105 results about "Citrate salt" patented technology

The present application provides polymorph of Ribociclib citrate salt and pharmaceutical compositions thereof. The present invention also relates to preparation method thereof. In particular, the invention relates to Ribociclib citrate dihydrate.

The present invention discloses a preparation method and production system for sodium nitroprusside. The preparation process comprises the following steps: first, reacting ferrocyanide with nitric acid to obtain a hydrogen nitroprusside aqueous solution; adding alcohol to the concentrated hydrogen nitroprusside aqueous solution to remove inorganic salts generated by the reaction, thereby obtaining a hydrogen nitroprusside alcohol solution; then, adding trisodium citrate to the hydrogen nitroprusside alcohol solution to react to obtain sodium nitroprusside and disodium citrate; separating and removing the citrate to obtain a sodium nitroprusside alcohol solution; and finally, concentrating, crystallizing, separating, and drying the sodium nitroprusside alcohol solution to obtain a sodium nitroprusside product. The present invention also provides a production system based on the preparation method. The production method of the present invention is simple to operate, operates under mild conditions, has a short production cycle, effectively prevents product oxidation, and has high purity. The obtained product is suitable for industrial production, and the production system requires less equipment and has low equipment requirements.

The invention discloses an oil-controlling and dandruff-removing shampoo composition containing hydroxy acid zinc salt. The oil-controlling and dandruff-removing shampoo composition is prepared from the following components in percentage by weight: 0.05 to 2 percent of hydroxy acid zinc salt compound, 5 to 20 percent of surfactant, 0.15 to 1 percent of hair conditioner, 0.2 to 2 percent of grease, 0.2 to 1.2 percent of preservative, 0.1 to 1.0 percent of essence, 0.05 to 0.1 percent of citric acid, 0.1 to 1.5 percent of salt and 71.3 to 94.2 percent of water. According to the oil-controlling and dandruff-removing shampoo composition, the hydroxy acid zinc salt component is selected, the dandruff-removing effect is good, mildness is achieved, oil controlling and dandruff removing can be achieved within 7 days, and mildness and no irritation are achieved.

The invention relates to the field of konjak food, provides konjak gel food as well as a preparation method and application thereof, and aims to solve the problems of poor stability, insufficient brittleness and poor antibacterial property of existing konjak gel food. According to the gel food, phosphorylated konjac glucomannan serves as a main body, chitosan / microcrystalline cellulose composite filler, carrageenan, sodium alginate, calcium salt, citrate and other auxiliary materials are added, a multi-cross-linked network structure is constructed through the synergistic effect of multiple components, and the stability and mechanical performance of gel are remarkably enhanced. In the preparation process, a temperature gradient control strategy is adopted, and ordered construction and layer-by-layer curing of a gel network are achieved. The obtained product has high gel strength, excellent brittleness, low bleeding rate and excellent antibacterial performance, can be widely applied to functional food simulating the mouth feel of animal cartilage, and has good storage stability and sensory quality.

The present application relates to a kind of high efficient preparation high-strength high-conductivity copper-based composite wire method, through high-purity citric acid or citrate one-step generation zero-dimensional GQDs load in two-dimensional GN surface multi-dimensional reinforcing phase, using stirring ball mill preparation kilogram-level GQDs@GN / Cu composite powder, then through pre-pressing and microwave sintering equipment preparation composite bar, finally using cold extrusion extrusion into wire material of cylindrical bar, the yield strength and tensile strength of the GQDs@GN / Cu composite wire material prepared by the method are 274MPa and 314MPa respectively, and the conductivity is as high as 95.3%IACS;The present application has short preparation time, simple process, low production cost, high yield, good reinforcing effect, and is suitable for mass production.

The present disclosure relates to a novel salt and salt forms of Compound (A). The disclosure is also directed to pharmaceutical compositions containing Compound (A) citrate salt or salt forms and to the therapeutic use of such salts, salt forms, and compositions thereof.

Sterile filtered liquid lactase composition comprising a lactase, preferably a neutral or acidic lactase, an anion selected from malate, tartrate, citrate, gluconate and / or EDTA and a cation selected from sodium and potassium. Preferably, the composition further comprises a polyol. Addition of the said anions to lactase improves filterability by reducing pressure in a filtration system. Preferably the filtration forms part of an in-line filtration system in the production of a dairy product.

The present invention relates to a compound selected from the group of a lactate salt, a hydrochloride salt, a tartrate salt, a succinate salt, a citrate salt and a maleate salt of the compound of formula (I), (I). The present invention also concerns certain formulations comprising the compound.

