Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

47 results about "Denatonium" patented technology

Denatonium, usually available as denatonium benzoate (under trade names such as BITTERANT-b, BITTER+PLUS, Bitrex or Aversion) and as denatonium saccharide (BITTERANT-s), is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. It was discovered in 1958 during research on local anesthetics by MacFarlan Smith of Edinburgh, Scotland, and registered under the trademark Bitrex.

Sensorially active substance embedded in plastic

Denatonium benzoate (Bitrex(TM)) dissolves in molten flexible polyvinyl chloride, imparting a bitter flavor to the plastic which discourages rats from gnawing on it. Denatonium benzoate can in all likelihood be added to polymers other than polyvinyl chloride (e.g., polyurethane or polyethylene) either directly or by first dissolving the denatonium benzoate in an organic solvent which is miscible with the chosen polymer and then mixing this solution of organic solvent and denatonium benzoate into a molten solution of the chosen polymer.
Owner:COMMSCOPE INC

Use of specific T2R taste receptors to identify compounds that block bitter taste

Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and / or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and / or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
Owner:SENOMYX INC

Production of bitter principle derivatives

It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1:For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.
Owner:JULIUS MAXIMILIANS UNIV WURZBURG

Sensorially active substances embedded in plastic

A bitter-tasting water-soluble compound is dissolved in a non-polar substrate, imparting a bitter flavor to the substrate. This bitter flavor discourages rodents from gnawing on an object formed from the treated substrate. Specifically, denatonium benzoate dissolves in molten flexible polyvinyl chloride, imparting a bitter taste to the plastic matrix. Objects formed from this embittered plastic matrix are granted a degree of immunity from the predations of chewing animals; rodents in particular.
Owner:ICHINO TED

Preparation method of natural fishnet antifoulant

The invention relates to the technical field of anti-fouling paints, and in particular relates to a preparation method of a natural fishnet antifoulant. The preparation method comprises the steps: extracting Naga chilli serving as a raw material to obtain a capsaicin liquid, extracting garlic serving as a raw material to obtain alliin concentrate, and reacting the capsaicin liquid and the alliin concentrate with palm oil, glycerol, denatonium benzoate, snail mucus and sodium carboxymethylcellulose under stirring to obtain the fishnet antifoulant. The adopted raw materials are environment-friendly and nontoxic; the prepared antifoulant is capable of paralyzing the nerves of attaching organisms and disturbing the mucus secretion of marine organisms, has inhibition effect on the propagation of the marine fouling organisms, does not destroy the marine environment and biological chain, can generate strong stimulus to the sense organs of the fouling organisms, and has good dispelling action on soft fouling organisms; the processed antifoulant is difficult to attach for the fouling organisms due to good smoothness, is capable of guaranteeing long-time permeation of anti-fouling components from the raw materials due to good permeability and has period of validity up to 2 years.
Owner:巢湖市鼎盛渔具有限公司

Sensorially active substances embedded in plastic

A bitter-tasting water-soluble compound is dissolved in a non-polar substrate, imparting a bitter flavor to the substrate. This bitter flavor discourages rodents from gnawing on an object formed from the treated substrate. Specifically, denatonium benzoate dissolves in molten flexible polyvinyl chloride, imparting a bitter taste to the plastic matrix. Objects formed from this embittered plastic matrix are granted a degree of immunity from the predations of chewing animals; rodents in particular.
Owner:ICHINO TED

