23 results about "Benzoates" patented technology

A method of synthesizing the benzoate salt of 5-MeO-DMT comprising the step of treating the hydrochloride salt of 5-MeO-DMT with a base, prior to the addition of benzoic acid.

A method of synthesizing the benzoate salt of 5-MeO-DMT comprising the step of treating the hydrochloride salt of 5-MeO-DMT with a base, prior to the addition of benzoic acid.

To provide a pharmaceutical composition for preventing or treating cognitive dysfunction.SOLUTION: The pharmaceutical composition contains benzoic acid or a benzoic acid salt.SELECTED DRAWING: None

The invention discloses a preparation method of a high-quality perovskite thick film for an X-ray detector, and relates to the technical field of radiation detection materials and devices. The preparation method of the thick film comprises the following steps: preparing a precursor solution from lead iodide, cesium iodide, formamidine iodide, methylamine iodide, 4-guanidinobenzoic acid hydrochloride, N, N-dimethylformamide and acetonitrile; a bulk phase functional additive is introduced to optimize a large number of Schottky defects at the grain boundary of the perovskite thick film; depositing onto a heated conductive glass substrate using a spray coating technique; and in combination with a low-temperature solvent atmosphere annealing process, secondary growth of crystal grains and grain boundary healing are promoted, and a large-area polycrystalline thick film can be obtained.

To provide a crystal of 2 - (4-acetylbenzyl) - 3 - ((4-fluorophenyl) amino) - 577 - trimethyl-7, 8-dihydro-pyrazolo-imidazo [1, 2-a] 2H [4, 3-e] pyrimidin-4 (5H) - one.SOLUTION: Provided is a crystal of an acid addition salt form selected from, for example, succinate form, citrate form, adipate form, tartrate form (e.g., L-tartrate form), malate form, gluconate form (e.g., D-gluconate form), maleate form, fumarate form, aspartate form (e.g., L-aspartate form), hippurate form, sebacate form, glycolate form, galactarate form, benzoate form, pamoate form, oxalate form and malonate form.SELECTED DRAWING: None

Provided herein are methods relating to the purification of a polypeptide comprising an Fc region (e.g., an antibody) via protein A chromatography; methods relating to the use of a wash solution comprising a benzoate salt and / or benzyl alcohol during protein A chromatography; and methods of adjusting a harvest using sodium benzoate prior to protein A chromatography.

This invention relates to novel 2-(1-hydroxypentyl)benzoate, its preparation method, and its applications. Specifically, it relates to a cycloalkanamine 2-(1-hydroxypentyl)benzoate with the structure shown in Formula I, its preparation method, pharmaceutical compositions with the compound as the active ingredient, and the application of the compound in the treatment and / or prevention of ischemic cardiovascular and cerebrovascular diseases, especially mild, moderate, and severe acute ischemic stroke.

The invention belongs to the technical field of agricultural biology, and particularly relates to application of ningnanmycin salt to prevention and treatment of tobacco mosaic virus diseases. Derivatives of ningnanmycin salts are developed on the basis of ningnanmycin, and the derivatives comprise ningnanmycin acetate, ningnanmycin lactate, ningnanmycin phosphate, ningnanmycin sulfate, ningnanmycin citrate, ningnanmycin benzoate, ningnanmycin oxalate, ningnanmycin hydrochloride, ningnanmycin nitrate and the like. When the ningnanmycin salts are applied to prevention and treatment of the tobacco mosaic viruses, experiments show that compared with ningnanmycin, the ningnanmycin salts have the advantages that the prevention and treatment effect on the tobacco mosaic viruses is remarkably improved, the prevention and treatment effect of moroxydine hydrochloride can be achieved or even exceeded, and the application prospect is good.

This application discloses a traditional Chinese medicine oral ulcer patch containing camellia oil and its preparation method, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine oral ulcer patch containing camellia oil, by weight fraction, comprises: 7.1-9.1 parts camellia oil, 5-7 parts propolis, 2-4 parts Bletilla striata extract, 2-4 parts honeysuckle extract, 2-4 parts Artemisia argyi volatile oil, 4.4-6.4 parts collagen peptides, 14-16 parts polyvinyl alcohol, 4-6 parts hydroxypropyl methylcellulose, 4-6 parts glycerin, 1-3 parts polyethylene glycol, 0.2-0.4 parts benzoate, 0.1-0.3 parts menthol, and 0.5-1.5 parts vitamin E. This traditional Chinese medicine oral ulcer patch not only has anti-inflammatory effects, relieves oral ulcer pain, and promotes ulcer healing, but also forms a stable protective film layer in the oral cavity, effectively isolating external stimuli such as food friction and saliva erosion, providing a stable microenvironment for mucosal repair.

