139results about How to "Eliminate infection" patented technology

A flexible patch is provided that is capable of emitting light in the UV, visible, and / or infrared electromagnetic spectrums. The patch contains a feedback process and system using one or more sensors and a controller on the patch to (1) accelerate the wound healing process by providing adaptable, controlled light exposure and electrical stimulation, (2) monitor the healing process for signs of infection (3) eliminate bacterial infections by sanitizing the infected site and (4) relaying the information wirelessly to a central location for storage and interpretation by a physician as well as by providing the ability to receive feedback and operating instructions from the physician from a remote location.

The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.

The invention describes compositions and methods for inhibiting microbial infections associated with the use of sanitary products, such as diapers, bandages, sanitary napkins, tampons and the like. The invention comprises providing for use a sanitary product containing an effective amount of a viable non-pathogenic lactic-acid bacteria, such as Bacillus coagulans, or an extracellular product thereof, useful for inhibiting growth of parasites and pathogens on the epithelial tissue in contact with the sanitary product during use of the product. The invention also provides for enhancing biodegradation of sanitary products after use and disposal. Also described are methods using the product and systems containing the compositions.

A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin. Based on the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and / or inflammatory response, and subsequently treat diseases and / or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis, osteoporosis and Alzheimer's disease.

Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.

The invention relates to nanoliposome human papillomavirus (HPV) resistant and gynecological inflammation pathogen resistant specific complex IgY and a combined preparation for the same. Laying poultry is preferred to respectively prepare laying poultry for immunity of tumor somatic cells, viral protein complex antigens, gene recombination protein antigens and bacterial virus complex antigens; and human papillomavirus resistant special IgY and gynecological inflammation pathogen resistant specific IgY undergo affinity chromatography and purification and are converted into nanoliposomes, and then the nanoliposome special complex IgY is prepared. The nanoliposome human papillomavirus (HPV) resistant and gynecological inflammation pathogen resistant specific complex IgY and the combined preparation for the same have the advantages that: the nanoliposome technology is applied to increase the infiltration capacity and the prolongation effect and improve the curative effect. The nanoliposome human papillomavirus (HPV) resistant and gynecological inflammation pathogen resistant specific complex IgY and the combined preparation for the same can be prepared into various vaginal spraying agents, other spraying agents, lotion, gel, capsules, suppository, vaginal membranes, tablets, effervescent tablets, ointment, cream and so on. The nanoliposome complex IgY can infiltrate into a vagina mucosa to effectively remove HPV viruses and gynecological inflammation pathogens which are absorbed on the vaginal surface layer and in the vagina mucosa, is absorbed through the vagina mucosa and enters into the body to give play to the functions of prevention and treatment, and also can effectively prevent recrudescence.

Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are activated in vitro with pokeweed mitogen and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.

The invention relates to an external-use Chinese medicine tincture for treating psoriasis. The Chinese medicine tincture is prepared by soaking cleaned rumex japonicus, golden-rod, plumbagella micrantha, cortex pseudolaricis, radix stemonae, cortex dictamni, radix sophorae flavescentis, golden cypress, coptis chinensis, Scutellaria baicalensis, fructus cnidii, belvedere fruit, fructus psoraleae, chaulmoogratree seed, clove and stemona japonica into 2,500g of 95% medicinal alcohol based on weight part, sealing in a jar, soaking for half to one mount, subsequently removing the medicine dregs to obtain a medicine liquid, mixing the medicine liquid with with borneol, benzoic acid and salicylic acid, and uniformly stirring. The Chinese medicine tincture can rapidly killing intractable fungi and viruses and eliminating skin infection, is applicable to treatment on various psoriasis, and also applicable to treatment on neurodermatitis, tinea cruris, tinea pedis, tinea manuum and tinea unguium. The Chinese medicine tincture is an external medicine, is convenient to use, rich in medicine resource, simple in preparation method, low in cost, free of blackspot after recovery after administration, harmless to human bodies, painless and free of toxic and side effect.

