to inhibit generation of IgE-mediated I-type anaphylaxis, so that the compound is used as an anti-drug anaphylaxis preparation to provide more possible treatment schemes for clinical drug anaphylaxis treatment.

The invention relates to the technical field of biological medicines, in particular to a peptide composition for treating allergic skin diseases, which comprises a lipid nanoparticle carrier, an active component, a stabilizer and deionized water, the lipid nanoparticle carrier is prepared from acetylated dioleoyl phosphatidyl glycerol, cholesterol and polyethylene glycol-100 stearate; the acetylated dioleoyl phosphatidyl glycerol is obtained by modifying dioleoyl phosphatidyl glycerol through an acetylation reagent; the active component is arginine / lysine polypeptide; the stabilizer is trehalose. According to the invention, acetylation-modified dioleoyl phosphatidyl glycerol is used for constructing a lipid nanoparticle carrier, and the lipid nanoparticle carrier is matched with an active component and a stabilizer to form the composition; the acetylated carrier can improve the stability and skin absorption efficiency of active ingredients and assist the active ingredients to play an anti-allergic role so as to treat allergic skin diseases, and meanwhile, the arginine / lysine polypeptide is cooperated with other components, so that the problem of facial contour aging caused by the skin diseases can be improved.

The invention discloses polygalacturonic acid (PGA) and application of a neohesperidin dihydrochalcone (NHDC) or neohesperidin (NH) embedded compound of the polygalacturonic acid (PGA) in preparation of anti-allergic food or drugs. The PGA has good biocompatibility and immune regulation and intestinal barrier repair functions. Experiments show that the PGA can significantly reduce IgE-mediated food anaphylaxis, alleviate allergic symptoms and improve intestinal structures. PGA is adopted as a carrier, and the PGA and NHDC / NH form non-covalent binding through intermolecular force to prepare the PGA-NHDC / PGA-NH compound, so that the solubility and the stability of the NHDC / NH are improved, and a synergistic anti-allergic effect is also generated. The PGA-NHDC / PGA-NH compound has the advantages of small molecular weight, fast absorption and non-immunogenicity, and can release NHDC / NH in colon in a targeted manner. On the basis, the invention further provides the application of the PGA-NHDC / PGA-NH compound in preparation of the orange juice, the obtained juice system is in a stable suspension state, has no precipitation layering phenomenon, has targeted synergistic antianaphylaxis and high storage stability, and remarkably improves the functionality and the storage stability of the juice.

The invention discloses a dehydroabietylamine carborane derivative, a preparation method and application in pharmacy, and belongs to the field of medicinal chemistry. The invention provides a dehydroabietylamine carborane derivative with a novel structure. An activity research result shows that the dehydroabietylamine carborane derivative not only has obvious anti-AD activity, but also has obvious anti-allergic activity. Therefore, the dehydroabietylamine carborane derivative provided by the invention has a prospect of being developed into an anti-Alzheimer disease or anti-allergy (such as food allergy) medicine.

The invention relates to the field of medicine preparation, and particularly discloses an anti-allergic heavy-metal-free black plaster and a preparation method thereof. The method comprises the following steps: crushing and sieving medicinal materials to obtain medicinal powder; mixing the medicinal powder with vegetable oil, and frying at a low temperature of 150-200 DEG C until the medicinal powder is carbonized and burnt black; grinding and refining the obtained mixture by using a colloid mill until the particle size of solid particles is less than 10 microns to obtain uniform slurry; heating the slurry, adding natural rubber and / or natural resin, and stirring to form uniform colloidal paste; and finally cooling, coating and forming. According to the invention, yellow lead and artificial color in the traditional process are completely abandoned, so that a heavy metal sensitization source is completely eradicated from the source; low-temperature stir-frying is combined with refining of a colloid mill, so that the paste is fine, uniform and natural in color while medicinal components are retained; and a natural high polymer material is used as a forming matrix, so that the biocompatibility of the product is further ensured. The prepared black plaster has a good anti-allergic characteristic, and keeps the appearance and the curative effect of the traditional black plaster at the same time.