Cubilose toner and manufacturing method thereof

The invention discloses cubilose toner and a manufacturing method thereof. Denatonium Benzoate, butanediol, trehalose, propylene glycol, glycerinum, ethyl alcohol, hydroxyethyl cellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexylglycerin, hyaluronic acid, polyethylene glycol-8, glycerin grape glycosides, ascorbic acid phosphatidic acid and a solvent are put into a container, heated to the temperature of 90 DEG C, stirred and dissolved; heat preservation is conducted for 15 min, and then cooling is conducted till the temperature is 42 DEG C; apus affinis cubilose extracts, beer saccharomycete extracts, hydrolyzed pearls and essence are added, and stirring is conducted for 3-10 min; citric acid is added for adjusting the pH; and standing is conducted for defoaming, cooling is conducted to the normal temperature, and filling is conducted so that finished products can be obtained. The apus affinis cubilose extracts, the beer saccharomycete extracts, the hydrolyzed pearls and the like are added, the irritation is low, a good skin care effect for moisturizing and nourishing the skin can be achieved, and the skin can be promoted to absorb the cubilose toner better.
Owner:李尧

Pharmaceutical waste disposal assembly

A pharmaceutical waste disposal assembly (10) for disposing of raw pharmaceutical waste comprises a first receiver body (19) and a first reaction agent (287). The first receiver body (19) receives the pharmaceutical waste. The first receiver body (19) includes a receiver bottom (283), The first reaction agent (287) is positioned within the first receiver body (19) and spaced apart from the receiver bottom (283), The pharmaceutical waste reacts with the first reaction agent (287) to change the pharmaceutical waste in one of a chemical and physical manner so that the pharmaceutical waste is unrecoverable. The first receiver body (19) can receive fluid pharmaceutical waste and / or solid pharmaceutical waste. The first reaction agent (287) may include one or more of a denaturant, an emetic and a bittering agent. For example, the first reaction agent (287) may include one or more of quinine, ipecac and denatonium benzoate.
Owner:STRYKER CORP

Anti-aging hydrating mask and preparation method thereof

The invention discloses an anti-aging hydrating mask and a preparation method thereof. The anti-aging hydrating mask is prepared from the following raw materials: polyvinyl alcohol, glycerinum, propylene glycol, sorbitol, a polyvinyl acetate emulsion, glycine betaine, hydrogenated lecithin, xanthan gum, guar gum, Carbomer, sodium trehalose, dipotassium glycyrrhizinate, soluble protein polysaccharide, arginine, platinum powder, beta-glucan, resveratrol, sodium hyaluronate, denatonium benzoate, inositol hexaphosphoric acid, silver oxide, volcanic powder, kieselguhr, tetrasodium pyrophosphate, pure water, fatty alcohol-polyoxyethy, sodium alginate, a xanthic gum, lucid Ganoderma, 4-methyl hydroxybenzoate, vitamin E and sodium methyl cocoyl taurate. The anti-aging hydrating mask is prepared through the steps of preparing powder, preparing a base material, modifying, sterilizing, disinfecting and the like. The SOD (Superoxide Dismutase) content of the mask and the kill ratio of acarids canbe improved, so that the mask provided by the invention has an excellent anti-aging efficacy.
Owner:CHANGSHA WUDAO IND DESIGN CO LTD

Snake gall neck essence

The invention discloses snake gall neck essence. The snake gall neck essence comprises the following components: snake gall extract, L-ascorbic acid 2-glucoside, benzethonium, L-hydroxyproline, butanediol, trehalose, propylene glycol, glycerol, ethanol, hydroxyethyl cellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexylglycerol, hyaluronic acid, polyethylene glycol-8, glycerol glucoside, ascorbic phosphatidic acid, citric acid, perfume, and a solvent. Substances such as the snake gall extract, the L-ascorbic acid 2-glucoside and the L-hydroxyproline are added, irrigation is low, good skin protecting effect of moisturizing and moistening the skin can be achieved, and absorption of the skin to the snake gall neck essence can be promoted.
Owner:南京禾宇化工有限公司

Eyelash pomade with excellent antibacterial performance, and preparation method thereof