The invention discloses a non-invasive arrhythmia treatment system, which comprises an imaging device, a processing device and a gathered energy transmission device. The imaging device is used for imaging an object to be treated to construct three-dimensional heart and body models of the object to be treated. The processing device comprises a body surface electric signal acquisition module, an electric activity computation module and an arrhythmia determination module. The body surface electric signal acquisition module is used for acquiring body surface electric signals detected by a plurality of electrodes which are placed at a plurality of positions on a body surface. The electric activity computation module is used for computing electric activities in the internal three-dimensional space of the heart through an inverse problem based on the acquired body surface electric signals and the three-dimensional heart and body models. The arrhythmia determination module is used for determining at least one origin position of arrhythmia at least based on the electric activities in the internal three-dimensional space of the heart obtained through computation. The gathered energy transmission device is used for transmitting gathered energy to the determined origin position to ablate cardiac muscle tissues at the origin position.

An intraosseous fixation implant and a preparation method therefor. In the intraosseous fixation implant, a biodegradable polymer material is used as a substrate, a drug coating is loaded on the surface of the substrate, the drug coating has a double-layer structure, the first layer close to the substrate is a slow-release drug layer, and the second layer on the outer side of the first layer is a quick-release hydrophilic layer. The intraosseous fixation implant has triple functions of being antibacterial, absorbable and fixable.

A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, viniferin, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin. Based on the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and / or inflammatory response, and subsequently treat diseases and / or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis, osteoporosis and Alzheimer's disease.

The invention belongs to the field of food processing and discloses a pinenut oil pinolenic acid microcapsule and a preparation method of the microcapsule. The pinenut oil pinolenic acid microcapsule has a weight reduction function and can reduce cholesterol (TC) and triglyceride (TG) and increase high density lipoprotein (HDL). The preparation method comprises the following preparation steps of: extracting pinolenic acid, preparing a core material solution, preparing a wall material solution, and encapsulating a microcapsule. By adopting the preparation method disclosed by the invention, the extraction rate of the pinolenic acid from pinenut oil is more than 70%, the pinenut oil pinolenic acid which is easily oxidized is microencapsulated to effectively prolong the quality guarantee period, and the encapsulation rate is more than 85%.

The invention discloses a pure traditional Chinese medicine preparation for treating dilated cardiomyopathy, which is prepared from astragali, radix salviae miltiorrhizae, red peony root, root-bark of peony, radix rehmanniae and the like as raw materials by steps of decocting twice, decocting filtrate, concentrating, granulating and packing in composite membrane bags. Shown by pharmacodynamic experiments of animals and clinical statistical results of patients, the pure traditional Chinese medicine preparation for treating dilated cardiomyopathy has the efficacies of supplementing qi, activating blood circulation, detoxifying and tranquilizing mind, and can eliminate the symptoms of chest distress, short breath, palpitation, edema, vexation, dark red tongue, yellow fur of tongue, thready rapid pulse, intermittent pulse and the like caused by deficiency of qi, blood stasis, toxic heat and heart disturbance due to dilated cardiomyopathy. The pure traditional Chinese medicine preparation can effectively resist myocardial fibrosis, improves the anoxia tolerance ability of myocardial cells and can be safely taken for a long time without toxic or side effect, the total effective rate in treating the dilated cardiomyopathy is 96.6%, and the curative effect is obviously better than that of conventional simple treatment of Western medicine.

Focused infrared light at wavelengths selected to target tissue below the skin may be used in a non-invasive procedure for vasectomies, varicose veins, hemorrhoids, or fungal nail infections. Infrared light from various sources selected for a particular application may be focused so that the cone of light has lower intensity on the skin / outer tissue and higher intensity at a desired depth to cause thermal coagulation or occlusion of the target tissue beneath the skin. Surface cooling techniques, such as cryogenic sprays or contact cooling may be used to protect the skin. More generally, the focused infrared light with or without surface cooling may be used in applications for thermally coagulating or occluding relatively shallow vessels while protecting or minimizing damage to outer layers of the tissue or skin.

