The invention discloses a weight-loss formula and a method capable of healthily clearing a body and decomposing fat. The weight-loss formula comprises a body clearing period, a slimming period and a metabolism adjustment period sequentially; each period comprises adjustment of a reasonable dietary structure, supplement of sufficient high-quality vitamin and mineral substances, and guarantee of daily exercise amount and water intake. The invention provides a weight-loss method capable of healthily clearing the body. Through the reasonable dietary structure, the supplement of sufficient vitamin and mineral substances, and the guarantee of daily exercise amount and water intake, the human weight is reduced. According to the method, a hunger gene of a human body is not stimulated, a new slim memory system of the body is established, and a well-managed weight and living habit is formed. The formula and the method has the characteristics of no dieting, no strenuous exercise and no bounce, can be beneficial to effectively improving blood pressure, blood fat and other symptoms while losing weight, and truly realize scientific, safe, healthy and effective weight loss.