The present disclosure provides a method of preventing or treating cognitive dysfunction in a subject in need thereof, including administering to the subject an effective amount of a benzoic acid salt.

The application discloses a preparation method of a naphthomostat mesylate impurity standard substance, and specifically comprises the following steps: firstly, reacting m-aminobenzoic acid with a hydrochloric acid solution to obtain an m-aminobenzoic acid hydrochloride solution; then, adding a magnetic solid acid catalyst and a 20-30% mass concentration cyanamide aqueous solution, and stirring and reacting at room temperature under a pulse magnetic field to obtain 3-guanidinobenzoic acid hydrochloride; then, adding 3-guanidinobenzoic acid hydrochloride, 6-amidino-2-naphthol mesylate, N,N'-dicyclohexyl carbodiimide and a supported catalyst into pyridine, stirring and reacting at room temperature to obtain 6-amidino-2-naphthyl-3-guanidinobenzoic acid ester; and finally, salifying to obtain 6-amidino-2-naphthyl-3-guanidinobenzoic acid ester mesylate. The 6-amidino-2-naphthyl-3-guanidinobenzoic acid ester mesylate with high purity and high yield obtained by the application is of great significance for the quality research of naphthomostat mesylate.

The present application belongs to the technical field of mining, and particularly relates to a leaching agent and application thereof, and a method for exploiting ion-type rare earth ore. The leaching agent provided by the present application comprises a main leaching agent and an auxiliary leaching agent; the auxiliary leaching agent is a benzoate salt having the same cation as the main leaching agent. The present application uses the leaching agent to leach ion-type rare earth ore, and the obtained rare earth leaching mother liquor and a precipitant are mixed to perform precipitation, and then solid-liquid separation is performed to obtain supernatant and rare earth precipitate, respectively; the supernatant is recycled and used as water for preparing the leaching agent; the rare earth precipitate is subjected to acid dissolution with hydrochloric acid, and then solid-liquid separation is performed to obtain a chlorinated rare earth solution and benzoic acid; the obtained benzoate salt can be reused as the auxiliary leaching agent by mixing the benzoate salt with an alkaline solution to perform a neutralization reaction. The present application can efficiently leach rare earth while effectively inhibiting aluminum leaching, and the leaching agent ions that are not used during leaching can be returned to the mine for reuse, thereby avoiding the introduction of new non-rare earth impurities in the process of exploiting ion-type rare earth while inhibiting aluminum.

There is provided an aerosolisable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerol and mixtures thereof; and (ill) a buffer comprising benzoic acid and a benzoate.

Disclosed in the present invention is a palladium-catalyzed coupling reaction of a secondary propargyl benzoate to a sulfonamide, which realizes highly selective synthesis of a 2-amino-substituted conjugated diene. The method is suitable for the coupling of a series of functionalized propargyl benzoates and sulfonamides, and enables late-stage functionalization modification of complex small-molecule drugs, which provides a new method for synthesizing a sulfonamide compound containing a conjugated diene structure, and has significant application prospects.

To provide treprostinil derivatives that can act as prodrugs of treprostinil.SOLUTION: A compound of formula (I), or a pharmaceutically acceptable salt thereof or the like. Wherein R1 and R2 are independently hydrogen, alkylcarbonyl, alkoxyalkylcarbonyl, and the like, with the proviso that R1 and R2 are not both hydrogen, and -OR1 and -OR2 do not both form acetates, benzoates, and the like; ) SELECTED DRAWING: None