The present application relates to the technical field of water treatment, and discloses a composite carbon source for removing nitrate in an aquarium system, a preparation method and application thereof. The components of the composite carbon source include glycerol, slow-release carbon source, zeolite, citrate, vitamin, HEPES and binder. The glycerol and slow-release carbon source in the composite carbon source form synergy, the former can quickly start microbial action and rapidly reduce the concentration of nitrate, and the latter provides long-term support to ensure the sustainability of the degradation effect. The combination not only improves the denitrification efficiency, but also avoids the side effects caused by excessive short-term carbon source. In addition, the glycerol and citrate are synergistic in both chemical and biological aspects: the former is a short-term and rapid energy source, and the latter plays a role in metal buffering and environmental regulation, and both provide good support for efficient denitrification of microorganisms. In combination with the physical and chemical properties of other components, the stability and efficiency of the composite carbon source for denitrification are improved.

Dairy products are produced by subjecting a starting dairy material to nanofiltration to remove monovalent ions to produce an ion-depleted dairy permeate; passing the ion-depleted dairy permeate through an ion exchange column and subsequently with a sodium-containing eluting solution to produce sodium phosphate and sodium citrate derived from the starting material; concentrating the sodium phosphate and sodium citrate; and combining the concentrated sodium phosphate and sodium citrate with dairy components. The dairy product contains an amount of the concentrated sodium phosphate and sodium citrate sufficient to cause fat in the dairy product to be emulsified and protein in the dairy product to be hydrated. In addition or alternatively, a dairy by-product stream may be subjected to ion exchange to remove calcium therefrom; concentrated, and combined with dairy materials naturally containing phosphate and citrate in order to adjust the citrate+phosphate-to-calcium ratio to reach an emulsified dairy product.

The invention discloses a high performance liquid chromatography detection method for the content of cibopadol in cibopadol citrate. Chromatographic conditions are as follows: a reversed-phase chromatographic column is adopted, and a phosphate buffer solution and tetrahydrofuran-acetonitrile are taken as mobile phases. By detecting the content of the cibopadol in the cibopadol citrate, the quality of a cibopadol preparation product is favorably controlled, whether the content of the cibopadol meets the requirement or not is judged, and the stability of the cibopadol product is improved. The detection method disclosed by the invention is high in accuracy, good in separation degree, good in stability, simple and convenient to operate, good in repeatability, strong in pertinence and very good in application value.

The invention discloses a two-way humidifying bag, which belongs to the technical field of humidifying, and comprises a humidifying core material and a packaging body for packaging the humidifying core material, the humidifying core material is formed by adsorbing a saturated salt solution by a porous carrier, the mass ratio of the salt solution to the porous carrier is 1: (1-3), the saturated salt solution comprises the following components in percentage by weight: 30% of water, 30-70% of citrate and 0-40% of chlorine salt, and the saturated salt solution comprises the following components in percentage by weight: 20-30% of water, 30-70% of citric acid and 0-40% of chlorine salt. The mass ratio of the water to the citrate to the chlorine salt is 10: (10-23): (0-13), the packaging body is of a three-layer composite structure and sequentially comprises an outer protection layer, a middle layer and an inner contact layer from outside to inside, the outer protection layer is made of PET, the inner contact layer is made of PE, inner air holes are evenly distributed in the inner contact layer in an array mode, outer air holes corresponding to the inner air holes in a staggered mode are formed in the outer protection layer, and the middle layer is made of PE. And the hole positions of the outer air holes correspond to gap areas among the four adjacent inner air holes. Two-way precise humidity adjustment is achieved, the packaging body is excellent in air permeability and humidity resistance, core material leakage is effectively avoided, and the humidity balance rate is increased.

The invention discloses a carbon nanodot as well as a preparation method and application thereof, and relates to the technical field of carbon nanomaterials. The carbon nanodots are prepared from raw materials including nicotinamide, urea and citric acid or a derivative thereof through solvent heat treatment, and the derivative of the citric acid is selected from citrate, a citric acid hydrate or a hydrate of the citrate. According to the invention, nicotinamide is used as a precursor to synthesize the carbon nanodot under solvent heat treatment, so that the carbon nanodot integrates intrinsic biological activity, efficient photothermal conversion capability and red fluorescence imaging function at the same time, and the limitation of a single therapy is overcome through multifunctional synergistic therapy. In addition, the carbon nanodot provided by the invention has extremely high biological safety.