The invention discloses an eyelash pomade with excellent antibacterial performance, and a preparation method thereof. The eyelash pomade with excellent antibacterial performance comprises following raw materials: polyvinyl alcohol, glycerin, propylene glycol, Sorbitol, polyvinyl acetate emulsion, betaine, hydrogenated lecithin, xanthan gum, guar gum, carbomer, sodium trehalose, dipotassium glycyrrhizinate, soluble protein polysaccharide, Arginine, platinum powder, beta-glucan, Resveratrol, sodium hyaluronate, denatonium benzoate, inositol hexaphosphate, silver oxide, volcanic rock powder, diatomite, tetrasodium pyrophosphate, pure water, fatty acid polyoxyethylene ether, algin, xanthan gum, Mythic Fungus, 4-hydroxybenzoic acid methyl ester, vitamin E, and an antibacterial modification auxiliary agent. The eyelash pomade with excellent antibacterial performance is prepared through steps including powder material preparation, base material preparation, modification, sterilization, and disinfection, and is excellent in antibacterial performance.
Owner:长沙浩然医疗科技有限公司

Mask for activating cell re-growth and awakening young state and preparation method thereof

The invention discloses a mask for activating cell re-growth and awakening young state and a preparation method thereof. The mask comprises the following raw materials: polyvinyl alcohol, vegetable hydrolyzed collagen, propylene glycol, sorbitol, tamaric acid, reuben oil, hydrogenated lecithin, xanthan gum, aloe gum, carbomer, sodium trehalose, dipotassium glycyrrhizinate, hydrolyzed silk protein,arginine, platinum powder, beta; dextran, resveratrol, sodium hyaluronate, benzalkonium hyaluronate, inositol hexaphosphate, silver oxide, volcanic rock powder, diatomite, tetrasodium pyrophosphate,pure water, fatty acid polyoxyethylene ether, algal fiber, tea powder, ganoderma lucidum, 4-methyl hydroxybenzoate, vitamin E and antibacterial modifying agent, wherein the mask for activating the cell to grow again and awakening the young state is obtained through the steps of preparing material A, preparing material B, preparing mixture, sterilizing the mixture, and the like. The mask has excellent antibacterial effect.
Owner:长沙浩然医疗科技有限公司

Liquefied-gas aerosol dusting composition containing denatonium benzoate

A liquefied-gas aerosol dusting composition is disclosed for preventing inhalation abuse incidents. The composition comprises at least one liquefied gas and denatonium benzoate, wherein the concentration of said denatonium benzoate in said aerosol dusting composition ranges from about 5 ppm to about 50 ppm.
Owner:THE CHEMOURS CO FC LLC

Liquefied-gas aerosol dusting composition containing denatonium benzoate

A liquefied-gas aerosol dusting composition is disclosed for preventing inhalation abuse incidents. The composition comprises at least one liquefied gas and denatonium benzoate, wherein the concentration of said denatonium benzoate in said aerosol dusting composition ranges from about 5 ppm to about 50 ppm.
Owner:THE CHEMOURS CO FC LLC

Cable with insect repellant

InactiveCN109659080AExtended service lifePrevent bite damageBiocidePest repellentsMicroparticleCynoglossum amabile
The invention discloses a cable with an insect repellant, and the cable comprises a wire core and a protective layer wrapping the outer side of the wire core. The protective layer comprises a braidedlayer and a sheath layer which sequentially wrap the wire core from inside to outside. Capsule particles are arranged in the sheath layer, and the insect repellant is arranged in the capsule particles. The insect repellant contains the following components in percentage by weight: 10-25% of fructus caryophylli; 1%-3% of denatonium benzoate; 20-30% of flos caryophylli; 15-25% of lavender; 8-15% ofradix bupleuri; 3-8% of xanthium sibiricum; 10-15% of cynoglossum amabile; 8-12% of the root of Chinese pulsatilla. The insect repellant is prepared from various components such as clove, denatonium benzoate, cat sweat gland oil and the like, and the insect repellant is filled in the capsule particles arranged in the sheath, so that smell and taste of rats and insects can be strongly stimulated, the rat and termite can be effectively prevented from biting and damaging the cable, and the service life of the cable in a rat and termite environment is prolonged.
Owner:武汉武湖电缆有限公司