A pest control composition includes from about 4 wt% to about 10 wt % of sodium lauryl sulfate; a C5 to C9 hydrotropic salt, especially salts of benzoic acid or of sorbic acid; from about 1 wt% to about 12 wt% of one or more active ingredients chosen from corn mint oil, peppermint oil, spearmint oil, rosemary oil, thyme oil, citronella oil, clove oil, cedarwood oil, cinnamon oil, geranium oil, eugenol, 2-phenylethyl propionate, menthol, menthone, thymol, carvone, camphor, methyl salicylate, p-cymene, linalool, geraniol, cinnamyl acetate, cinnamic alcohol, cinnamaldehyde, citronellol, eucalyptol / l,8-cineole, alpha¬ pinene, bornyl acetate, gamma-terpinene, or combinations thereof; and from about 60 wt% to about 95 wt% of water. The ratio of hydrotropic salt to sodium lauryl sulfate of from about 0.15 to about 0.9. The pest control composition exhibits a receding contact angle of less than 20 degrees. A method of controlling weeds using the pest control composition..

Synthetic kava analog compounds of formula I are disclosed. Specifically, kava analogs of the structural type 3-oxoclclohex-1-en-1-yl benzoates, and corresponding benzamides are disclosed. The compounds of the within invention are useful, in the inhibition of cytokine TNF-α, the management of chronic inflammation such as but not limited to Porphyromonas gingivalis induced periodontitis, and in infective arthritis, either as compounds, pharmaceutically acceptable salts (when appropriate), pharmaceutical composition ingredients, whether or not in combination with other anti-inflammatory active pharmaceutical ingredients. Methods of treating chronic inflammation such as periodontitis and infective arthritis are also disclosed.

The present invention relates to a process for the preparation of 4-cyanobenzoyl chlorides of formula I from alkali metal 4-carbamoyl-benzoate of formula II with a chlorinating agent and a catalyst.

An anti-microbially inhibited waterborne coating composition comprising;a) A waterborne polymer resin,b) An antimicrobial composition,a) The polymer resin is based on an emulsion polymer resin or a an-ionic or non-ionic stabilized polyurethane dispersion or an alkyd resin.b) Said antimicrobial composition comprise;b i) At least one compound selected from the group consisting of, formic acid, metal formate, ammonium formate, propionic acid, metal propionate, ammonium propionate, and optionally acetic acid and / or metal acetate and / or ammonium acetate, andb ii) At least one compound selected from the group consisting of, sorbic acid, metal sorbate, ammonium sorbate, benzoic acid, metal benzoate, ammonium benzoate, andb iii) At least one compound selected from the group consisting of;benzisothiazolinone in the range 10-360 ppm, calculated on the coating composition including water diluent and bronopol in the range 10-2000 ppm, calculated on the coating composition including water diluent.The antimicrobial composition compound b i) together with b ii) constitutes 0.2-5.0% by weight of the coating composition, and the benzisothiazolinone b iii) comprises 10-360 ppm of the coating composition including water diluent.

This invention provides a method for synthesizing deferasirox. The method involves reacting starting material A with hydrochloric acid-ethanol solution in solvent a to generate intermediate B; intermediate B reacts with salicylyl chloride and pyridine in solvent b to generate intermediate C; and intermediate C reacts with p-hydrazide benzoate in solvent c to generate deferasirox. This method is simple to operate, has mild reaction conditions, high yield, low cost, is environmentally friendly, and is suitable for large-scale industrial production of deferasirox.

Provided herein are methods relating to the purification of a polypeptide comprising an Fc region (e.g., an antibody) via protein A chromatography; methods relating to the use of a wash solution comprising a benzoate salt and / or benzyl alcohol during protein A chromatography; and methods of adjusting a harvest using sodium benzoate prior to protein A chromatography.

The daylily fixation agent comprises sodium pyrosulfite, malic acid and soluble benzoate, the mass ratio of the sodium pyrosulfite to the malic acid is 1: (1-10); the mass ratio of the sodium pyrosulfite to the soluble benzoate is 1: (0.1-10). The invention also comprises a daylily de-enzyming method and a daylily product manufacturing method. The daylily fixation agent has the characteristic of high utilization rate of sodium pyrosulfite, can effectively reduce the use amount of sodium pyrosulfite, and reduces the residue of sodium pyrosulfite in the product, so that a healthier daylily product is obtained; the day lily treated by the enzyme deactivation agent disclosed by the invention is free from spoilage, yellow in color and appropriate in mouth feel; the amount of wastewater generated by desulfurization can be reduced, the production cost is saved, and the environmental pollution is reduced; the method is green, environment-friendly and low in cost.