Artificial joint prosthesis with anti-infection function
An artificial joint and anti-infection technology, applied in the direction of prosthesis, metal material coating process, ion implantation plating, etc., to achieve the effect of increasing sensitivity, effective antibacterial effect, and inhibiting the growth of bacteria
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Embodiment 1
[0029] An artificial joint prosthesis with anti-infection function is prepared by the following method:
[0030] (1) Artificial joint surface treatment: The surface of the artificial joint made of Ti-6Al-4V alloy material was polished smooth, ultrasonically cleaned with acetone, ethanol and deionized water, and then dried for use;
[0031] (2) Implantation or deposition of silver ions on the surface of artificial joints: use magnetron sputtering (the specific parameter of magnetron sputtering is vacuum degree 6.6×10-6 Pa, deposit silver ions on the surface of artificial joints, and the deposition thickness is 0.5 μm .
[0032] (3) Deposit a polydopamine coating on the silver-containing film layer: prepare a 10 mM Tris-HCl buffer solution with a pH of 8.5, and add 2 mg / mL dopamine hydrochloride solution to it to complete the preparation of the dopamine solution. The artificial joint was placed in the dopamine solution for 12 h, and the reaction was protected from light, and th...
Embodiment 2
[0035] Example 2 Contrast experiment of anti-fibroblast proliferation
[0036] The present invention respectively carries out the experiments of fibroblast culture on titanium alloy sheets coated with silver ions and polydopamine film layer, magnetron sputtering silver ion titanium alloy sheets, titanium alloy sheets and normal culture dishes, and the detected OD values and different surface The results of the relative proliferation rate of fibroblasts are as follows:
[0037] 1. The detection of the OD value of fibroblast cultured for 24 hours, the specific experimental results are shown in Table 1:
[0038] Table 1 OD value of fibroblasts cultured for 24 hours
[0039] Titanium alloy sheet covered with silver ion and polydopamine film layer Magnetron sputtering silver ion titanium alloy sheet Titanium alloy sheet normal cell group OD value 2.021±0.011 2.314±0.018 2.891±0.088 3.037±0.482
[0040] 2. For the relative proliferation rate of fib...
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