Artificial joint prosthesis with anti-infection function

An artificial joint and anti-infection technology, applied in the direction of prosthesis, metal material coating process, ion implantation plating, etc., to achieve the effect of increasing sensitivity, effective antibacterial effect, and inhibiting the growth of bacteria

Active Publication Date: 2021-07-13
常熟中科世纪生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Purpose of the invention: Aiming at the above-mentioned deficiencies existing in the existing artificial joint prosthesis, the purpose of the present invention is to provide an artificial joint prosthesis with anti-infection function, A silver / polydopamine-modified artificial joint, the surface of the artificial joint contains silver ions, the silver ions are physically injected or deposited on the surface of the artificial joint, and polydopamine is deposited on the surface of the artificial joint containing silver ions coating

Method used

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Experimental program
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Effect test

Embodiment 1

[0029] An artificial joint prosthesis with anti-infection function is prepared by the following method:

[0030] (1) Artificial joint surface treatment: The surface of the artificial joint made of Ti-6Al-4V alloy material was polished smooth, ultrasonically cleaned with acetone, ethanol and deionized water, and then dried for use;

[0031] (2) Implantation or deposition of silver ions on the surface of artificial joints: use magnetron sputtering (the specific parameter of magnetron sputtering is vacuum degree 6.6×10-6 Pa, deposit silver ions on the surface of artificial joints, and the deposition thickness is 0.5 μm .

[0032] (3) Deposit a polydopamine coating on the silver-containing film layer: prepare a 10 mM Tris-HCl buffer solution with a pH of 8.5, and add 2 mg / mL dopamine hydrochloride solution to it to complete the preparation of the dopamine solution. The artificial joint was placed in the dopamine solution for 12 h, and the reaction was protected from light, and th...

Embodiment 2

[0035] Example 2 Contrast experiment of anti-fibroblast proliferation

[0036] The present invention respectively carries out the experiments of fibroblast culture on titanium alloy sheets coated with silver ions and polydopamine film layer, magnetron sputtering silver ion titanium alloy sheets, titanium alloy sheets and normal culture dishes, and the detected OD values ​​and different surface The results of the relative proliferation rate of fibroblasts are as follows:

[0037] 1. The detection of the OD value of fibroblast cultured for 24 hours, the specific experimental results are shown in Table 1:

[0038] Table 1 OD value of fibroblasts cultured for 24 hours

[0039] Titanium alloy sheet covered with silver ion and polydopamine film layer Magnetron sputtering silver ion titanium alloy sheet Titanium alloy sheet normal cell group OD value 2.021±0.011 2.314±0.018 2.891±0.088 3.037±0.482

[0040] 2. For the relative proliferation rate of fib...

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Abstract

The invention relates to an artificial joint prosthesis with an anti-infection function, the artificial joint prosthesis is prepared by the following method: (1) surface treatment of the artificial joint prosthesis: polishing the surface of the artificial joint prosthesis to be smooth, then performing ultrasonic cleaning with acetone, ethanol and deionized water, and drying for later use; (2) implanting or depositing silver ions on the surface of the artificial joint prosthesis: depositing the silver ions on the surface of the artificial joint in a magnetron sputtering manner; (3) deposition of a polydopamine coating: firstly preparing a Tris-HCl buffer solution, adding a dopamine hydrochloride solution into the Tris-HCl buffer solution to complete preparation of a dopamine solution, putting the artificial joint prosthesis containing the silver film layer into the dopamine solution, carrying out a reaction in a dark place, and depositing the polydopamine coating on the surface of the artificial joint containing silver ions; and a photothermal effect is generated through irradiation of a 808nm near-infrared light source, so that silver ions generated through in-vivo release and local high temperature generated by near-infrared light have an excellent synergistic sterilization effect, infection can be reduced, and the anti-infection capability of the artificial joint can be enhanced.

Description

technical field [0001] The invention relates to an artificial joint prosthesis with anti-infection function, which belongs to the technical field of anti-infection on the surface of medical instruments. Specifically, it relates to an artificial joint prosthesis through light-controlled antibacterial, which can reduce the occurrence of infection and can quickly and efficiently remove biofilm after infection occurs. Background technique [0002] With the aging of the world's population, more and more people who participate in strenuous exercise that cause bone tissue damage, and people's higher requirements for quality of life, the demand for orthopedic implants is increasing year by year. However, after the artificial joint is implanted into the human body, implantation failure often occurs, and the occurrence of infection is a very important reason for the failure. Periprosthetic infection is a serious complication of artificial joint implantation surgery, which can lead to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/06A61L27/50A61L27/54A61L2/08C23C14/35C23C14/16
CPCA61L27/306A61L27/34A61L27/06A61L27/50A61L27/54A61L2/0058C23C14/35C23C14/165A61L2430/24A61L2400/18A61L2420/02A61L2420/08A61L2300/104A61L2300/204A61L2300/404A61L2300/602A61L2300/608A61L2202/21C08L79/02
Inventor 曹永平夏丹丹杨威陈力建
Owner 常熟中科世纪生物科技有限公司
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