The utility model relates to reaction device processing technical field discloses a reaction device for synthesizing octanoic acid diethylamino ethanol ester citrate, including the reaction kettle, one end of reaction kettle is equipped with the heat dissipation shell, the inner wall fixed connection of heat dissipation shell has the motor, the output fixed connection of motor has the first bevel gear, one side fixed connection of first bevel gear has the worm, the outer wall screw thread connection of worm has the worm wheel, one side fixed connection of worm wheel has the connecting post, one side fixed connection of connecting post has the stirring piece, one side of first bevel gear is provided with the rotating assembly, and the rotating assembly includes the second bevel gear. In the utility model, the motor is started to drive the first bevel gear to rotate, the worm drives the worm wheel to rotate, the stirring piece rotates, and the material for synthesizing octanoic acid diethylamino ethanol ester citrate in the storage tank can be premixed.

The application relates to the technical field of intelligent detection, and discloses an intelligent detection method and system for illegal addition of food and a storage medium. The method comprises the following steps: preparing a multi-target SERS substrate for interference suppression; extracting a food sample and injecting the substrate, and obtaining a multi-dimensional spectrum by scanning with three wavelengths of laser; performing noise reduction and alignment on spectrum data to extract characteristic peak fingerprints and form a unique identification matrix; training a multi-path parallel attention network to simultaneously identify multiple additives and concentrations through feature fusion. The application solves the problem that SERS technology is affected by interference substances such as citrate in food safety detection, resulting in insufficient detection sensitivity and specificity, breaks through the technical bottleneck that traditional methods are difficult to simultaneously detect multiple illegal food additives, and overcomes the problem that the existing technology lacks intelligent data processing, resulting in low accuracy and efficiency of detection results.

Provided herein are methods of determining the concentration of diethylenetriamene pentaacetate (DTPA) in a pharmaceutical formulation. In exemplary embodiments, the method comprises providing (i) a reference standard comprising, citrate and a known concentration of DTPA and (ii) a sample of a pharmaceutical formulation comprising DTPA, citrate and a protein; wherein the citrate concentration of the reference standard is the same as the citrate concentration of the sample of the pharmaceutical formulation; wherein each of the reference standard and the sample of the pharmaceutical formulation further comprise iron and the iron concentration of the reference standard is the same as the iron concentration of the sample of the pharmaceutical formulation and the iron present in each of the reference standard and sample is in excess of the citrate present in each of the reference standard and sample, and applying each of the reference standard and sample to an RPLC column.

The invention provides betahistine freeze-dried powder and a preparation method thereof.The betahistine freeze-dried powder comprises a drug-loaded microcapsule and a freeze-drying matrix, the drug-loaded microcapsule and the freeze-drying matrix are dissolved in water to form freeze-drying liquid for freeze-drying, the drug-loaded microcapsule is formed by coating a betahistine raw material medicine and citric acid nanoparticles through a pH-sensitive polymer layer, and the pH-sensitive polymer layer is coated with the freeze-drying liquid. The freeze-dried matrix comprises histidine, citrate and a freeze-dried skeleton agent. Histidine and citrate in the freeze-dried matrix release buffer capacity in the storage period to maintain the overall pH stable (3.5-4.5), and pH drift is prevented; if moisture invades in the storage period and the pH value is increased to 5.0 or above, the pH sensitive polymer layer is dissolved, the citric acid nanoparticles inside serve as an emergency buffer agent to further adjust the pH value, and the requirement for pH stability in the storage period is met through the synergistic effect of the endogenous emergency buffer microcapsules and the exogenous active buffer matrix.

To provide a myalgia inhibitor or a myalgia inhibitory functional food that allow daily continuous use, have excellent safety and can reduce and prevent the occurrence of myalgia.SOLUTION: A myalgia inhibitory composition contains citrate. The myalgia inhibitory composition may further comprise citric acid.SELECTED DRAWING: None

Solid purified plant protein compositions and methods of making and using thereof are described. In some embodiments, the plant protein compositions exhibit one or more desired physical and / or functional properties, e.g., viscosity, gelation capability, gel quality, protein stability, and / or one or more desired organoleptic properties (e.g., aroma, taste, etc.). The solid plant protein composition can contain one or more plant proteins; one or more phosphate salts; one or more Group I and / or Group II metal halide salts; and optionally, one or more citrate salts. The method for producing a solid plant protein composition can include: suspending a purified plant protein in a solvent; adding a phosphate salt, a Group I and / or Group II metal halide salt, and optionally a citrate salt, to form a plant protein composition; and drying the plant protein composition.

