928 results about "Anti allergy" patented technology

A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1):[wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents —COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

A activator for prekallikrein includes isolated, purified, or substantially purified heat shock protein 90, a phosphate ion, and mixtures thereof. The prekallikrein activator is part of an in vitro system for activating prekallikrein in the absence of FXIIa. The system includes the activator, high-molecular weight kininogen, and zinc ions. A method for activating prekallikrein to produce kallikrein in the absence of FXIIa includes mixing prekallikrein with the activator and a composition comprising high molecular weight kininogen and zinc ions. A method for evaluating the activity of a test drug for the production of kallikrein comprises activating prekallikrein and determining the kallikrein produced. The activity (promoting or inhibiting ability) of the tested drug against the production of kallikrein in the absence of FXIIa can be easily measured. The test drug may be an analgesic, anti-allergy, anti-inflammatory drug.

The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1):[wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

The invention discloses a soothing repair serum containing a bifida ferment lysate. The soothing repair serum is prepared from, by weight, 1-10 parts of polyhydric alcohol, 1-10 parts of a moisturizing agent, 0.5-10 parts of a skin moisturizing agent, 0.5-5 parts of an emulsifying agent, 0.1-2 parts of a thickening agent, 0.1-2 parts of a pH adjusting agent, 0.1-5 parts of an anti-allergy soothingagent, 0.1-10 parts of a skin conditioning agent, 0.1-1 part of a preservative, 0.01-0.05 pat of essence and the balance deionized water, wherein the sum of the weight parts of all the components is100. The soothing repair serum can obviously reduce wrinkles, reduce the content of pigment, improve the glossiness of skin, brighten the skin color, improve the skin elasticity, repair the skin barrier and reduce moisture loss; the soothing repair serum is free of irritation to the skin, has the functions of preventing skin aging and perpetually moisturizing the skin and makes the skin in a healthy natural bright white status.

The invention relates to the cosmetic technology field, and especially relates to a cosmetic or skin care product preparation rich in growth factors and a preparation method therefor. A cosmetic or skin care product preparation rich in growth factors and composed of main ingredients: cell growth factors, micromolecule polypeptides, water, grease, surfactants, humectants, anti-oxidants and preservatives and a preparation method are provided. Through mutual cooperation of ingredients, the composition preparation can accelerate metabolism of skin cells, restore fractured shallow epidermal layer fibrocytes, has protruding rapid restoration function to skin wound surfaces, and has a plurality of functions of whitening, wrinkle removing, calmness, anti-allergy, skin smoothing, anti-wrinkle, brightening, refreshing, anti-aging, anti-radiation, stain prevention and reduction and the like.

The invention discloses a skin care agent capable of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing, and a preparation method of the skin care agent. The skin care agent is characterized by comprising the following raw materials in parts by weight: 0.1-10 parts of an aloe extract, 0.1-5 parts of vitamin A, 0.1-10 parts of vitamin D, 0.1-0.5 part of hyaluronic acid, 0.1-5 parts of a swertia mileensis extract, 0.1-2 parts of alpha-lipoic acid, 0.1-5 parts of a licorice extract, 0.1-3 parts of a green tea extract, 0.1-2 parts of a fructus viticis extract and 0.1-3 parts of a grape seed extract. The preparation method comprises the following steps of: respectively adding the substances into deionized water at 75-85 DEG C, and maintaining the constant temperature for 20min; cooling the water to 50 DEG C, and adding 1-2 parts of Twain-200 into the cooled product; and stirring and cooling the solution to obtain the skin care agent. The skin care agent has the beneficial effects of being reasonably prepared from the natural extracts, being capable of permeating into a corium layer so as to accelerate metabolism, repair damaged skin and recover and maintain the elasticity of the skin, and being capable of rapidly achieving the special effects of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing.

The invention relates to the technical field of skin care products, in particular to multifunctional liquid crystal mask liquid and a preparation method thereof. The multifunctional liquid crystal mask liquid comprises liquid crystal emulsifiers, thickening agents, humectants, sodium hyaluronate, preservatives, various functional components and water. The functional components comprise water-soluble or oil-soluble substances with skin whitening, anti-wrinkling, anti-allergy and anti-acne functions. The mask liquid is liquid crystal emulsion, the various functional components can be solubilizedby the aid of lamellar liquid crystals of an oil-water interface, the functions of a mask are remarkably increased, water-soluble substances in a liquid crystal layer and oil-soluble functional components in an oil phase can be effectively protected, failure of the mask liquid is avoided, and performance of the functional components in the mask liquid is promoted. According to the multifunctionalliquid crystal mask liquid produced by the method, a liquid crystal structure is similar to a human skin structure, has high skin safety, simulates human skins and is called a 'second human skin layer', the permeability of the mask liquid is improved, and skin absorption is facilitated.