Disclosed is a formulation and method for the treatment of fungal infections of the nail (onychomycosis) utilizing a topical composition comprising zinc pyrithione, a solubilizer for the zinc pyrithione, a film former, and a volatile solvent. The formulation is preferably in the form of a lacquer. The composition containing the metal pyrithione complex is topically applied to the infected nail preferably as a nail polish or lacquer which may be applied with a dropper, swab or the like to the afflicted nail surface. The treatment can be done at least two times a day, with a course of treatment lasting from several weeks to several months or until a cure is effected or a significant reduction of the infection is achieved.

A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin. Based on the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and / or inflammatory response, and subsequently treat diseases and / or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis, osteoporosis and Alzheimer's disease.

The invention relates to external traditional Chinese medicine liquor for treating psoriasis. The external traditional Chinese medicine liquor comprises the following components: solidago decurrens, cortex pseudolaricis, the tuber of stemona, cortex dictamni, radix sophorae flavescentis, golden cypress, coptis chinensis, scutellaria baicalensis, fructus cnidii, fructus kochiae, divaricate saposhnikovia root, radix bupleuri, clove, radix stemonae, borneol and 75 percent of medicinal alcohol. The traditional Chinese medicine liquor can rapidly kill stubborn fungi and bacteria, eliminate skin infection, is applied to treating psoriasis of various types as well as neurodermatitis, tinea cruris, athlete's foot, fungal infection of the hand and ringworm of the nails, is wide in drug source, low in cost, simple in preparation method, convenient to use, is harmless to the human body, does not cause pain and does not have any toxic or side effect, and no scar is left after medication healing.

An intraoral surgical prop is manufactured entirely from two different Shore A hardness variants of the same high performance biocompatible sterilisable thermoplastic elastomer. It comprises an outer anatomically shaped compressible surgical prop body component (1) and an inner integrally-moulded, permanently attached, flexible and extensible tether and tether grip component (2, 3) with a thumb grip indentation (4) moulded such that it retains a permanently curved profile.

An assembly structured to secure a catheter, such as an IV tube to a predetermined portion of a patient's body such that the IV tube is anchored adjacent an entry site. A base is structured and configured to engage the predetermined body portion and includes an opening for exposure of and access to the entry site. A support member is selectively positionable at variable locations relative to the opening in adjacent relation to the entry site such that the IV tube is mounted on an exterior or exposed portion of the support member so as to access the entry site through the opening and eliminate any type of adhesive strip or like connector contacting or being secured to the patient's skin.

The invention discloses an agrobacterium-mediated spirodela polyrhiza stable transformation system establishment method, which comprises the following steps: A, inducing calli of spirodela polyrhiza; B, connecting a target gene with a T vector; C, connecting the target gene with a plant expression vector; D, transforming the plant expression vector in agrobacterium tumefaciens LBA4404; E, preparing an infective bacteria solution; F, co-culturing the calli and the agrobacterium tumefaciens; G, performing regeneration and selective culturing: determining that the target gene is successfully integrated into a genome of the spirodela polyrhiza if a GUS (glucuronidase) staining result of thalli is blue, and determining that a part which is stained to be blue by thallus tissues is a part expressed by the target gene. The target gene is inserted into the plant expression vector and then transferred into the agrobacterium tumefaciens LBA4404 for callus infection, and the concentration of antibiotics is finally controlled to screen a positive plant to obtain transgenetic spirodela polyrhiza, and an established transformation system can still ensure continuous and stable inheritance after asexual reproduction of the spirodela polyrhiza, and has bio-safety and development and application value.

The invention discloses a typing method of resistance for resisting a subgroup A avian leukosis virus by quality chickens, which adopts an SNP locus at the 619th site of a TVA gene sequence as a research object; PCR-RLFP analysis is performed to detect whether mutation occurs at the SNP locus, and also to detect whether 4 bases are inserted into SNP loci at the 305th-308th sites of the TVA gene sequence; the two detection results are combined together to determine whether the detected chicken is a genetic resistance type or a genetic susceptibility type. The resistance typing method of the invention performs detection from the source, and omits troubles of later-stage detection; the detection method is rapid, accurate, strong in purposiveness, and simple in operation, has practice significance, and can realize rapid selection of chicken genetic characters and improvement of disease resistance of strains.