The present invention relates to an environmentally friendly, stable colored mud and a preparation method and application thereof, and belongs to the technical field of gel materials. The colored mud includes the following raw materials in parts by weight: 30-40 parts of modified starch, 5-10 parts of vegetable gum, 10-20 parts of lithium magnesium silicate, 10-20 parts of stabilizer, 5-10 parts of cross-linking agent, 20-30 parts of citrate, 2-5 parts of polyol, and 0-5 parts of toner; wherein the stabilizer is a composition of glycerol, cellulose and casein; the cross-linking agent is N, N'-methylenebisacrylamide; the colored mud of the present invention does not add a cross-linking agent harmful to the human body, and the raw materials selected are all environmentally friendly and harmless to the human body. The colored mud of the present invention has good tensile properties, excellent stability, and improved playability. The environmentally friendly and stable colored mud is suitable as a children's toy.

The use of electrolytes, particularly sodium and potassium ions, in combination with caffeine, taurine, and a small amount of "counter-alcohol," can mitigate the negative effects of alcohol consumption and significantly and sustainably improve the general well-being of those affected the following day. Accordingly, the invention proposes a preparation containing the electrolytes sodium and potassium cations, preferably with chloride and citrate as counterions, caffeine, taurine, and a small amount of alcohol. The preparation can be taken as a tablet or powder in combination with a small amount of alcohol, e.g., in the form of diluted ethanol, a little beer, or a commercially available spirit or liqueur; however, administration as an aqueous solution is preferred, as the additional intake of plenty of water enhances the effect.

The present invention discloses a chemical mechanical polishing liquid and a chemical mechanical polishing method for a cobalt interconnected barrier layer titanium. The chemical mechanical polishing liquid comprises 1-10 wt.% of an abrasive, 0.5-5 wt.% of an oxidant, 10-150 mmol / L of a complexing agent, a pH regulator, and the remainder of water, wherein the complexing agent is citric acid or a citrate. The chemical mechanical polishing liquid of the present invention selects suitable oxidant, complexing agent types and concentration ratios, and under the synergistic effect of the chemical reaction of the chemical substances in the polishing liquid and the mechanical wear of the abrasive particles, improves the material removal rate of the metallic titanium, and obtains a high-quality smooth surface. The polishing liquid has broad application prospects in the CMP process of the cobalt interconnected barrier layer titanium.

The invention relates to the technical field of food fermentation, and discloses umami peptidyl low-salt thick broad-bean sauce and a production process thereof, the production process of the umami peptidyl low-salt thick broad-bean sauce comprises the following steps: preparing anhydrous betaine, zinc salt and citrate into a thermal saturation solvation embedded zinc source precursor; dispersing in saline water to prepare fermentation liquor; and inoculating finished koji and carrying out variable-temperature fermentation. Fermentation is divided into three stages: in a starting stage, temperature is controlled to establish a bacterial system; in the enzymolysis period, the temperature is increased, zinc ions are triggered to be released by utilizing pH reduction caused by acid production, and neutral protease is activated; and supplementing anhydrous betaine in the after-ripening stage to reduce the water activity and construct an anti-corrosion fence. The enzymolysis efficiency is improved through controlled release of zinc ions, and low-salt corrosion prevention is achieved through betaine. The salt content of the obtained product is less than or equal to 8.0 g / 100g, the amino acid nitrogen content is more than or equal to 0.8 g / 100g, and the product is rich in delicate flavor and stable in normal-temperature storage.

The method comprises the following steps: putting a preheated citrate-sodium hydroxide buffer solution into a test bottle filled with a sample, putting the test bottle into a constant-temperature water bath kettle, carrying out closed heat preservation, opening the test bottle, carrying out suction filtration, and collecting the filtrate; adding a sodium hydrosulfite aqueous solution into the test bottles, oscillating, uniformly mixing, preserving heat for a period of time, taking out the test bottle rack, quickly cooling to room temperature, sequentially adding a sodium hydroxide aqueous solution, sodium chloride and an internal standard solution into the test bottles, sealing the test bottles, overturning the test bottle rack by 90 degrees, and enabling the test bottles in the test bottle rack to be in a horizontal state; after the test bottle is shaken for a period of time at a certain amplitude and vibration frequency, the test bottle rack is reset to an initial vertical state, and supernatant liquid in the test bottle is taken for determination after two phases are completely separated. According to the invention, the composition of the detection equipment is improved, and the integrated automatic rapid extraction device is adopted to realize rapid and efficient extraction of banned azo dyes.