The invention provides a novel skin anti-allergy and repair composition, and also provides skin repair cream containing the skin anti-allergy and repair composition, and a preparation method of the skin repair cream. An anti-allergy and anti-inflammatory traditional Chinese medicine composition extract aiming at sensitive or damaged skin multi-dermatitis is adopted, meanwhile, other component rawmaterials are supplemented, and after compounding, the skin repair cream has synergetic effects of clearing heat, detoxifying and cooling blood, and can be beneficial to diminishing inflammation, sterilizing, astringing, repairing, improving skin resistance, eliminating scytitis, astringing, moistening, lustring skins, repairing damaged parts, and recovering elasticity and luster of the skins. Theskin repair cream can be used for eliminating carbuncle swell, cleansing, lustring, nourishing and protecting the skins, and is suitable for skin types with skin allergy, pruritus, desquamation, inflammation and the like caused by misusing cosmetics.

The invention discloses an anti-allergy skin care cream and a preparing method thereof, aims at providing an anti-allergy skin care cream which has the moisture preserving, anti-allergy and repairing effects and is safe, mild and free of irritation to the human body and belongs to the technical field of cosmetics. According to the technical scheme, the anti-allergy skin care cream is prepared, by weight, 3.5-6.5% of an emulsifying agent, 0.5-2% of a co-emulsifying agent, 5-12% of grease, 2-5% of functional grease, 0.5-2% of antioxidant, 0.05-0.1% of a metal ion chelating agent, 6-12% of polyhydric alcohol, 2-8% of a humectant, 0.2-0.7% of an aqueous-phase thickening agent, 0.1-0.6% of a thickening stabilizing agent, 6-20% of a skin conditioner, 0.5-1.5% of plant preservative and the balance water, wherein the total weight percent is 100%. The skin conditioner includes mirabilis jalapa extract.

The invention discloses a preparation process of dalteparin sodium. The preparation process comprises the following steps: preparing a heparin sodium solution, a heparin degradation fluid, a reducing solution and a crude product, refining, freeze-drying and the like. The average molecular weight of the obtained product is 5,500 to 6,500, the peak molecular weight is 3,500 to 6,000, a component with the molecular weight of less than 3,000 is not greater than 13% , a component with the molecular weight of greater than 8,000 is not greater than 15%, anti-Xa activity is more than or equal to 130IU / mg. The invention has the advantages of rich source of raw materials, high yield, stable and reliable quality, high purity, low cost, simple process, easiness in operation and no waste discharge. The dalteparin sodium has the anticoagulant, antithrombotic, anti-tumor, anti-inflammatory, anti-allergy and blood lipid regulating effects, thereby having a significant curative effect. The dalteparin sodium can be used for preventing preoperative and postoperative thrombosis of general surgery, orthopedic surgery and neurosurgery, effectively preventing venous thromboembolism of ischemic stroke patients, greatly reducing the risk of stroke, effectively preventing the solidification caused by extracorporeal circulation of blood, effectively preventing the instable coronary heart disease, and having a wide usable range.

The invention discloses a novel anti-allergy repairing composition for skin. The anti-allergy repairing composition comprises the following components by weight percent: 5%-12% of moisturizing agent, 0.1%-3.0% of thickener, 1%-4% of skin repairing agent, 0.1%-1.5% of preservative, and the balance of water. The invention also discloses a preparation method of the skin repairing agent. The anti-allergy repairing composition for skin can be prepared into cream or water aqua, can be directly smeared at the infected part and has no toxicity or harm to human skin. The skin repairing composite component has strong effects of clearing heat and detoxifying, being anti-allergy, repairing skin, diminishing inflammation and astringing; other auxiliary additive components are selected from the moisturizing agent, preservative and thickener and the like which can keep the skin tender and smooth and moisturize the skin and are mild and non-irritant to skin. The anti-allergy repairing composition is convenient to use, achieves the purposes of moisturizing, diminishing inflammation and relieving itching and repairing damaged skin, and is applicable to sensitive skin and skin allergy, pruritus, desquamation, red and swollen skin and couperose skin that are caused by misuse of cosmetics.