Method for detecting content of denatonium benzoate in toy material

The invention discloses a method for detecting the content of denatonium benzoate in a toy material. The method comprises steps of separately preparing a standard stock solution, an intermediate working standard solution and a series of concentration standard solution; preprocessing a sample to be tested for high performance liquid chromatography detection; using an acetonitrile-water (30:70, v / v)solution as an extraction solvent, performing ultrasonic extraction, constant volume, and filtration; and performing gradient elution with the acetonitrile-water as mobile phase: using a C-18 columnas a chromatographic column, and using a photodiode array detector, a denatonium benzoate detection wavelength of 227.4 nm, a detection limit of 2.66ng (based on 3 times signal-to-noise ratio), an average recovery rate of 99.3%, and a precision of 0. 81% to 2.36%. The method has a low detection limit and high precision, is suitable for measuring the content of bitterant denatonium benzoate in thefield, and has great significance to improve the level of controlling liquid or viscous toys in China, protect the legitimate rights and interests of children's consumers in China, and promote the smooth export of toy products in China.
Owner:义乌市产品(商品)质量监督检验研究院

Application of denatonium benzoate in preparing bactericide for preventing and controlling plant diseases caused by phytopathogen

ActiveCN105746516ASingle mechanism of actionReproduce fastBiocideFungicidesPlant diseaseBiology
The invention discloses application of denatonium benzoate in preparing a bactericide for preventing and controlling plant diseases caused by phytopathogen.It is proved through indoor toxicity measurement that denatonium benzoate has good inhibitory activity to phytopathogen.Serving as a bactericide, denatonium benzoate has the advantages of being efficient and low in toxicity and meeting the requirement for chemically preventing and controlling plant diseases.At present, bactericide resistance of pathogen is enhanced as a great number of bactericides are used, and the traditional bactericides pollute the environment seriously, are high in residual amount and directly threat food safety of human.Denatonium benzoate is a small molecule compound which is degradable, free of pollution and environmentally friendly, is low in bactericide resistance, safe to non-target organisms, people and livestock and capable of ensuring high quality of agricultural products, fruits and vegetables, meets the requirement for sustainable development and has wide research and market application prospects.
Owner:QINGDAO AGRI UNIV

Smearing agent for protecting nails and method for manufacturing smearing agent

The invention relates to a smearing agent for protecting nails. The smearing agent comprises the following ingredients in mass percent: 0.0014-0.003% of a bitter ingredient, 0.08-1% of an adsorbing agent, 0.1-1% of material for promoting the nails to grow, and the balance of a solvent, wherein the bitter ingredient is denatonium benzoate, the adsorbing agent is acrylate / diacetone acrylamide AMP salt, the material for promoting the nails to grow is keratin amino acid, and the solvent consists of water and ethanol, wherein the content of the ethanol accounts for 0.6-1% of that of the smearing agent in mass percent. The application method of the smearing agent is simple, only one or two drops need to drip on fingernails to be directly smeared, or the smearing agent is poured in a subpackage bottle, brushed on the nails by utilizing a hairbrush, and then air dried naturally for 2-3 minutes to play a role in protecting the nails. The invention further relates to a method for manufacturing the smearing agent.
Owner:刘小立

Papaya neck essence

The invention discloses papaya neck essence. The papaya neck essence comprises the following components: papaya extract, L-ascorbic acid 2-glucoside, denatonium benzoate, L-hydroxy proline, butylene glycol, trehalose, propylene glycol, glycerol, ethanol, hydroxyethyl cellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexylglycerin, hyaluronic acid, polyethylene glycol-8, glycerol glucoside, ascorbic acid phosphatidic acid, citric acid, perfume and solvents. The papaya neck essence disclosed by the invention is added with substances of the papaya extract, L-ascorbic acid 2-glucoside, L-hydroxy proline and the like, thereby having less irritation, and further being capable of playing a role of having good skin-care effects of moisturizing and nourishing skin, and promoting better skin absorption.
Owner:南京禾宇化工有限公司