The application belongs to the technical field of fertilizers, and particularly relates to a medium-element liquid fertilizer and a preparation method thereof. The medium-element liquid fertilizer comprises 52.5wt%-53.5wt% calcium nitrate tetrahydrate, 4.44wt%-4.56wt% medium-element nitrate, 0.09wt%-0.11wt% manganese nitrate solution with a concentration of 50wt%, 5.95wt%-6.05wt% first chelating agent, 1.45wt%-1.55wt% second chelating agent, 0.39wt%-0.41wt% compound amino acid, 0.49wt%-0.51wt% boric acid, 0.39wt%-0.41wt% first active substance, 0.29wt%-0.31wt% second active substance, 0.29wt%-0.31wt% alginic acid, and the balance of water. The mass ratio of the first active substance to the second active substance is 4:3. The first active substance is diethylaminoethanol succinate citrate, and the second active substance is fatty alcohol citric acid monoester dipotassium salt. The preparation method adopts a sugar alcohol and citric acid monohydrate mild room temperature double-chelating process, so that the fertilizer has both quick-acting and sustained-acting properties. The medium-low temperature chelating process has high chelating degree and good fertilizer mixing property.

In the ferric iron citrate monohydrate defined by the chemical formula FeC6H6O7 H2O (ferrous citrate monohydrate or ferric iron citrate monohydrate) obtained according to a specific production method, the citric acid and the elemental iron are combined in a molecular complex in which the iron is gathered in the citrate moving into a ring-like form and the iron is bound to the O groups of the carboxyls 1 and 3 through ionic bonds, forming two enantiomers D and L (R and S), both of which are completely water-soluble and highly absorbable by the human body. Formula (L) and Formula (D). With a different absorption mechanism than traditional iron molecules, said ferric iron citrate monohydrate can be used in pharmaceutical compositions and / or nutritional compositions and / or food compositions, in particular for the treatment and prevention of iron deficiency anemia and all diseases and conditions associated with iron deficiency. The effectiveness is demonstrated through several examples.

The invention relates to a polymer film obtainable from the crosslinking reaction between pectin and carboxymethylcellulose in the presence of an organic calcium salt and a plasticiser. The film can comprise zeolite, loaded or not loaded with silver ions. The organic calcium salt is selected from: calcium propionate, calcium acetate, calcium lactate, calcium sorbate, calcium glutamate, calcium oleate, calcium palmitate, calcium laurate, calcium stearate and calcium myristate. The plasticising agent is a saturated or unsaturated fatty acid selected from: oleic acid and palmitic, stearic, lauric, myristic, myristoleic, palmitoleic and linoleic acid; polyethylene glycol; glycerol; glycerol derivatives; and citric acid salts, preferably sodium citrate. The polymer film can be laminated to at least one film / layer of plastic material, possibly biodegradable, or to a layer of paper and used for packaging foods, in particular baked products, with the aim of preserving them and extending their shelf life.

Provided are a salt and / or a crystal form of a compound degrading BTK and preparation and application thereof. The pharmaceutically acceptable salt and crystal form of the compound as shown in formula (I), wherein the pharmaceutically acceptable salt is selected from a maleate salt, a fumarate salt, a hydrogen halide salt (preferably a hydrobromide salt and a hydrochloride salt), a sulfate salt, a phosphate salt, an L-tartrate salt, a citrate salt, an L-malate salt, a hippurate salt, a D-glucuronate salt, a glycolate salt, a mucate salt, a succinate salt, a lactate salt, an orotate salt, a pamoate salt, a glycine salt, an alanine salt, an arginine salt, a cinnamate salt, a benzoate salt, a benzene sulfonate salt, a p-toluene sulfonate salt, an acetate salt, a propionate salt, a valerate salt, a triphenylacetic acid salt, an L-proline salt, a ferulic acid salt, a 2-hydroxyethanesulfonate salt, a mandelate salt, a nitrate salt, a methanesulfonate salt, a malonate salt, a gentisate salt, a salicylate salt, an oxalate salt or a glutarate salt:

The invention relates to a dishwasher-cleaning composition comprising between 10 wt.% and 35 wt.% of a mixture comprising a tribasic acid or salt thereof, preferably citric acid or a citric acid salt, and an acid or an acid salt; wherein said acid or acid salt comprises a total of 1 to 3 atoms selected from C, S or a combination thereof and at least 1 acidic proton. The invention further relates to a product comprising a container comprising a dispensing means, wherein the container comprises such a dishwasher cleaning composition.

The aqueous oral care composition comprises calcium, fluoride, citrate, and water. The composition comprises at least 2 moles of citrate for every 3 moles of calcium, and at least 1 mole of fluoride for every mole of calcium. The water is present in the composition in an amount of at least 50% by weight, based on the total weight of the composition. The composition is a solution.