A medicament for the preventive and / or therapeutic treatment of allergic diseases and / or endometriosis and / or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

The invention relates to a medicinal composition containing ibuprofen sodium salt, which is prepared by taking ibuprofen sodium salt and other one or a plurality of medicinal components as active ingredients, and combing the active ingredients with pharmaceutically appropriate auxiliary materials. The medicinal composition can be made into oral preparations, including conventional tablets, dispersible tablets, sustained release tablets, capsules, sustained release capsules, soft capsules, particles, dry suspension, suspension and the like, and used for symptomatic treatment of being antipyretic, antiphlogistic, analgesic and anti-allergic, and improving sleeping.

The desensitization tablet is prepared with 13 kinds of Chinese medicinal materials including ledebouriella root, chrysanthemum, cassia twig, cicada slough, mint, etc. The present invention compounds the medicine based on the Chinese medicine theory of strengthening body's resistance and eliminating evils and with the medicine materials possessing functions of warming spleen and stomach, dispelling cold, clearing away heat, cooling blood, dispelling wind and expelling surficial evils. The medicine has wide spectrum antiallergic effects, fast acting and no side effect.

The invention relates to an anti-allergic mask with moisturizing and repairing functions. The mask is prepared from macromolecular hyaluronic acid, intermediate-molecular hyaluronic acid, micromolecular hyaluronic acid, urea, ceramide, nicotinamide, polydimethylsiloxane, glycerin, butanediol, boric acid, green tea extract-tea polyphenol and deionized water through mixing. The components of the mask do not contain perfume and are non-irritating to skin, effective ingredients of the mask can rapidly permeate into the skin, a good moisturizing effect is realized, and the mask has the functions of being resistant to inflammation and allergy, calming and repairing the skin and restoring the skin barrier.

The present invention provides an antianaphylactic medicine solution preparation containing Levocetirizine. In 1000 ml of medicine composite solution 0.5-20g of zocetirizine or its pharmacal acceptable salt, 20-100 g of polyvinyl pyrrolidone, 5-50g of poloxamer and 10-250g of polyethylene glycol 400 are contained.

The invention belongs to the technical field of cosmetics and discloses a skin-care matrix with anti-ageing and anti-allergy effects as well as a preparation method and application thereof. The skin-care matrix is prepared from the following components in parts by weight: 35 to 40 parts of oat protein, 30 to 35 parts of oat beta-glucan, 1 to 2 parts of sodium hyaluronate and 23 to 34 parts of water. The skin-care matrix disclosed by the invention has remarkable anti-allergy and relieving effects; active ingredients in the matrix are degraded by skins and are percutaneously absorbed to provide nutrients to the skins; the skin-care matrix has long-acting moisture-keeping and anti-wrinkle effects; when the skin-care matrix is used in the cosmetics, products have the effects of relieving, resisting allergy, keeping moisture and increasing the elasticity.

The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.

The invention relates to whitening and moisture-preserving mask liquid containing common nostoc extract and a preparation method thereof. The raw materials of the whitening and moisture-preserving mask liquid comprise the common nostoc extract, a moisture-preserving agent, NT-7WAN, oat beta-glucan, radix ampelopsis root extract, white atractylodes rhizome root and stem extract, bletilla striata root extract, rhizoma nardostachyos extract, opuntia streptacantha stem extract, radix ophiopogonis root extract, radix sophorae flavescentis root extract, a chelating agent, a solubilizing agent, a preservative, a thickening agent, essence, citric acid and water. The mask liquid provided by the invention has the effects of whitening and preserving moisture and increasing the elasticity of skins, so that the skins are fine, smooth and glossy; the mask liquid passes an anti-allergy test, has a remarkable whitening effect, has no side effect, is safe and reliable and can be used for a long period as a mask type skin-protecting product.

The invention relates to the field of cosmetics, in particular to a beauty product with the effects of repair and regeneration, moisturizing and senility delaying. The invention provides a skin care Chinese medicinal composition, which includes: an atractylodes macrocephala root extract, a Radix Ampelopsis japonica extract, an Angelica sinensis extract, an almond extract, a Dendrobium officinale extract, an aloe vera extract, vitex silkworm powder and bletilla striata powder. The composition has the effects of repair and regeneration, moisturizing, allergy prevention and resisting, and senility delaying, and can be applied to preparation of skin care products. Experiments prove that after use of the product containing the skin care Chinese medicinal composition provided by the invention, most people respond that skin redness and itching symptoms disappear, and the product has desensitization and anti-allergy effects; and also, color spots fade and the skin is whiter, thus reaching the effects of whitening and spot lightening.