Fructus hippophae neck essence

The invention discloses fructus hippophae neck essence. The essence is prepared from the following components: fructus hippophae extract, L-ascorbic acid 2-glucoside, denatonium, L-hydroxyproline, butanediol, trehalose, propylene glycol, glycerinum, ethanol, hydroxyethyl cellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexylglycerin, hyaluronic acid, polyethylene glycol-8, glycosylglycerol, ascorbate phosphatidic acid, citric acid, perfume and solvent. The fructus hippophae extract, L-ascorbic acid 2-glucoside, denatonium, L-hydroxyproline and other subtances are added into the essence, so that the essence has small irritation, and can be used for moistening and well protecting skins and promoting better skin absorption.
Owner:南京禾宇化工有限公司

Method for determining naringin and denatonium benzoate serving as bitterants in finger painting inkpad for children by ultra-high performance liquid chromatography

The invention discloses a method for determining naringin and denatonium benzoate serving as bitterants in finger painting inkpad for children by ultra-high performance liquid chromatography. According to the method, two bitterants in a sample of the finger painting inkpad of children are extracted in an ultrasonic extracting mode by taking methyl alcohol-0.02 mol / L KH2PO4 (30:70, v / v) as a solvent; and the two bitterants are quantified through an external standard method and are analyzed through the UPLC. The linear ranges of the naringin and the denatonium benzoate are both 0.1 to 5 mg / L (R2is greater than or equal to 0.99), and the detection limits (S / N>3) are respectively 0.75 and 1.15 mg / kg. The mark recovery rate ranges of the naringin and the denatonium benzoate in the finger painting inkpad for the children at three concentration levels are 86.7 to 108.4 percent; and the relative standard deviation (RSD, n=6) is less than 5.0 percent.
Owner:上海海关机电产品检测技术中心

A method and composition for insect repellency using aversive agent

The present invention relates to a composition comprising aversive agent as insect repellant in agriculture and horticulture. The present invention more particularly relates to Denatonium compound which acts as repellant without harming the life of environmentally useful insects such as honey bees, in addition to reptiles such as lizards, also the mammals such as deer, rodents, nilgai.
Owner:UNITED PHOSPHORUS LTD

Bitter nail lotion and preparation method thereof

The invention discloses a picrasma quassioides liquid and a preparation method thereof. The picrasma quassioides liquid comprises the following raw materials in parts by weight: 20-30 parts of a goldthread root extract, 15-20 parts of a bitter gourd extracting solution, 12-20 parts of mint, 0.2-1 part of denatonium benzoate, 0.1-0.5 part of citric acid and 10-15 parts of cellulose. The mint extract has a poor effect of preventing cariogenic bacteria such as streptococcus mutans, lactobacillus and actinomycetes existing in the oral cavity of a person, no organic solvent is used in the bitter gourd extracting solution processing process, the product is safe and free of pollution, the extracting process does not pollute the environment, the extracting method is simple and rapid, and the extracting cost is low; the bitter gourd extracting solution is rich in nutritional ingredients, high in nutritional ingredient concentration and obvious in effect, the purpose of reasonably utilizing rawmaterials is achieved, waste and environment pollution are avoided, and mint serves as an envoy drug and can clear away heat and toxic materials and inhibit viruses; meanwhile, the cool and fragrant smell of mint can be easily accepted by children; and the formula medicinal material sources are wide.
Owner:福州弘海生物科技有限公司