Provided are bioerodible compositions that can be implanted into cavities of mammalian tissue as a liquid or semi-liquid and which solidify upon exposure to body temperature of the mammal. The implants erode over a prescribed period of time and elute a drug. The implants also form a seal with the skin or mucosa surrounding the cavity to prevent the entry of bacterial pathogens.

The invention relates to an artificial joint prosthesis with an anti-infection function, the artificial joint prosthesis is prepared by the following method: (1) surface treatment of the artificial joint prosthesis: polishing the surface of the artificial joint prosthesis to be smooth, then performing ultrasonic cleaning with acetone, ethanol and deionized water, and drying for later use; (2) implanting or depositing silver ions on the surface of the artificial joint prosthesis: depositing the silver ions on the surface of the artificial joint in a magnetron sputtering manner; (3) deposition of a polydopamine coating: firstly preparing a Tris-HCl buffer solution, adding a dopamine hydrochloride solution into the Tris-HCl buffer solution to complete preparation of a dopamine solution, putting the artificial joint prosthesis containing the silver film layer into the dopamine solution, carrying out a reaction in a dark place, and depositing the polydopamine coating on the surface of the artificial joint containing silver ions; and a photothermal effect is generated through irradiation of a 808nm near-infrared light source, so that silver ions generated through in-vivo release and local high temperature generated by near-infrared light have an excellent synergistic sterilization effect, infection can be reduced, and the anti-infection capability of the artificial joint can be enhanced.

The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

An antibacterial lotion for treating tinea manuum, tinea pedis, sweat foot, smelly foot, and rhagas of hand or foot is prepared from 7 Chinese-medicinal materials including forsythia fruit, ledebouriella root, flavescent sophora root, senecio, etc through crushing, immersing in aged vinegar for 5-15 days, and filtering.

The invention discloses a field bionic hatching method of fertilized salmon eggs and belongs to the technical field of salmon breeding. A hatcher comprises a first side plate, a second side plate and nylon bolts. The first side plate and the second side plate can be symmetrically fastened to each other and are provided with nylon bolt plug holes which are symmetric; after symmetric fastening, the first side plate and the second side plate are fixed through nylon bolt plugs; the first side plate and the second side plate are both evenly provided with egg carrier cells in diamond shapes; the egg carrier cells of the first and second side plates are symmetrically fastened; the center of each egg carrier cell of the first side plate is provided with an escape hole; one corner of each egg carrier cell, on the same side, of the second side plate is provided with another escape hole. The hatcher can sink well in water, has stable shape and structure, allows smooth passage of water and allows water flow to be evenly distributed; the hatcher has the advantages that the size is small, materials are easy to obtain and assembly is simple; egg survival rate is up to greater than 70%.

The invention provides a segmented copolymer nano-composite antibacterial material and a preparation method and application thereof. By the utilization of a coupling agent having 2 isocyanates with different activities, 3-hydroxybutanoic acid and 3-hydroxyvalerate copolyester (PHBV) are synthesized with polyethylene glycol (PEG) to obtain a PEG-PHBV-PEG amphiphilic triblock copolymer, which is used as a base material to be self-assembled with a nano-antibacterial agent to obtain the segmented copolymer nano-composite antibacterial material. Controllable synthesis and regulation of antibacterial properties of the segmented copolymer are realized by the method. Number-average molecular weight of the obtained segmented copolymer is between 0.35-13 thousand, and molecular weight distribution is relatively narrow. The segmented copolymer nano-composite antibacterial material has antibacterial and antimicrobial dual functions. Antibacterial effect and bactericidal effect are remarkably raised. A micelle coated nano-antibacterial agent is dispersed uniformly, is stable in a water phase, has good cytocompatibility and has a wide application prospect.