The invention discloses a complex probiotics solid drink. The product is prepared from 0.04g of anti-allergy complex bacterial powder, 1.76g of inulin and 0.2g of stachyose; each bag of the product contains 6 billion of bacterial powder, the complex bacterial powder includes lactobacillus reuteri, lactobacillus paracasei, bifidobacterium longum and bifidobacterium lactis, and the 6 billion of bacterial powder includes 1 billion of lactobacillus reuteri, 3 billion of lactobacillus paracasei, 1.5 billion of bifidobacterium longum and 0.5 billion bifidobacterium lactis. The complex probiotics solid drink has the beneficial effects of being suitable for any people, regulating immunologic balance, relieving allergy, giving consideration to both regulation of intestinal flora and relieving of diarrhea and constipation.

The invention relates to crowfoot crack resistant cream for infants and a preparing method thereof. The cream comprises solid grease, liquid grease, a solid emulsifier, a plant anti-allergy component, a humectant, a plant extract and an antiseptic. The cream is suitable for skin dryness, peeling, crowfoot cracks in severe cases of infants which are caused by dry weather in autumn and winter. The cream is particularly nourishing and mild, and is extremely high in safety requirements and good in grease compatibility and compatibleness. Oat glucan having high moisturizing effects and the polyol type humectant are adopted so that moisturizing effects are good. The liquorice root extract and natural bisabolol are added further to solve a sensitive skin problem.

The invention discloses anti-allergy and repair essence and a preparation method thereof, and aims to provide essence which is resistant to strong charge, makes skin moist, realizes anti-allergy and repair, and is safe and free of irritation. According to the technical scheme adopted by the invention, the anti-allergy and repair essence is prepared from the following components in percentage by weight: 0.35-0.5% of radix astragali membranaci extract, 0.1-0.5% of bighead atractylodes rhizome extract, 1.7-2.5% of tremella fruiting body extract, 0.1-5% of lactobacillus ferment lysate, 0.5-1% of nicotinamide, 0.1-0.15% of sodium hyaluronate, 1.0-2.5% of ceramide, 0.1-0.3% of allantoin, 5.0-8.0% of 1,3-butanediol, 2.0-5.0% of glycerinum, 1.5-2.3% of polyglycerol-10, 1-2% of glycerol polyether,1-5% of methyl gluceth-20, 1.8-2.5% of glyceryl polyacrylate / acrylic copolymer, 0.1-0.25% of carbomer, 0.2-0.35% of p-hydroxyacetophenone, 0.3-0.6% of octyl hydroxamic acid, 0.1-0.25% of triethanolamine and the balance of deionized water. The anti-allergy and repair essence belongs to the technical field of comestics.

The invention discloses a moisturizing composition with an anti-allergy repairing efficacy and preparation and application to skincare products. The composition is prepared from xanthan gum, pullulan,polyglutamic acid, hyaluronic acid, trehalose, allantoin, urea and chondroitin sulfate by reasonable compounding. The composition has a function of stereo moisturizing of all skin layers including acorium layer, an epidermal layer, a cuticle layer and a skin surface, the skin moisture content can be increased, and skin moisture loss is reduced. The composition is capable of inhibiting hyaluronidase activity, soothing skin allergy and pruritus and repairing skin barrier. The composition has excellent moisturizing effects and an anti-allergy repairing efficacy in vitro and on human skin, effects are remarkably improved as compared with those of single use of each component, and accordingly synergistic effects are achieved by combination of the components in an appropriate ratio. The composition is solid powder and free of any preservatives, and convenience in long-time storage and transport is achieved. The composition can be applied to all types of skincare and cleansing products.