Preparation method of neck essence containing snake gallbladder components

The invention discloses a preparation method of neck essence containing snake gallbladder components. Trehalose, glycerin, butanediol, propylene glycol, ethanol, denatonium benzoate, hydroxyethyl cellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexylglycerin, hyaluronic acid, polyethylene glycol-8, glycerin glucoside, ascorbic acid phosphatidic acid and a solvent are put in a container, heated to 90 DEG C and stirred to be dissolved; the mixture is kept at the temperature for 10 min and then cooled to 42 DEG C; a snake gallbladder extract, L-ascorbic acid-2-glucoside, L-hydroxyproline and spice are added and stirred for 3-10 min; citric acid is added, and pH is adjusted; the mixture is left to stand for defoaming and cooled to the normal temperature, filling is performed, and a finished product is obtained. Substances such as the snake gallbladder extract, L-ascorbic acid-2-glucoside, L-hydroxyproline and the like are added, and the neck essence has less irritation, can have a good skin-care effect of moisturizing skin and can promote the skin to better absorb the essence.
Owner:南京禾宇化工有限公司

Artichoke leaf neck essence

The invention discloses an artichoke leaf neck essence comprises the following components: artichoke leaf extract, 2-glucoside L-ascorbate, denatonium benzoate, L-oxyproline, butanediol, trehalose, propanediol, glycerol, ethanol, hydroxyethyl cellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexyl glycerol, hyaluronic acid, polyethyleneglycol-8, glycerol heteroside, ascorbic phosphatidate, citric acid, essence and solvent. By adding the artichoke leaf extract, 2-glucoside L-ascorbate, L-oxyproline and other substances, the artichoke leaf neck essence has lower irritation, can have favorable skin-care effect of moisturizing the skin, and can promote better absorption of skin.
Owner:南京禾宇化工有限公司

A method for detecting denatonium benzoate content in toy materials

The invention discloses a method for detecting the content of denatonium benzoate in toy materials, which comprises preparing standard stock solutions, intermediate working standard solutions and serial concentration standard solutions respectively, preprocessing samples to be tested, and performing high performance liquid chromatography detection , using acetonitrile-water (30:70, v / v) solution as the extraction solvent, after ultrasonic extraction, constant volume, after filtration, gradient elution is carried out with acetonitrile-water as the mobile phase, and a C-18 column is used as the chromatographic column, With a photodiode array detector, the detection wavelength of denatonium benzoate is 227.4nm, the detection limit is 2.66ng (based on 3 times the signal-to-noise ratio), the average recovery rate is 99.3%, and the method precision is 0.81%-2.36%. This method has low detection limit and high precision, and is suitable for the determination of the bittering agent denatonium benzoate content in this field. It can improve the level of management of liquid or viscous toys in my country, protect the legitimate rights and interests of children and consumers in China, and at the same time promote the development of toys in my country. The smooth export of products is of great significance.
Owner:义乌市产品(商品)质量监督检验研究院

Aloe gel neck part essence liquid

The present invention discloses an aloe gel neck part essence liquid, which comprises an aloe gel, L-ascorbic acid 2-glucoside, denatonium benzoate, L-hydroxyproline, butanediol, trehalose, propylene glycol, glycerol, ethanol, hydroxyethylcellulose, polydimethylsiloxane, potassium sorbate, sorbic acid, ethylhexylglycerol, hyaluronic acid, polyethyleneglycol-8, glycerol glucoside, ascorbic acid phosphatidic acid, citric acid, perfume, and a solvent. According to the present invention, the aloe gel, the L-ascorbic acid 2-glucoside, the L-hydroxyproline and other substances are added, such that the irritation is low, the good skin care effects of moisture retention and moisturizing can be provided, and the skin can be promoted to well absorb the aloe gel neck part essence liquid.
Owner:南京禾宇化工有限公司

Aminomethyl-functionalized denatonium derivatives, their preparation and use

The present invention is directed to compounds of the general formula (I) and salts thereofwherein X− is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1-C10-alkyl; and R1-R9 independently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and / or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.
Owner:JULIUS MAXIMILIANS UNIV WURZBURG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products