The invention discloses derivatives of 3-O-caffeoyloleanane type pentacyclic triterpene represented by general formula (I) in the specification (R1 and R2 in the general formula (I) are selected from -CH3, COOH, COOQ, CONQ2, or COSQ, wherein Q is hydrogen, alkyl, substituted alkyl, aryl, or substituted aryl; X is -C=O or CH2; and Y-Z is -CH2-CH2-, cis-CH=CH-, or trans-CH=CH-), a preparation method thereof, and pharmaceutically acceptable esters or salts thereof. The invention also discloses a medicinal composition. The composition comprises an effective dose of the derivatives of 3-O-caffeoyloleanane type pentacyclic triterpene or the pharmaceutically acceptable esters or salts thereof, and pharmaceutically acceptable carriers thereof. The invention also discloses an application of the derivatives of 3-O-caffeoyloleanane type pentacyclic triterpene or the pharmaceutically acceptable esters or salts thereof in the preparation of anti-inflammatory medicines, antiallergic medicines, liver protection medicines, antivirus medicines and the like.

The invention discloses a preparation method of an anti-allergy and anti-pruritus composite plant extract. The preparation method comprises the following steps of (1) taking panax notoginseng, adding water in the panax notoginseng, performing ultrasonic cell wall-breaking treatment for subsequent use, and pulverizing honeysuckle and chamomile for subsequent use; (2) uniformly mixing the panax notoginseng, the honeysuckle and the chamomile which are pretreated in the step (1), and adding cellulase and maltase to carry out enzymolysis so as to obtain enzymatic hydrolysate; and (3) extracting the enzymatic hydrolysate by using extracting solvent to obtain extracting solution, and performing follow-up treatment on the extracting solution to obtain the anti-allergy and anti-pruritus composite plant extract. The invention also discloses the anti-allergy and anti-pruritus composite plant extract prepared by the method. The composite plant extract is safe and non-irritant, and can be used for preparing anti-allergy and anti-pruritus medicines or cosmetics. The anti-allergy and anti-pruritus effect of the anti-allergy and anti-pruritus composite plant extract is obviously higher than that of a plant extract prepared by a traditional method.

The invention discloses an anti-allergy preparation and a preparation method and application of the anti-allergy preparation. The anti-allergy preparation comprises the following raw materials by weight percent: 10-30% of plum blossom, 20-40% of ginger, 10-35% of cactus, 10-20% of bamboo leaves and 5-15% of licorice. The preparation method of the anti-allergy preparation comprises the following steps: drying the 10-30% of plum blossom, the 20-40% of ginger, the 10-35% of cactus, the 10-20% of bamboo leaves and the 5-15% of licorice in the air, mixing, grinding into particles, extracting by using 50-90% ethanol solution, centrifuging after finishing extracting, taking supernatant, adding activated carbon into the supernatant, standing, centrifuging to obtain supernatant, distilling the supernatant and drying to obtain the anti-allergy preparation. The anti-allergy preparation disclosed by the invention has high anti-allergy effect and can be applied to the skincare and shower products to reduce the irritation of the cosmetics and the allergic reaction.

The invention relates to multifunctional Chinese medicinal toothpaste composition. The composition comprises Chinese herb extracts, wherein the Chinese herb extracts comprise components in parts by mass as follows: 0.1-5 parts of hairyvein agrimonia herb and bud extracts, 0.05-4 parts of philippine violet herb extracts, 0.05-3 parts of wild chrysanthemum extracts and 0.05-4 parts of dandelion extracts. The invention provides toothpaste prepared from the composition and a preparation method of the toothpaste. The toothpaste can effectively clean teeth and keep the mouth fresh, also has the efficacy of hemostasis, pain relieving, detumescence, apocenosis, heat and toxic material clearing, antisepsis, anti-inflammation, oxidation resistance and allergy resistance and can remarkably relieve, inhibit and treat dental ulcer, gingival bleeding, tooth ache, throat pain, mumps and other diseases. Besides, the toothpaste can also be used for face cleaning and applied to the surface of skin.

The invention relates to an anti-allergy relieving composition and application thereof. The anti-allergy relieving composition is prepared from the following components: a first anti-allergy composition, a second anti-allergy composition and an anti-allergy peptide composition, wherein active components of the first anti-allergy composition comprise 4-tert-butylcyclohexanol and hydroxyphenyl propionamide benzoic acid; active components of the second anti-allergy composition comprise radix stephaniae tetrandrae extract, potassium lactate, phenoxyethanol and dipotassium glycyrrhizinate; active components of the anti-allergy peptide composition comprise palmitoyl tripeptide-8 and acetyl tetrapeptide-15. After the anti-allergy relieving composition provided by the invention is evaluated through a macrophage nitric oxide inflammatory release model, the inhibition rate on the nitric oxide is 38.62 percent and the inhibition rate on histamine is 41.92 percent.